| Project/Area Number |
17591960
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Osaka University |
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Principal Investigator |
FURUKAWA Souhei Osaka University, Graduate School of Dentistry, Professor (80173524)
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| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI Shumei Osaka University, Graduate School of Dentistry, Associate Professor (00263301)
UCHIYAMA Yuka Osaka University, Graduate School of Dentistry, Assistant Professor (80322171)
KAKIMOTO Naoya Osaka University, Graduate School of Dentistry, Assistant Professor (50324794)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,700,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2005: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | head and neck cancers / radiation therapy / xerostomia / clinical evaluation / image evaluation / 悪性腫瘍 / 唾液腺 |
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| Research Abstract |
The xerostomia is one of complications for the radiation therapy for the head and neck cancer. It is considered the xerostomia is the most important factor for the patient's qualiy of life after rediation therapy far head and neck cancers.The aims of this study were to grasp correctly and analyze the sideration pattern of xerostomia after radiation therapy for head and neck cancers. We estimated the patients with head and neck cancers treated by exernal beam radiation therapy using questionnaire survey and amount measurement of saliva before radiation therapy, at one month, at six month, and at 32 months after radiation therapy, respectively.
The questionnaire: item was evaluated based on a patient's self report, by the Visual analog scale method, entered the questionnaire in the patient itself. When radiation dose evaluation created a dose distribution figure with curative program equipment, it enforced dose evaluation of major salivary gland and minor salivary gland. However, since major salivary gland and minor salivary gland were three dimensional shapes, they made the average dose of the whole volume of these organs. The amount measuring method of saliva performed measurement which used all the amount measurement of mouth saliva, and a mouth moisture meter. About image evaluation, it evaluated using CT value and the contrast enhancement ratio of major salivary glands and minor salivary gland area.
By evaluating these temporal change of xerostomia by clinical salivary gland feature on CT imaging, we could examine the relation patient's QOL obtained by subjective xerostomia with objective examination data of xerostomia or image diagnosis for salivary glands. As a result, it was suggested that there was correlation between a patients's xerostomia contrast enhancement ratio on CP imaging of a major salivary gland.
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