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Study on sedation using dexmedetomidine-Evaluation by EEG Entropy^<TM>

Research Project

Project/Area Number 17592115
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionTsurumi University

Principal Investigator

NOGUCHI Izumi  Tsurumi Univ., School of Dent. Med., Associate Prof., 歯学部, 助教授 (60103545)

Co-Investigator(Kenkyū-buntansha) SHIMADA Rikako  Tsurumi Univ., School of Dent. Med., Assistant Prof., 歯学部, 助手 (10329229)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2005: ¥3,000,000 (Direct Cost: ¥3,000,000)
Keywordsdexmedetomidine / propofol / sedation / EEG Entropy / BIS / Dental Anesthesiology / Ramsay score / cardiorespiratory change / デクストデトミジン / 鎮静度 / 体温 / ボランティア
Research Abstract

The effects of sedative doses of propofol (Prop) and dexmedetomidine (Dex) on EEG (BIS and Entropy^<TM>), and cardiorespiratory changes were studied. The characteristics of Entropy^<TM>(SE, RE) were also evaluated. Twelve young male volunteers participated in two different sessions : Group P received Prop (8mg/kg/hr) for 10 min followed by 4mg/kg/hr for 20 min and Group D received Dex (6μg/kg/hr) for 10 min followed by 0.2μ g/kg/hr for 20 min. Each drug was injected for the first 30 min and stimulation by scaling was applied from the first 10 to 20 min. BIS, SE, RE, Ramsay score, amnesia, heart rate, blood pressure, Spo2, respiratory rate and Etco2 were measured until 120min. During infusion, BIS・SE and RE decreased in both groups. When stimulation was given, the value of BIS, SE and RE of both groups increased. Ramsay score increased and amnesia was observed. The increase of heart rate and decrease of blood pressure were observed in Group P, and decrease of heart rate was observed in Group D. In Group P, Spo2 decreased transiently, but Etco2 and RR showed no change. In Group D, Spo2 decreased transiently, Etco2 decreased, and RR showed no change. During recovery period, the values of all parameters of Group D returned to control values more slowly than those of Group P. When comparing BIS with SE, there was a correlation between BIS and SE in both groups. Both BIS and SE were also correlated with Ramsay scores. The correlation coefficient was higher in Group P than in Group D during infusion. From this study, patients receiving Dex are readily awakened by stimulation from hypnosis, and need longer time to recover from sedation, and showed slight cardiorespiratory depression effects. There is a correlation between BIS and Entropy^<TM>. Both values also correlate with sedation level with higher correlation in Prop compared to Dex.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (9 results)

All 2007 2006 2005

All Journal Article (8 results) Book (1 results)

  • [Journal Article] 鎮静量のデクスメデトミジンとプロポフォールが脳波と呼吸循環動態に及ぼす影響2007

    • Author(s)
      島田利加子, 野口いづみ
    • Journal Title

      日本歯科麻酔学会雑誌 35・2

      Pages: 170-178

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Effects of Sedative Doses of Dexmedetomidine and Propofol on EEG and Cardiorespiratory Changes2007

    • Author(s)
      Shimada R, Noguchi I
    • Journal Title

      Journal of Japanese Dental Society of Anesthesiology 35(2)

      Pages: 170-178

    • NAID

      10019920981

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Fatal hyperthermie due to dental treatment2006

    • Author(s)
      Noguchi I(他5名, 1番目)
    • Journal Title

      Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics 101・3

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Disturbance of microcirculation due to unhealthy life style : Cause of type 2 diabetes2006

    • Author(s)
      Noguchi I(他4名, 3番目)
    • Journal Title

      Medical Hypothesis 66・3

      Pages: 550-553

    • Related Report
      2005 Annual Research Report
  • [Journal Article] インプラント手術時のミダゾラムとプロポフォールを用いた静脈内鎮静法の患者満足度のアンケート調査による検討2005

    • Author(s)
      野口いづみ(他9名、9番目)
    • Journal Title

      日本歯科麻酔学会雑誌 33・5

      Pages: 714-719

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 血圧計のマンシェットにより著しい出血斑を生じた1症例2005

    • Author(s)
      野口いづみ(他6名、2番目)
    • Journal Title

      日本歯科麻酔学会雑誌 33・5

      Pages: 730-731

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 過換気発作を生じやすいComplex Regional Pain Syndrome type1患者の全身麻酔経験2005

    • Author(s)
      野口いづみ(他6名、2番目)
    • Journal Title

      日本歯科麻酔学会雑誌 33・3

      Pages: 443-444

    • NAID

      10016607114

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 静脈内鎮静法施術直前に心電図モニタ上で虚血性変化が疑われた1例2005

    • Author(s)
      野口いづみ(他5名、5番目)
    • Journal Title

      日本歯科麻酔学会雑誌 33・2

      Pages: 193-194

    • Related Report
      2005 Annual Research Report
  • [Book] 山の救急医療ハンドブック2005

    • Author(s)
      野口いづみ(編集)
    • Total Pages
      159
    • Publisher
      山と渓谷社
    • Related Report
      2005 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2016-04-21  

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