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ハイブリット生体分子デバイスの創製と応用技術

Research Project

Project/Area Number 17635004
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section企画調査
Research Field Functional materials/Devices
Research InstitutionOsaka University

Principal Investigator

藤塚 守  大阪大学, 産業科学研究所, 助教授 (40282040)

Co-Investigator(Kenkyū-buntansha) 真嶋 哲朗  大阪大学, 産業科学研究所, 教授 (00165698)
新井 達郎  筑波大学, 大学院・数理物質科学研究科, 教授 (50151139)
中谷 和彦  大阪大学, 産業科学研究所, 教授 (70237303)
Project Period (FY) 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2005: ¥3,400,000 (Direct Cost: ¥3,400,000)
Keywords生体分子 / ハイブリット化 / 生体分子デバイス / ソフトマテリアル / ハードマテリアル / 時間空間制御 / 分子設計 / ナノ複合体
Research Abstract

生体の生命機能を発現させる様々な生体分子の化学的機能に着目した人工生体分子に関する研究はこれまでに活発になされ、数多くの成果が蓄積されている。そのような中、互いが異なる特異性を有する異種分子・異種集合体間の結合(ハイブリッド化)は、天然分子の欠点を補ったり、新たな機能を発現させる上で特に重要である。例えば、ナノ粒子やナノチューブなどのナノ材料(ハードマテリアル)と生体分子(ソフトマテリアル)のナノ複合体は、新たな機能を生み出している。このような既存の生体分子とは本質的に異なった高度な要求に対応できるような新たな機能性ナノ複合体の創出と応用展開を指標としたハイブリッド生体分子デバイスの創製は、ナノサイエンス、ナノテクノロジーの中心課題の一つであり、学問的のみならず社会的要請の強い研究課題である。そこで、本研究企画調査では、優れた機能を有するハイブリッド生体分子デバイスの創製と応用に向けて、生体分子の組織化をいかに行うべきか、人工生体分子とナノ材料との複合化による新機能の発現は可能なのか、デバイス構築にいかなる方法が可能なのか、また、いかにして機能を発現させ、その機能を制御することができるかを検討する。したがって、本研究企画調査を円滑に行うために、様々な分野の研究者からなる研究グループを立ち上げ、ハイブリッド生体分子の時間空間制御、分子設計、機能性ナノ複合体の開発とデバイス化、人工DNA分子デバイスに焦点をあてて議論し、光、熱、pHなどの外部刺激により機能を発現させその機能を制御することによる人工生体分子デバイスの創製の方向性、可能性を検討した。具体的には、研究者による個別の調査結果に基づいて、第1回全体会議を平成17年8月26-27日、第2回全体会議を平成18年3月4-5日にいずれも大阪大学・産業科学研究所で開催し、それぞれ調査結果を報告し、討議を行った。

Report

(1 results)
  • 2005 Annual Research Report
  • Research Products

    (55 results)

All 2005 Other

All Journal Article (49 results) Book (2 results) Patent(Industrial Property Rights) (4 results)

  • [Journal Article] Remarkable Reactivities of Xanthone Ketyl Radicals in the Excited State Compared with that in the Ground State2005

    • Author(s)
      Masanori Sakamoto
    • Journal Title

      J.Am.Chem.Soc. (Commun.) 127・11

      Pages: 3702-3703

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Kinetics of Transient End-to-End Contact of Single-Stranded DNAs2005

    • Author(s)
      Kiyohiko Kawai
    • Journal Title

      J.Am.Chem.Soc. 127・38

      Pages: 13232-13237

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Fast Exciton Migration in Porphyrin-Functionalized Polypeptides2005

    • Author(s)
      Mamoru Fujitsuka
    • Journal Title

      J.Phys.Chem. B (Commun.) 109・1

      Pages: 33-35

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Inhibition of the formation and decay of core-stilbene radical cations by the dendron-phenoxyl groups during the photoinduced electron transfer2005

    • Author(s)
      Michihiro Hara
    • Journal Title

      J.Phys.Chem.B 109・2

      Pages: 973-976

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Hofmeister Effects on the Electron Transfer Reactions of 1-Pyrenesulfonic Acid Radical Cation with Nucleophilic Anions in Nafion Membrane2005

    • Author(s)
      Takashi Tachikawa
    • Journal Title

      J.Phys.Chem.B 109・8

      Pages: 3381-3386

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Photophysical Properties of Oligo(2,3-Thienyleneethynylene)s2005

    • Author(s)
      Yosuke Oseki
    • Journal Title

      J.Phys.Chem.B 109(21)

      Pages: 10695-10698

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Efficient emission from charge recombination during the pulse radiolysis of electrochemical luminescent substituted quinolines with donor-acceptor character2005

    • Author(s)
      Shingo Samori
    • Journal Title

      J.Phys.Chem.B 109・23

      Pages: 11735-11742

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Exclusion of Aromatic Radical Cations from Cyclodextrin Nanocavity Studied by Pulse Radiolysis2005

    • Author(s)
      Takashi Tachikawa
    • Journal Title

      J.Phys.Chem.B. 109・37

      Pages: 17460-17466

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Ultrafast Photoinduced Intramolecular Charge Separation and Recombination Processes in the Oligothiophene-Substituted Benzene Dyads with Amide Spacer2005

    • Author(s)
      Yosuke Oseki
    • Journal Title

      J.Phys.Chem.B. 109・37

      Pages: 17460-17466

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Single-Molecule Fluorescence Imaging of the Remote TiO_2 Photocatalytic Oxidation2005

    • Author(s)
      Kazuya Naito
    • Journal Title

      J.Phys.Chem.B (Lett.) 109・49

      Pages: 23138-23140

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Remarkable Reactivities of Xanthone Ketyl Radicals in the Excited State Compared with that in the Ground State2005

    • Author(s)
      Masanori Sakamoto
    • Journal Title

      J.Phys.Chem.A 109・11

      Pages: 2452-2458

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Formation of Highly Stabilized Intramolecular Dimer Radical Cation and π-Complex of [3_n]Cyclophanes (n=3,5,6) during Pulse Radiolysis2005

    • Author(s)
      Mamoru Fujitsuka
    • Journal Title

      J.Phys.Chem.A 109・16

      Pages: 3531-3534

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Stepwise Photocleavage of C-O Bonds of Bis(substituted-methyl)naphthalenes with Stepwise Excitation by Two-Color Two-Laser and Three-Color Three-Laser Irradiations2005

    • Author(s)
      Xichen Cai
    • Journal Title

      J.Phys.Chem.A 109・17

      Pages: 3797-3802

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Significant Effects of Substituents on Substituted Naphthalenes in the Higher Triplet Excited States2005

    • Author(s)
      Masanori Sakamoto
    • Journal Title

      J.Phys.Chem.A 109・21

      Pages: 4657-4661

    • Related Report
      2005 Annual Research Report
  • [Journal Article] C-O Bond Cleavage of Benzophenones Substituted by 4-CH_2OR (R=C_6H_5 and CH_3) with Stepwise Two-photon Excitation2005

    • Author(s)
      Xichen Cai
    • Journal Title

      J.Phys.Chem.A 109・27

      Pages: 5989-5994

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Dual Electron Transfer Pathways from 4,4'-Dimethoxybenzophenone Ketyl Radical in the Excited State to Parent Molecule in the Ground State2005

    • Author(s)
      Masanori Sakamoto
    • Journal Title

      J.Phys.Chem.A 109・31

      Pages: 6830-6835

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Importance of Properties of the Lowest and Higher Singlet Excited States on the Resonant Two-photon Ionization of Stilbene and Substituted Stilbenes using Two-color Two-lasers2005

    • Author(s)
      Michihiro Hara
    • Journal Title

      J.Phys.Chem.A 109・43

      Pages: 9831-9835

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Monitoring of Microenvironmental Changes in the Major and Minor Grooves of DNA by Dan Modified Oligonucleotides2005

    • Author(s)
      Takumi Kimura
    • Journal Title

      Org.Lett. 7・26

      Pages: 5829-5832

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Reaction of Triarylphosphine Radical Cations Generated from Photo-Induced Electron Transfer in the Presence of Oxygen2005

    • Author(s)
      Shinro Yasui
    • Journal Title

      J.Org.Chem. 70・4

      Pages: 1276-1280

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Dihydrophenanthrene-type Intermediates during Photoreaction of trans-4'-Benzyl-5-styrylfuran2005

    • Author(s)
      Shingo Samori
    • Journal Title

      J.Org.Chem. 70・7

      Pages: 2708-2712

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effect of Oxygen on Trans-4-methoxystilbene during Resonat Two-photon Inonization in Acetonitrile2005

    • Author(s)
      Michihiro Hara
    • Journal Title

      J.Org.Chem. 70・11

      Pages: 4370-4374

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Efficient emission from charge recombination during the pulse radiolysis of electrochemical luminescent donor-acceptor molecules with an ethynyl linkage2005

    • Author(s)
      Shingo Samori
    • Journal Title

      J.Org.Chem. 70・17

      Pages: 6661-6668

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Four Double Helix DNA Bundled Structures Assembled by Porphyrin Connectors2005

    • Author(s)
      Masayuki Endo
    • Journal Title

      J.Org.Chem. 70・19

      Pages: 7468-7472

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Photochemical Control of Restriction Enzyme BamHI Activity Using Azobenzene Derivatives Incorporated Site-Selectively into the Dimer Interface2005

    • Author(s)
      Koji Nakayama
    • Journal Title

      Bioconjugate Chem.

      Pages: 1360-1366

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Selective guanine oxidation by UVB-irradiation in telomeric DNA2005

    • Author(s)
      Kiyohiko Kawai
    • Journal Title

      Chem.Comm.

      Pages: 1476-14772

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Programmable DNA translation system using cross-linked DNA mediators2005

    • Author(s)
      Masayuki Endo
    • Journal Title

      Chem.Commun

      Pages: 3153-3155

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Structural Arrangement of DNA Constrained by a Cross-linker2005

    • Author(s)
      Masayuki Endo
    • Journal Title

      Org.Biomol.Chem 3

      Pages: 3476-3478

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Anisotropic interfacial Electron Transfer Across a Semiconductor-Solution Interface Studied by Time-Resolved EPR2005

    • Author(s)
      Kimio Akiyama
    • Journal Title

      Angew.Chem.Int.Ed. 44・23

      Pages: 3591-3594

    • Related Report
      2005 Annual Research Report
  • [Journal Article] DNA Tube Structures Controlled by a Four-Way Branched DNA Connector2005

    • Author(s)
      Masayuki Endo
    • Journal Title

      Angew.Chem.Int.Ed 44

      Pages: 2-4

    • Related Report
      2005 Annual Research Report
  • [Journal Article] One-Electron Redox Processes during the Polyoxometalate-Mediated TiO_2 Photocatalytic Reactions Studied by Two-Color Two-Laser Flash Photolysis2005

    • Author(s)
      Takashi Tachikawa
    • Journal Title

      Chem.Eur.J. 34・11

      Pages: 1522-1523

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Contributions of the Distance-Dpendent Reorganization Energy and Proton Transfer Process to Hole Transfer in DNA2005

    • Author(s)
      Tadao Takada
    • Journal Title

      Chem.Eur.J. 11

      Pages: 3835-3843

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Higher Triplet Excited State of Benzophenone and its Substituted Benzophenones during ns-ps Two-color Two-laser Flash Photolysis2005

    • Author(s)
      Xichen Cai
    • Journal Title

      Chem.Eur.J. 11

      Pages: 6471-6477

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Consecutive adenine sequence are potential targets in photosensitized DNA damage2005

    • Author(s)
      Kiyohiko Kawai
    • Journal Title

      Chem.Biol. 12

      Pages: 1049-1054

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Recognition of Substituted Cytosine Derivatives by the Base Pairing with Guanine Connected to Pyrene2005

    • Author(s)
      Takahiro Kawai
    • Journal Title

      Chem.Phys.Lett 407

      Pages: 58-62

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Homolytic cleavage of C-Si bond of p-trimethylsilylmethylacetophenone upon stepwise two-photon excitation using two-color two-laser flash photolysis2005

    • Author(s)
      Xichen Cai
    • Journal Title

      Chem.Phys.Lett 407

      Pages: 402-406

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Synthesis and Properties of Terthiophene Modified Oligodeoxynucletides2005

    • Author(s)
      Kiyohiko Kawai
    • Journal Title

      Bioorg.Med.Chem.Lett 15・20

      Pages: 4547-4549

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Photocatalytic Electron Transfer in Hybrid Titania Nanosheets Studied by Nanosecond Laser Flash Photolysis2005

    • Author(s)
      Takashi Tachikawa
    • Journal Title

      Chem.Lett 34・11

      Pages: 1522-1523

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Photosensitized one-electron oxidation of DNA2005

    • Author(s)
      Kiyohiko Kawai
    • Journal Title

      Pure Appl.Chem 77・6

      Pages: 963-975

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Spectroscopic Investigation of Oxidative Hole Transfer in DNA" in "Charge Transfer in DNA2005

    • Author(s)
      Kiyohiko Kawai
    • Journal Title

      Wiley-VCH, Weinheim

      Pages: 117-132

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Probing the Surface Adsorption and Photocatalytic Degradation of Catechols on the TiO_2 by Solid-State NMR Spetroscopy

    • Author(s)
      Takashi Tachikawa
    • Journal Title

      Langmuir (Lett.). (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Intramolecular Exciplex and Intermolecular Excimer Formation of 1,8-Naphthalimide- liker-Phenothiazine Dyads

    • Author(s)
      Dae Won Cho
    • Journal Title

      J.Phys.Chem.B (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] High Yield Generation of Long-Lived Charge-Separated State in Diphenylacetylene-Modified DNA

    • Author(s)
      Tadao Takada
    • Journal Title

      Angew.Chem.Int.Ed. (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Properties of Excited Ketyl Radicals of Benzophenone Analogues Depending on the Size and Electronic Character of Aromatic Rings

    • Author(s)
      Masanori Sakamoto
    • Journal Title

      Chem.Eur.J. (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Detection of G-quadruplex-TMPyP4 Complex by 2-Aminopurine Modified Human Telomeric DNA

    • Author(s)
      Takumi Kimura
    • Journal Title

      Chem.Comm. (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Two-color Two-laser Fabrication of Gold Nanoparticles in a PVA Film

    • Author(s)
      Masanori Sakamoto
    • Journal Title

      Chem.Phys.Lett. (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Important Factors for the Formation of Radical Cations of Stilbene and Substituted Stilbenes during Resonant Two-Photon Ionization with a 266- or 355-nm Laser

    • Author(s)
      Shingo Samori
    • Journal Title

      J.Photochem.Photobiol.A (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Formation of Pyrene Dimer Radical Cation at the Minor Groove of DNA

    • Author(s)
      Kiyohiko Kawai
    • Journal Title

      Bull.Chem.Soc.Jpn. (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Photochemistry of Short-lived Species using Multi-beam Irradiation

    • Author(s)
      Mamoru Fujitsuka
    • Journal Title

      Advanced in Photochemistry (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] DNA Supramolecular Structures for the Creation of Functional Nannomaterials "Soft Nanomaterials"

    • Author(s)
      Masayuki Endo
    • Journal Title

      American Scientific Publishers (in press)

    • Related Report
      2005 Annual Research Report
  • [Book] 光触媒〜基礎・材料開発・応用〜 酸化チタン光触による有機物の一電子酸化2005

    • Author(s)
      立川貴士, 真嶋哲朗
    • Publisher
      エヌ・ティー・エス
    • Related Report
      2005 Annual Research Report
  • [Book] 光科学研究の最前線 DNA光化学2005

    • Author(s)
      真嶋哲朗
    • Publisher
      強光子場科学研究懇談会
    • Related Report
      2005 Annual Research Report
  • [Patent(Industrial Property Rights)] High-sensitive Detection Method of SNIPS by Photocurrent Measurement2005

    • Inventor(s)
      真嶋 哲朗, 高田 忠雄, 川井 清彦, 藤塚 守
    • Industrial Property Rights Holder
      真嶋 哲朗, 高田 忠雄, 川井 清彦, 藤塚 守
    • Filing Date
      2005-05-19
    • Related Report
      2005 Annual Research Report
  • [Patent(Industrial Property Rights)] 金属ナノ粒子、金属ナノ線、金属ナノコンポジットの作成方法2005

    • Inventor(s)
      真嶋 哲朗, 坂本 雅典, 立川 貴士, 藤塚 守
    • Industrial Property Rights Holder
      真嶋 哲朗, 坂本 雅典, 立川 貴士, 藤塚 守
    • Filing Date
      2005-08-10
    • Related Report
      2005 Annual Research Report
  • [Patent(Industrial Property Rights)] 金属ナノ粒子の高速、高効率生成法2005

    • Inventor(s)
      真嶋 哲朗, 坂本 雅典, 立川 貴士, 藤塚 守
    • Industrial Property Rights Holder
      真嶋 哲朗, 坂本 雅典, 立川 貴士, 藤塚 守
    • Filing Date
      2005-08-12
    • Related Report
      2005 Annual Research Report
  • [Patent(Industrial Property Rights)] 媒体中に二つまたは複数の金属からなる合金もしくはコアシェル等の多様な構造を持つ金属ナノ粒子を形成する方法2005

    • Inventor(s)
      真嶋 哲朗, 坂本 雅典, 藤塚守
    • Industrial Property Rights Holder
      真嶋 哲朗, 坂本 雅典, 藤塚守
    • Filing Date
      2005-12-26
    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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