| Project/Area Number |
17592200
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Fundamental nursing
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
KONYA Chizuko Kanazawa University, Graduate school of medical science, Associate professor (20303282)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SANADA Hiromi The University of Tokyo, Graduate school of medine, Professor (50143920)
SUGAMA Junko Kanazawa University, Graduate school of medical science, Professor (00203307)
OKUWA Mayumi Kanazawa University, Graduate school of medical science, Research associate (30303291)
KITAGAWA Atsuko The University of Tokyo, Graduate school of medine, Research associate (80343185)
|
|---|
| Project Period (FY) |
2005 – 2006
|
| Project Status |
Completed (Fiscal Year 2006)
|
| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2006: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2005: ¥2,900,000 (Direct Cost: ¥2,900,000)
|
|---|
| Keywords | nursing / clinical / Pressure ulcers / molecular biology |
|---|
| Research Abstract |
The purpose of this study was investigated the change in cytokines in refractory pressure ulcers and relationship between its changing and wound healing process. We investigated cytokines in pressure ulcers and wound change patterns in order to clarify cytokine behaviour at each status. After three days and seven days changing care measurements were performed of the levels in retained exudate of the cytokines; interleukin lα and 1β (IL-lα, 1β), basic fibroblast growth factor (bFGF), platelet-derived growth factor-AB (PDGF-AB), interleukin-4 (IL-4), transforming growth factor-β1 (TGF-β1) and vascular endothelial growth factor (VEGF). Wounds were observed weekly. All subjects had consented to participate in the study. Cytokines were increased at each wound change: for undermining adhesion, it was six out of seven (elevation in VEGF at seven three days); for increased granulation, eight out of eight (bFGF at after three days); and for epithelialization also eight out of ten (bFGF at after three days). Standard care evaluation of pressure ulcers was developed from these results. The results of our standard care evaluation were as follow: positive predictive value of bFGF 70.0% and positive predictive value of VEGF 66.7%. Therefore, it was suggested that our standard care evaluation of pressure ulcers was effective.
|
