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Development of an oral appliance driven by artificial muscles that induce mandibular protrusion only when sleep apnea develops

Research Project

Project/Area Number 17592074
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionKyoto University

Principal Investigator

YOSHIDA Kazuya  Kyoto University, Graduate School of Medicine, instructor, 医学研究科, 助手 (90263087)

Co-Investigator(Kenkyū-buntansha) CHIN Kazuo  Kyoto University, Graduate School of Medicine, Associate Protessor, 医学研究科, 助教授 (90197640)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2005: ¥2,200,000 (Direct Cost: ¥2,200,000)
Keywordssleep apnea syndrome / oral appliance / artificial muscle / life style related disease / hypertension / periodontal disease / magnetoencephalography / near infrared spectroscopy / 血圧
Research Abstract

1.We measured practical load and kinetic distortion of a metal-based artificial muscle. We recorded real practical load, distance and direction in order to advance the mandible during sleep.
2.One hundred sixty-one patients (mean age : 54.3years) diagnosed with sleep apnea syndrome (mean apnea-hypopnea index : 17.9) were studied before and after insertion of an oral appliance. Systolic, diastolic and mean blood pressure (132.0, 82.1, 107.1mmHg, respectively at baseline) decreased significantly (p<0.001) (127.5, 79.2, 103.4mmHg, respectively) after the insertion of the device. The responders (mean blood pressure fall>3.7mmHg) and the partial responders (0<fall≦3.7 mmHg) showed significantly (p<0.05) higher AHI reduction (69.6%, 65.9%, respectively) than that (52.5 %) of nonresponders (fall≦0mmHg). Effective oral appliance therapy can lead to a substantial reduction in blood pressure.
3.We measured the brain blood volume with near-infrared spectroscopy, jaw closing and opening movements, tongue protrusion movement, a measurement at the time of pronunciation, brain blood volume changes during sleep, and those in the frontal lobe during a word fluency task.
We measured the somatosensory evoked magnetic fields following air-puff stimulation by using a 122-channel neuromagnetometer. Responses were identified symmetrically in the bilateral parietotemporal regions with a mean latency of about 130 ms. Corresponding equivalent current dipoles were estimated around the Sylvian fissures. The responses were derived from the second somatosensory areas.
4.The ratio of moderate periodontal disease having pockets of 4-6mm was 38.4%, and 58.9% showed severe periodontal disease presenting 6mm at the deepest pocket. Patients with a periodontal pocket equal to or less than 3mm accounted for only 2.7% of the patients receiving periodical periodontal treatment. Most patients have periodontal disease with medium or severe grade symptom, who had not received periodical periodontal treatment.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (34 results)

All 2007 2006 2005

All Journal Article (28 results) Book (6 results)

  • [Journal Article] 睡眠時無呼吸症候群の治療と予後 3. 口腔内装置2007

    • Author(s)
      吉田和也
    • Journal Title

      Mebio睡眠時無呼吸症候群特集号 24

      Pages: 124-138

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Modified hygienic Epitec System abutment for magnetic retention of orbital prostheses.2007

    • Author(s)
      K.Yoshida, A.Takagi, Y.Tsuboi, K.Bessho
    • Journal Title

      Journal of Prosthodontics (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Treatment and prognosis of sleep apnea syndrome part 3. Oral appliance.2007

    • Author(s)
      Yoshida K.
    • Journal Title

      Mebio special issue 24

      Pages: 124-138

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Sleep and oral hygiene.2007

    • Author(s)
      Yoshida K.
    • Journal Title

      Honda K, Fukuda K, Shiomi T (eds), Sleep Medicine, Asakura, Tokyo (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Involuntary movements in the orofacial region.2007

    • Author(s)
      Miyawaki S, Yoshida K.
    • Journal Title

      Cyclopedia of Mouth and Teeth. Asakura, Tokyo (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Modified hygienic Epitec System abutment for magnetic retention of orbital prostheses.2007

    • Author(s)
      Yoshida K, Takagi A, Tsuboi Y, Bessho K.
    • Journal Title

      Journal of Prosthodontics (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 睡眠に関する口腔衛生.睡眠学(本田和樹,福田一彦,塩見利明ほか編)2007

    • Author(s)
      吉田和也
    • Journal Title

      朝倉書店 (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effect on blood pressure of oral appliance therapy for sleep apnea syndrome.2006

    • Author(s)
      K.Yoshida
    • Journal Title

      International Journal of Prosthodontics 19

      Pages: 61-66

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Somatosensory evoked magnetic fields to air-puff stimulation on the soft palate.2006

    • Author(s)
      K.Yoshida, H.Maezawa, T.Nagamine, H.Fukuyama, K.Murakami, T.Iizuka
    • Journal Title

      Neuroscience Research 55

      Pages: 116-122

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Botulinum toxin treatment for upper airway collapse resulting from temporomandibular joint dislocation due to jaw-opening dystonia.2006

    • Author(s)
      K.Yoshida, T.Iizuka
    • Journal Title

      Journal of Craniomandibular Practice 24

      Pages: 217-222

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Coronoidotomy as treatment for trismus due to jaw-closing oromandibular dystonia.2006

    • Author(s)
      K.Yoshida
    • Journal Title

      Movement Disorders 21

      Pages: 1028-1031

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effect of oral appliance therapy for sleep apnea syndrome on blood pressure.2006

    • Author(s)
      Yoshida K.
    • Journal Title

      Proceedings of the1st Congress of the World Association of Sleep Medicine

      Pages: 115-118

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effect on blood pressure of oral appliance therapy for sleep apnea syndrome.2006

    • Author(s)
      Yoshida K.
    • Journal Title

      International Journal of Prosthodontics 19

      Pages: 61-66

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Somatosensory evoked magnetic fields to air-puff stimulation on the soft palate.2006

    • Author(s)
      Yoshida K, Maezawa H, Nagamine T, Fukuyama H, Murakami K, Iizuka T.
    • Journal Title

      Neuroscience Research 55

      Pages: 116-122

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Coronoidotomy as treatment for trismus due to jaw-closing oromandibular dystonia.2006

    • Author(s)
      Yoshida K.
    • Journal Title

      Movement Disorders 21

      Pages: 1028-1031

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Botulinum toxin treatment for upper airway collapse resulting from temporomandibular joint dislocation due to jaw-opening dystonia.2006

    • Author(s)
      Yoshida K, Iizuka T.
    • Journal Title

      Journal Craniomandibl Pract 24

      Pages: 217-222

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Coronoidotomy as treatment for trismus due to jaw-closing oromandibular dystonia.2006

    • Author(s)
      K.Yoshida.
    • Journal Title

      Movement Disorders 21

      Pages: 1028-1031

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effect on blood pressure of oral appliance therapy for sleep apnea syndrome.2006

    • Author(s)
      K.Yoshida.
    • Journal Title

      International Journal of Prosthodontics 19

      Pages: 61-66

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Botulinum toxin treatment for upper airway collapse resulting from temporomandibular joint dislocation due to jaw-opening dystonia.2006

    • Author(s)
      K.Yoshida, T.Iizuka.
    • Journal Title

      Journal of Cranioinandibular Practice (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Coronoidotomy as treatment for trismus due to jaw-closing oromandibular dystonia.2006

    • Author(s)
      K.Yoshida.
    • Journal Title

      Movement Disorders (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Somatosensory evoked magnetic fields to air-puff stimulation on the soft palate.2006

    • Author(s)
      K.Yoshida, H.Maezawa, T.Nagamine, H.Fukuyama, K.Murakami, T.Iizuka.
    • Journal Title

      Neuroscience Research (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Contingent negative variation for voluntary mandibular movements in humans.2005

    • Author(s)
      K.Yoshida, T.Iizuka
    • Journal Title

      Journal of Oral Rehabilitation 32

      Pages: 871-879

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Rehabilitation with dental prosthesis can increase cerebral regional blood volume.2005

    • Author(s)
      I.Miyamoto, K.Yoshida, Y.Tsuboi, T.Iizuka
    • Journal Title

      Clinical Oral Implants Research 16

      Pages: 723-727

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Dental and surgical therapies of sleep apnea syndrome.2005

    • Author(s)
      Yoshida K, Iizuka T.
    • Journal Title

      Ueda M, Noma H, Katsuki T, (eds), Hand manual of Oral and Maxillofacial Surgery '05. Quintessence, Tokyo

      Pages: 27-39

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Contingent negative variation for voluntary mandibular movements in humans.2005

    • Author(s)
      Yoshida K, Iizuka T.
    • Journal Title

      Journal of Oral Rehabilitation 32

      Pages: 871-879

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Rehabilitation with dental prosthesis can increase cerebral regional blood volume.2005

    • Author(s)
      Miyamoto I, Yoshida K, Tsuboi Y, Iizuka T.
    • Journal Title

      Clinical Oral Implants Research 16

      Pages: 723-727

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Contingent negative variation for voluntary mandibular movements in humans.2005

    • Author(s)
      K.Yoshida, T.Iizuka.
    • Journal Title

      Journal of Oral Rehabilitation 32

      Pages: 871-879

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Rehabilitation with dental prosthesis can increase cerebral regional blood volume.2005

    • Author(s)
      Z.Miyamoto, K.Yoshida, Y.Tsuboi, T.Iizuka.
    • Journal Title

      Clinical Oral Implants Research 16

      Pages: 723-727

    • Related Report
      2005 Annual Research Report
  • [Book] 睡眠に関する口腔衛生(睡眠学)(本田和樹,福田一彦,塩見利明ほか編)2007

    • Author(s)
      吉田和也
    • Publisher
      朝倉書店(印刷中)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 「顎顔面領域の不随意運動.」口と歯の事典2007

    • Author(s)
      宮脇正一, 吉田和也
    • Publisher
      朝倉書店(印刷中)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 睡眠に関する口腔衛生.睡眠学(本田和樹,福田一彦,塩見利明ほか編)2007

    • Author(s)
      吉田和也
    • Publisher
      朝倉書店,東京
    • Related Report
      2006 Annual Research Report
  • [Book] "Effect of oral appliance therapy for sleep apnea syndrome on blood pressure." Proceedings of the 1st Congress of the World Association of Sleep Medicine2006

    • Author(s)
      K.Yoshida
    • Publisher
      Medimond
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 睡眠に関する口腔衛生.睡眠学(本田和樹, 福田一彦, 塩見利明ほか編)2006

    • Author(s)
      吉田和也.
    • Publisher
      朝倉書店,東京(印刷中)
    • Related Report
      2005 Annual Research Report
  • [Book] 睡眠時無呼吸症候群の歯科口腔外科的治療法(口腔外科ハンドマニュアル'05)(上田 実,香月 武,野間弘康ほか編)2005

    • Author(s)
      吉田和也, 飯塚忠彦
    • Publisher
      クインテッセンス出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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