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Analysis of regeneration of oral maxillofacial region of network in homeotic gene

Research Project

Project/Area Number 17592114
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionNihon University

Principal Investigator

SEKIWA Tadanobu  Nihon University, School of Dentistry, Assistant Professor, 歯学部, 講師 (00154659)

Co-Investigator(Kenkyū-buntansha) INAGE Toshihiko  Nihon University, School of Dentistry, Associate Professor, 歯学部, 助教授 (90096769)
OIDA Shinichiro  Tsurumi University, School of Dental Medicine, Associate Professor, 歯学部, 助教授 (10114745)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2006: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2005: ¥2,700,000 (Direct Cost: ¥2,700,000)
KeywordsBMP / RANKL / RANK / OPG / bone formation / 骨芽細胞 / 破骨細胞 / 線維芽細胞 / nano-HAP / 異所性骨形成 / 成長因子 / 担体
Research Abstract

Growth factor and homeotic gene play an important role in the formation of oral maxillofacial region. Gene expression and localization of growth factor was investigated by in situ hybridization and immunohistochemistry by various stages of mouse embryos. BMP was expressed in the precursor cells osteoblasts in the region of initial bone formation stage. Noggin was expressed in the same stage of precursor cells. Receptor activator of nuclear factor-kB ligand (RANKL), a member of tumor necrosis factor (TNF) super family, regulates the differentiation, activation, and apoptosis of osteoclasts through binding to its cognate receptor, Receptor activator of nuclear factor-kB (RANK). Osteoprotegerin (OPG) is a recently identified cytokine with an important role in bone remodeling that acts as a decoy receptor for RANKL; OPG was shown to be an important inhibitor of osteoclasts differentiation and activation. Tumor necrosis factor receptor-associated factor 6 (TRAF6) is a crucial signaling transducer that regulates osteoclasts differentiation. Thus, RANKL/RANK/OPG system controls bone remodeling. The distributions of this system were examined by immunohistochemistry. RANKL expressed in the cells of osteogenic layer. The early stage of osteoblasts and osteocytes showed strong expression. RANK expressed in the late stage of osteoblasts and osteocytes. The osteoclasts showed the strongest expression. OPG was detected in the osteoblasts. The intracellular signal transmitter of TRAF6 showed the same distributions of RANKL.RANKL/RANK/OPG system plays an important role by controlling the differentiation and maturation of osteoclasts during remodeling of the bone. Expression of Runx2 mRNA also regulates with BMP. Expression of Runx2 appeared in early stage of osteoblast differentiation. Ectopic bone formation also studied.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (9 results)

All 2007 2006

All Journal Article (9 results)

  • [Journal Article] 著者への手紙 関和忠信先生、嶋田淳先生、鈴木善雄先生 さらにレベルの高い顎変形症のチームアプローチを歯科医療界に定着させよう!!(レター)2007

    • Author(s)
      伊東隆利, 関和忠信
    • Journal Title

      日本歯科評論 67 (1)

      Pages: 47-48

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Letter to editor, Let's generalize higher level in team approach for jaw deformities (Letter)2007

    • Author(s)
      Ito T, Sekiwa S
    • Journal Title

      J of Jap oral hyg and the Nippon dent rev 67(1)

      Pages: 47-48

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 血管腫、白板症および扁平苔癖に対する凍結外科療法の臨床的検討2006

    • Author(s)
      上原浩之, 寺門正昭, 本田雅彦, 白壁秀規, 筒井祐介, 秋山裕, 秀真理子, 関和忠信, 松本光彦, 橋本光二, 久村智子
    • Journal Title

      日本口腔診断学会雑誌 19 (2)

      Pages: 246-250

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 顎変形症のさまざまな病態と対応法の概要について 知っておきたい現状と問題点、今後求められること2006

    • Author(s)
      土手秀美, 大野繁, 月村直樹, 富田貴志, 岩成進吉, 関和忠信, 本田雅彦, 上原任, 上原浩之, 中田智子
    • Journal Title

      日本歯科評論 66 (12)

      Pages: 53-64

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] ラット切歯におけるRunx2 mRNAの発現2006

    • Author(s)
      稲毛稔彦, 山本達也, 関和忠信, 中田智子, 鴨川紘征, 佐藤吉則, 寺門正昭, 桑田文幸, 下川仁弥太
    • Journal Title

      日大歯学 81 (1)

      Pages: 21-27

    • NAID

      10031154553

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Clinical consideration on freeze techinique forheamangiouma, leukoplakia and lichen planus2006

    • Author(s)
      Uehara H, Terakado M, Honda M, Shirakabe H, Tutui Y, Akiyama H, Hide M, Sekiwa T, Matumoto M, Hasimoto K, Hisamura T
    • Journal Title

      J of Jap Soci of Oral Diag and Oral Med 19(2)

      Pages: 246-250

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The condition of a patient and a summary of, The present conditions and the problems in various pathological condition and correspondence method for jaw deformities2006

    • Author(s)
      Tuchite H, Ohno S, Tsukimura M, Tomits T, Iwaki S, Sekiwa T, Honda, Uehara H, Uehara H, Nakada T
    • Journal Title

      J of Jap oral hyge and the Nippon dent rev 66(12)

      Pages: 53-64

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Expression of Runx2 mRNA in Rat Incisors2006

    • Author(s)
      Inage T, Yamamoto T, Sekiwa S, Nakada T, Kamogawa H, Sato Y, Terakado M, Kuwata F, Shimokawa H
    • Journal Title

      Nihon Univ Dent J 81(1)

      Pages: 21-27

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] ラット切歯におけるRunx2 mRNAの発現2006

    • Author(s)
      稲毛稔彦, 山本達也, 関和忠信, 中田智子, 鴨川絋征, 佐藤吉則, 寺門正昭, 桑田文幸, 下川仁弥太
    • Journal Title

      日大歯学 80・1

      Pages: 21-27

    • NAID

      10031154553

    • Related Report
      2006 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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