| Project/Area Number |
17605002
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
睡眠学
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| Research Institution | Akita University |
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Principal Investigator |
HISHIKAWA Yasuo Akita University, Professor Emeritus, 名誉教授 (60028454)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMIZU Tetsuo Akita University, School of Medicine, Professor, 医学部, 教授 (90170977)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2005: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | Habitual ethanol intake / Sleep / Blood Pressor / Autonomic nervous system / Heart rate variability |
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| Research Abstract |
Regular use of ethanol is associated with elevaton of blood pressure but the underlying mechanism is not known. In the first year we investigated the relationship of chronic alcohol intake, blood pressure, and nocturnal heart rate variability. Thirty-seven subjects were enrolled in the study. The measurement was performed for 24 hours from the midday. Power spectral analysis of heart rate variability was performed by maximum entropy method. Simultaneously ambulatory blood pressure monitoring and nocturnal pulse oximeter monitoring were performed. The results of this study suggested that chronic ethanol intake inhibited nocturnal autonomic function dose-dependently and, together with sleep apnea, attributed to elevation of daytime blood pressure.
Next year we investigated the acute effect of ethanol on the relationship between sleep and heart rate variability (HRV) during sleep. Ten healthy male university students were enrolled in the study. An alcoholic beverage was given to each subject at a dosage of 0 (control), 0.5 (low dose : LD) or 1 (high dose : HD) g of pure ethanol/kg of body weight. The alcohol drinking experiments were performed at an interval of 3 weeks. On the experiment day, a Holter ECG was applied at 12:00 and the subject was instructed to drink the above-described dosage of alcoholic beverage 100 min before going to bed ; polysomnography was then performed for 8 hours. Acute ethanol intake inhibited vagal activity and caused a predominance of sympathetic nerve activity during sleep in a dosage-dependent manner. On the other hand, the sleep architecture was not affected by a higher dosage of ethanol, especially during the first half of the sleep period. The results of this study suggest that ethanol interfered with the restorative function of sleep. Such interference may be a key factor in the pathophysiology of habitual drinking related diseases, such as hypertension.
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