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Establishment of database of IFN-α production test and risk management of hepatocellular carcinoma in patients with hepatitis C virus.

Research Project

Project/Area Number 17606005
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 臨床疫学
Research InstitutionLouis Pasteur Center for Medical Research

Principal Investigator

UNO Kazuko  Louis Pasteur Center for Medical Research, Basic Research, Head Researcher, 基礎研究部, 室長 (50211082)

Co-Investigator(Kenkyū-buntansha) SHIRAKAWA Taro  Kyoto University, Graduate School of Public Health, Department of Health Promotion & Human Behavior, 医学研究科・社会医学, 教授 (40196613)
KAKIMI Kazuhiro  The University of Tokyo, Graduate School of Medicine, Department of Immunotherapeutics, 医学部附属病院・寄付講座, 客員助教授 (80273358)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2005: ¥2,500,000 (Direct Cost: ¥2,500,000)
KeywordsIFN-a production / Hepatitis C virus infection / Hepatocellular carcinoma / Cancer Risk / Plasmacytoid dendritic cell
Research Abstract

Previously, we published a manuscript entitled "Impairment of IFN-α production capacity in patients with hepatitis C virus and the risk of the development of hepatocellular carcinoma" in World J Gastroenterology, which forms the basis of this project. The project entailed the establishment of a database of IFN-α production and blood tests spanning 17 years by the Louis Pasteur Center for Medical Research. Data for IFN-α production was obtained retrospectively over a 17-year period by examining medical records in a study population of 2,315 individuals, of which 112 healthy controls and 20 HCV-infected patients were selected. Sixty percent of the HCV-infected patients had impaired or declining IFN-α production in comparison to 17% in the healthy control group. Mean IFN-α levels were lower in patients who developed hepatocellular carcinoma than in the HCV-infected patients who remained cancer-free. These results have been published in J IFN & Cytokine Research as "Impaired interferon-a production and the risk of cancer development." Further, we established the methodto detect IFN-α producing cells by Sendai virus stimulation using FACS, and the main IFN-α producing cells were plasmacytoid dendritic cells. This method will be useful to understand the analysis of impaired IFN-α production.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (34 results)

All 2007 2006 2005 Other

All Journal Article (33 results) Book (1 results)

  • [Journal Article] Another Road to Interferon : Yasuichi Nagano's Journey2007

    • Author(s)
      Keiko Ozato, Kazuko Uno, Yoichiro Iwakura
    • Journal Title

      J IFN & Cytokine Res. 27

      Pages: 349-352

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Another Road to Interferon : Yasuichi Nagano's Journey2007

    • Author(s)
      Keiko Ozato, Kazuko Uno, Yoichiro Iwakura
    • Journal Title

      JIFN & Cytokine Res 27

      Pages: 349-352

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 腎機能の憎悪にて診断に至ったMPO-ANCA"偽"陰性の顕微鏡的多発血管炎一例 -MPO-ANCA陽性度の測定法によるheterogeneityについて-2007

    • Author(s)
      猪原登志子, 宇野賀津子, 古宮俊幸, 辻井知美, 米本智美, 田中麻理, 田原佐知子, 塚本達雄, 小野孝彦, 柳田素子, 深津敦司, 北徹, 鈴木和男, 武曾恵理
    • Journal Title

      Pharma Medica 25(5)

      Pages: 173-198

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Clinical utility of 2', 5' -oligoadenylate synthetase activity measurement : Using whole blood as a highly sensitive method to detect the effects of IFN2006

    • Author(s)
      Uno K, Suginoshita Y, Kakimi K, Moriyasu F, Nakano K, Nakamura N, Fujita T, Horino Y, Sato T, Kishida T
    • Journal Title

      J. Virol. Methods 136

      Pages: 185-192

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 図説 インターフェロンの多様な作用2006

    • Author(s)
      宇野賀津子
    • Journal Title

      日本臨床 インターフェロンの治療学 第64巻・第7号

      Pages: 1210-1214

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Pleiotropic interferon functions2006

    • Author(s)
      Uno K
    • Journal Title

      Nippon Rinsho vol.64, No.7

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Clinical utility of 2',5'-oligoadenylate synthetase activity measurement : Using whole blood as a highly sensitive method to detect the effects of IFN.2006

    • Author(s)
      Uno K, Suginoshita Y, Kakimi K, Moriyasu F, Nakano K, Nakamura N, Fujita T, Horino Y, Sato T, Kishida T.
    • Journal Title

      J Virol.Methods 136

      Pages: 185-192

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Clinical utility of 2',5'-oligoadenylate synthetase activity measurement : Using whole blood as a highly sensitive method to detect the effects of IFN2006

    • Author(s)
      Uno K, Suginoshita Y, Kakimi K, Moriyasu F, Nakano K, Nakamura N, Fujita T, Horino Y, Sato T, Kishida T
    • Journal Title

      J Virol. Methods 136

      Pages: 185-192

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Intracellular glutathione levels of monocytes indicate peritumoral stroma development and T-cell infiltration within tumor cell nests in patients with colorectal carcinoma2006

    • Author(s)
      Uno K, T.Matsuzaki, S.Tada-Oikawa, T.Kato, J.Hamuro, T.Kishida, K.Okuno.
    • Journal Title

      Eur. Cytokine Netw. Vol17

      Pages: 91-91

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Intracellular glutathione levels indicate peritumoral stroma development and T-cell infiltration in patients with colon carcinoma. Proceedings of 6^<th> international Cytokine Conference2006

    • Author(s)
      Uno K, Matsuzaki T, Tada-Oikawa S, Kato T, Hamuro J, Kishida T, Okuno K
    • Journal Title

      Proceedings of 6^<th> international Cytokine Conference, MEDIMOND

      Pages: 152-157

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 図説 インターフェロンの多様な作用2006

    • Author(s)
      宇野賀津子
    • Journal Title

      日本臨床 第64巻・第7号

      Pages: 1210-1214

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 晩期癌集学的治療における栄養・代謝の意義2006

    • Author(s)
      済陽 高穂, 河合宏美, 朴成進, 吉村哲規, 桑原公亀, 大日向祥子, 宇野賀津子
    • Journal Title

      栄養と治療 vol.23, no.6

      Pages: 44-49

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 腎機能の憎悪にて診断に至ったMPO-ANCA"偽"陰性の顕微鏡的多発血管炎一例 -MPO-ANCA陽性度の測定法によるheterogeneityについて-2006

    • Author(s)
      古宮俊幸, 田原佐知子, 辻井知美, 塚本達雄, 武曾恵理, 宇野賀津子, 岸田綱太郎, 猪原登志子, 大川原明子, 鈴木和男
    • Journal Title

      Pharma Medica 24(5)

      Pages: 122-122

    • Related Report
      2006 Annual Research Report
  • [Journal Article] MPO-ANCA関連血管炎急性期のサイトカイン動態と大量ガンマグロブリン(IVIg)療法による変動2006

    • Author(s)
      猪原登志子, 宇野賀津子, 田中麻里, 他
    • Journal Title

      Pasken J 18

      Pages: 67-78

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Type I インターフェロンの多様な作用2006

    • Author(s)
      宇野賀津子
    • Journal Title

      Pasken J 18

      Pages: 7-11

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Impairment of IFN-α production capacity in patients with hepatitis C virus and the risk of the development of heapatocellular carcinoma2005

    • Author(s)
      Uno K, Suginoshita Y, Kakimi K, Moriyasu F, Hirosaki M, Lei C, Shirakawa T, Kishida T
    • Journal Title

      World Journal of Gastroenterology vol.11(46)

      Pages: 7330-7334

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] インターフェロンーα,β,γ2005

    • Author(s)
      宇野賀津子
    • Journal Title

      日本臨床 広範囲血液・尿化学検査 免疫学検査-その数値をどう読むか-[第6版] 63巻増刊号8

      Pages: 89-92

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] インターフェロン発見から半世紀 : 自然免疫から獲得免疫へ、Type Iインターフェロン再評価の時2005

    • Author(s)
      宇野賀津子
    • Journal Title

      実験医学 Vol. 23 No. 14

      Pages: 2174-2179

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Impaired IFN-α production capacity and the risk of cancer2005

    • Author(s)
      Uno K, Hirosaki M, Kakimi K, Tominaga M, Hasegawa G, Suginoshita Y, Fukui M, Nakamura N, Shirakawa T, Kishida T
    • Journal Title

      Cell Res Vol. 15, No. 10

      Pages: 158-158

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 末梢血樹状細胞サブセットのフローサイトメトリーによる検討2005

    • Author(s)
      尾松芳樹, 宇野賀津子, 猪原登志子, 椛田美由紀, 三石瑤子, 岸田綱太郎, 稲葉カヨ, 武曾恵理, 鈴木和男
    • Journal Title

      Pasken J 18

      Pages: 79-84

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Type Iインターフェロンの多様な作用2005

    • Author(s)
      宇野賀津子
    • Journal Title

      Pasken J 18

      Pages: 7-11

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Impairment of IFN-α production capacity in patients with hepatitis C virus and the risk of the development of heapatocellular carcinoma.2005

    • Author(s)
      Uno K, Suginoshita Y, Kakimi K, Moriyasu F, Hirosaki M, Lei C, Shirakawa T, Kishida T.
    • Journal Title

      World Journal of Gastroenterology 46

      Pages: 7330-7334

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Impaired IFN-α production capacity and the risk of cancer2005

    • Author(s)
      Uno K, Hirosaki M, Kakimi K, Tominaga M, Hasegawa G, Suginoshita Y, Fukui M, Nakamura N, Shirakawa T. Kishida T.
    • Journal Title

      Cell Res Vol.15, No.10

      Pages: 158-158

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Interferon-α,β,γ2005

    • Author(s)
      Uno K
    • Journal Title

      Nippon Rinsho vol.63,Suppl 8

      Pages: 89-92

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Half century since the discovery of the interferon.2005

    • Author(s)
      Uno K
    • Journal Title

      Jikkenigaku vol.23, No.14

      Pages: 2174-2179

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Pleiotropic Type I Interferon Functions2005

    • Author(s)
      Uno K
    • Journal Title

      Pasken J Vol.18

      Pages: 7-11

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Correlation between peripheral dendritic cell amounts and IFN-α production.2005

    • Author(s)
      Omatsu Y, Uno K, Ito-Ihara T, Kabata M, Mitsuishi Y, Kishida T, Inaba K, Muso E, Suzzuki K.
    • Journal Title

      Pasken J Vol.18

      Pages: 79-83

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] インターフェロン-α,β,γ2005

    • Author(s)
      宇野賀津子
    • Journal Title

      日本臨床 広範囲血液・尿化学検査 免疫学検査-その数値をどう読むか-[第6版] 63巻増刊号8

      Pages: 89-92

    • Related Report
      2005 Annual Research Report
  • [Journal Article] インターフェロン発見から半世紀:自然免疫から獲得免疫へ、Type Iインターフェロン再評価の時2005

    • Author(s)
      宇野賀津子
    • Journal Title

      実験医学 Vol.23 No.14

      Pages: 2174-2179

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Impaired IFN-α production capacity and the risk of cancer2005

    • Author(s)
      Uno K, Hirosaki M, Kakimi K, Tominaga M, Hasegawa G, Suginoshita Y, Fukui M, Nakamura N, Shirakawa T, Kishida T.
    • Journal Title

      Cell Res Vol.15, No.10

      Pages: 158-158

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Impairment of IFN-α production capacity in patients with hepatitis C virus and the risk of the development of heapatocellular carcinoma2005

    • Author(s)
      Uno K, Suginoshita Y, Kakimi K, Moriyasu F, Hirosaki M, Lei C, Shirakawa T, Kishida T.
    • Journal Title

      World Journal of Gastroenterology vol.11(46),

      Pages: 7330-7334

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Impaired interferon-α production and the risk of cancer development

    • Author(s)
      Kazuko Uno, Mayumi Hirosaki, Kazuhiro Kakimi, Masumi Tominaga, Yoshiki Suginoshita, Goji Hasegawa, Michiaki Fukui, Naoto Nakamura, Taro Shirakawa, Tsunataro Kishida
    • Journal Title

      J IFN & Cytokine Res. (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Impaired interferon-α production and the risk of cancer development

    • Author(s)
      Kazuko Uno, Mayumi Hirosaki, Kazuhiro Kakimi, Masumi Tominaga, Yoshiki Suginoshita, Goji Hasegawa, Michiaki Fukui, Naoto Nakamura, Taro Shirakawa, Tsunataro Kishida
    • Journal Title

      J IFN & Cytokine Res. (In press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 生体防御医学事典 分担執筆 : 61.感染とサイトカイン2007

    • Author(s)
      宇野賀津子
    • Publisher
      朝倉書店
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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