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Arginine effect on the gastrointestinal motility in the growing rat after massive small bowel resection

Research Project

Project/Area Number 17591859
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatric surgery
Research InstitutionAkita University

Principal Investigator

HEBIGUCHI Tatsuzo  Akita University, School of Medicine, Professor (00124644)

Co-Investigator(Kenkyū-buntansha) KATO Tetsuo  Akita University, School of Medicine, Professor (20004963)
YOSHINO Hiroaki  Akita University, School of Medicine, Research Associate (90182807)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2006: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2005: ¥1,600,000 (Direct Cost: ¥1,600,000)
Keywordsmassive small intestinal resection / Arginine / gastrointestinal motility / telemeter system / 消化管運動 / 吸収能 / マイクロダイアリシス / 消化吸収
Research Abstract

[Objective] Using our short-small intestine model that is suitable for investigating the importance of arginine in vivo, the motor functions of the stomach, duodenum, jejunum, and ileum were recorded without any restraint, and the results were compared to those of control rats.
[Subjects and Methods] 1) Using 4-week-o1d male rat, 90% proximal small bowel resection (SBR) was performed, and in the control group, the intestine was cut and then anastomosed at 5 cm oral to the ileocecal valve. Either Elental-P with arginine or glycine was administered to rats that underwent this surgery and rats with a normal length of smal1 intestine. A total of four groups were prepared in this manner. 2) On the third week after surgery, the abdomen was reopened and a force transducer (FT) was sutured to the serous membrane of the pyloric portion of the stomach, the duodenum 3 cm anal to the pyloric ring, the jejunum 3 cm ana1 from Treitz ligament, and the ileum 2 cm anal to the anastomosis. From three day … More s later, gastrointestinal motility was recorded using a multichannel telemeter system (Star Medical Co.). 3) After fasting for 12 to 24 hours, gastrointestinal motility was repeatedly recorded and analyzed for 1-3 days. A single test cycle consisted of 12 hours of feeding and 12 hours of fasting. After the end of the test, the rats were sacrificed to ensure that the FTs were positioned properly.
[Results] 1) For the control groups, immediately before feeding, migrating motility complexes(MMC) lasting 3-5 minutes were seen every 3-5 minutes in the duodenum, and then MMC lasting 3-4 minutes were seen in the jejunum. MMC disappeared with the start of feeding. However, MMC appeared 3-4 hours later and persisted at low-frequency. MMC increased gradually from 12 hours after the start of feeding and their frequency changed to every 3-5 minutes after 18 hours. The same MMC patterns were repeated with every administration. 2) For the SBR groups, immediately before feeding, MMC lasting 3-5 minutes were seen in the duodenum, but these disappeared with the start of feeding. Three to four hours later, MMC were again seen every 1-2 hours and MMC lasting 2-3 minutes were observed every 8-10 minutes from 18 hours later.MMC that occurred at the duodenum did not transmit well to the remaining ileum. 3) For both control and SBR groups, clear transmission of MMC to the ileum over the anastomosis was not seen.
[Conclusion] Based on the current observations the housekeeping role of MMC in the residua1 ileum appears to be suppressed after SBR. There was no arginine effect on the gastrointestina1 motility in our model. Less

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (9 results)

All 2006

All Journal Article (9 results)

  • [Journal Article] 消化吸収機能からみたHirschsprung病類縁疾患の栄養管理-広範囲腸管神経節細胞減少症の1例を経験して-2006

    • Author(s)
      蛇口 達造
    • Journal Title

      小児外科 36

      Pages: 695-700

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] アルギニン代謝からみた短腸症候群の栄養管理2006

    • Author(s)
      蛇口 達造
    • Journal Title

      小児外科 38

      Pages: 1028-1035

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 小児における在宅静脈栄養法の進歩と限界-Broviac型カテーテル使用によるカテーテル敗血症の検討から-2006

    • Author(s)
      蛇口 達造
    • Journal Title

      栄養評価と治療 23

      Pages: 244-247

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Nutritional management of disseminated Hypoganglionosis, a pseudo-Hirschsprung's disease, from the perspective of intestinal absorption capacity : A case report2006

    • Author(s)
      Hebiguchi Tatsuzo, et. al.
    • Journal Title

      Jpn J Pediatr Surg 38(6)

      Pages: 695-700

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Arginine metabolism and nutritional management in short bowel Syndrome2006

    • Journal Title

      Jpn J Pediatr Surg 38(9)

      Pages: 1028-1035

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Progress and a limit in the pediatric home parenteral nutrition-From a viewpoint of catheter sepsis in the patients used Broviac catheter-2006

    • Journal Title

      Nutritional assessment and Therapy(in Japanese) 23(3)

      Pages: 244-247

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 消化吸収機能からみたHirschsprung病類縁疾患の栄養管理-広範囲腸管神経節細胞減少症の1例を経験して-2006

    • Author(s)
      蛇口達造
    • Journal Title

      小児外科 Vol.38No.6

      Pages: 695-700

    • Related Report
      2006 Annual Research Report
  • [Journal Article] アルギニン代謝からみた短腸症候群の栄養管理2006

    • Author(s)
      蛇口達造
    • Journal Title

      小児外科 Vol.38No.9

      Pages: 1028-1035

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 小児における在宅静脈栄養法の進歩と限界-Broviac型カテーテル使用によるカテーテル敗血症の検討から-2006

    • Author(s)
      蛇口達造
    • Journal Title

      米養-評価と治療 Vol.23No.3

      Pages: 244-247

    • Related Report
      2006 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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