Basic study about cell-based therapy by cell life span control using human papillomavirus
Project/Area Number |
17591931
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Morphological basic dentistry
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Research Institution | National Research Institute for Child Health and Development |
Principal Investigator |
TERAI Masanori National Research Institute for Child Health and Development, 生殖医療研究部, 共同研究員 (70359917)
|
Co-Investigator(Kenkyū-buntansha) |
UMEZAWA Akihiro 国立成育医療センター(研究所), 生殖医療研究部, 部長 (70213486)
HATA Junichi 国立成育医療センター, 名誉総長 (90051614)
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Project Period (FY) |
2005 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
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Budget Amount *help |
¥4,000,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥600,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2006: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2005: ¥700,000 (Direct Cost: ¥700,000)
|
Keywords | 再生医学 / 細胞・組織 / ウイルス |
Research Abstract |
臍帯血からの間葉系細胞のstrainの樹立さらに寿命を延長することに成功し、それぞれの細胞の特徴性格づけも行った。さらに月経血からの間葉系細胞の骨格筋への高率な分化誘導にも成功した。この技術はヒト正常体細胞を用いた将来の細胞移植治療の応用の際に大きな利益をもたらすと考える。
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Report
(5 results)
Research Products
(19 results)
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[Journal Article] A role of Wnt/{beta}-catenin signals in hepatic fate specification of human umbilical cord blood-derived mesenchymal stem cells.2007
Author(s)
Yoshida Y, Shimomura T, Sakabe T, Ishii K, Gonda K, Matsuoka S, Watanabe Y, Takubo K, Tsuchiya H, Hoshikawa Y, Kurimasa A, Hisatome I, Uyama T, Terai M, Umezawa A, Shiota G.
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Journal Title
American Journal of Physiology Gastrointestinal and Liver Physiology 293
Pages: 1089-1098
Related Report
Peer Reviewed
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[Journal Article] The Significant Cardiomyogenic Potential of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Vitro.2007
Author(s)
Nishiyama N, Miyoshi S, Hida N, Uyama T, Okamoto K, Ikegami Y, Miyado K, Segawa K, Terai M, Sakamoto M, Ogawa S, Umezawa A.
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Journal Title
Stem Cells 25
Pages: 2017-2024
Related Report
Peer Reviewed
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[Journal Article] Chromosomal instability in human mesenchymal stem cells Immortalized with human papilloma yirus E6, E7, and hTERT genes2007
Author(s)
Takeuchi M, Takeuchi K, Kohara A, Satoh M, Shioda S, Ozawa Y, OhtaniA, Morita K, Hirano T, Terai M, Umezawa A, Mizusawa H.
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Journal Title
In Vitro Cellular&Developmental Biology-Animal 43巻3-4号
Pages: 129-138
Related Report
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[Journal Article] The Significant Cardiomyogenic Potential of Human Umbilical CordBlood-Derived Mesenchymal Stem Cells in Vitro2007
Author(s)
Nishiyama N, Miyoshi S, Hida N, Uyama T, Okamoto K, Ikegami Y, Miyado K, Segawa K, Terai M, Sakamoto M, Ogawa S, Umezawa A.
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Journal Title
Stem Cells 25巻8号
Pages: 2017-2024
Related Report
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[Journal Article] A role of Wnt/{beta}-catenin signals in hepatic fate specification of human umbilical cord blood-derived mesenchymal stem cells2007
Author(s)
Yoshida Y, Shimomura T, Sakabe T, Ishii K, Gonda K, Matsuoka S, Watanabe Y, Takubo K, Tsuchiya H, Hoshikawa Y, Kurimasa A, Hisatome I, Uyama T, Terai M, Umezawa A, Shiota G.
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Journal Title
American Journal of Physiology Gastrointestinal and Liver Physiology 293巻5号
Pages: 1089-1098
Related Report
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