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Effect of rinsing by sugar solution on oral malodor of tube fad patients

Research Project

Project/Area Number 17592188
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Social dentistry
Research InstitutionIwate Medical University

Principal Investigator

KISHI Mitsuo  Iwate Medical University, School of Dentistry, Associate Professor (60295988)

Co-Investigator(Kenkyū-buntansha) ABE Akiko  Iwate Medical University, School of Dentistry, Lecturer (90185992)
AIZAWA Fumie  Iwate Medical University, School of Dentistry, Assistant Professor (80216754)
SUGIURA Goh  Iwate Medical University, School of Dentistry, Assistant Professor (50382627)
YONEMITSU Masami  Iwate Medical University, School of Dentistry, Professor (80092451)
YOSHIDA Yasuo  Iwate Medical University, School of Dentistry, Associate Professor (10315096)
南 健太郎  岩手医科大学, 歯学部, 助手 (10364374)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,680,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2006: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2005: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsVolatile sulfur comnounds (VSC) / Hydrogen sulfide (H_2S) / Oral malodor / β C-S lyase / Glucose / Tube feeding / Sorbitol / Saliva / 舌苔 / メチルメルカプタン / Streptococcus anginosus / 舌清掃 / プロフェッショナルケア / βC-Sリアーゼ / Porpyromonas gingivalis / 揮発性硫化物 / 経管栄養者 / ブドウ糖 / ガスクロマトグラフィ / 特別養護老人ホーム
Research Abstract

1. Healthy young adults were ordered to rinse their mouth with 10% glucose solution. Before and after rinsing, VSC in mouth air were determined. Consequently, in rinsing with glucose solution, VSC concentrations was significantly lower than that in the control.
Saliva samples from same subjects were incubated for 90min at 37℃ under anaerobic condition with 2% glucose or sorbitol. After the incubation, hydrogen sulfide (H_2S) production was measured. Consequently, the amounts of H2S from saliva with glucose were significantly lower than the control. Furthermore, we determined the cell number of total bacteria, T, forsythia and Fusobacterium in the saliva samples using real-time PCR method. The proportion of T forsythia against total bacteria was constant in all conditions (glucose or sorbitol added and control). From those results, sugar supply was supposed to be effective for reduction of VSC in mouth air. Further, it was suggested that the phenomenon occurred by not only inactivation of anaerobic microbe under low pH condition by sugar fermentation.
2. We purified H2S producting enzyme from Streptococcus anginosus. The activities were determined with and without glucose. Consequently, there was no effect of glucose on the activities. It was suggested that the glucose did not effect on the enzyme.
3. We determined VSC in mouth air of elderly with and without tube feeding in a nursing institution. The two groups were matched by the oral conditions. Consequently, there was no significant difference in VSC concentration. However, the high correlations between VSC levels and oral malconditions in the elderly with tube feeding. From the results, it was supposed that tube feeding was not causative for oral malodor in case the whole oral health control was successful, but if the some oral conditions were poor, VSC levels got higher especially in the subjects with tube feeding.

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (23 results)

All 2008 2007 2006 2005 Other

All Journal Article (10 results) (of which Peer Reviewed: 4 results) Presentation (13 results)

  • [Journal Article] Molecular and Enzymatic Characterization of bG S lyase in Streptococcus constellatus2008

    • Author(s)
      Yoshida Y, Ito S., Sasaki T, Kis hi M, et. al.
    • Journal Title

      Oral Microbiol.Immunol 23

      Pages: 246-263

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Molecular and Enzymatic Characterization of bC-S lyase in Streptococcus constellatus2008

    • Author(s)
      Yoshida Y, Ito, S. Sasaki T, Kishi M, et. al.
    • Journal Title

      Oral Microbiol. Immun 23

      Pages: 245-263

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 舌苔中の歯科疾患関連細菌と口降内状況との関連性2006

    • Author(s)
      高橋 雅洋, 岸 光男
    • Journal Title

      口腔衛生会誌 56

      Pages: 137-147

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 口腔ケアの評価指標とreal-time PCRによる舌苔中細菌数との関連2006

    • Author(s)
      岸 光男, 高橋 雅洋, 岸 香代, 他
    • Journal Title

      口腔衛生会誌 56

      Pages: 665-672

    • NAID

      110006164435

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Relationship between dental pathogenic bacteria in tongue coat and clinical oral status2006

    • Author(s)
      Takahasi M, Kishi, M
    • Journal Title

      J Dent Hlth 56

      Pages: 137-147

    • NAID

      110004729663

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Relationship between clinical indicators and the total amount of bacteria in the tongue coat assessed by real-time PCR in oral care evaluation2006

    • Author(s)
      Kishi M, Takahashi M, Kishi K, et. al.
    • Journal Title

      J Dent Hlth 56

      Pages: 665-672

    • NAID

      110006164435

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 舌苔中の歯科疾患関連細菌と口腔内状況との関連性2006

    • Author(s)
      高橋雅洋, 岸 光男
    • Journal Title

      日本口腔衛生学会雑誌 56(2)

      Pages: 137-147

    • NAID

      110004729663

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 口腔ケアの評価指標とreal-time PCRによる舌苔中細菌数との関連2006

    • Author(s)
      岸 光男, 他
    • Journal Title

      日本口腔衛生学会雑誌 56(5)

      Pages: 665-672

    • NAID

      110006164435

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Outcome Measures2006

    • Author(s)
      Aizawa, F., Kishi, M.
    • Journal Title

      The Bulletin of Kanagawa Dental College 34

      Pages: 37-40

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Molecular and Enzymatic Characterization of bC-S lyase in Streptococcus constellatus.

    • Author(s)
      Y. Yoshida, S. lto, T. Sasaki, M. Kishi, et. al.
    • Journal Title

      Oral Microbiol.Immunol. (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 非経口栄養摂取が要介護高齢者の口臭に及ぼす影響2007

    • Author(s)
      岸 光男, 岸 香代, 高橋 光恵, 米満 正美
    • Organizer
      第56回口腔衛生学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-10-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] The effect of tube feeding on oral malodor of elderly needing for nursing2007

    • Author(s)
      Kishi M, Kishi K, Takahashi M, Yonemitsu, M
    • Organizer
      The 56th general meeting of association of Japanese Dental Health
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-10-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 歯科衛生士による訪問口腔ケアが家庭介護に及ぼす影響第1報事業概要と著明な効果のみられた1例2006

    • Author(s)
      高橋 光恵, 岸 光男, 佐々木 勝忠, 清水 潤, 岸 香代, 米満 正美
    • Organizer
      第55回口腔衛生学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2006-10-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 歯科衛生士による訪問口腔ケアが家庭介護に及ぼす影響第2報要介護高齢者の口腔内と介護家族のQOLの変化2006

    • Author(s)
      岸 光男, 高橋 光恵, 岸 香代, 相澤 文恵, 佐々木 勝忠, 清水 潤, 高橋 雅洋, 米満 正美
    • Organizer
      第55回口腔衛生学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2006-10-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effect of professional oral care by dental hygienist for home bound elderly on family nursing. Part 1. Outline of the project and a case report2006

    • Author(s)
      Takahasi M, Kishi M, Sasaki K, et. al.
    • Organizer
      The 55th general meeting of association of Japanese Dental Health
    • Place of Presentation
      Osaka
    • Year and Date
      2006-10-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effect of professional oral care by dental hygienist for home bound elderly on family nursing. Part 2. Improvement of oral status in elderly needing for nursing and QOL in care giver in the family2006

    • Author(s)
      Kishi M, Takahashi M, Kishi K, et. al.
    • Organizer
      The 55th general meeting of association of Japanese Dental Health
    • Place of Presentation
      Osaka
    • Year and Date
      2006-10-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Distribution of periodontopathic bacteria in tongue coats in aged subjects2006

    • Author(s)
      TAKAHASHI, M., KISHI, M., OHARA-NEMOTO, Y., KIMURA, S. and YONEMITSU, M.
    • Organizer
      84th General Session of the LADR
    • Place of Presentation
      Brisbane,Australia
    • Year and Date
      2006-06-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Distribution of periodontopathic bacteria in tongue coats in aged subjects2006

    • Author(s)
      Takahashi, M. Kishi, M. Ohara-Nemoto Y, et. al.
    • Organizer
      84th General Session of the IADR, Brisbane
    • Place of Presentation
      Australia
    • Year and Date
      2006-06-29
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 訪問口腔ケアが介護家族のQOLに及ぼす影響2006

    • Author(s)
      岸 光男, 高橋 光恵, 晴山 婦美子, 阿部 晶子, 相澤 文恵, 岸 香代, 高橋 雅洋, 米満 正美
    • Organizer
      第18回日本口腔衛生学会東北地方会
    • Place of Presentation
      秋田
    • Year and Date
      2006-05-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 口臭測定を指標とした口腔ケアの評価2005

    • Author(s)
      岸 光男, 阿部 晶子, 杉浦 剛, 高橋 雅洋, 晴山 婦美子, 相澤 文恵, 米満 正美
    • Organizer
      第54回口腔衛生学会総会
    • Place of Presentation
      東京
    • Year and Date
      2005-10-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 舌苔と歯垢の歯周病原性細菌定着状況の関連2005

    • Author(s)
      高橋 雅洋, 岸 光男, 阿部 晶子, 杉浦 剛, 田村 光平, 米満 正美
    • Organizer
      第54回口腔衛生学会総会
    • Place of Presentation
      東京
    • Year and Date
      2005-10-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 君毫要介護高齢者の口臭に対する家族介護者の認識とQOL2005

    • Author(s)
      相澤 文恵, 岸 光男, 佐々木 勝忠, 清水 潤, 米満 正美
    • Organizer
      第56回口腔衛生学会総会
    • Place of Presentation
      東京
    • Year and Date
      2005-10-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Relationship between oral malodor in elderly needing for nursing and QOL in care giver in the family2005

    • Author(s)
      Aizawa F, Kishi M, Sasaki K, et. al.
    • Organizer
      The 54th general meeting of association of Japanese Dental Health
    • Place of Presentation
      Tokyo
    • Year and Date
      2005-10-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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