Effect of CPP-ACP containing paste on the demineralization and remineralization of enamel
| Project/Area Number |
17592150
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
OGATA Kiyokazu The Nippon Dental University, School of Life Dentistry at Tokyo, Associate Professor (90257006)
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| Co-Investigator(Kenkyū-buntansha) |
WARITA Sachie The Nippon Dental University, School of Life Dentistry at Tokyo, Assistant Professor (50386257)
SHIRASE Toshiomi The Nippon Dental University, School of Life Dentistry at Tokyo, Lecturer (20247018)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,180,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2006: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2005: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | CPP-ACP / Sodium fluoride / Demineralization / Remineralization / Bovine enamel / キシリトール |
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| Research Abstract |
MI Paste [○!R] ("MI"), which is produced by GC and contains 10% CPP-ACP, is a paste product that is similar to a dentifrice. We created an experimental environment in which enamel demineralization was promoted by lowering the concentrations of calcium and phosphorus in bate in order to study the effects of MI and fluoride interactions on both decalcification and remineralization. For our experiment, we used bovine incisor teeth. In this study, after the sample blocks were soaked in their respective process solutions (0.5 hour), the process of soaking them in bate (0.1 M of lactic acid, 0.1 M of sodium lactate, 3 mM of CaCl_2, 1.8 mM of KH_2PO_4 : pH 5.3, 23.5 hours) was repeated for 4 days, and we examined the efficacy of each processing solvent for inhibiting demineralization and promoting remineralization. Each processing solution is as follows : a. Control : 3.5 ml of sterile purified water b. 3.5 ml of 0.05% NaF solution (225 ppm) c. 3.5 ml of 0.02% NaF solution (90 ppm) d. 3.5 ml
… More
of 0.02% NaF solution and 1.5 g of MI e. 3.5 ml of 0.01% NaF solution (45 ppm) f. 3.5 ml of 0.01% NaF solution and 1.5 g of MI
On the sliced samples, the effects of the different processing solvents were observed using a polarizing microscope and microradiographs.
In a conventional experiment, the demineralization depression effect was not found in an MI simple substance, but it was shown by combination with fluoride definitely. As for this, fluorine used calcium and phosphorus in MI, and acceleration of remineralization was enhanced, and we thought that the mineral which it was calcified again showed acid resistance without it being decalcified again by acid. In addition, the effect of MI was evident in environment with a little calcium and phosphoric acid. In clinic, the area where saliva is not gone around that is the area where there are little Ca^<+2> and PO_4^3- can expect application of MI. Furthermore, the fluoride of the low concentration that used MI together showed that demineralization depression effect an equivalence or more was obtained when we used only fluoride of high concentration. These results suggested that MI can enhance the efficacy of fluorine to prevent dental caries. Less
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Use of CPP-ACP with fluoride inhibits demineralization on enamel lesions2007
Author(s)
S., Warita, K., Ogata, S., Shonai, T., Kawakami, T., Shirase, H., Karibe
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Journal Title
International J. Pediatric Dentistry 17(Suppl.1)
Pages: 42-43
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Effect of CPP-ACP containing paste on the remineralization of enamel2005
Author(s)
K., Ogata, A., Kuroda, S., Warita, S., Shonai, T., Kawakami, T., Shirase, Uchikawa, Y
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Journal Title
Jpn. J. Ped. Dent 43(2)
Pages: 325-325
Description
「研究成果報告書概要(欧文)」より
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[Presentation] The effect of CPP-ACP containing paste on the demineralization of enamel2007
Author(s)
K., Ogata, S., Warita, S., Shonai, T., Kawakami, K., Aoyagi, H., Karibe
Organizer
The 7th Workshop of Cariology Today inJapan
Place of Presentation
Kyoto
Year and Date
2007-06-02
Description
「研究成果報告書概要(欧文)」より
Related Report
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