• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

自然流産発症機転におけるNK細胞抑制受容体(KIR)とHLAclassIの関与

Research Project

Project/Area Number 17659510
Research Category

Grant-in-Aid for Exploratory Research

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionHokkaido University

Principal Investigator

山田 秀人  北海道大学, 大学院医学研究科, 助教授 (40220397)

Co-Investigator(Kenkyū-buntansha) 古田 伊都子  北海道大学, 大学院医学研究科, 助手 (70238682)
森川 守  北海道大学病院, 医員 (00374380)
島田 茂樹  北海道大学, 北海道大学病院, 医員 (60374378)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2006: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2005: ¥1,900,000 (Direct Cost: ¥1,900,000)
Keywords不育症 / 習慣流産 / NK細胞 / NKT細胞 / Th1サイトカイン / Th2サイトカイン / トポロジー / 胎児発育
Research Abstract

前方視的コホート研究として、以下の研究成果をあげた。
1.自然流産の脱落膜中で、NK細胞%、NKT細胞%、Th1/2、Tc1/2を調べた。IA群(n=14)に比べて、Th細胞のIFN-γ+細胞%とIL-4+/TNF-α+比の上昇、およびTc細胞のIL-4+細胞%、IL-4+/IFN-γ+比とIL-4+/TNF-α+比の低下がSA群で認められたが、SANK(n=14)とSAAK(n=26)には差がなかった。SANKにおけるTh1優位は確認されなかった(Shimada et a1.,Am J Reprod Immuno1 2006)。
2.993妊婦において妊娠初期に子宮頚管スワブからDNAを採取し、サイトメガロウイルス(CMV)の存在をPCR法で調べた。7.7%の妊婦でCMVが陽性であった。CMV陽性妊婦の流産率は、有意に高率であった(RR7.0,95% CI2.O-23.8,p<0.01)(Tanaka et a1.,J Med Virol 2006)。潜在性CMV性器感染は、流産のリスク因子であることが判明した。
3.出生コホート研究として、412妊婦よりDNAを採取した。Catechol-0-methyltransferase(COMT)遺伝子多型を解析した結果、COMT-Lアレルは、低出生体重(OR3.0,95%CI1.1-8.1)および子宮内胎児発育遅延(OR2.6,95%CI1.1-6.1)のリスク因子であることが判明した(Sata et al.,Pharmacogenetics 2006)。
ほかに、胎盤表面血管のトポロジー解析により、血管トポロジー因子(ノード数)と胎児発育との間に正の相関があることを世界で初めて発見した(Yamada et a1.,Hokkaido J Med Sci 2006)。

Report

(2 results)
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (14 results)

All 2006 2005

All Journal Article (12 results) Book (2 results)

  • [Journal Article] Functional maternal catechol-O-methyltransferase polymorphism and fetal growth restriction.2006

    • Author(s)
      Fumihiro Sata
    • Journal Title

      Pharmacogenetics 16・11

      Pages: 775-781

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Natural killer, natural killer T, helper and cytotoxic T cells in the decidua from sporadic miscarriage.2006

    • Author(s)
      Shigeki Shimada
    • Journal Title

      Am J Reprod Immunol 56・3

      Pages: 193-200

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Topological factors in placental surface arteries correlate with neonatal birth weight.2006

    • Author(s)
      Hideto Yamada
    • Journal Title

      Hokkaido J Med Sci 81・5

      Pages: 365-370

    • NAID

      10029920061

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Screening for vaginal shedding of cytomegalovirus in healthy pregnant women using real-time PCR : correlation of CMV in vagina and adverse outcome of pregnancy.2006

    • Author(s)
      Kaori Tanaka
    • Journal Title

      J Med Virol 78・6

      Pages: 757-759

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Pregnancy-associated plasma protein-A polymorphism and the risk of recurrent pregnancy loss2006

    • Author(s)
      Kana Suzuki
    • Journal Title

      J Reprod Immunol 70・1-2

      Pages: 99-108

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Association between preterm birth and vaginal colonization by mycoplasma in early pregnancy.2006

    • Author(s)
      Soromon Kataoka
    • Journal Title

      J Clin Microbiol 44・1

      Pages: 51-55

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Divergence of natural killer cell receptor and related molecule in the decidua from sporadic miscarriage with normal chromosome karyotype.2005

    • Author(s)
      Hideto Yamada
    • Journal Title

      Molecular Human Reproduction 11・6

      Pages: 451-457

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Caffeine intake, CYP1A2 polymorphism and the risk of recurrent pregnancy loss2005

    • Author(s)
      Fumihiro Sata
    • Journal Title

      Molecular Human Reproduction 11・5

      Pages: 357-360

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Recurrent miscarriage and embryonic loss (letter to the editor).2005

    • Author(s)
      Hideto Yamada
    • Journal Title

      Human Reproduction 20・7

      Pages: 2036-2037

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Maternal genetic polymorphisms in CYP1A1, GSTM1 and GSTT1 and the risk of hypospadias.2005

    • Author(s)
      Noriko Kurahashi
    • Journal Title

      Molecular Human Reproduction 11・2

      Pages: 93-98

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Geneticfactors of fetal growth restriction and miscarriage.2005

    • Author(s)
      Hideto Yamada
    • Journal Title

      Seminar in Thrombosis and Hemostasis 31・3

      Pages: 334-345

    • Related Report
      2005 Annual Research Report
  • [Journal Article] MTHFR C677T polymorphism and Leiden mutation of factor V are not associated with recurrent spontaneous abortion of unexplained etiology in Japanese women.2005

    • Author(s)
      Gen Kobashi
    • Journal Title

      Seminar in Thrombosis and Hemostasis 31・3

      Pages: 266-271

    • Related Report
      2005 Annual Research Report
  • [Book] 臨床エビデンス産科学,血液疾患2006

    • Author(s)
      山田秀人
    • Total Pages
      8
    • Publisher
      メジカルビュー社
    • Related Report
      2006 Annual Research Report
  • [Book] 今日の治療指針2005版2005

    • Author(s)
      山田秀人
    • Total Pages
      1
    • Publisher
      医学書院
    • Related Report
      2005 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi