• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Molecular Mechanism of invasion in Oral squamous cell carcinomas,-small GTPase regulates the invasion.

Research Project

Project/Area Number 17592075
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionOsaka University

Principal Investigator

NAKAHARA Hirokazu  Osaka University, Dental Hospital, Associate Professor, 歯学部附属病院, 助教授 (70324796)

Co-Investigator(Kenkyū-buntansha) KOGO Mikihiko  Osaka University, Graduate School of Dentistry Hospital, Professor, 歯学研究科, 教授 (20205371)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2006: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2005: ¥2,700,000 (Direct Cost: ¥2,700,000)
Keywordscancer / invasion / metastasis / small GTPase / 低分子G蛋白質 / 低分子G蛋白
Research Abstract

Epithelial-mesenchymal interaction is crucial in invade surrounding tissues by metastatic tumor cells. Here, we presented modified an in vitro fibronectin degradation/invasion assay that was co-cultured tumor cell with fibroblast. Using this assay, we estimated invasive activity as to three cell lines derived from human oral squamous cell carcinomas with different invasion mode. According to Yamamoto Kohama's classification, OSC20 was classified into grade 3,OSC19 into grade 4C and HOC313 into grade 4D. HOC313 showed strong invasiveness in co-cultured with fibroblast than OSC20 and OSC19 did. Also, knock down for MT1-MMP of cancer cell or/and fibroblast completed inhibit in vitro invasiveness.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (10 results)

All 2006 2005

All Journal Article (10 results)

  • [Journal Article] Molecular mechanism of invadopodia formation of oral squamous cell carcinoma : involvement of small G proteins.2006

    • Author(s)
      Otani T., Nakahara H., Miura Y., Matsuoka Y.et al.
    • Journal Title

      Dentistry in Japan 42

      Pages: 65-68

    • NAID

      10019595414

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Small G protein Rhoファミリーによるロ腔扁平上皮癌細胞の浸潤能の制御2006

    • Author(s)
      中原寛和, 大谷朋弘, 松岡裕大, 三浦康寛, 久島潔, 古郷幹彦
    • Journal Title

      日口組織培養学会誌 15

      Pages: 49-50

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Molecular mechanism of invadopodia formation of oral squamous cell carcinoma : involvement of small G proteins.2006

    • Author(s)
      Otani T., Nakahara H., Miura Y., Matsuoka Y., et al.
    • Journal Title

      Dentistry in Japan 42

      Pages: 65-68

    • NAID

      10019595414

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Small GTPases regulate invadopodia formation of oral squamous cell carcinoma.2006

    • Author(s)
      Nakahara H., Otani T., Matsuoka Y., Mikihiko Kogo.
    • Journal Title

      Jap.J.Tissue Cult.Dent.Res. 15

      Pages: 49-50

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Small G protein Rhoファミリーによる口腔扁平上皮癌細胞の浸潤能の制御2006

    • Author(s)
      中原寛和, 大谷朋弘, 松岡裕大, 三浦康寛, 久島潔, 古郷幹彦
    • Journal Title

      日口組織培養学会誌 15

      Pages: 49-50

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 大阪大学歯学部附属病院検査部における過去30年間の病理組織検査の臨床統計的観察2006

    • Author(s)
      中原寛和, 永田雅英, 石田久枝, 松岡裕大, 他
    • Journal Title

      阪大歯学誌 51

      Pages: 11-17

    • NAID

      10026061317

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Molecular mechanism of invadopodia formation of oral squamous cell carcinoma : involvement of small G proteins2006

    • Author(s)
      Otani T., Nakahara H., Miura Y., Matsuoka Y., Yamanishi T., Ueda T., Nozaki S., Tanaka A., Yamamoto E., Kogo M.
    • Journal Title

      Dentistry in Japan (In press)

    • NAID

      10019595414

    • Related Report
      2005 Annual Research Report
  • [Journal Article] B7.2 Ig fusion protein enhance IL-4 dependent differentiation of tumor-sensitized CD8^+ cytotoxic T lymphocyte precursors,2005

    • Author(s)
      Hiraoka S., Takeuchi N., Bian Y., Nakahara H., Kogo M., Dunussi-Joannopoulos K., Wolf S., Ono S., Fujiwara H
    • Journal Title

      Int. Immunology 8

      Pages: 1071-1079

    • NAID

      10019357444

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Inhibition of invasion and metastasis in oral cancer experimental models by antisense nucleic acid targeting urokinase-type plasminogen activator receptor.2005

    • Author(s)
      Nozaki S., Endo Y., Nakahara H., Yoshizaw K., Hashiba Y., Kawashiri S., Tanaka A., Nakagawa K., Matsuoka Y., Kogo M., Sasaki T., Yamamoto E
    • Journal Title

      Oral Oncology 41

      Pages: 1019-1027

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Induction of surface CCR4 and its functionality in mouse Th2 cells is regulated differently during Th2 development.2005

    • Author(s)
      Morimoto, Y., Bian, Y., Yashiro-Ohtani, Y., Zhou, X.Y., Ono, S., Nakahara, H., Kogo, M., Hamaoka, T., Fujiwara, H.
    • Journal Title

      J Leukoc Biol 78

      Pages: 753-761

    • Related Report
      2005 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi