| Project/Area Number |
17592096
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
KAWAHARA Hiroshi Kyushu Dental College, Faculty of Dentistry, Associate Professor, 歯学部, 助教授 (10186124)
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| Co-Investigator(Kenkyū-buntansha) |
SHIIBA Shunji Kyushu Dental College, Faculty of Dentistry, Assistant Professor, 歯学部, 講師 (20285472)
YOSHIDA Mitshuhiro Kyushu Dental College, Faculty of Dentistry, Instructor, 歯学部, 助手 (40364153)
KAWAHARA Yukie Kurume University School of Medicine, Faculty of Dentistry, Instructor, 医学部, 助手 (10279135)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2005: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | Stress / Chaos / Pharmacology / Neuroscience / Plethysmogram / Lyapunov Exponent / Microdialysis / Dentistry |
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| Research Abstract |
The development of non-benzodiazepine drugs that have only the anxiolytic or sedative action of benzodiazepines started in the latter half of the 1980's. These drugs have been developed using two approaches: development of partial benzodiazepine receptor agonists, and development of drugs with selectivity for the a subunit of the GABAA receptor, at which the benzodiazepine receptor binding site exists. Anxioselective drugs have been developed using the former approach, whereas sedative-selective drugs have emerged from the latter.
The actions of the anxioselective drug Y-23684 and the sedative-selective drug zolpidem on the central nervous system have been studied by dual-probe microdialysis. This approach has shown that anxioselective drugs suppress accentuation of the locus coeruleus-medial prefrontal cortex norepinephrine neural activity under stress, while sedative-selective drugs suppress accentuation of the ventral tegmental area-nucleus accumbens dopamine neuron activity in the stress state. These findings suggest that the difference in the effect on the neural network relates to the selectivity for anxiolytic or sedative action.
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