毛様体扁平部多点参照電極を用いた網膜貫通型電流刺激による人工視覚の検討

• Project/Area Number: 17791231
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Osaka University
• Principal Investigator: 坂口 裕和 Osaka University, 医学系研究科, 助教 (80379172)
• Project Period (FY): 2005 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥3,000,000 (Direct Cost: ¥3,000,000); Fiscal Year 2007: ¥1,200,000 (Direct Cost: ¥1,200,000); Fiscal Year 2006: ¥800,000 (Direct Cost: ¥800,000); Fiscal Year 2005: ¥1,000,000 (Direct Cost: ¥1,000,000)
• Keywords: 人工視覚 / 網膜貫通型電流 / 網膜刺激電極 / 参照電極 / 誘発電位

Research Abstract

(1)4方向からの毛様体扁平部参照電極を用いた網膜貫通型電流刺激による誘発電位の変化(急性実験);家兎眼を用い、眼球毛様体扁平部のうち、上方、下方、耳側、鼻側の4方向に随時参照電極の位置を変え、同じ網膜後極部の強膜内に設置された刺激電極からの網膜貫通型電流で網膜を刺激した場合の誘発電位を調べたところ、いずれにおいても波形を認めが、有意な波形の変化は認められないという結果を得た。
(2)形状の異なる6種類の参照電極による誘発電位の変化;上記をさらに確認するため、同一の毛様体扁平部から硝子体内の長さの異なる6種類の参照電極を随時挿入し、それによる誘発電位の波形の変化について検討したところ、6種類すべての参照電極において大脳皮質で誘発電位を得たが、硝子体内の長さによる誘発電位の有意な相違は確認できなかった。
(3)強膜上あるいは耳に参照電極を設置した場合の誘発電位の変化;さらに、強膜上あるいは耳に、すなわち硝子体内に参照電極をおかずに、毛様体扁平部付近眼球上および眼球外に参照電極を設置し、上記(2)と同様の実験を行ったところ、強膜上では上記(2)と同様の波形が得られ、耳に設置した場合は、波形は得られたものの、他のものと同様の波形は得られなかった(反応波数が少なく、電位も低下している)。
以上のことから、網膜貫通型の電流刺激を施行する場合、毛様体扁平部であれば強膜上においても、硝子体内に長く突出するものを用いても、大脳皮質においては同様の誘発電位が得られることが確認された。

Research Products

• [Journal Article] Evaluation of phosphenes elicited by extraocular stimulation in normals and by suprachoroidal-transretinal stimulation in patients with retinitis pigmentosa. (2007)
  • Author(s): Fujikado T, et. al.
  • Journal Title: Graefes Arch Clin Exp Ophthalmol. 245(10) Pages: 1411-9
  • Peer Reviewed
• [Journal Article] Threshold suprachoroidal-transretinal stimulation current resulting in retinal damage in rabbits. (2007)
  • Author(s): Nakauchi K, et. al.
  • Journal Title: J Neural Eng. 4(1)
  • Peer Reviewed
• [Journal Article] 27-gayge transonjuntival nonvitrectomizing vitreous surgery for epiritinal membrane removal. (2007)
  • Author(s): Sakaguchi H, Oshima Y, Tano Y
  • Journal Title: Retina. 27(8) Pages: 1131-2
  • Peer Reviewed
• [Journal Article] Intravitreal injevtion of bevacizumab for choroidal neovscularisation associated with pathological myopia. (2007)
  • Author(s): Sakaguchi H, et. al.
  • Journal Title: Br J Ophthalmol. 91(2) Pages: 161-5
  • Peer Reviewed
• [Journal Article] Intravitreal bevacizumab for idiopathic choroidal neovascularization after previous injection with posterior subtenon triamcinolone. (2007)
  • Author(s): Gomi F, et. al.
  • Journal Title: Am J Ophthalmol 143(3) Pages: 507-10
  • Peer Reviewed
• [Journal Article] Regression of iris neovascularization after intravitreal injection of bevacizumab in patients with proliferative diabetic retinopathy. (2006)
  • Author(s): Oshima Y, Sakaguchi H, Gomi F, Tano Y
  • Journal Title: Am J Ophthalmol. 142(1) Pages: 155-158
• [Journal Article] Forceps with scale marks for the transconjunctival sutureless vitrectomy system. (2006)
  • Author(s): Ohji M, Sakaguchi H, Tano Y
  • Journal Title: Retina. 26(5) Pages: 583-585
• [Journal Article] Radial optic neurotomy for the management of hemicentral retinal vein occlusion : long-term follow-up study. (2006)
  • Author(s): Sakaguchi H, Ohji M, Kamei M, et al.
  • Journal Title: Retina. 26(5) Pages: 555-561
• [Journal Article] Sub-Tenon's injection of triamcinolone acetonide for choroidal neovascularization (2006)
  • Author(s): Kim A, Gomi F, Sakaguchi H, Oshima Y, Ikuno Y, Kamei M, Oji M, Tano Y
  • Journal Title: Nippon Ganka Gakkai Zasshi. 110(1) Pages: 19-24
  • NAID: 10017326802
• [Journal Article] Electrophysiological and histological studies of chronically implanted intrapapillary microelectrodes in rabbit eyes. (2006)
  • Author(s): Fang X, Sakaguchi H, Fujikado T, et al.
  • Journal Title: Graefes Arch Clin Exp Ophthalmol. 244(3) Pages: 364-375
• [Presentation] Analysis of Macular Microstructures Following Successful Repair of Rhegmatogenous Retinal Detachment Involving Macula by Fourier-Domain Optical Coherence Tomography. (2007)
  • Author(s): T.Wakabayashi, et al.
  • Organizer: Association for Research in Vision and Ophthalmology annual meeting
  • Place of Presentation: Fort Lauderdale,FL
  • Year and Date: 2007-05-10
• [Presentation] Artificial Vision by Direct Optic Nerve Electrode(AV-DONE)for a Patient with Retinitis Pigmentosa. (2007)
  • Author(s): H.Sakaguchi, et, al.
  • Organizer: Association for Research in Vision and Ophthalmology annual meeting
  • Place of Presentation: Fort Lauderdale,FL
  • Year and Date: 2007-05-09
• [Presentation] Middle-Sized Animal Model of Retinal Degeneration. (2007)
  • Author(s): K.Nishida, et al.
  • Organizer: Association for Research in Vision and Ophthalmology annual meeting
  • Place of Presentation: Fort Lauderdale,FL
  • Year and Date: 2007-05-09
• [Presentation] Systemic and Ocular Adverse Events Following Intravitreal Injection of Bevacizumab. (2007)
  • Author(s): C, Shima, et al.
  • Organizer: Association for Research in Vision and Ophthalmology annual meeting
  • Place of Presentation: Fort Lauderdale,FL
  • Year and Date: 2007-05-07
• [Presentation] Systemic Administration of IL-6 Receptor Antibody Suppresses Choroidal Neovascularization(CNV)in Mice. (2007)
  • Author(s): S.Hohki, et al.
  • Organizer: Association for Research in Vision and Ophthalmology annual meeting
  • Place of Presentation: Fort Lauderdale,FL
  • Year and Date: 2007-05-07