| Project/Area Number |
17592056
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
補綴理工系歯学
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| Research Institution | OSAKA DENTAL UNIVERSITY |
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Principal Investigator |
HIGUCHI Yuichi Osaka Dental University, Dentistry, Lecturer, 歯学部, 講師 (10181083)
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| Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Yoshiya Osaka Dental University, Dentistry, Instructor, 歯学部, 助手 (20228430)
HONTSU Shigeki Kinki University, Biology oriented science and technology, professor, 生物理工学部, 教授 (40157102)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2005: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | Implant / Hydroxyapatite / Pulse Laser-Deposited Methods / Biocompatibility |
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| Research Abstract |
In order to supply better biocompatibility to an implant such as an artificial tooth-root (ATR) and/or an artificial joint, thin films of 300nm in thickness of the natural and synthetic apatite were coated on titanium ATR (substrates) by pulsed laser deposition (PLD). It is impossible that the film of the natural apatite was coated on the substrate by the current coating method of plasma spraying. The film was evaluated by X-ray diffraction (XRD), energy dispersive X-ray analysis (EDX) and Fourier transform infrared spectroscopy (FT-IR). Biocompatibility of the coated ATR was also examined through an animal experiment.
The chemical contents and crystallinity of the coated film were similar to those of the apatite-target for PLD as a raw material. In the in vivo test by mandible of canine for observation of new bone formation within the peri-implant interface zone, experimental groups with natural and synthetic apatite films showed higher bone formation than that of the control group without the films after 8 weeks of healing. In the same in vivo test, new bone has already constructed a cancellous bone structure in the natural apatite group : clear bone growth occurred, however, no construction of the cancellous structure was found in the synthetic apatite group. It was concluded that the natural apatite ultra-thin film coating on implants with this PLD could provide higher bone integration, or better biocompatibility to a metallic and ceramic implants.
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