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Development of chair-side assay system for ongoing bone loss with peri-implant sulcus fluids

Research Project

Project/Area Number 17592025
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 補綴理工系歯学
Research InstitutionOkayama University

Principal Investigator

ARAKAWA Hikaru  Okayama University, Graduate School of Medicine and Dentistry, Assistant Professor (30304314)

Co-Investigator(Kenkyū-buntansha) KUBOKI Takuo  Okayama University, Graduate School of Medicine and Dentistry, Professor (00225195)
KANYAMA Manabu  Okayama University, Hospital, Senior Assistant Professor (90294420)
UEHARA Junji  Okayama University, Hospital, Assistant Professor (10379836)
NAWACHI Kumiko  Okayama University, Graduate School of Medicine and Dentistry, Assistant Professor (10379787)
SEIYA Yamasaki  Okayama University, Hospital, staff (40444666)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,440,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2005: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsPeri-implantitis / Matrix metalloproteinases / Peri-implant sulcular fluids / Risk marker / Risk factor / multivariate analysis / QoL / Response Sift / 腫瘍壊死因子 / ELISA / 残存率 / 単純除去率 / 可溶型レセプター / QOL / 骨破壊 / 力学的因子
Research Abstract

The first aim of this study was to detect MMP-1, MMP-8 and MMP-13 in the pen-implant sulcular fluid (PISF) collected from peri-implantitis sites and to determine any correlations between the MMPs presence/absence and the ongoing or future bone loss. Four peri-implantitis and four matched control patients were included in this study. Annually adjusted vertical bone loss (AVBL) was calculated to determine the annual velocity of the bone loss. PISF was analyzed by Western blotting utilizing anti-human monoclonal antibodies specific for MMP-1, -8 and -13. In the group of peri-implantitis patients, MMP-8 was detected in the PISF from three active peri-implantitis sites whose AVBL were more than 0.8 mm per year. Meanwhile, MMP-8 was not detected in the PISF from the remaining six implants whose AVBL at PISF sampling was less than 0.6 mm per year. In the control patients, MMP-8 was not detected in any PISF. MMP-1 and -13 could not be found in any PISF samples. According to the findings, it was clarified that MMP-8 could be a good marker for predicting ongoing bone loss around dental implants. The next aim was to identify the risk factors in clinical success rates of osseointegration (SRO) using multivariate analysis. Subjects were consecutive patients who had been installed dental implants with rough surface in our hospital from February 1990 to March 2007. Logistic regression analysis showed that no predictor variables were risk factors for SRO with recent rough surface dental implants. The third aim was to assess oral-health-related QoL (OHQoL) levels before and after treatment in partial edentulous patients with implant-supported dentures, fixed and removable partial dentures and to compare OHQoL-based treatment effectiveness among those treatment modalities. This indicates that implant-supported dentures can improve the patients OHQoL level much higher than the fixed and removable restorations.

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (16 results)

All 2007 2006 2005

All Journal Article (13 results) (of which Peer Reviewed: 2 results) Presentation (3 results)

  • [Journal Article] インプラント義歯装着患者のQOL測定におけるレスポンスシフトの影響2007

    • Author(s)
      荒川 光, ら
    • Journal Title

      日本口腔インプラント学会誌 20(1)

      Pages: 78-78

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] Effects of Response Shift on Measurement of QoL Levels in Partially Edentulous Patients with Implant-supported Dentures2007

    • Author(s)
      Arakawa, H., Kimura, A., Noda, k., Kanyama, M., Kuboki, T
    • Journal Title

      Journal of Japanese Society of Oral Implantology 20(1)

      Pages: 78-78

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 金属アレルギー患者に対するインプラント治療:チタン製修復物による暴露試験を行った1症例2007

    • Author(s)
      完山 学, ら
    • Journal Title

      日本口腔インプラント学会誌 20(2)

      Pages: 49-54

    • NAID

      10019575133

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 歯科補綴研究に役立つ統計学-臨床研究における予測・結果因子,統計解析-2007

    • Author(s)
      窪木 拓男, ら
    • Journal Title

      日本補綴歯科学会雑誌 51(1)

      Pages: 1-10

    • NAID

      10018731299

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 日本人を対象とした口腔インプラント治療の臨床成績に関するSystematic Review2006

    • Author(s)
      荒川 光, 窪木拓男
    • Journal Title

      歯界展望 108(1)

      Pages: 131-140

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Systematic Review on Survival of Osseointegrated Implants in Japanese patients2006

    • Author(s)
      Arakawa, H., Kuboki, T
    • Journal Title

      DENTAL OUTLOOK 108(1)

      Pages: 131-140

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] インプラント義歯装着患者のQoLレベル測定におけるレスポンスシフトの影響2006

    • Author(s)
      荒川 光ら
    • Journal Title

      第36回日本口腔インプラント学会学術大会プログラム・抄録集

      Pages: 148-148

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 日本人を対象とした口腔インプラント治療の臨床成績に関するSystematic Review2006

    • Author(s)
      荒川 光, 窪木拓男
    • Journal Title

      歯界展望 108 (1)

      Pages: 131-140

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 金属アレルギー患者に対するインプラント治療・チタン製修復物による暴露試験でチタンの安全性を確認した症例2006

    • Author(s)
      完山 学ら
    • Journal Title

      日本口腔インプラント学会誌 (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 比例ハザードモデルを用いたインプラント上部構造トラブルに関するリスク因子の同定2006

    • Author(s)
      野田欣志ら
    • Journal Title

      平成17年度社団法人日本補綴歯科学会中国・四国支部 九州支部合同学術大会 プログラム・抄録集

      Pages: 27-27

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 少数歯欠損患者の補綴治療後の口腔関連QOL2006

    • Author(s)
      荒川光ら
    • Journal Title

      第35回社団法人 日本口腔インプラント学会総会・学術大会 プログラム・抄録集

      Pages: 92-92

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 補綴学的にみた治療効果の評価-患者の主観的な観点から-2005

    • Author(s)
      荒川 光, 窪木拓男
    • Journal Title

      臨床家のための矯正YEAR BOOK 05 別冊

      Pages: 120-129

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Assessment of Treatment Outcomes in Prosthodontic Practice-Subjective Measures2005

    • Author(s)
      Arakawa, H., Kuboki, T
    • Journal Title

      Year Book for Orthodontics 2005

      Pages: 120-129

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 高齢者を対象とした口腔インプラント治療の疫学調査2007

    • Author(s)
      野田欣志, ら
    • Organizer
      第27回日本口腔インプラント学会中国・四国支部学術大会総会
    • Place of Presentation
      高松
    • Year and Date
      2007-12-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] Response Shifts in Oral Health-Related Quality of Life Measurement in Partially Edentulous Patients Treated with Dental Implants.2007

    • Author(s)
      Kimura A, Arakawa A, et. al.
    • Organizer
      The 2nd Joint Meeting of the Japan Prosthodontic Society and the Greater New York Academy of Prosthodontics
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-10-21
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Response Shifts in Oral Health-Related Quality of Life Measurement in Partially Edentulous Patients Treated with Dental Implants2007

    • Author(s)
      Kimura, A., Arakarwa, H., Noda, K., Matsuka, Y., Kuboki, T
    • Organizer
      The 2.4 Joint Meeting of the Japan Prosthodontic Society and the Greater New York Academy of Prosthodontics
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-10-21
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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