Development of chair-side assay system for ongoing bone loss with peri-implant sulcus fluids
| Project/Area Number |
17592025
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
補綴理工系歯学
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| Research Institution | Okayama University |
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Principal Investigator |
ARAKAWA Hikaru Okayama University, Graduate School of Medicine and Dentistry, Assistant Professor (30304314)
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| Co-Investigator(Kenkyū-buntansha) |
KUBOKI Takuo Okayama University, Graduate School of Medicine and Dentistry, Professor (00225195)
KANYAMA Manabu Okayama University, Hospital, Senior Assistant Professor (90294420)
UEHARA Junji Okayama University, Hospital, Assistant Professor (10379836)
NAWACHI Kumiko Okayama University, Graduate School of Medicine and Dentistry, Assistant Professor (10379787)
SEIYA Yamasaki Okayama University, Hospital, staff (40444666)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,440,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2005: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | Peri-implantitis / Matrix metalloproteinases / Peri-implant sulcular fluids / Risk marker / Risk factor / multivariate analysis / QoL / Response Sift / 腫瘍壊死因子 / ELISA / 残存率 / 単純除去率 / 可溶型レセプター / QOL / 骨破壊 / 力学的因子 |
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| Research Abstract |
The first aim of this study was to detect MMP-1, MMP-8 and MMP-13 in the pen-implant sulcular fluid (PISF) collected from peri-implantitis sites and to determine any correlations between the MMPs presence/absence and the ongoing or future bone loss. Four peri-implantitis and four matched control patients were included in this study. Annually adjusted vertical bone loss (AVBL) was calculated to determine the annual velocity of the bone loss. PISF was analyzed by Western blotting utilizing anti-human monoclonal antibodies specific for MMP-1, -8 and -13. In the group of peri-implantitis patients, MMP-8 was detected in the PISF from three active peri-implantitis sites whose AVBL were more than 0.8 mm per year. Meanwhile, MMP-8 was not detected in the PISF from the remaining six implants whose AVBL at PISF sampling was less than 0.6 mm per year. In the control patients, MMP-8 was not detected in any PISF. MMP-1 and -13 could not be found in any PISF samples. According to the findings, it was clarified that MMP-8 could be a good marker for predicting ongoing bone loss around dental implants. The next aim was to identify the risk factors in clinical success rates of osseointegration (SRO) using multivariate analysis. Subjects were consecutive patients who had been installed dental implants with rough surface in our hospital from February 1990 to March 2007. Logistic regression analysis showed that no predictor variables were risk factors for SRO with recent rough surface dental implants. The third aim was to assess oral-health-related QoL (OHQoL) levels before and after treatment in partial edentulous patients with implant-supported dentures, fixed and removable partial dentures and to compare OHQoL-based treatment effectiveness among those treatment modalities. This indicates that implant-supported dentures can improve the patients OHQoL level much higher than the fixed and removable restorations.
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Report
(4 results)
Research Products
(16 results)
