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高齢者地域住民における咀嚼機能と消化管ホルモンのグレリンとの関係

Research Project

Project/Area Number 17659663
Research Category

Grant-in-Aid for Exploratory Research

Allocation TypeSingle-year Grants
Research Field Social dentistry
Research InstitutionKyushu Dental College

Principal Investigator

高田 豊  Kyushu Dental College, 歯学部, 教授 (40163208)

Co-Investigator(Kenkyū-buntansha) 園木 一男  九州歯科大学, 歯学部, 助教 (50316155)
安細 敏弘  九州歯科大学, 歯学部, 准教授 (80244789)
秋房 住郎  九州歯科大学, 歯学部, 特別研究員 (40295861)
吉田 明弘  九州歯科大学, 歯学部, 助教 (20364151)
竹原 直道  九州歯科大学, 歯学部, 教授 (00038879)
福原 正代  九州歯科大学, 歯学部, 特別研修員 (90360057)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2007: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2006: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2005: ¥2,400,000 (Direct Cost: ¥2,400,000)
Keywords歯学 / 老化 / 栄養学 / 咀嚼 / 消化管ホルモン / 高齢者 / 歯科 / 住民 / 疫学調査 / 口腔 / グレリン
Research Abstract

平成18年度実績報告書で行った福岡県民60・65歳393名を対象とした解析では、グレリン、レプチンと健全歯数、未処置歯数、喪失歯数、残存歯数、咀嚼食品数の間に有意の関係を認めなかった。平成19年度はこの393名に260名の高齢者を対象に加えて総数653名とし、グレリンとレプチンを測定した617名について上記の口腔指標の他に歯肉ポケット深さ(PD)、アタッチメントロス(AL)、出血個数(Bo)との関係も解析した。
グレリンと健全歯数、未処置歯数、喪失歯数、残存歯数、咀嚼食品数の間に単回帰で有意な関係を認めなかったが、PD最大値(r=-0.115、P=0.005)、PD平均値(r=-0.082、P=0.043)、AL最大値(r=-0.120、P=0.003)、AL平均値(r=-0.218、P=0.000)、Bo平均個数(r=-0.088、P=0.029)との間に有意な負の関係を認めた。レプチンは健全歯数(r=-0.081、P=0.045)、残存歯数(r=-0.118、P=0.003)、残存根除去歯数(r=-0.107、P=0.008)と負の関係、PD最大値(r=0.107、P=0.008)、PD平均値(r=0.097、P=0.016)、AL平均値(r=0.171、P=0、000)と正の関係を認めた。また、年齢との間にグレリン(r=-0.377、P=0.000)は負の、レプチンは(r=0.419、P=0.000)正の関係があった。グレリン(男159.3±165.2女201.1±168.8、P=0.002)、レプチン(男16.9±25.4女33.4±54.2、P=0.000)に男女差を認めた。しかし、年齢と性差で補正をした重回帰分析においては、グレリンとPD最大値、PD平均値、AL最大値、AL平均値、Bo個数の間に有意の関係はなく、レプチンと健全歯数、残存歯数、残存根除去歯数、PD最大値、PD平均値、AL平均値の間にも有意の関係は認められなかった。
以上から、単回帰で認められた有意の関係は年齢と性差を介したものであったと考えられる。

Report

(3 results)
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (18 results)

All 2007 2006 2005 Other

All Journal Article (15 results) (of which Peer Reviewed: 3 results) Presentation (1 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Association between Body Mass Index and Mortality in an80-Year-Old Population.2007

    • Author(s)
      Takata Y, Ansai T, Soh I, Akifusa S, Sonoki K, Fujisawa K, Awano S, Kagiyama S, Hamasaki T, Nakamichi I, Yoshida A, Takehara T
    • Journal Title

      Journal of American Geriatric Society 55(6)

      Pages: 913-917

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between chewing ability and 4-year mortality in a cohort of 80-year-old Japanese people.2007

    • Author(s)
      Ansai T, Takata Y, Soh I, Akifusa S, Sogame A, Shimada N, Yoshida A, Hamasaki T, Awano S, Fukuhara M, and Takehara T
    • Journal Title

      Oral Diseases 13

      Pages: 214-219

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Physical Fitness and 4-Year Mortality in an 80-Year-Old Population.2007

    • Author(s)
      Takata Y, Ansai T, Akifusa S, Soh I, Yoshitake Y, Kimura Y, Sonoki K, Fujisawa K, Kagiyama S, Nakamichi I, Takehara T
    • Journal Title

      J Gerontology A Biol Sci Med Sci 62A(8)

      Pages: 851-858

    • NAID

      110006453305

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prediction of Cognitive Impairement by Arterial Stiffness in the Very Elderly.2006

    • Author(s)
      Fukuhara M, Matsumura K, Ansai T, Takata Y, Sonoki K, Akifusa S, Wakisaka M, Hamasaki T, Fujisawa K, Yoshida K, Fujii K, Iida M, Takehara T
    • Journal Title

      Circulation Journal 70(6)

      Pages: 756-761

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Decreased lipid peroxidation following periodontal therapy in diabetic patients.2006

    • Author(s)
      Sonoki K, Nakashima S, Takata Y, Naito T, Fukuhara M, Wakisaka M, Iwase M, Iida M, Yokota M
    • Journal Title

      Journal of Periodontology 77(11)

      Pages: 1907-1913

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Chewing and quality of life in an 80-year-old population.2006

    • Author(s)
      Takata Y, Ansai T, Awano S, Fukuhara M, Sonoki K, Wakisaka M, Fujisawa K, Takehara T
    • Journal Title

      Journal of Oral Rehabilitation 33 (5)

      Pages: 330-334

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Clinical significance and variation of the advanced calcified stylohyoid complex detected by panoramic radiographs among 80-year-old subjects.2006

    • Author(s)
      Okabe S, Morimoto Y, Ansai T, Yamada K, Tanaka T, Awano S, Kito S, Takata Y, Takehara T, Ohba T
    • Journal Title

      Dentomaxillofacial Radiology 35 (3)

      Pages: 191-199

    • NAID

      120006735365

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Prevalence of periodontopathic bacteria on the tongue dorsum of elderly people.2006

    • Author(s)
      Tachibana M, Yoshida A, Ansai T, Takata Y, Akifusa S, Fukuhara M, Hamasaki T, Okuda K, Takehara T
    • Journal Title

      Gerodontology 23

      Pages: 123-126

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Can presence of carotid artery calcification on panoramic radiographs predict vascular-related risks among old subjects?2006

    • Author(s)
      Tanaka T, Morimoto Y, Ansai T, Okabe S, Yamada K, Taguchi A, Awano S, Kito S, Takata Y, Takehara T, Ohba T
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101 (6)

      Pages: 777-783

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Clnical significance and variation of the advanced calcified stylohyoid complex detected by panoramic radiographs among 80-year-old subjects.2006

    • Author(s)
      Okabe S, Morimoto Y, Ansai T, Yamada K, Tanaka T, Awano S, Kito S, Takata Y, Takehara T, Ohba T
    • Journal Title

      Dentomaxillofacial Radiology 35(In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Chewing and quality of life in an 80-year-old population.2006

    • Author(s)
      Takata Y, Ansai T, Awano S, Fukuhara M, Sonoki K, Wakisaka M, Fujisawa K, Takehara T
    • Journal Title

      Journal of Oral Rehabilitation (In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Evaluation of the relationship between peripheral lesions/sclerotic bone and general bone density as a possible gauge of general health among 80-year olds.2005

    • Author(s)
      Ohba T, Takata Y, Ansai T, Morimoto Y, Tanaka T, Kito S, Hamasaki T, Akifusa S, Takehara T
    • Journal Title

      Oral Surgery Oral Medicine Oral Pathology Oral Radiology Endodontics 99(3)

      Pages: 353-358

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Relationship of number of remaining teeth to health-related quality of life in community-dwelling elderly.2005

    • Author(s)
      Akifusa S, Soh I, Ansai T, Hamasaki T, Takata Y, Yoshida A, Fukuhara M, Sonoki K, Takehara T
    • Journal Title

      Gerodontology 22(1)

      Pages: 91-97

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Tooth loss associated with abnormal electrocardiographic findings in octogenarians.2005

    • Author(s)
      Takata Y, Ansai T, Awano S, Sonoki K, Akifusa S, Fukuhara M, Wakisaka M, Takehara T
    • Journal Title

      Journal of Kyushu Dental Society 59(4)

      Pages: 153-160

    • NAID

      110006420801

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 福岡県85歳追跡調査の概要2005

    • Author(s)
      秋房住郎, 高田豊, 竹原直道
    • Journal Title

      8020,財団法人8020推進財団 4

      Pages: 69-73

    • Related Report
      2005 Annual Research Report
  • [Presentation] 長寿につながる咀嚼の効果-福岡県8020調査研究から-2007

    • Author(s)
      安細 敏弘, 高田 豊, 粟野 秀慈, 吉田 明弘, 藤澤 聖, 竹原 直道
    • Organizer
      第27回日本医学会総会, シンポジウム「歯・咀嚼とQOL-認知症を改善する」
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2007 Annual Research Report
  • [Book] 宋養指導マニュアル改訂4版2006

    • Author(s)
      高田豊, 下田妙子
    • Publisher
      南山堂
    • Related Report
      2006 Annual Research Report
  • [Remarks]

    • URL

      http://www.kyu-dent.ac.jp/researcher/

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2016-04-21  

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