| Project/Area Number |
17591856
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
HORI Sadao Tokyo Women's Medical University, School of Medicine, Professor (20143498)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGUCHI Naoto Tokyo Women's Medical University, School of Medicine, Professor (80119031)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,700,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2005: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | diabetic retinopathy / photocoagulation / randomized clinical trial / 多施設臨床研究 / prospective clinical study |
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| Research Abstract |
To evaluate the efficacy of timing and method of photocoagulation for pre-proliferative diabetic retinopathy, treated group and non-treated group were compared at 36 months after randomized prospective clinical trial.
Forty nine eyes were involved in the study with moderately severe pre-proliferative diabetic retinopathy and randomly divided into two groups; 23 eyes for treated group and 26 for non-treated, the eyes followed more than 36 months were 12 in the treated eyes and 20 in the non-treated eyes. In the treated group, selective photocoagulation was performed at the beginning of the trial to the non-perfused areas detected by fluorescein angiography (FAG). Additional coagulation was performed when the non-perfused area was progressed and detected at periodical examinations after the selective coagulation. In the non-treated group, scattered coagulation was performed when the neovascularization (NV) was detected by FAG at every 6-months examination.
At 36 months, 2 eyes developed NV in the treated group whereas 12 eyes in the non-treated group (p=0.02). When the visual acuity was compared between the baseline and at 36months, it reduced more than 2 lines in the treated group (p=0.047) and no reduction of visual acuity was noted in the non-treated group.
The photocoagulation was recommended for the moderately severe pre-proliferative diabetic retinopathy to prevent progression of proliferative diabetic retinopathy.
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