Molecular Mechanism of invasion in Oral squamous cell carcinomas,-small GTPase regulates the invasion.
Project/Area Number |
17592075
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Surgical dentistry
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Research Institution | Osaka University |
Principal Investigator |
NAKAHARA Hirokazu Osaka University, Dental Hospital, Associate Professor, 歯学部附属病院, 助教授 (70324796)
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Co-Investigator(Kenkyū-buntansha) |
KOGO Mikihiko Osaka University, Graduate School of Dentistry Hospital, Professor, 歯学研究科, 教授 (20205371)
|
Project Period (FY) |
2005 – 2006
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Project Status |
Completed (Fiscal Year 2006)
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Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2006: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2005: ¥2,700,000 (Direct Cost: ¥2,700,000)
|
Keywords | cancer / invasion / metastasis / small GTPase / 低分子G蛋白質 / 低分子G蛋白 |
Research Abstract |
Epithelial-mesenchymal interaction is crucial in invade surrounding tissues by metastatic tumor cells. Here, we presented modified an in vitro fibronectin degradation/invasion assay that was co-cultured tumor cell with fibroblast. Using this assay, we estimated invasive activity as to three cell lines derived from human oral squamous cell carcinomas with different invasion mode. According to Yamamoto Kohama's classification, OSC20 was classified into grade 3,OSC19 into grade 4C and HOC313 into grade 4D. HOC313 showed strong invasiveness in co-cultured with fibroblast than OSC20 and OSC19 did. Also, knock down for MT1-MMP of cancer cell or/and fibroblast completed inhibit in vitro invasiveness.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Inhibition of invasion and metastasis in oral cancer experimental models by antisense nucleic acid targeting urokinase-type plasminogen activator receptor.2005
Author(s)
Nozaki S., Endo Y., Nakahara H., Yoshizaw K., Hashiba Y., Kawashiri S., Tanaka A., Nakagawa K., Matsuoka Y., Kogo M., Sasaki T., Yamamoto E
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Journal Title
Oral Oncology 41
Pages: 1019-1027
Related Report
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[Journal Article] Induction of surface CCR4 and its functionality in mouse Th2 cells is regulated differently during Th2 development.2005
Author(s)
Morimoto, Y., Bian, Y., Yashiro-Ohtani, Y., Zhou, X.Y., Ono, S., Nakahara, H., Kogo, M., Hamaoka, T., Fujiwara, H.
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Journal Title
J Leukoc Biol 78
Pages: 753-761
Related Report