Localization of ASICs in the sensory nervous system in the head and neck under chronic hypoxia.
| Project/Area Number |
17591795
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Yokohama City University |
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Principal Investigator |
MATSUDA Hideki Yokohama City University, School of Medicine, Associate Professor, 医学部, 準教授 (80305458)
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| Co-Investigator(Kenkyū-buntansha) |
KUSAKABE Tatsumi Kokushikan University, Department of Sports and Medical Science, Professor, 体育学部, 教授 (80117663)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2006: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2005: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | Chronic hypoxia / Carotid body / Neuropeptide / ASICs / Immunohistochemistry / Taste bud / Sensory nervous system / Calcium binding proteins / in situ hybridization |
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| Research Abstract |
1. Effect of carbon dioxide on the structure of the carotid body.
The carotid bodies of the systemic hypoxic rats were found to be enlarged, and the mean diameter of the hypercapnic hypoxic carotid bodies were smaller than the hypocapnic and isocapnic hypoxic carotid bodies. The morphological changes in the hypoxic carotid bodies may depend on the arterial CO2 tension. (Histol Hitopathol.20:987.997, 2005, Adv.Exp.Med.Biol.580:55-61, 2006).
2. Morphological changes in the carotid body in acclimatization and deacclimatization to hypoxia.
The mean diameter of the carptid bodies exposed to hypoxia for 2, 4, and 8 weeks was 1.2, 1.4, and 1.6 times longer than in normoxic controls. The carotid bodies 1 week after the termination of chronic hypoxia were diminished in size. The carotid bodies 8 weeks after the termination of hypoxia were similar to the normoxic controls in size. (Histol.Histopathol.20:987-997, 2005, Adv.Exp.Med.Biol.580:49-54, 2006).
3. Chronic hypoxia alters calbindin D-28k immunoreactivity in the taste buds.
Calbindin D-28k immunoreactivity in the lingual taste buds was decreased under chronic hypoxia. In the laryngeal taste buds calbindin D-28k immumoreactive fibers in hypoxic rats were more than in normoxic rats. (Histol.Histopathol.21:1271-1276, 2006.
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Report
(3 results)
Research Products
(9 results)
