Development of new glaucoma drugs wing experimental glaucoma models and clinical study on pertinence of modem glaucoma management

• Project/Area Number: 17591828
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Gifu University
• Principal Investigator: YAMAMOTO Tetsuya Gifu University, Graduate School of Medicine, Professor (50134581)
• Co-Investigator(Kenkyū-buntansha): KAWASE Kazuhide Gifu University, Graduate School of Medicine, Associate professor (40234067) ; AOYAMA Yumiko Gifu University, Hospital, Lecturer (00222498) ; SAWADA Akira Gifu University, Hospital, Assistant professor (80293570) ; ISHIDA Kyoko Gifu University, Hospital, Assistant professor (80334936) ; SUEMORI Shinsuke Gifu University, Hospital, Assistant professor (80377663) ; 近藤 雄司 岐阜大学, 医学部附属病院, 講師 (20329486) ; 青山 陽 岐阜大学, 医学部附属病院, 医員 (80397330)
• Project Period (FY): 2005 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥3,810,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥210,000); Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2006: ¥700,000 (Direct Cost: ¥700,000); Fiscal Year 2005: ¥2,200,000 (Direct Cost: ¥2,200,000)
• Keywords: glaucoma / normal-tension glaucoma / neuroprotection / intraocular pressure / opticnerve / experimental glaucoma / 視野 / ラタノプロスト / 視神経乳頭解析装置

Research Abstract

Basic research
1. A new calpain inhibitor was Lund to have neuroprotective effect against NMDA-induced retinal ganglion cell damage.
2. Several commercial anti-glaucoma drugs have anti-proliferative effect on cultured human conjunctival cells.
3. Lomerizine, a calcium-channel blocker, was found. To have neuroprotective effect against retinal ganglion cell damage in a mouse model.
4. Metallothionein also has neuroprotective effect against NMDA-induced retinal ganglion cell damage in a mouse model.
5. Cobalt may induce selective loss of photoreceptor cells in mice.
6. The role of tissue type plasminogen activator was investigated in relation with apoptosis of retina and optic nerve.
Clinical research
1. Prognosis of primary angle-closure/primary angle-closure glaucoma was analyzed. It was found that PAS extent and presence of GON were closely correlated with the poor prognosis.
2. Anew method to analyze glaucomatous optic nerve pathology was established using a new stereo-fundus camera.
3. Asymmetry of the second kernel response measured by multifocal ERG between nasal and temporal regions was found to be related with the degree of visual field deterioration in normal-tension glaucoma.
4. It was Lund that sufficient IOP reduction significantly reduced the development of optic disc hemorrhages in both primary open-angle glaucoma and normal-tension glaucoma.
5. We established basic data of 24-hr variation of IOP in normal-tension glaucoma.
6. A population-based study found that the prevalence of total glaucoma was 5.0% and that of PACG to be 0.6% in Japanese aged 40 or older.
7. Basic data on optic disc topography measured by Heidelberg Retina Tomograph were established in Japanese.
8. An analysis on IOP reduction and aqueous outflow did not reveal definite relationship between IOP reduction by latanoprost and pretreatment tonographic C-value.

Research Products

• [Journal Article] Decreased nasal-temporal asymmetry of the second-order kernel response of multifocal electroretinograms in eyes with normal-tension glaucoma. (2007)
  • Author(s): Asano E, Mochizuki K, Sawada A, Nagasaka E, Kondo Y, Yamamoto T
  • Journal Title: Jpn J Ophthalmol 51(5) Pages: 379-389
  • NAID: 10019830036
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Long-term therapeutic outcome of acute primary angle closure in Japanese. (2007)
  • Author(s): Sawada A, Aoyama A, Yamamoto T, Takatsuka N
  • Journal Title: Jpn J Ophthalmol 51(5) Pages: 353-359
  • NAID: 10019829941
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Three-dimensional reconstruction of optic nerve head from stereo fundus images and its quantitative estimation (2007)
  • Author(s): Nakagawa, T., Hayashi, Y., Hatanaka, Y., Aoyama, A., Hara, T., Fujita, A., Kakogawa, M., Fujita, H., Yamamoto, T
  • Journal Title: Proceedings of the 29th Annual International Conference of the IEEE EMBS Pages: 6747-6750
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Decreased nasal-temporal asymmetry of the second-order kernel response of multifocal electroretinograms in eyes with normal-tension glaucoma (2007)
  • Author(s): Asano, E., Mochizuki, K., Sawada, A., Nagasaka, E., Kondo, Y., Yamamoto, T
  • Journal Title: Jpn J Ophthalmol 51(5) Pages: 379-389
  • NAID: 10019830036
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Long-term therapeutic outcome of acute primary angle closure in Japanese (2007)
  • Author(s): Sawada, A., Aoyama, A., Yamamoto, T., Takatsuka, N
  • Journal Title: Jpn J Ophthalmol 51(5) Pages: 353-359
  • NAID: 10019829941
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] eds. Angle Closure Glaucoma. 2007 (2007)
  • Author(s): Hong, C., Yamamoto, T
  • Journal Title: Kugler Publications, Amsterdam, The Netherlands
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Three-dimensional reconstruction of optic nerve head from stereo fundus images and its quantitative estimation. (2007)
  • Author(s): Nakagawa T, Hayashi Y, Hatanaka Y, Aoyama A, Hara T, Fujita A, Kakogawa M, Fujita H, Yamamoto T:
  • Journal Title: Proceedings of the 29th Annual International Conference of the IEEE EMBS 2007年号 Pages: 6748-6751
  • Peer Reviewed
• [Journal Article] Decreased nasal-temporal asymmetry of the second-order kernel response of multifocal electroretinograms in eyes with nor mal-tension glaucoma. (2007)
  • Author(s): Asano E, Mochizuki K, Sawada A, Nagasaka E, Kondo Y, Yamamoto T
  • Journal Title: Jpn J Ophthalmol 51(5) Pages: 379-389
  • NAID: 10019830036
  • Peer Reviewed
• [Journal Article] Correlation between individual differences in intraocular pressure reduction and outflow facility due to latanoprost in normal-tension glaucoma patients. (2006)
  • Author(s): Kondo N, Sawada A, Yamamoto T, Taniguchi T
  • Journal Title: Jpn J Ophthalmol 50(1) Pages: 20-24
  • NAID: 10020386285
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The incidence of disc hemorrhage in open-angle glaucoma before and after trabeculectomy. (2006)
  • Author(s): Miyake T, Sawada A, Yamamoto T, et. al.
  • Journal Title: J Glaucoma 15(2) Pages: 164-171
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Intraocular injection of folate antagonist methotrexate induces neuronal differentiation of embryonic stem cells transplanted in the adult mouse retina. (2006)
  • Author(s): Hara A, Niwa M, Kumada M, Aoki H, Yamamoto T, et. al.
  • Journal Title: Brain Res 1085 Pages: 33-42
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A new calcium channel antagonist, lomerizine, alleviates secondary retinal ganglion cell death after optic nerve injury in the rat (2006)
  • Author(s): Karim MZ, Sawada A, Kawakami H, Yamamoto T, Taniguchi T
  • Journal Title: Curr Eye Res 31 Pages: 273-283
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Metallothionein, an endogenous antioxidant, protects against retinal neuron damage in mice. (2006)
  • Author(s): Suemori S, Shimazawa Satoh M, Yamamoto T, et. al.
  • Journal Title: Invest Ophthalmol Vis Sci 47(9) Pages: 3975-3982
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Diurnal variation of intraocular pressure in suspected normal-tension glaucoma. (2006)
  • Author(s): Hasegawa K, Ishida K, Sawada A, Kawase K, Yamamoto T.
  • Journal Title: Jpn J Ophthalmol 50(5) Pages: 449-454
  • NAID: 10019263671
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A new model of retinal photoreceptor cell degeneration induced by a chemical hypoxia-mimicking agent, cobalt chloride. (2006)
  • Author(s): Hara A, Niwa M, Kumada M, Yamamoto T, et. al.
  • Journal Title: Brain Res 1109(1) Pages: 192-200
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Three-dimensional reconstruction of optic nerve head from stereo fundus images and its quantitative estimation. (2006)
  • Author(s): Nakagawa T, Hayashi Y, Yamamoto T, et. al.
  • Journal Title: Proceedings of the 29th Annual International Conference of the IEEE EMBS Pages: 6747-6750
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Correlation between individual differences in intraocular pressure reduction and outflow facility due to latanoprost in normal-tension glaucoma patients (2006)
  • Author(s): Kondo, N., Sawada, A., Yamamoto, T., Taniguchi, T
  • Journal Title: Jpn J Ophthalmol 50(1) Pages: 20-24
  • NAID: 10020386285
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The incidence of disc hemorrhage in open-angle glaucoma before and after trabeculectomy (2006)
  • Author(s): Miyake, T., Sawada, A., Yamamoto, T., Miyake, K., Sugiyama, K., Kitazawa, Y
  • Journal Title: J Glaucoma 15(2) Pages: 164-171
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Intraocular injection of folate antagonist methotrexate induces neuronal differentiation of embryonic stem cells transplanted in the adult mouse retina (2006)
  • Author(s): Hara, A., Niwa, M., Kumada, M., Aoki, H., Kunisada, T., Oyama, T., Yamamoto, T., Kozawa, O., Mori, H
  • Journal Title: Brain Res 1085 Pages: 33-42
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A new calcium channel antagonist, lomerizine, alleviates secondary retinal ganglion cell death after optic nerve injury in the rat (2006)
  • Author(s): Karim, MZ, Sawada, A., Kawakami, H., Yamamoto, T., Taniguchi, T
  • Journal Title: Curr Eye Res 31 Pages: 273-283
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Metallothionein, an endogenous antioxidant, protects against retinal neuron damage in mice (2006)
  • Author(s): Suemori, 5., Shimazawa, M., Kawase, K., Satoh, M., Nagase, H., Yamamoto, T., Hara, H
  • Journal Title: Invest Ophthalmol Vis Sci 47(9) Pages: 3975-3982
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Diurnal variation of intraocular pressure in suspected normal-tension glaucoma (2006)
  • Author(s): Hasegawa, K., Ishida, K., Sawada, A., Kawase, K., Yamamoto, T
  • Journal Title: Jpn J Ophthalmol 50(5) Pages: 449-454
  • NAID: 10019263671
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A new model of retinal photoreceptor cell degeneration induced by a chemical hypoxia-mimicking agent, cobalt chloride (2006)
  • Author(s): Hara, A., Niwa, M., Aoki, H., Kumada, M., Aoki, H., Kunisada, T., Oyama, T., Yamamoto, T., Kozawa, O., Mori, H
  • Journal Title: Brain Res 1109(1) Pages: 192-200
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The incidence of disc hemorrhage in open-angle glaucoma before and after trabeculectomy. (2006)
  • Author(s): Miyake T, Sawada A, Yamamoto T, Miyake K, Sugiyama K, Kitazawa Y.
  • Journal Title: J Glaucoma 15(2) Pages: 164-171
• [Journal Article] Intraocular injection of folate antagonist methotrexate induces neuronal differentiation of embryonic stem cells transplanted in the adult mouse retina. (2006)
  • Author(s): Hara A, Niwa M, Kumada M, Aoki H, Kimisada T, Oyama T, Yamamoto T, Kozawa O, Mori H.
  • Journal Title: Brain Res 1085 Pages: 33-42
• [Journal Article] A new calcium channel antagonist, lomerizine, alleviates secondary retinal ganglion cell death after optic nerve injury in the rat. (2006)
  • Author(s): Karim MZ, Sawada A, Kawakami H, Yamamoto T, Taniguchi
  • Journal Title: Curr Eye Res 31 Pages: 273-283
• [Journal Article] Metallothionein, an endogenous antioxidant, protects against retinal neuron damage in mice. (2006)
  • Author(s): Suemori S, Shimazawa M, Kawase K, Satoh M, Nagase H, Yamamoto T, Hara H.
  • Journal Title: Invest Ophthalmol Vis Sci 47(9) Pages: 3975-3982
• [Journal Article] A new model of retinal photoreceptor cell degeneration induced by a chemical hypoxia-mimicking agent. cobalt chloride. (2006)
  • Author(s): Hara A, Niwa M, Aoki H, Kumada M, Aoki H, Kumada T, Oyama T, Yamamoto T, Kozawa 0, Mori H.
  • Journal Title: Brain Res 1109(1) Pages: 192-200
• [Journal Article] Correlation between individual differences in intraocular pressure reduction and outflow facility due to latanoprost in normal-tension glaucoma patients. (2006)
  • Author(s): Kondo N, Sawada A, Yamamoto T, Taniguchi T.
  • Journal Title: Jpn J Ophthalmol 50(1) Pages: 20-24
  • NAID: 10020386285
• [Journal Article] Tissue type plasminogen activator facilitates NMDA-receptor-mediated retinal apoptosis through an independent fibrinolytic cascade. (2005)
  • Author(s): Kumada M, Niwa M, Hara A, Yamamoto T, et. al.
  • Journal Title: Invest Ophthalmol Vis Sci 46(4) Pages: 1504-1507
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The Tajimi Study Report 2. Prevalence of primary angle closure and secondary glaucoma in a Japanese population. (2005)
  • Author(s): Yamamoto T, et. al. The Tajimi Study Group, Japan Glaucoma Society
  • Journal Title: Ophthalmology 112(10) Pages: 1661-1669
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Topographic characteristics of the optic nerve head measured with scanning laser tomography in normal Japanese subjects. (2005)
  • Author(s): Uchida H, Yamamoto T, et. al. the HRT Study Group
  • Journal Title: Jpn J Ophthalmol 49(6) Pages: 469-476
  • NAID: 10019218897
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Tissue type plasminogen activator facilitates NMDA-receptor-mediated retinal apoptosis through an independent fibrinolytic cascade (2005)
  • Author(s): Kumada, M., Niwa, M., Hara, A., Matsuno, H., Mod, H., Matsuo, O., Ueshima, S., Matsuo, O., Yamamoto, T., Kozawa, O
  • Journal Title: Invest Ophthalmol Vis Sci 46(4) Pages: 1504-1507
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The Tajimi Study Group, Japan Glaucoma Society : The Tajimi Study Report 2. Prevalence of primary angle closure and secondary glaucoma in a Japanese population (2005)
  • Author(s): Yamamoto, T., Iwase, A., Araie, M., Suzuki, Y., Abe, H., Shirato, S., Kuwayama, Y., Mishima, HK., Shimizu, H., Tomita, G., Inoue, Y., Kitazawa, Y
  • Journal Title: Ophthalmology 112(10) Pages: 1661-1669
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] the HRT Study Group : Topographic characteristics of the optic nerve head measured with scanning laser tomography in normal Japanese subjects (2005)
  • Author(s): Uchida, H., Yamamoto, T., Araie, M., Tomita, G., Shirakashi, M., Yoshikawa, K
  • Journal Title: Jpn J Ophthalmol 49(6) Pages: 469-476
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Tissue type plasminogen activator facilitates NMDA-receptor-mediated retinal apoptosis through an independent fibrinolytic cascade. (2005)
  • Author(s): Kumada M, Niwa M, Hara A, Matsuno H, Mori H, Matsuo O, Ueshima S, Matsuo O, Yamamoto T, Kozawa O.
  • Journal Title: Invest Ophthalmol Vis Sci 46(4) Pages: 1504-1507
• [Journal Article] The Tajimi Study Report 2. Prevalence of primary angle closure and secondary glaucoma in a Japanese population. (2005)
  • Author(s): Yamamoto T, Iwase A, Araie M, Suzuki Y, Abe H, Shirato S, Kuwayama Y, Mishima HK, Shimizu H, Tomita G, Inoue Y, Kitazawa Y, The Tajimi Study Group, Japan Glaucoma Society.
  • Journal Title: Ophthalmology 112(10) Pages: 1161-1169
• [Journal Article] Topographic characteristics of the optic nerve head measured with scanning laser tomography in normal Japanese subjects. (2005)
  • Author(s): Uchida H, Yamamoto T, Araie M, Tomita G, Shirakashi M, Yoshikawa K, the HRT Study Group.
  • Journal Title: Jpn J Ophthalmol 49(6) Pages: 469-476
  • NAID: 10019218897
• [Presentation] ヒト培養結膜細胞に対するチモロール関連薬の影響. (2007)
  • Author(s): 川瀬和秀、林文中、青山裕美子, 山本哲也、嶋澤雅光、原英彰
  • Organizer: 第61回日本臨床眼科学会
  • Place of Presentation: 京都市
  • Year and Date: 2007-10-12
• [Presentation] ヒト培養結膜細胞に対するαおよびαβ遮断薬の作用. (2007)
  • Author(s): 川瀬和秀、林文中、青山裕美子, 山本哲也、嶋澤雅光、原英彰
  • Organizer: 第27回日本眼薬理学会
  • Place of Presentation: 岐阜市
  • Year and Date: 2007-09-16
• [Presentation] カルパイン阻害剤の網膜神経保護作用の検討. (2007)
  • Author(s): 末森晋典、嶋澤雅光、松永望、中島佳美、山本哲也、原英彰
  • Organizer: 第18回日本緑内障学会
  • Place of Presentation: 岐阜市
  • Year and Date: 2007-09-15
• [Presentation] 新しいステレオ眼底カメラを用いた視神経乳頭陥凹部の定量的な深さ計測. (2007)
  • Author(s): 中川俊明、林 佳典、畑中裕司、石田恭子、白木玲子、藤田明宏藤田広志、山本哲也
  • Organizer: 第18回日本緑内障学会
  • Place of Presentation: 岐阜市
  • Year and Date: 2007-09-15
• [Presentation] 緑内障における視野進行眼と非進行眼の視神経乳頭の形態比較. (2007)
  • Author(s): 白木玲子、内田英哉、山本哲也
  • Organizer: 第18回日本緑内障学会
  • Place of Presentation: 岐阜市
  • Year and Date: 2007-09-14
• [Presentation] Impact of Collaborative Normal-tension Glaucoma Study on glaucoma management in Japan (2007)
  • Author(s): Yamamoto T
  • Organizer: WGC 2007 Course 27. Impact of Western clinical trials
  • Place of Presentation: Singapore
  • Year and Date: 2007-07-19
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Impact of Collaborative Normal-tension Glaucoma Study on glaucoma management in Japan. (2007)
  • Author(s): Yamamoto T
  • Organizer: WGC 2007 Course 27: Impact of Western clinical trials
  • Place of Presentation: Singapore
  • Year and Date: 2007-07-19
• [Presentation] Involvement of endoplasmic reticulum stress in retinal cell death (2007)
  • Author(s): Suemori S, Shimazawa M, Yamamoto T, Hara H
  • Organizer: ARVO 2007 poster presentation
  • Place of Presentation: Ft. Lauderdale, USA
  • Year and Date: 2007-05-08
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Involvement of endoplasmic reticulum stress in retinal cell death. (2007)
  • Author(s): Suemori S, Shimazawa M, Yamamoto T, Hara H
  • Organizer: ARVO 2007
  • Place of Presentation: Ft. Lauderdale, USA
  • Year and Date: 2007-05-08
• [Presentation] Target pressure determined in progressive normal-tension glaucoma cases (2007)
  • Author(s): Aoyama A, Ishida K, Yamamoto T
  • Organizer: ARVO 2007 poster presentation
  • Place of Presentation: Ft. Lauderdale, USA
  • Year and Date: 2007-05-07
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Target pressure determined in progressive normal-tension glaucoma cases. (2007)
  • Author(s): Aoyama A, Ishida K, Yamamoto T
  • Organizer: ARVO 2007
  • Place of Presentation: Ft. Lauderdale, USA
  • Year and Date: 2007-05-07
• [Presentation] Incidence and risk factors of late-onset bleb-related infection following trabeculectomy (2007)
  • Author(s): Ishida K, Mochizuki K, Yamamoto T
  • Organizer: ARVO 2007 poster presentation
  • Place of Presentation: Ft. Lauderdale, USA
  • Year and Date: 2007-05-06
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The prevalence of hypotony maculopathy after trabeculectomy with adjunctive mitomycin C (2007)
  • Author(s): Kondo Y, Miyake T, Yamamoto T
  • Organizer: ARVO 2007 poster presentation
  • Place of Presentation: Ft. Lauderdale, USA
  • Year and Date: 2007-05-06
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Incidence and risk factors of late-onset bleb-related infection following trabeculectomy (2007)
  • Author(s): Ishida K, Mochizuki K, Yamamoto T
  • Organizer: ARVO 2007
  • Place of Presentation: Ft. Lauderdale, USA
  • Year and Date: 2007-05-06
• [Presentation] The prevalence of hypotony maculopathy after trabeculectomy with adjunctive mitomycin C (2007)
  • Author(s): Kondo Y, Miyake T, Yamamoto T:
  • Organizer: ARVO 2007
  • Place of Presentation: Ft. Lauderdale, USA
  • Year and Date: 2007-05-06
• [Presentation] Rates and causes of visual impairment in Japan (2007)
  • Author(s): Yamamoto T
  • Organizer: Asia ARVO Meeting 2007, Symposium 5 Ocular Epidemiology/International Ophthalmology
  • Place of Presentation: Singapore
  • Year and Date: 2007-03-03
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Rates and causes of visual impairment in Japan (2007)
  • Author(s): Yamamoto, T
  • Organizer: Asia ARVO Meeting 2007, Symposium 5 Ophthalmology
  • Place of Presentation: Singapore
  • Year and Date: 2007-03-03
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Cup region extraction of optic nerve head for three-dimensional retinal fundus image (2007)
  • Author(s): Nakagawa T, Hayashi Y, Hatanaka Y, Yamamoto T, et. al.
  • Organizer: Asian Forum on Medical Imaging 2007.
  • Place of Presentation: Cheju, Korea.
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Detection of retinal nerve fiber layer defects in retinal fundus images using Gabor filtering. (2007)
  • Author(s): Hayashi Y, Nakagawa T, Hatanaka Y, Yamamoto T, et. al.
  • Organizer: International Society for Optical Engineering 2007, poster presentation
  • Place of Presentation: San Diego, USA
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Comparison of the depth of an optic nerve head obtained using stereo retinal images and HRT (2007)
  • Author(s): Nakagawa T, Hayashi Y, Hatanaka Y, Yamamoto T, et. al.
  • Organizer: International Society for Optical Engineering 2007, poster presentation
  • Place of Presentation: San Diego, USA
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Cup region extraction of optic nerve head for three-dimensional retinal fundus image (2007)
  • Author(s): Nakagawa, T., Hayashi, Y., Hatanaka, Y., Aoyama, A., Hara, T., Kakogawa, M., Fujita, H., Yamamoto, T
  • Organizer: Asian Forum on Medical Imaging 2007
  • Place of Presentation: Cheju, Korea
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Detection of retinal nerve fiber layer defects in retinal fundus images using Gabor filtering (2007)
  • Author(s): Hayashi, Y., Nakagawa, T., Hatanaka, Y., Aoyama, A., Kakogawa, M., Hara, T., Fujita, H., Yamamoto, T
  • Organizer: International Society for Optical Engineering 2007, poster presentation
  • Place of Presentation: San Diego, USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Current status of PACG management and prevention of blindness-Japan & the World (2006)
  • Author(s): Yamamoto T
  • Organizer: The 6th WHO Inter-country Workshop
  • Place of Presentation: Korat, Thailand
  • Year and Date: 2006-11-23
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Consensus report on management of acute angle closure crisis (2006)
  • Author(s): Quigley H, Yamamoto T
  • Organizer: The 3rd Global AIGS Consensus Meeting
  • Place of Presentation: Hollywood, USA
  • Year and Date: 2006-05-03
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Comparison of three different methods for longitudinal evaluation of visual fields (2006)
  • Author(s): Ban T, Ishida K, Kawase K, Yamamoto T
  • Organizer: ARVO 2006 poster presentation
  • Place of Presentation: Ft. Lauderdale, USA
  • Year and Date: 2006-05-02
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Etiology of open-angle glaucoma: Importance of disc hemorrhage. Symposium "Basic and Clinical Aspects of Open-angle Glaucoma" (2006)
  • Author(s): Yamamoto T
  • Organizer: World Ophthalmology Congress 2006
  • Place of Presentation: Sao Paulo, Brazil
  • Year and Date: 2006-02-23
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Etiology of open-angle glaucoma : Importance of disc hemorrhage. Symposium "Basic and Clinical Aspects of Open-angle Glaucoma" (2006)
  • Author(s): Yamamoto, T
  • Organizer: World Ophthalmology Congress 2006
  • Place of Presentation: Sao Paulo, Brazil
  • Year and Date: 2006-02-23
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Multicenter randomized clinical trials: Conduct. AAO symposium-Landmark Clinical Trials in Glaucoma-How They Have Impacted Clinical Practice (2006)
  • Author(s): Yamamoto T
  • Organizer: World Ophthalmology Congress 2006
  • Place of Presentation: Sao Paulo, Brazil
  • Year and Date: 2006-02-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Multicenter randomized clinical trials : Conduct (2006)
  • Author(s): Yamamoto, T
  • Organizer: AAO symposium-Landmark Clinical Trials in Glaucoma -How They Have Impacted Clinical Practice, World Ophthalmology Congress 2006
  • Place of Presentation: Sao Paulo, Brazil
  • Year and Date: 2006-02-22
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Incidence and risk factors of bleb-related infection following trabeculectomy. (2006)
  • Author(s): Ishida K, Mochizuki K, Yamamoto T
  • Organizer: The 21st Congress of the Asia-Pacific Academy of Ophthalmology, poster presentation
  • Place of Presentation: Singapore
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Extraction of nerve fiber layer defects in ocular fundus images (2006)
  • Author(s): Hayashi Y, Nakagawa T, Aoyama A, Yamamoto, T, et. al.
  • Organizer: (CAR52006)poster presentation
  • Place of Presentation: Osaka, Japan
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Incidence and risk factors of bleb-related infection following trabeculectomy (2006)
  • Author(s): Ishida, K., Mochizuki, K., Yamamoto, T
  • Organizer: The 21st Congress of the Asia-Pacific Academy Ophthalmology, poster presentat
  • Place of Presentation: Singapore
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Extraction of nerve fiber layer defects in ocular fundus images (2006)
  • Author(s): Hayashi, Y., Nakagawa, T., Aoyama, A., Hara, T., Fujita, H., Yamamoto, T., Hatanaka, Y., Mizukusa, Y., Fujita, A., Kakogawa, M
  • Organizer: The 20th International Congress and Exhibition on Computer Assisted Radiology and Surgery (CARS2006) poster presentation
  • Place of Presentation: Osaka, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Normal-tension Glaucoma. Is this clinical entity the same as or different from POAG? (2005)
  • Author(s): Yamamoto T
  • Organizer: The Cojoint Meeting of the Asian Oceanic Glaucoma Society and the ANZ Glaucoma Club.
  • Place of Presentation: Cairns, Australia
  • Year and Date: 2005-09-01
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Normal-tension Glaucoma. Is this clinical entity the same as or different from POAG? (2005)
  • Author(s): Yamamoto, T
  • Organizer: The Cojoint Meeting of the Asian ceanic Glaucoma Society and the ANZ Glaucoma Club
  • Place of Presentation: Cairns, Australia
  • Year and Date: 2005-09-01
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Normal-tension glaucoma: An enigma to all of us. (2005)
  • Author(s): Yamamoto T
  • Organizer: World Glaucoma Congress, Glaucoma Society Session
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2005-07-09
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Normal-tension glaucoma : An enigma to all of us (2005)
  • Author(s): Yamamoto, T
  • Organizer: World Glaucoma Congress, Glaucoma Society Session #5 by the Japan Glaucoma Society "Normal-tension glaucoma"
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2005-07-09
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Diurnal variation of intraocular pressure in suspected normal-tension glaucoma. (2005)
  • Author(s): Kawase K, Hasegawa K, Sawada A, Yamamoto T
  • Organizer: ARVO 2005 poster presentation
  • Place of Presentation: Ft. Lauderdale, USA
  • Year and Date: 2005-05-02
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Diurnal variation of intraocular pressure in suspected normal-tension glaucoma (2005)
  • Author(s): Kawase, K., Hasegawa, K., Sawada, A., Yamamoto, T
  • Organizer: ARVO 2005 poster presentation
  • Place of Presentation: Ft. Lauderdale, USA
  • Year and Date: 2005-05-02
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Diurnal variation of intraocular pressure in suspected normal-tension glaucoma. (2005)
  • Author(s): Yamamoto T, Hasegawa K, Sawada A, Ishida K, Kawase K
  • Organizer: World Glaucoma Congress poster presentation.
  • Place of Presentation: Vienna, Austria
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Diurnal variation of intraocular pressure in suspected normal-tension glaucoma (2005)
  • Author(s): Yamamoto, T., Hasegawa, K., Sawada, A., Ishida, K., Kawase, K
  • Organizer: World Glaucoma Congress poster presentation
  • Place of Presentation: Vienna, Austria
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] Angle Closure Glaucoma (2007)
  • Author(s): Hong C, Yamamoto T, eds.
  • Total Pages: 278
  • Publisher: Kugler Publications, Amsterdam, The Netherlands
  • Description: 「研究成果報告書概要(和文)」より
• [Book] Angle Closure Glaucoma. (2007)
  • Author(s): Hong C, Yamamoto T, eds.
  • Publisher: Kugler Publications, Amsterdam, The Netherlands