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What is the mechanism for paresthesia following nerve injury?

Research Project

Project/Area Number 17592068
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionNiigata University

Principal Investigator

SEO Kenji  Niigata University, Institute of Medicine and Dentistry, Associate professor, 医歯学系, 助教授 (40242440)

Co-Investigator(Kenkyū-buntansha) FUJIWARA Naoshi  Niigata University, Institute of Medicine and Dentistry, Professor, 医歯学系, 教授 (70181419)
MAEDA Takeyasu  Niigata University, Institute of Medicine and Dentistry, Professor, 医歯学系, 教授 (40183941)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2005: ¥2,300,000 (Direct Cost: ¥2,300,000)
Keywordsnerve injury / trigeminal / paresthesia / peptide / substance p / optical imaging / capsaicin / mice / peptide / optical imaging / mechanical touch threshold / unmyelinated fiber / caudalis
Research Abstract

1.Immuno-histochemical study : Temporo-spatial changes of substance P distribution in the trigeminal caudalis after nerve injury
(1)Neonatal capsaicin treatment induces a disappearance of substance p in deep part of the trigeminal caudalis (Vc) in adult and a transient decrease of substance p in superficial layers of the Vc recovered at 2 weeks of age.
(2)This emerged substance p in superficial layers of the Vc does not have any immunoreactivity either for N-200 (the marker for myelinated fiber) or IB4 (the marker for non-peptidergic neuron).
These results suggest that neonatal capsaicin treatment induces a long term deficit in nociceptive transmission in the Vc and it is caused by unavailability of neurotransmitter releasing but not by an disappearance of neural transmitters.
2.Behavioral study : Long term observation of changes in the mechanical-touch threshold after partial injury of mental nerve
(1)Ligation of the mental nerve in mice induces an apparent elevation of mechanical touch threshold just after nerve injury and this state lasts for 1 week.
(2)This elevation of the threshold decreases around 1 weeks and relative high level of the threshold remains for 4 weeks. After that, this elevation decreases and reaches to the control level.
(3)Changes in the threshold of this animal model look similar to clinical observation of peripheral nerve injury.
Combined with these results, it was suggested that peripheral nerve injury relates to neuropeptide from the afferent terminals in the Vc and mechanism for sensory impairment following nerve injury and its recovery has some relationships to change in the neuropeptide.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (5 results)

All 2007 2005

All Journal Article (5 results)

  • [Journal Article] Iteration of high-frequency stimulation enhances long-lasting excitatory responses in the spinal dorsal horn of rats : Characterization by optical imaging of spinal propagation2007

    • Author(s)
      Ogawa M, Takamatsu M, Okamoto M, Baba H, Seo K, Fujiwara N
    • Journal Title

      Neuroscience Research 57

      Pages: 467-472

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Iteration of high-frequency stimulation enhances long-lasting excitatory responses in the spinal dorsal horn of rats Characterization by optical imaging of spinal propagation,2007

    • Author(s)
      Ogawa M, Takamatsu M, Okamoto M, Baba H, Seo K, Fuiiwara N
    • Journal Title

      Neuroscience Research 57

      Pages: 467-472

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Postnatal development of substance P-immunoreaction in the trigeminal caudalis of neonatally capsaicin-treated mice2005

    • Author(s)
      Aita M, Maeda T, Takagi R, Seo K
    • Journal Title

      Archives of Histology and Cytology 68・4

      Pages: 311-320

    • NAID

      10017160871

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Postnatal development of substance P-immunoreaction in the trigeminal caudalis of neonatally capsaicin-treated mice2005

    • Author(s)
      Aita M, Maeda T, Takagi R, Seo K
    • Journal Title

      Archives of Histology and Cytology 68

      Pages: 311-320

    • NAID

      10017160871

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Postnatal development of substance P-immunoreaction in the trigeminal caudalis of neonatally capsaicin-treated mice2005

    • Author(s)
      Aita M, Maeda T, Takagi R, Seo K
    • Journal Title

      Achives of Histology and Cytology 68・4

      Pages: 311-320

    • NAID

      10017160871

    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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