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Clinical and verifiable study of drug extravasation of the effectiveness of compresses for its management

Research Project

Project/Area Number 17592212
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Fundamental nursing
Research InstitutionIwate Prefectural University

Principal Investigator

TAKEDA Toshiaki  Iwate Prefectural University, Faculty of Nursing, Professor (40305248)

Co-Investigator(Kenkyū-buntansha) HIRANO Akihiko  Iwate Prefectural University, Faculty of Nursing, Associate Professor (30305255)
INOUE Satoshi  Iwate Prefectural University, Faculty of Nursing, Lecturer (00281254)
ISHIDA Yoko  Iwate Prefectural University, Faculty of Nursing, Research Associate (60322335)
OYAMA Natsuko  Iwate Prefectural University, Faculty of Nursing, Research Associate (40347191)
KOJIMA Yoshikazu  Tokai university, Faculty of Health Sciences, Associate Professor (60215259)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,550,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2006: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2005: ¥2,400,000 (Direct Cost: ¥2,400,000)
Keywordsextravasation / compresses / nursing arts / pharmacology / pathology / experimental animals / Mitomycin / Paclitaxel / 抗がん剤 / 血管外漏出 / 看護学 / エキザール / セルシン / アレビアチン / メイロン
Research Abstract

We carried out an experimental animal study to investigate the characteristics of skin lesions induced by extravasation of intravenously instilled drugs, and the use of a compress, which has been advocated for management of extravasation of such drugs. We also studied the mechanism responsible for the effects of a compress on extravasation. The following findings were obtained from these basic studies : (1) When extravasation of drugs occurred, an inflammatory reaction was triggered, histologically similar to a foreign body reaction. The severity of the lesions was dependent on the pH as well as the osmotic pressure of the drug solution, but not on the pharmaceutical effects of the drugs. In particular, anesthetic drugs, which were strongly alkaline, immediately caused tissue necrosis upon extravasation. (2) The skin lesions caused by extravasation of the anticancer drug Mitomycin^[○!R], which is a vesicant drug, were not evident macroscopically because they arose in the deep skin tissue. However, other anticancer drugs such as Paclitaxel^[○!R] and Exal^[○!R] immediately caused skin ulcers when they passed into tissues from blood vessels. Also, because of their cytotoxic effects, the lesions induced by anticancer drugs persisted. (3) Cold compress was a useful treatment for extravasation of drugs except anticancer drugs. Hot compress was useful for the treatment of extravasation of anesthetic drugs. The mechanism of the effects of a cold compress was thought to be suppression of radical formation in the areas of the lesions. (4) A compress was not always a useful treatment for the skin lesions induced by extravasation of anticancer drugs. In fact in some cases, a compress made the lesion worse. (5) It has been accepted that the effects of a hot compress are due to absorption of drug solution. However, we were unable to obtain evidence of such absorption through pathological and physiological studies using Cercine^[○!R] as well asAleviatin^[○!R].

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (13 results)

All 2008 2007 2006

All Journal Article (9 results) (of which Peer Reviewed: 3 results) Presentation (3 results) Book (1 results)

  • [Journal Article] 抗生物質製剤(セフォチアム塩酸塩)の血管外漏出に対する羅法の効果に関する基礎的研究2008

    • Author(s)
      小山 奈都子, 石田 陽子, 武田 利明
    • Journal Title

      岩手県立大学看護学部紀要 10

      Pages: 1-7

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Experimental study of the effects of applying a poultice to skin lesions produced by extravasation of antibiotics2008

    • Author(s)
      Natsuko, Oyama, Yoko, Ishida, Toshiaki, Takeda
    • Journal Title

      Journal of the faculty of nursing, Iwate prefectural university 10

      Pages: 1-7

    • NAID

      110007124383

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 点滴漏れ時の器法施行による薬剤の吸収への影響に関する基礎研究2007

    • Author(s)
      小山 奈都子, 石田 陽子, 武田 利明
    • Journal Title

      岩手県立大学看護学部紀要 9

      Pages: 87-91

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Basic research on the Absorption of the effects of applying a poulitice to skin lesions induced by extravasation of medical drugs2007

    • Author(s)
      Natsuko, Oyama, Yoko, Ishida, Toshiaki, Takeda
    • Journal Title

      Journal of the faculty of nursing, Iwate prefectural university 9

      Pages: 87-91

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 薬剤の血管外漏出時のケア2007

    • Author(s)
      武田利明, 石田陽子, 小山奈都子
    • Journal Title

      日本看護技術学会誌 6巻1号

      Pages: 33-35

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2007

    • Author(s)
      小山奈都子, 石田陽子, 武田利明
    • Journal Title

      岩手県立大学看護学部紀要 9巻

      Pages: 87-91

    • Related Report
      2006 Annual Research Report
  • [Journal Article] "点滴漏れ"とその対処2007

    • Author(s)
      武田利明
    • Journal Title

      看護実践の科学 32巻4号

      Pages: 27-33

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 薬剤漏出による組織傷害の軽減(局所罨法)2007

    • Author(s)
      武田利明
    • Journal Title

      Nursing Today 22巻2号

      Pages: 26-26

    • Related Report
      2006 Annual Research Report
  • [Journal Article] ビンカアルカロイド系抗がん剤漏出時における罨法の有効性を示す実験的研究に関する文献調査2006

    • Author(s)
      武田利明, 石田陽子, 小山奈都子
    • Journal Title

      岩手県立大学看護学部紀要 8巻

      Pages: 101-105

    • Related Report
      2005 Annual Research Report
  • [Presentation] 薬剤の血管外漏出時のケアについて考える2007

    • Author(s)
      小山 奈都子, 武田 利明, 石田 陽子, 及川 正広, 熊谷 真澄, 小澤 希美
    • Organizer
      日本看護技術学会第6回学術集会
    • Place of Presentation
      前橋市
    • Year and Date
      2007-10-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Thermal application on skin lesions Produced by extravasation2007

    • Author(s)
      Natsuko, Oyama, Toshiaki, Takeda, Yoko, Isida, Masahiro, Oikawa, Masumi, Kumagai, Nozomi, Kosawa
    • Organizer
      The 6th Academic Conference of Japanese Society of Nursing Art and Science
    • Place of Presentation
      Maebashi City
    • Year and Date
      2007-10-20
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 抗がん剤漏出による皮膚傷害の特徴に関する基礎的研究2007

    • Author(s)
      及川正広, 武田利明
    • Organizer
      日本看護技術学会
    • Place of Presentation
      前橋市
    • Year and Date
      2007-10-20
    • Related Report
      2007 Annual Research Report
  • [Book] 菱沼典子、小松浩子編 : 看護実践の根拠を問う、第16章薬剤の血管外漏出のケア;罨法の有効性について2007

    • Author(s)
      武田利明
    • Total Pages
      253
    • Publisher
      南江堂
    • Related Report
      2006 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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