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The Expression of Id2 Protein is Associated with Oral and Oropharyngeal Squamous Cell Carcinoma Prognosis.

Research Project

Project/Area Number 17591781
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionUniversity of Fukui

Principal Investigator

YAMAMOTO Takehito (2006)  University of Fukui Hospital, Assistant Professor, 医学部附属病院, 助手 (80303379)

都築 秀明 (2005)  福井大学, 医学部附属病院, 講師 (90236927)

Co-Investigator(Kenkyū-buntansha) YAMADA Takechiyo  University of Fukui Hospital, Senior Assistant Professor, 医学部附属病院, 講師 (70283182)
TSUZUKI Hideaki  University of Fukui Hospital, Senior Assistant Professor, 医学部附属病院, 講師 (90236927)
山本 健人  福井大学, 医学部附属病院, 助手 (80303379)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2005: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsId / head and neck cancer / anti-cancer drug / radiation
Research Abstract

The Id proteins act to inhibit the basic helix-loop-helix proteins that play an important role as transcriptional factors in cellular development, proliferation, and differentiation. In several cancers, overexpression of Id proteins has been reported, indicating an association between the function of Id proteins and carcinogenesis. We investigated the expression of Id1-Id4 proteins in normal epithelia, hyperplasias, dysplasias and squamous cell carcinomas (SCCs) derived from oral and oropharynx tissues. All Id proteins were detected increasingly from normal epithelia to SCCs, and expressed at high levels in SCCs as compared with other epithelia, suggesting an association between the overexpression of Id proteins and the carcinogenesis of oral and oropharyngeal SCC. Among four kinds of Id proteins, the expression of Id2 protein in SCC cases was significantly correlated with large tumor size, high recurrence rate and frequent cancer death. The patients with SCCs expressing Id2 protein had significantly lower survival for 5 years and a lower disease-free interval as compared with patients with SCCs not expressing Id2 protein. There were no associations between the expressions of other Id proteins and clinical factors. Among seven factors including sex, tumor size, metastasis of cervical lymph nodes, and expressions of Id1-Id4 proteins, the expressions of Id2 protein was a second independent risk factor in multivariate analysis using Cox's proportional hazard model, following the presence of cervical lymph nodes metastasis. The inhibition of Id2 protein expression may prevent carcinogenesis in oral and oropharynx tissues, and may be an available therapeutic strategy for oral and oropharyngeal SCC.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (4 results)

All 2006 2005

All Journal Article (4 results)

  • [Journal Article] Oral and oropharyngeal squamous cell carcinoma expressing CCR7 have poor prognosis2006

    • Author(s)
      Hideaki Tsuzuki
    • Journal Title

      Auris Nasus Larynx 33 (1)

      Pages: 37-42

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Oral and oropharyngeal squamous cell carcinoma expressing CCR7 have poor prognosis2006

    • Author(s)
      Hideaki Tsuzuki
    • Journal Title

      Auris Nasus Larynx 33(1)

      Pages: 37-42

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Oral and oropharyngeal squamous cell carcinomas expressing CCR7 have poor prognoses.2006

    • Author(s)
      Hideaki Tsuzuki
    • Journal Title

      Auris Nasus Larynx 33(1)

      Pages: 37-42

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Reliability of platelet-derived endothelial cell growth factor as a prognostic factor for oral and oropharyngeal carcinomas.2005

    • Author(s)
      Hideaki Tsuzuki
    • Journal Title

      Arch Otolaryngol Head Neck Surg 131(12)

      Pages: 1071-1078

    • Related Report
      2005 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2016-04-21  

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