| Co-Investigator(Kenkyū-buntansha) |
YAMADA Takechiyo University of Fukui Hospital, Senior Assistant Professor, 医学部附属病院, 講師 (70283182)
TSUZUKI Hideaki University of Fukui Hospital, Senior Assistant Professor, 医学部附属病院, 講師 (90236927)
山本 健人 福井大学, 医学部附属病院, 助手 (80303379)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2005: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Research Abstract |
The Id proteins act to inhibit the basic helix-loop-helix proteins that play an important role as transcriptional factors in cellular development, proliferation, and differentiation. In several cancers, overexpression of Id proteins has been reported, indicating an association between the function of Id proteins and carcinogenesis. We investigated the expression of Id1-Id4 proteins in normal epithelia, hyperplasias, dysplasias and squamous cell carcinomas (SCCs) derived from oral and oropharynx tissues. All Id proteins were detected increasingly from normal epithelia to SCCs, and expressed at high levels in SCCs as compared with other epithelia, suggesting an association between the overexpression of Id proteins and the carcinogenesis of oral and oropharyngeal SCC. Among four kinds of Id proteins, the expression of Id2 protein in SCC cases was significantly correlated with large tumor size, high recurrence rate and frequent cancer death. The patients with SCCs expressing Id2 protein had significantly lower survival for 5 years and a lower disease-free interval as compared with patients with SCCs not expressing Id2 protein. There were no associations between the expressions of other Id proteins and clinical factors. Among seven factors including sex, tumor size, metastasis of cervical lymph nodes, and expressions of Id1-Id4 proteins, the expressions of Id2 protein was a second independent risk factor in multivariate analysis using Cox's proportional hazard model, following the presence of cervical lymph nodes metastasis. The inhibition of Id2 protein expression may prevent carcinogenesis in oral and oropharynx tissues, and may be an available therapeutic strategy for oral and oropharyngeal SCC.
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