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Relationship between central perceptivity of noradrenalin and oral dryness

Research Project

Project/Area Number 17591944
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional basic dentistry
Research InstitutionKyushu Dental College

Principal Investigator

HONDA Eiko  Kyushu Dental College, Physiology, Special trainees, 歯学部, 特別研修員 (00047812)

Co-Investigator(Kenkyū-buntansha) INENAGA Kiyotoshi  Kyushu Dental College, Physiology, Professor, 歯学部, 教授 (90131903)
ONO Kentaro  Kyushu Dental College, Physiology, Assistant Professor, 歯学部, 助手 (40316154)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2005: ¥2,600,000 (Direct Cost: ¥2,600,000)
Keywordsoral dryness / central noradrenaline / subfornical organ / patch clamp / a receptor / rat / slice nrenaration / ノルアドレナリン / パッチクランプ / フェニレフリン / アドレナリン受容体 / 抑制性シナプス後電流 / コンダクタンス
Research Abstract

Activation of the subfornical organ (SFO) induces drinking behavior, that is, oral dryness. In this study, the effects of NA and its analogues on SFO neurons in rat slice preparations were investigated by using whole cell patch clamp recording. In the current clamp mode, the application of NA at 10-100 μM produced membrane depolarization (63%, 17 responsive neurons /27 neurons tested) and hyperpolarization (22%, 6/27 neurons). In the voltage clamp mode, NA application at 1-100 μM produced inward currents (69%, 42/61 neurons) and outward currents (23%, 14/61 neurons). These currents were remained in the presence of TTX or in the coapplication of glutamate and GABA receptor antagonists. In most of the neurons (25/31 neurons) showing inward currents in the presence of NA, the membrane conductance was not changed by voltage ramps or hyperpolarizing pulse stimulation. Similar responses were obtained by the application of the αl agonist phenylephrine. The phenylephrine-induced inward currents were inhibited by the α1 antagonist prazosin. In addition, the α2 agonist clonidine decreased the frequency of spontaneous GABAergic inhibitory postsynaptic currents (4/10 neurons). The results suggest that SFO neurons in rats are activated postsynaptically through α1 adrenoceptors, and that the activation is enhanced by suppressing GABAergic inhibitory synaptic inputs through presynaptic α2 adrenoceptors.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (25 results)

All 2007 2006 2005 Other

All Journal Article (25 results)

  • [Journal Article] Effects of cevimeline on salivation and thirst in conscious rats2007

    • Author(s)
      Sato Nら
    • Journal Title

      Arch. Oral Biol. (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Subpopulation of nicotine-sensitive neurons in the rat subfornical organ2007

    • Author(s)
      Ono Kら
    • Journal Title

      Dentistry in Japan 43

      Pages: 28-32

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Relationship of chewing-stimulated whole saliva flow rate and salivary gland size2007

    • Author(s)
      Ono Kら
    • Journal Title

      Arch. Oral Biol. 52

      Pages: 427-431

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Subpopulation of nicotine-sensitive neurons in the rat subfornical organ.2007

    • Author(s)
      Ono K, Kai A, Honda E, Inenaga.
    • Journal Title

      Dentistry in Japan 43

      Pages: 28-32

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Relationship of chewing-stimulated whole saliva flow rate and salivary gland size.2007

    • Author(s)
      Ono K, Inoue H, Masuda W, Morimoto Y, T Tanaka, M Yokota, K Inenaga.
    • Journal Title

      Arch. Oral Biol. 52

      Pages: 427-431

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Relationship of chewing-stimuIated whole saliva flow rate and salivary gland size2007

    • Author(s)
      Ono Kら
    • Journal Title

      Arch. Oral Biol. 52

      Pages: 427-431

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Activation of subfornical organ neurons in rats through pre- and post-synaptic alpha-adrenoceptors.2006

    • Author(s)
      Honda E, Ono K, Kataoka S, Inenaga K
    • Journal Title

      Am. J. Physiol. Regul. Integr. Comp. Physiol. 290

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Gender difference in unstimulated whole saliva flow rate and salivary gland sizes2006

    • Author(s)
      Inoue Hら
    • Journal Title

      Arch. Oral Biol. 51

      Pages: 1055-1060

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Galanin inhibits neural activity in the subfornical organ in rat slice preparation2006

    • Author(s)
      Kai Aら
    • Journal Title

      Neuroscience 143

      Pages: 769-777

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Relationship of the unstimulated whole saliva flow rate and salivary gland size estimated by magnetic resonance image in healthy young humans.2006

    • Author(s)
      Ono K, Morimoto Y, Inoue H, Masuda W, Tanaka T. Inenaga K.
    • Journal Title

      Arch. Oral Biol. 51

      Pages: 345-349

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Pilocarpine-induced salivation and thirst in conscious rats.2006

    • Author(s)
      Sato N, Ono K, Honda E, Haga K, Yokoda M, Inenaga K.
    • Journal Title

      J. Dental Res. 85

      Pages: 64-68

    • NAID

      130005447482

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Dynamic MR sialography as a new diagnostic technique for patients with Sjogren syndrome.2006

    • Author(s)
      Morimoto Y, Habu M, Tomoyose T, Ono K, Tanaka T, Yoshioka I, Tominaga K, Yamashita Y, Kito S, Okabe S, Takakahashi T, Takahara T, Fukuda J, Inenaga K, Ohba T.
    • Journal Title

      Oral Disease. 12

      Pages: 408-414

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Activation of subfornical organ neurons in rats through pre-and post-synaptic alpha-adrenoceptors.2006

    • Author(s)
      Honda E, Ono K, Kataoka S, Inenaga K.
    • Journal Title

      Am. J. Physiol. Regul. Integr. Comp. Physiol. 290

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Gender difference in unstimulated whole saliva flow rate and salivary gland sizes.2006

    • Author(s)
      Inoue H, Ono K, Masuda W, Morimoto Y, Tanaka T, Yokota M, Inenaga K.
    • Journal Title

      Arch. Oral Biol. 51

      Pages: 1055-1060

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Galanin inhibits neural activity in the subfornical organ in rat slice preparation.2006

    • Author(s)
      Kai A, Ono K, Kawano H, Honda E, Nakanishi O, Inenaga K.
    • Journal Title

      Neuroscience 143

      Pages: 769-777

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Activation of subfornical organ neurons in rats through pre- and post-synaptic alpha-adrenoceptors.2006

    • Author(s)
      Honda E, Ono K, Kataoka S, Inenaga K.
    • Journal Title

      Am.J.Physiol.Regul.Integr.Comp.Physiol. 290

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Activation of subfornical organ neurons in rats through pre- and postsynaptic alpha-adrenoceptors.2006

    • Author(s)
      Honda E., Ono S., Kataoka S., Inenaga K.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol (In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Pilocarpine-induced salivation and thirst in conscious rats.2006

    • Author(s)
      Sato N., Ono K., Honda E., Haga K., Yokota M., Inenaga K.
    • Journal Title

      J Dent Res 85・1

      Pages: 64-68

    • NAID

      130005447482

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Central nicotinic stimulation reduces vascular conductance in the gingival in anesthetized rats.2005

    • Author(s)
      Nakamura T, Ono K, Honda E, Yokota M, Inenaga.
    • Journal Title

      J Periodontal Research 40

      Pages: 67-72

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The functional evaluation of salivary glands using dynamic MR sialograph following citric acid stimulation : a preliminary study.2005

    • Author(s)
      Morimoto Y, Ono K, Tanaka T, Kito S, Inoue H, Shinohara Y, Yokota M, Inenaga K, Ohba T.
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod 100

      Pages: 357-64

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Transient outward K+ currents in rat dissociated subfornical organ neurons and angiotensin II effects.2005

    • Author(s)
      Ono K, Toyono T, Honda E, Inenaga K.
    • Journal Title

      J. Physiol 568

      Pages: 979-991

    • NAID

      110006420874

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Down regulation of AQP2 expression in the kidney of polydipsic STR/N mice.2005

    • Author(s)
      Tsumura K, Li X, Murdiastuti K, Nahid M P, Akamatsu T, Yao C, Kanamori N, Inenaga K, Yamashita H, Hosoi K.
    • Journal Title

      Am. J. Physiol. 290

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Transient outward K^+ currents in rat dissociated subfornical organ neurones and angiotensin II effects.2005

    • Author(s)
      Ono K., Toyono T., Honda E., Inenaga K.
    • Journal Title

      J Physiol 583・3

      Pages: 979-991

    • NAID

      110006420874

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Central nicotinic stimulation reduces vascular conductance in the gingival in anesthetized rats.2005

    • Author(s)
      Nakamura T., Ono K., Honda E., Yokota M., Inenaga K.
    • Journal Title

      J Periodont Res 40

      Pages: 67-72

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effects of cevimeline on salivation and thirst in conscious rats.

    • Author(s)
      Sato N, Ono K, Haga K, Yokota M, Inenaga K.
    • Journal Title

      Arch. Oral Biol. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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