• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

MR sialographyによる口腔乾燥症の病態解明

Research Project

Project/Area Number 17791344
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionKyushu Dental College

Principal Investigator

田中 達朗  九州歯科大学, 歯学部, 講師 (50326469)

Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2006: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2005: ¥800,000 (Direct Cost: ¥800,000)
Keywords唾液 / 口腔乾燥症 / MRI / sialography / 機能 / シェーグレン症候群 / クエン酸
Research Abstract

昨年度の研究により、これまで静的な状態でしか撮像・診断ができなかった唾液腺のMRI検査を動的な状態での検出を可能とするようなMR sialographyの開発に成功した。今年度は、この撮像法を用いて、実験ボランティアで、クエン酸による味覚刺激を行いその唾液の流出状態を30秒ごとにMR信号として検出したものと、実際のヒトからの唾液の流出状態を測定したものと示すことで証明した。また、味覚刺激を行ってからの時間と撮像したMR画像の信号からグラフを描くことにより、様々な唾液の流出パターンがあることもこの検査法で判明した。さらに、シェーグレン症候群と診断された患者や口腔の乾燥感を訴える患者に対しても応用することで、味覚刺激後の唾液の流量、反応時間、流出パターンなどが健常者とは異なる様相を呈することを示した。これは核医学検査を行わなければ検出出来なかった唾液腺の機能状態をMRIにより検出し、診断を行うことを可能にするもので、口腔乾燥症、シェーグレン症候群などの疾患の診断に際しての新たな指標となり得るものと考える。さらに、得られたMR画像から計測した唾液腺の体積と唾液量とも関連性があることも示した。現在は健常者及び患者から採取された唾液の成分の違いによるMRIでの特異的な信号の有無について検討している。現在は患者の画像所見や唾液の流出パターンの違いによる治療効果の違いについて検討を行っている。今後はこれらの結果をもとに、口腔乾燥症の病態解明、治療法の確立を行っていく予定である。

Report

(2 results)
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (13 results)

All 2006 2005

All Journal Article (13 results)

  • [Journal Article] Can the presence of carotid artery calcification on panoramic radiographs predict the risk of vascular diseases among 80-year-olds?2006

    • Author(s)
      Tanaka T.
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101

      Pages: 777-783

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Gender difference in unstimulated whole saliva flow rate and salivary gland sizes.2006

    • Author(s)
      Inoue H
    • Journal Title

      Arch Oral Biol 51

      Pages: 1055-1060

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Dynamic MR sialography as a new diagnostic technique for patients with Sjogren syndrome.2006

    • Author(s)
      Morimoto Y
    • Journal Title

      Oral Dis 12

      Pages: 408-414

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Relationship of the unstimulated whole saliva flow rate and salivary gland size estimated by magnetic resonance image in healthy young humans.2006

    • Author(s)
      Ono K
    • Journal Title

      Arch Oral Biol 51

      Pages: 345-349

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Clinical significance and variation of the advanced calcified stylohyoid complex detected by panoramic radiographs among 80-year-old subjects.2006

    • Author(s)
      Okabe S
    • Journal Title

      Dentomaxillofac Radiol 35

      Pages: 191-199

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Utility of diffusion-weighted images using fast asymmetric spin-echo sequences for detection of abscess formation in the head and neck region.2006

    • Author(s)
      Kito S
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101

      Pages: 233-240

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Utility of diffusion-weighted images using fast asymmetric spin-echo sequences for detection of abscess formation in the head and neck resion.2006

    • Author(s)
      Kito S.
    • Journal Title

      Oral Surg.Oral Med.Oral Pathol.Oral Radiol.Endod. 101

      Pages: 231-238

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Correlation between the incidence of central nodal necrosis in cervical lymph node metastasis and the extent of differentiation in oral squamous cell carcinoma.2006

    • Author(s)
      Morimoto Y.
    • Journal Title

      Dentomaxillofacial Radiology 35

      Pages: 18-23

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Three-dimensional identification of hemangiomas and feeding arteries in head and neck resion using combined phase-contrast MR angiography and fast asymmetric spin-echo sequences.2005

    • Author(s)
      Tanaka T.
    • Journal Title

      Oral Surg.Oral Med.Oral Pathol.Oral Radiol.Endod. 100

      Pages: 609-613

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The functional evaluation of salivary glands using dynamic MR sialography following citric acid stimulation : a pleliminary study.2005

    • Author(s)
      Morimoto Y.
    • Journal Title

      Oral Surg.Oral Med.Oral Pathol.Oral Radiol.Endod. 100

      Pages: 357-364

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A proposal for the study of the flow void features of maxillary vessels on the coronal plane of the temporomandibular joints as detected through magnetic resonance imaging2005

    • Author(s)
      Tanaka T.
    • Journal Title

      Jpn J Oral Diag/Oral Med 18

      Pages: 373-378

    • NAID

      10025563529

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Cleavage of nucleolin and AgNOR proteins during apoptosis induced by anti-cancer drugs in human salivary gland cells.2005

    • Author(s)
      Kito S.
    • Journal Title

      Journal of Oral Pathology & Medicine 34

      Pages: 478-485

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Utility of magnetic resonance cisternography using three-dimensional fast asymmetric spin-echo sequences with multiplanar reconstruction : the evaluation of sites of neurovascular compression of the trigeminal nerve.2005

    • Author(s)
      Tanaka T.
    • Journal Title

      Oral Surg.Oral Med.Oral Pathol.Oral Radiol.Endod. 100

      Pages: 215-225

    • Related Report
      2005 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi