Effects of zinc deficiency on the transduction of taste sensation
| Project/Area Number |
17591919
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
TOYOSHIMA Kuniaki Kyushu Dental College, School of Dentisry, Professor (10112559)
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| Co-Investigator(Kenkyū-buntansha) |
SETA Yuji Kyushu Dental College, School of Dentisry, Associate Professor (90291616)
TOYONO Takashi Kyushu Dental College, School of Dentisry, Assistant Professor (10311929)
KATAOKA Sinji Kyushu Dental College, School of Dentisry, Assistant Professor (80364149)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,710,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2005: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | taste bud / taste transduction / zinc / transcription / promoter / umami / sweet / taste sensation / 免疫組織化学 / II型細胞 / P450scc / P450aroma / プレグネノロン / エストロゲン / RT-PCR / III型細胞 / シナプトタグミン / セロトニン |
|---|
| Research Abstract |
Taste disorders have been linked to zinc deficiency. Zinc plays structural roles in so called Zinc fingers. Zinc fingers are exploited by transcription factors for interacting with DNA and regulating the activity of genes. Although the mechanisms of transcriptional regulation of the taste receptor genes have not been revealed, it is possible that the zinc is concerned with the transcriptional regulation of taste receptor genes. Therefore, we examined the molecular mechanisms regulating the promoter of human umami and sweet receptor, T1R3 gene in a human intrahepatic bile duct carcinoma cell line, H_uCCT1. The luciferase reporter assay showed that the 226-bp region upstream of the ATG had promoter activity.
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Report
(4 results)
Research Products
(144 results)
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[Journal Article] Physical fitness and cognitive function in an 85-year-old community-dwelling population2008
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Takata Y, Ansai T, Soh I, Kimura Y, Yoshitake Y, Sonoki K, Awano S, Kagiyama S, Yoshida A, Nakamichi I, Hamasaki T, Torisu T, Toyoshima K, Takehara T
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[Journal Article] Physical fitness and cognitive function in an 85-year-old community-dwelling population2008
Author(s)
Takata Y, Ansai T, Soh I, Kimura Y, Yoshitake Y, Sonoki K, Awano S, Kagiyama S, Yoshida A, Nakamichi I, Hamasaki T, Torisu T, Toyoshima K, Takehara, T
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[Journal Article] Physical fitness and cognitive function in an 85-year-old community-dwelling population2008
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Takata Y, Ansai T, Soh I, Kimura Y, Yoshitake Y, Sonoki K, Awano S, Kagiyama S, Yoshida A, Nakamichi I, Hamasaki T, Torisu T, Toyoshima K, Takehara T
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Gerontology 300(in press)
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[Journal Article] 高齢者における血清レプチンと味覚感度との関連について2007
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安細 敏弘, 瀬田 祐司, 豊野 孝, 園木 一男, 吉田 明弘, 粟野 秀慈, 邵 仁浩, 濱崎 朋子, 高田 豊, 竹原 直道, 豊島 邦昭
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日本味と匂学会誌 14(3)
Pages: 599-600
NAID
Description
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[Journal Article] S.Kataoka, R.Yang, Y.Ishimaru, H.Matsunami, J.Sevigny, JC.Kinnamon,and TE.Finger;The Candidate Sour Taste Receptor,PKD2L1, Is Expressed by Type III Taste Cells in the Mouse2007
Author(s)
S.Kataoka, R.Yang, Y.Ishimaru, H.Matsunami, J.Sdvigny, JC.Kinnamon, and TE.Finger
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Chemical Senses 33(3)
Pages: 243-253
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[Journal Article] 高齢者における血清レプチンと味覚感度との関連について2007
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安細, 敏弘, 瀬田, 祐司, 豊野, 孝, 園木, 一男, 吉田, 明弘, 粟野, 秀慈, 郡, 仁浩, 濱崎, 朋子, 高田, 豊, 竹原, 直道, 豊島, 邦昭
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日本味と匂い学会誌 14(3)
Pages: 599-600
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「研究成果報告書概要(欧文)」より
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[Journal Article] The bHLH transcription factors, Hes6 and Mashl, are expressed in distinct subsets of cells within adult mouse taste buds.2006
Author(s)
Seta, Y., Stoick-Cooper, C.L., Toyono, T., Kataoka, S., Toyoshima, K., Barlow, L.A.
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Arch. Histol. Cytol. 69(3)
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[Presentation] Promoter analysis of human umami receptor, T1R1 gene2007
Author(s)
Toyono, T., Seta, Y., Kataoka, S., Toyoshima, K
Organizer
The 5th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception
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Nishijin Plaza,Kyushu University,Fukuoka
Year and Date
2007-11-02
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[Presentation] Promoter analysis of human umami receptor, T1R1 gene2007
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Toyono, T., Seta, Y., Kataoka, S., Toyoshima, K
Organizer
The 5th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception
Place of Presentation
Nishijin Plaza, Kyushu University, Fukuoka
Year and Date
2007-11-02
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[Presentation] Promoter analysis of human umami receptor,T1R1 gene.2007
Author(s)
Toyono, T., Seta, Y., Kataoka, S., Toyoshima, K.
Organizer
The 5th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception
Place of Presentation
Nishijin Plaza,Kyushu University,Fukuoka
Year and Date
2007-11-02
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[Presentation] Mash1 regulates the type III cell differentiation of taste bud.,2007
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Seta, Y., Toyono, T., Kataoka, S., Toyoshima, K.
Organizer
The 5th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception
Place of Presentation
Nishijin Plaza, Kyushu University,Fukuoka
Year and Date
2007-11-02
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[Presentation] 高齢者における血清レプチンと味覚感度との関連について2007
Author(s)
安細 敏弘, 瀬田 祐司, 豊野 孝, 園木 一男, 吉田 明弘, 粟野 秀慈, 邵 仁浩, 濱崎 朋子, 高田 豊, 竹原 直道, 豊島 邦昭
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安細, 敏弘, 瀬田, 祐司, 豊野, 孝, 園木, 一男, 吉田, 明弘, 粟野, 秀慈, 郡, 仁浩, 濱崎, 朋子, 高田, 豊, 竹原, 直道, 豊島, 邦昭
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[Presentation] 高齢者における血清レプチンと味覚感度との関連について.,2007
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