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Mannose-binding lectin gene polymorphism as a risk factor shared in periodontal disease and diabetes mellitus

Research Project

Project/Area Number 17592163
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Periodontal dentistry
Research InstitutionMeikai University

Principal Investigator

HAYASHI Joichiro  Meikai University, School of Dentistry, Associate Professor (50337507)

Co-Investigator(Kenkyū-buntansha) SHIN Kitetsu  Meikai University, School of Dentistry, Professor (40187555)
HASEGAWA Akihiko  Meikai University, School of Dentistry, Professor (20198708)
GOTO Seiichi  Meikai University, School of Dentistry, Lecturer (70306299)
NANBA Nanba  Meikai University, School of Dentistry, Assistant Professor (40406393)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,670,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2006: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2005: ¥1,300,000 (Direct Cost: ¥1,300,000)
Keywordsperiodontal disease / diabetes mellitus / mannose-binding lectin / gene polymorphism
Research Abstract

Mannose-binding lectin (MBL) plays an important role in aspects of natural immunity such as complement activation and opsonization. It has been reported that MBL deficiency caused by MBL gene polymorphism is related not only to systemic infections, but also to aggressive periodontitis and diabetes mellitus (DM). In this study, we investigated the effect of MBL gene polymorphism and the serum concentration of MBL on the development and progression of type 2 DM, and on the progression of periodontal disease.
Sixty-two patients with DM and the same number of healthy subjects (HS) were included in this study. MBL codon 54 gene polymorphism and the serum MBL concentration were investigated in each individual The frequency of the MBL gene mutation was not significantly different between DM patients and HS. The serum MBL concentration was significantly lower in the subjects with the mutated gene (mutations) than in those with the wild-type one (wild-type), in both DM and HS groups. Furthermore, periodontal parameters were investigated in the DM patients. There was a significant difference in bleeding on probing between the mutation and wild-type groups of DM patients, the percentage being higher for the former. Especially in the wild-type group, there was a significant positive correlation between the serum MBL concentration and alveolar bone resorption.
In conclusion, our data suggest that MBL gene mutations possibly accelerate inflammation in the periodontal tissue of patients with type 2 diabetes mellitus and that the serum MBL concentration may be a systemic marker of periodontitis.

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (27 results)

All 2008 2007 2006 2005

All Journal Article (12 results) (of which Peer Reviewed: 5 results) Presentation (10 results) Book (5 results)

  • [Journal Article] マンノース結合レクチン遺伝子多型の2型糖尿病および歯周疾患との関連性に関する研究2008

    • Author(s)
      秦泉寺 傑
    • Journal Title

      明海歯科医学 37

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Relationship between Mannose-binding Lectin Gene Polymorphism and Type 2 Diabetes Mellitus/Periodontal Disease2008

    • Author(s)
      Suguru, Jinzenji, Joichiro, Hayashi, Satomi, Nanba, Yukihiko, Ochiai, Yoshihiro, Kami, Seiichi, Goto, Akihiko, Hasegawa, Kitetsu, Shin
    • Journal Title

      The Journal of Meikai Dental Medicine (in press)

    • NAID

      40016251328

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Hypoxia and Reoxygenation Augment Bone-resorbing Factor Production From Human Perindontal Ligament Cells2007

    • Author(s)
      Hitoshi Motohira
    • Journal Title

      Journal of periodontology 78

      Pages: 1803-1809

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Hypoxia and Reoxygenation Augment Bone-resorbing Factor Production From Human Periodontal Ligament Cells2007

    • Author(s)
      Hitoshi, Motohira, Joichiro, Hayashi, Junichi, Tatsumi, Masamichi, Tajima, Hiroshi, Sakagami, Kitetsu Shin
    • Journal Title

      Journal of Periodontology 78

      Pages: 1803-1809

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Hypoxia and Reoxygenation Augment Bone-resorbing Factor Production From Human Periodontal Ligament Cells.2007

    • Author(s)
      Hitoshi Motohira
    • Journal Title

      Journal of Periodontology 78

      Pages: 1803-1809

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 限局型侵襲性歯周炎患者に対して歯周組織再生療法を行った一症例2006

    • Author(s)
      林 丈一朗
    • Journal Title

      日本歯周病学会会誌 35

      Pages: 40-49

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 氏酸素状態からの再酸素化による培養ヒト歯根膜細胞の骨吸収性因子産生の促進2006

    • Author(s)
      菊池 一江
    • Journal Title

      明海大学歯学雑誌 35

      Pages: 35-41

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A Case Report of Localized Aggressive Periodontitis Treated with Several Periodontal Regeneration Techniques2006

    • Author(s)
      Joichiro, Hayashi, Hiroyuki, Takeda, Kitetsu, Shin
    • Journal Title

      Journal of the Japanese Society of Periodontology 48

      Pages: 40-49

    • NAID

      10018119512

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Stimulated Production of Bone-resorbing Factors by Reoxygenation after Hypoxia in Culture d Human Periodontal Ligament Cells2006

    • Author(s)
      Kazue, Kikuchi, Joichiro, Hayashi, Suguru, Jinzennji
    • Journal Title

      The Journal of Meikai Dental Medicine 35

      Pages: 35-41

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 限局型侵襲性歯周炎患者に対して歯周組織再生療法を行った一症例2006

    • Author(s)
      林 丈一朗
    • Journal Title

      日本歯周病学会会誌 48巻・1号

      Pages: 40-49

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 低酸素状態からの再酸素化による培養ヒト歯根膜細胞の骨吸収性因子産生の促進2006

    • Author(s)
      菊池 一江
    • Journal Title

      明海大学歯学雑誌 35巻・1/2号

      Pages: 35-41

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 限局型侵襲性歯周炎患者に対して歯周組織再生療法を行った一症例2006

    • Author(s)
      林 丈一朗
    • Journal Title

      日本歯周病学会会誌 48巻・1号(印刷中)

    • Related Report
      2005 Annual Research Report
  • [Presentation] 歯周病および糖尿病患者におけるレクチン遺伝子多型2008

    • Author(s)
      林 丈一朗
    • Organizer
      第51回春季日本歯周病学会学術大会 シンポジウム
    • Place of Presentation
      埼玉県さいたま市
    • Year and Date
      2008-04-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Lectin gene polymorphism in patients with periodontal disease and with diabetes mellitus2008

    • Author(s)
      Joichiro, Hayashi
    • Organizer
      51st Annual Meeting of the Japanese Society of Periodontology
    • Place of Presentation
      Saitama
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 2型糖尿病患者におけるマンノース結合レクチン遺伝子多型出現頻度と歯周疾患との関連性に関する研究2007

    • Author(s)
      秦泉寺 傑
    • Organizer
      第50回春季日本歯周病学会学術大会
    • Place of Presentation
      神奈川県横須賀市
    • Year and Date
      2007-05-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Kitetsu Shin : A study of mannose-binding lectin gene polymorphism and its relation to periodontal disease in type 2 diabetes mellitus2007

    • Author(s)
      Suguru, Jinzenji, Joichiro, Hayashi, Satomi, Nanba, Kazuhiro, Yatabe, Toshio, Ohashi, Junichi, Tatsumi, Seiichi, Goto, Akihiko, Hasegawa
    • Organizer
      50th Annual Meeting of the Japanese Society of Periodontology
    • Place of Presentation
      Kanagawa
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] マンノース結合レクチン遺伝子多型の歯周疾患および糖尿病との関連性2006

    • Author(s)
      秦泉寺 傑
    • Organizer
      第49回春季日本歯周病学会学術大会
    • Place of Presentation
      千葉県市川市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mannose-binding lectin gene polymorphism in periodontal disease and diabetes mellitus2006

    • Author(s)
      Joichiro Hayashi
    • Organizer
      92nd Annual Meeting Of the American Academy of Periodontology
    • Place of Presentation
      サンディエゴ,アメリカ
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Kitetsu Shin : Possible association of mannose-binding lectin gene polymorphism with periodontal disease and diabetes mellitus2006

    • Author(s)
      Suguru, Jinzenji, Joichiro, Hayashi, Satomi, Namba, Kaoru, Sugihara, Kanako, Yamamura, Kazuhiro, Yatabe, Seiichi, Goto, Akihiko, Hasegawa
    • Organizer
      49th Annual Meeting of the Japanese Society of Periodontology
    • Place of Presentation
      Chiba
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Kitetsu Shin : Mannose-binding lectin gene polymorphism in periodontal disease and diabetes mellitus2006

    • Author(s)
      Joichiro, Hayashi, Suguru, Jinzenji, Seiichi, Goto, Junichi, Tatsumi, Akihiko, Hasegawa
    • Organizer
      92nd Annual Meeting of the American Academy of Periodontology
    • Place of Presentation
      San Diego
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 侵襲性歯周炎患者に対して歯周組織再生療法を行った一症例2005

    • Author(s)
      林 丈一朗
    • Organizer
      第47回春季日本歯周病学会学術大会
    • Place of Presentation
      長崎県長崎市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A case report of aggressive periodontitis treated by regenerative therapy2005

    • Author(s)
      Joichiro, Hayashi, Hiroyuki, Takeda, Kitetsu, Shin
    • Organizer
      47th Annual Meeting of the Japanese Society of Periodontology
    • Place of Presentation
      Nagasaki
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 臨床歯周病学2007

    • Author(s)
      申 基てつ
    • Total Pages
      8
    • Publisher
      医歯薬出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Book] 臨床歯科エビデンス 歯周病と微生物学のビジュアルラーニング2007

    • Author(s)
      林 丈一朗
    • Total Pages
      12
    • Publisher
      南山堂
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 臨床歯科エビデンス 歯周病と微生物学のビジュアルラーニング2007

    • Author(s)
      林 丈一朗(分担)
    • Total Pages
      12
    • Publisher
      南山堂
    • Related Report
      2006 Annual Research Report
  • [Book] 別冊QuintessenceYEAR BOOK 2005現代の治療指針全治療分野と欠損補綴2005

    • Author(s)
      林 丈一朗
    • Total Pages
      2
    • Publisher
      クインテッセンス出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 別冊QuintessenceYEAR BOOK 2005 現代の治療指針 全治療分野と欠損補綴2005

    • Author(s)
      林 丈一朗(分担執筆)
    • Total Pages
      2
    • Publisher
      クインテッセンス出版
    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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