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Search for the cause of trigeminal neuralgia and development of its treatment procedures - Effects of newly developed gamma knife surgery -

Research Project

Project/Area Number 17592110
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionMatsumoto Dental University

Principal Investigator

TOMIDA Mihoko  Matsumoto Dental University, Oral Physiolosy, Associate Professor, 歯学部, 助教授 (00366329)

Co-Investigator(Kenkyū-buntansha) HAYASHI Motohiro  Tokyo Women's Medical University, Neurosurgery, Research Associate, 医学部, 助手 (20256499)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2005: ¥2,500,000 (Direct Cost: ¥2,500,000)
KeywordsGamma Knife / Radiosurgery / Trigeminal neuralgia / pain / 突発性疼痛 / ガンマ線
Research Abstract

Gamma knife surgery (GKS) has been increasingly utilized to manage a wide variety of indications including arteriovenous malformations, brain tumors, Parkinson disease, or focal epilepsy. Although in clinical practice, GKS is thought to be a safe and effective treatment for these diseases, little is understood about the alteration of biological properties induced by gamma irradiation. In recent studies using animals, it has been shown that high-dose gamma irradiation causes marked degeneration of the capillary endothelial cells, consequently inducing edema and necrosis in the irradiated area. Displacement of the irradiation sites in the anteromedical direction increased spontaneous activity, and posterolateral shift provoked circling behavior on the apomorphin test. The observation of rat sciatic nerve irradiated by 100 Gy indicated that the gamma irradiation might not affect the sensitivity of the normal nerve, but does affect the release of inflammatory mediators or the activity of endogenous inhibitors.
More recently, GKS has also been employed to treat intractable pain, such as trigeminal neuralgia, thalamic pain and cancer pain. For the treatment of trigeminal neuralgia, the retro gasserian was targeted and irradiated using a 4mm collimator to deliver 90 Gy. All patients experienced a significant pain reduction within 6 months. Thus, it is very important to conduct further basic experiments to determine the optimal treatment protocol using GKS for various diseases across many fields.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (13 results)

All 2007 2006

All Journal Article (13 results)

  • [Journal Article] Gamma Knife Radiosurgery Targeting Protocols for the Experiments with Small Animals.2007

    • Author(s)
      Osamu Tokumaru, et al.
    • Journal Title

      Stereotact Funct Neurosurg 85・4

      Pages: 135-143

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Gamma Knife Radiosurgery Targeting Protocols for the Experiments with Small Animals.2007

    • Author(s)
      Osamu Tokumaru, et al.
    • Journal Title

      Stereotact Funct Neurosurg 85(4)

      Pages: 135-143

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Abnormal crystal Groth of Rat Teeth by Excessive Gamma Knife Irradiation of Brain : Microscope ATR/FT-IR Spectroscopy Study2006

    • Author(s)
      Koichi Murayama, et al.
    • Journal Title

      ITE Letters 7・1

      Pages: 84-86

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The Sensitivity of the Rat Sciatic Nerve after Gamma Knife Irradiation.2006

    • Author(s)
      Mihoko Tomida, et al.
    • Journal Title

      ITE Letters 7・5

      Pages: 87-91

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Effect of unpleasant loud noise on hippocampal activities during picture encoding : An fMRI study.2006

    • Author(s)
      Hirano Yoshiyuki, et al.
    • Journal Title

      Brain Cogn. 61・3

      Pages: 280-285

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Correlation between the oxidative state of the synovial fluid and the radiological morphology of the temporomandibular joint in patients with temporomandibular joint disorder.2006

    • Author(s)
      Atsushi Kobayashi, et al.
    • Journal Title

      Asian J Oral Maxillofac Surg 18

      Pages: 185-190

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] ガンマナイフによる組織変化と臨床応用2006

    • Author(s)
      富田美穂子 他
    • Journal Title

      松本歯学 32・3

      Pages: 188-198

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Abnormal crystal Growth of Rat Teeth by Excessive Gamma Knife Irradiation of Brain : Microscope ATR/FT-IR Spectroscopy Study.2006

    • Author(s)
      Koichi Murayama, et al.
    • Journal Title

      ITE Letters 7(1)

      Pages: 84-86

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The Sensitivity of the Rat Sciatic Nerve after Gamma Knife Irradiation.2006

    • Author(s)
      Mihoko Tomida, et al.
    • Journal Title

      ITE Letters 7(5)

      Pages: 87-91

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effect of unpleasant loud noise on hippocampal activities during picture encoding : An fMRI study.2006

    • Author(s)
      Hirano Yoshiyuki, et al.
    • Journal Title

      Brain Cogn 61 (3)

      Pages: 280-285

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Histological changes and clinical outcomes after gamma knife surgery.2006

    • Author(s)
      Mihoko Tomida, et al.
    • Journal Title

      Matsumoto Shigaku 32(3)

      Pages: 188-198

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] ガンマナイフによる組織変化と臨床応用2006

    • Author(s)
      富田美穂子 他
    • Journal Title

      松本歯学 32・3(In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Abnormal crystal Groth of Rat Teeth by Excessive Gamma Knife Irradiation of Brain : Microscope ATR/FT-IR Spectroscopy Study2006

    • Author(s)
      Koichi Murayama, et al.
    • Journal Title

      ITE Letters 7・1(In press)

    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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