| Project/Area Number |
17591864
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Pediatric surgery
|
|---|
| Research Institution | KYUSHU UNIVERCITY |
|---|
Principal Investigator |
HIGASHI Mayumi Kyushu university, hospital, staff, 大学病院, 医員 (10380453)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAJIRI Tatsuro Kyushu university, Graduate School of Medical Science, Associate professor, 医学研究院, 助教授 (80304806)
TAGUCHI Tomoaki Kyushu university, Graduate School of Medical Science, Professor, 医学研究院, 教授 (20197247)
SUITA Sachiyo Kyushu university, hospital, Professor, 大学病院, 教授 (30038856)
SUITA Yoshiaki Kyushu university, hospital, Assistant professor, 大学病院, 助手 (80345529)
TAKAHASHI Yukiko Kyushu university, hospital, Assistant professor, 大学病院, 助手 (80380442)
竜田 恭介 九州大学, 大学病院, 医員 (10380445)
|
|---|
| Project Period (FY) |
2005 – 2006
|
| Project Status |
Completed (Fiscal Year 2006)
|
| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2005: ¥1,900,000 (Direct Cost: ¥1,900,000)
|
|---|
| Keywords | neuroblastoma / prognostic factor / neuronatin / neuronatin |
|---|
| Research Abstract |
We compared gene expressions between favorable and unfavorable neuroblastomas by microarray system, and it showed about 400 of unfavorable tumor dominant genes and about 40 of favorable tumor dominant genes. A high expression of neuronatin (Nnat) gene in favorable neuroblastomas were found. Neuronatin is a gene which is considered to relate to the neurogenesis, and the expression appears in nervous systems from the hindbrain to the peripherals during the prenatal periods. It is an imprinted gene, highly conserved in mammalian spices. The neuronatin mRNA expression was investigated in 70 of neuroblastoma samples by quantitative RT-PCR, and the expression was significantly high in favorable groups than unfavorable groups. Although the detailed function is not revealed, the high expressions of neuronatin were found to be associated with good prognoses in neuroblastoma, which might indicate the tumor differentiation, and its expressions in unfavorable tumors were supposed to be epigenetically suppressed.
|
