Function and regulatory system of water transporting aquaporin channels

• Project/Area Number: 17GS0312
• Research Category: Grant-in-Aid for Creative Scientific Research
• Allocation Type: Single-year Grants
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: SASAKI Sei Tokyo Medical and Dental University, 医歯学総合研究科, 教授 (60170677)
• Co-Investigator(Kenkyū-buntansha): ISHIBASHI Kenichi 明治薬科大学, 薬学部, 教授 (80223022) ; UCHIDA Sinichi 東京医科歯科大学, 医歯学総合研究科, 准教授 (50262184) ; KOBAYASHI Katsuki 国立病院機構千葉東病院, 臨床研究センター, 室長 (40415451) ; NODA Yumi 東京医科歯科大学, 医歯学総合研究科, 特任准教授 (30372436)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥434,590,000 (Direct Cost: ¥334,300,000、Indirect Cost: ¥100,290,000); Fiscal Year 2009: ¥69,160,000 (Direct Cost: ¥53,200,000、Indirect Cost: ¥15,960,000); Fiscal Year 2008: ¥69,160,000 (Direct Cost: ¥53,200,000、Indirect Cost: ¥15,960,000); Fiscal Year 2007: ¥93,730,000 (Direct Cost: ¥72,100,000、Indirect Cost: ¥21,630,000); Fiscal Year 2006: ¥88,660,000 (Direct Cost: ¥68,200,000、Indirect Cost: ¥20,460,000); Fiscal Year 2005: ¥113,880,000 (Direct Cost: ¥87,600,000、Indirect Cost: ¥26,280,000)
• Keywords: 水チャネル / アクアポリン / 水輸送 / 尿崩症 / 膵炎 / 嚢胞腎 / リン脂質結合蛋白 / アクチン / トロポミオシン / 蛍光相関分光 / 遺伝子改変マウス / リト脂質結合蛋 / AKAP / 酵母two-hybrid法 / 細胞内輸送 / プロテオミクス / チャネル / グリセロール / 膜蛋白質

Research Abstract

Physiological roles of AQPs were investigated by generating and analyzing AQP gene targetting mice. Regulatory mechanisms of AQPs were also clarified by identifying AQP-binding protein complexes. These results shed light on development of new drugs modulating the functions of AQPs.

Research Products

• [Journal Article] Aquaporins in kidney pathophysiology (2010)
  • Author(s): 野田裕美
  • Journal Title: Nat.Rev.Nephrol. 6 Pages: 168-178
  • Peer Reviewed
• [Journal Article] Effect of angiotensin II on the WNK-OSR1/SPAK-NCC phosphorylation cascade in cultured mpkDCT cells and in vivo mouse kidney (2010)
  • Author(s): Talati G
  • Journal Title: Biochem Biophys Res Commun. (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Mechanisms for hypercalciuria in pseudohypoaldosteronism type II-causing WNK4 knock-in mice (2010)
  • Author(s): Yang SS
  • Journal Title: Endocrinology (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure (2009)
  • Author(s): Ohta A, Rai T, Yui N, Chiga M, Yang SS, Lin SH, Sohara E, Sasaki S, Uchida S.
  • Journal Title: Hum.Mol.Genet. 18 Pages: 3978-86
• [Journal Article] Pancreas-specific aquaporin 12 null mice showed increased susceptibility to caerulein-induced acute pancreatitis (2009)
  • Author(s): Ohta E, Itoh T, Nemoto T, Kumagai J, Ko SB, Ishibashi K, Ohno M, Uchida K, Ohta A, Sohara E, Uchida S, Sasaki S, Rai T.
  • Journal Title: Am.J.Physiol.Cell Physiol. 297 Pages: 1368-78
• [Journal Article] FAPP2 is required for aquaporin-2 apical sorting at trans-Golgi network in polarized MDCK cells (2009)
  • Author(s): Yui N, Okutsu R, Sohara E, Rai T, Ohta A, Noda Y, Sasaki S, Uchida S.
  • Journal Title: Am.J.Physiol.Cell Physiol. 297 Pages: 1389-1396
• [Journal Article] New members of mammalian aquaporins : AQP10-AQP12 (2009)
  • Author(s): 石橋賢一
  • Journal Title: Handbook of Experimental Pharmacology 190 Pages: 251-261
  • Peer Reviewed
• [Journal Article] Aquaporin water channels in mammals (2009)
  • Author(s): 石橋賢一
  • Journal Title: Clin.Exp.Nephrol 13 Pages: 107-117
  • NAID: 10005661794
  • Peer Reviewed
• [Journal Article] The role of a group III AQP, AQP11 in intracellular organelle homeostasis (2009)
  • Author(s): 石橋賢一
  • Journal Title: The Journal of Medical Investigation 56 supplement Pages: 312-317
  • NAID: 130004822627
  • Peer Reviewed
• [Journal Article] Aquaporin-2 regulates cell volume recovery via tropomyosin (2009)
  • Author(s): Li YH
  • Journal Title: Int.J.Biochem.Cell Biol. 41 Pages: 2466-2476
  • Peer Reviewed
• [Journal Article] Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure (2009)
  • Author(s): Ohta A
  • Journal Title: Hum.Mol.Genet 18 Pages: 3978-3986
  • Peer Reviewed
• [Journal Article] Pancreas-specific aquaporin 12 null mice showed increased susceptibility to caerulein-induced acute pancreatitis (2009)
  • Author(s): Ohta E
  • Journal Title: Am.J.Physiol.Cell Physiol. 297 Pages: 1368-1378
  • Peer Reviewed
• [Journal Article] Vasopressin-dependent upregulation of aquaporin-2 gene expression in aged rats with glucocorticoid deficiency (2009)
  • Author(s): Saito T
  • Journal Title: Acta.Physiol. 196 Pages: 239-47
  • Peer Reviewed
• [Journal Article] Function of aquaporin-7 in the kidney and the male reproductive system (2009)
  • Author(s): 蘇原映誠
  • Journal Title: Handbook of Experimental Pharmacology 190 Pages: 219-31
  • Peer Reviewed
• [Journal Article] Expression and phosphorylation of the Na^+-Cl^- cotransporter NCC in vivo is regulated by dietary salt, potassium, and SGK1 (2009)
  • Author(s): Vallon V
  • Journal Title: Am.J.Physiol.Renal 279
  • Peer Reviewed
• [Journal Article] FAPP2 is required for aquaporin-2 apical sorting at trans-Golgi network in polarized MDCK cells (2009)
  • Author(s): Yui N
  • Journal Title: Am.J.Physiol.Cell Physiol. 297
  • Peer Reviewed
• [Journal Article] 水チャネルと体液調節の異常 (2009)
  • Author(s): 石橋賢一
  • Journal Title: Current Therapy 27 Pages: 52-55
• [Journal Article] 大学院特論講義:水電解質研究の進歩 (2009)
  • Author(s): 石橋賢一
  • Journal Title: 明治薬科大学研究紀要 38 Pages: 21-28
• [Journal Article] 基礎研究の新たな方向性を解く疾患解明 Overview 遺伝子性腎性尿崩症アクアポリン水チャネルによる尿濃縮機構とその破綻 (2009)
  • Author(s): 蘇原映誠
  • Journal Title: 実験医学 27 Pages: 589-594
• [Journal Article] 尿細管での水輸送 (2009)
  • Author(s): 野田裕美
  • Journal Title: 腎と透析 67 Pages: 333-338
• [Journal Article] Reciprocal interaction with G-actin and tropomyosin is essential for aquaporin-2 trafficking (2008)
  • Author(s): Noda Y, Horikawa S, Kanda E, Yamashita M, Meng H, Eto E, Li Y, Kuwahara M, Hirai K, Pack C, Kinjo M, Okabe S, Sasaki S.
  • Journal Title: J.Cell Biol. 182 Pages: 587-601
• [Journal Article] Dietary salt regulates the phosphorylation of OSRI/SPAK kinases and the sodium chloride cotransporter through aldosterone. (2008)
  • Author(s): Chiga M
  • Journal Title: Kidney Int. 74 Pages: 1403-1409
  • Peer Reviewed
• [Journal Article] AKAP220 colocalizes with AQP2 in the inner medullary collecting ducts (2008)
  • Author(s): Okutsu R
  • Journal Title: Kidnev Int. 74 Pages: 1429-1433
  • Peer Reviewed
• [Journal Article] Reciprocal interaction with G-actin and tropomyosin is essential for aquaporin-2 trafficking. (2008)
  • Author(s): Noda Y
  • Journal Title: Journal of Cell Biologv 182 Pages: 587-601
  • Peer Reviewed
• [Journal Article] Aquaporin-11 knockout mice and polycystic kidney disease animals share a common mechanism of cyst formation. (2008)
  • Author(s): Okada S
  • Journal Title: FASEB J 22(10) Pages: 3672-3684
  • Peer Reviewed
• [Journal Article] Neuromyelitis optica and anti-aquaporin-4 antibodies measured by an enzyme-linked immunosorbent assay. (2008)
  • Author(s): Hayakawa S
  • Journal Title: J Neuroimmunol 196 Pages: 181-187
  • Peer Reviewed
• [Journal Article] Single amino acid substitution in aquaporin 11 causes renalfailure. (2008)
  • Author(s): Tchekneva EE
  • Journal Title: J Am Soc Nephrol. 19 Pages: 1955-1964
  • Peer Reviewed
• [Journal Article] Intraceilular aquaporins: clues for intracellular water transport? (2008)
  • Author(s): Nozaki K
  • Journal Title: Pflugers Arch 456 Pages: 701-707
  • Peer Reviewed
• [Journal Article] Invited Review: Introduction for special issue for aquaporin. Expanding the world of aquaporins: new members and new functions. (2008)
  • Author(s): Sasaki S
  • Journal Title: Pflugers Arch 456 Pages: 647-649
  • Peer Reviewed
• [Journal Article] Is oxytocin a player in antidiuresis? (2008)
  • Author(s): Sasaki S
  • Journal Title: J Am Soc Nephrol. 19 Pages: 225-232
  • Peer Reviewed
• [Journal Article] Is oxytocin a player in antidiuresis? (2008)
  • Author(s): Sasaki S
  • Journal Title: J Am Soc Nephrol 19 Pages: 189-190
• [Journal Article] The role of actin remodeling in the trafficking of intracellular vesicles, transporters and channels: focusing on aquaporin-2. (2008)
  • Author(s): Noda Y, et. al.
  • Journal Title: Pflugers Archiv (印刷中)
  • Peer Reviewed
• [Journal Article] Actin-binding channels. (2008)
  • Author(s): Noda Y, et. al.
  • Journal Title: Prog Brain Res 170(印刷中)
  • Peer Reviewed
• [Journal Article] Intracellular aquaporins: clues for intracellular water transport? (2008)
  • Author(s): Nozaki K, et. al.
  • Journal Title: Pflugers Arch (印刷中)
  • Peer Reviewed
• [Journal Article] Introduction for special issue for aquaporin: Expanding the world of aquaporins. (2008)
  • Author(s): Sasaki S
  • Journal Title: Pflugers Archiv (印刷中)
  • Peer Reviewed
• [Journal Article] Molecular pathogenesis of pseudohypoaldosteronism type II : generation and analysis of a Wnk4 D561A/+ knock-in mouse model (2007)
  • Author(s): Yang SS, Morimoto T, Rai T, Chiga M, Sohara E, Ohno M, Uchida K, Lin S-H, Moriguchi T, Shibuya H, Kondo Y, Sasaki S, Uchida S.
  • Journal Title: Cell Metab 5 Pages: 331-344
• [Journal Article] A case of nephrogenic diabetes insipidus with a novel missense mutation in the AVPR2 gene. (2007)
  • Author(s): Ashida A, et. al.
  • Journal Title: Pdeiatr Nephrol 22 Pages: 670-673
  • Peer Reviewed
• [Journal Article] Lithium effectively complements vasopressin V2 receptor antagonist in the treatment of hyponatraemia of SIADH rats. (2007)
  • Author(s): Kazama I, et. al.
  • Journal Title: Nephrol Dial Transplant 22 Pages: 68-76
  • Peer Reviewed
• [Journal Article] Expression of bone type 1 PTH receptor in rats with chronic renal failure. (2007)
  • Author(s): Kuwahara M, et. al.
  • Journal Title: Clin Exp Nephrol 11 Pages: 34-40
  • Peer Reviewed
• [Journal Article] Aquaporin-2 protein dynamics within the cell. (2007)
  • Author(s): Sasaki S., et. al.
  • Journal Title: Curr Opin Nephrol Hypertens 16 Pages: 348-352
  • Peer Reviewed
• [Journal Article] Morphologic and functional analysis of sperm and testes in aquaporin 7 knockout mice. (2007)
  • Author(s): Sohara E, et. al.
  • Journal Title: Fertil Steril 87 Pages: 671-676
  • Peer Reviewed
• [Journal Article] Barttin binds to the outer lateral surface of the ClC-K2 chloride channel. (2007)
  • Author(s): Tajima M, et. al.
  • Journal Title: Biochem Biophys Res Commun. 362 Pages: 858-864
  • Peer Reviewed
• [Journal Article] Study of the oral microbial flora in patients with renal disease. (2007)
  • Author(s): Takeuchi Y, et. al.
  • Journal Title: Nephrology 12 Pages: 182-190
  • Peer Reviewed
• [Journal Article] Important role of apoptosis signal-regulating kinase 1 in ischemic acute kidney injury. (2007)
  • Author(s): Terada Y, et. al.
  • Journal Title: Biochem Biophys Res Commun 28 Pages: 1043-1049
  • Peer Reviewed
• [Journal Article] Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4 (D561A/+) knockin mouse model. (2007)
  • Author(s): Yang SS, et. al.
  • Journal Title: Cell Metab 5 Pages: 331-344
  • Peer Reviewed
• [Journal Article] Aquaporin-11 containing a divergent NPA motif has normal water channel activity. (2007)
  • Author(s): Yakata K, et. al.
  • Journal Title: Biochim Biophys Acta 1768 Pages: 688-693
  • Peer Reviewed
• [Journal Article] Morphologic and functional analysis of sperm and testes in Aquaporin 7 knockout mice. (2007)
  • Author(s): Sohara E, et al.
  • Journal Title: Fertil Steril 87(3) Pages: 671-676
• [Journal Article] Aquaporin-11 containing a divergent NPA motif has normal water channel activity. (2007)
  • Author(s): Yakata K, et al.
  • Journal Title: Biochim Biophys Acta 1768(3) Pages: 688-693
• [Journal Article] Splenic artery ligation improves remnant liver function in partially hepatectomized rats with ischemia/reperfusion injury. (2007)
  • Author(s): Ito K, et al.
  • Journal Title: Liver Int 27 Pages: 400-407
• [Journal Article] Amelioration of hepatic ischemia/reperfusion injury in the remnant liver after partial hepatectomy in rats. (2007)
  • Author(s): Hiranuma S, et al.
  • Journal Title: J Gastroenterol Hepatol (in press.)
• [Journal Article] A case of nephrogenic diabetes insipidus with a novel missense mutation in the AVPR2 gene. (2007)
  • Author(s): Ashida A, et al.
  • Journal Title: Pediatr Nephrol (in press.)
• [Journal Article] The polarized trafficking of the aquaporin-3 water channel is mediated by an N-Terminal Sorting Signal (2006)
  • Author(s): Rai T, Sasaki S, Uchida S.
  • Journal Title: Am J Physiol Cell Physiol. 290(1)
• [Journal Article] Pathogenesis and treatment of autosomal-dominant nephrogenic diabetes insipidus caused by an aquaporin 2 mutation (2006)
  • Author(s): Sohara E, Rai T, Yang SS, Uchida K, Nitta K, Horita S, Ohno M, Harada A, Sasaki S, Uchida S.
  • Journal Title: Proc Natl Acad Sci USA 103 Pages: 14217-14222
• [Journal Article] Pathogenesis and treatment of autosomal-dominant nephrogenic diabetes insipidus caused by an aquaporin 2 mutation. (2006)
  • Author(s): Sohara E, et al.
  • Journal Title: Proc Natl Acad Sci USA 103 Pages: 14217-14222
• [Journal Article] Aquaporin subfamily with unusual NPA boxes. (2006)
  • Author(s): Ishibashi K
  • Journal Title: Biochim Biophys Acta 1758 Pages: 989-993
• [Journal Article] Aquaporin subfamily with unusual NPA boxes : S-aquaporins (Superfamily, SIP-like and Subcellular aquaporins). (2006)
  • Author(s): Ishibashi K
  • Journal Title: Cell Mol Biol 52(9) Pages: 20-27
• [Journal Article] Identification of a keratinocarcinoma cell line expressing AQP3. (2006)
  • Author(s): Nakakoshi M, et al.
  • Journal Title: Biol Cell 98 Pages: 95-100
• [Journal Article] Overexpression of human WNK1 increases paracellular chloride permeability and phosphorylation of claudin-4 in MDCKII cells. (2006)
  • Author(s): Ohta A, et al.
  • Journal Title: Biochem Biophys Res Commun 349 Pages: 804-808
• [Journal Article] Postnatal expression of KLF12 in the inner medullary collecting ducts of kidney and its trans-activation of UT-A1 urea transporter promoter. (2006)
  • Author(s): Suda S, et al.
  • Journal Title: Biochem Biophys Res Commun 344(1) Pages: 246-252
• [Journal Article] The polarized trafficking of the aquaporin-3 water channel is mediated by an N-Terminal Sorting Signal. (2006)
  • Author(s): Rai T, et al.
  • Journal Title: Am J Physiol Cell Physiol 290(1)
• [Journal Article] Intracellular localization of ClC chloride channels and their ability to form hetero-oligomers. (2006)
  • Author(s): Suzuki T, et al.
  • Journal Title: J Cell Physiol 206 Pages: 792-798
• [Journal Article] Splenic artery ligation ameliorates hepatic ischemia and reperfusion injury in rats. (2006)
  • Author(s): Ito K, et al.
  • Journal Title: Liver Int 26 Pages: 254-260
• [Journal Article] Regulation of aquaporin-2 trafficking and its binding protein complex. (2006)
  • Author(s): Noda Y, Sasaki S
  • Journal Title: Biochim Biophys Acta 1758 Pages: 1117-1125
• [Journal Article] Implications of the aquaporin-4 structure on array formation and cell adhesion. (2006)
  • Author(s): Hiroaki Y, et al.
  • Journal Title: J Mol Biol 355 Pages: 628-639
• [Journal Article] Physiological roles of AQP7 in the kidney : Lessons from AQP7 knockout mice. (2006)
  • Author(s): Sohara E, et al.
  • Journal Title: Biochim Biophys Acta 1758(8) Pages: 1106-1110
• [Journal Article] Atypical Gitelman syndrome with L623P mutation of the thiazide-sensitive Na-Cl cotransporter gene exhibiting lack of hypocalciuria and increased proximal tubule salt reabsorption. (2006)
  • Author(s): Mizumori Y, et al.
  • Journal Title: Nephrol Dial Transplant 21(11) Pages: 3340-3341
• [Journal Article] Nephrologists Sans Frontieres : Chronic kidney disease in Japan. (2006)
  • Author(s): Sasaki S
  • Journal Title: Kidney Int 69 Pages: 1485-1486
• [Journal Article] Identification of a keratinocarcinoma cell line expressing AQP3. (2006)
  • Author(s): Nakakoshi M, et al.
  • Journal Title: Biol. Cell. 98 Pages: 95-100
• [Journal Article] The polarized trafficking of the aquaporin-3 water channel is mediated by an N-terminal sorting signal. (2006)
  • Author(s): Rai T, et al.
  • Journal Title: Am. J. Physiol. Cell Physiol. 290(1)
• [Journal Article] Intracellular localization of CLC choloride channels and their ability to form hetero-oligomers. (2006)
  • Author(s): Suzuki T, et al.
  • Journal Title: J. Cell Physiol. 206 Pages: 792-798
• [Journal Article] Progressive adipocyte hypertrophy in aquaporin-7 deficient mice : Adipocyte glycerol permeability as a novel regulator of fat accumulation (2005)
  • Author(s): Hara-Chikuma M, Sohara E, Rai T, Ikawa M, Okabe M, Sasaki S, Uchida S, Verkman AS.
  • Journal Title: J Biol Chem. 280(16) Pages: 15493-15496
• [Journal Article] Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule (2005)
  • Author(s): Morishita Y, Matsuzaki T, Hara-Chikuma M, Ando A, Shimono M, Matsuki A, Kobayashi K, Ikeda M, Yamamoto T, Verkman A, Kusano E, Ookawara S, Takata K, Sasaki S, Ishibashi K.
  • Journal Title: Mol Cell Biol. 25 Pages: 7770-7779
• [Journal Article] Identification of a multiprotein "motor" complex binding to water channel aquaporin-2 (2005)
  • Author(s): Noda Y, Horikawa S, Katayama Y, Sasaki S.
  • Journal Title: Biochem Biophys Res Commun. 330 Pages: 1041-1047
• [Journal Article] Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice (2005)
  • Author(s): Sohara E, Rai T, Miyazaki J, Verkman AS, Sasaki S, Uchida S.
  • Journal Title: Am J Physiol Renal Physiol. 289(6)
• [Journal Article] Differential effects of hyperosmolality on Na-K-ATPase and vasopressin-dependent cAMP generation in the medullary thick ascending limb and outer medullary collecting duct. (2005)
  • Author(s): Sakuma Y, et al.
  • Journal Title: Hypertns. Res. 28 Pages: 671-679
• [Journal Article] Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice. (2005)
  • Author(s): Sohara E, et al.
  • Journal Title: Am. J. Physiol. 289
• [Journal Article] The C-terminal tail of aquaporin-2 determines apical trafficking. (2005)
  • Author(s): Kuwahara M, et al.
  • Journal Title: Kidney Int. 68 Pages: 1999-2009
• [Journal Article] Wnt4-transformed mouse embryonic stem cells differentiate into renal tubular cells. (2005)
  • Author(s): Kobayashi T, et al.
  • Journal Title: Biochem. Biophys. Res. Commun. 336 Pages: 585-595
• [Journal Article] Differential regulation of AQP2 trafficking in endosomes by microtubules and actin filaments. (2005)
  • Author(s): Tajika Y, et al.
  • Journal Title: Histochem. Cell Biol. 124 Pages: 1-12
• [Journal Article] Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule. (2005)
  • Author(s): Morishita Y, et al.
  • Journal Title: Mol. Cell Biol 25 Pages: 7770-7779
• [Journal Article] Water channel activities of Mimosa pudica plasma membrane intrinsic proteins are regulated by direct interaction and phosphorylation. (2005)
  • Author(s): Temmei Y, et al.
  • Journal Title: FEBS Lett. 579 Pages: 4417-4422
• [Journal Article] Impaired urea accumulation in the inner medulla of mice lacking the urea transporter UT-A2. (2005)
  • Author(s): Uchida S, et al.
  • Journal Title: Mol. Cell Biol 25 Pages: 7357-7363
• [Journal Article] CIC-3-independent sensitivity of apoptosis to Cl- channel blockers in mouse cardiomyocytes. (2005)
  • Author(s): Takahashi N, et al.
  • Journal Title: Cell Physiol. Biochem. 15 Pages: 263-270
• [Journal Article] Apical localization of renal K channel was not altered in mutant WNK4 transgenic mice. (2005)
  • Author(s): Yamauchi K, et al.
  • Journal Title: Biochem. Biophys. Res. Commun. 332 Pages: 750-755
• [Journal Article] BSCl inhibition complements effects of vasopressin V-2 receptor antagonist on hyponatremia in SIADH rats. (2005)
  • Author(s): Kazama I, et al.
  • Journal Title: Kidney Int. 67 Pages: 1855-1867
• [Journal Article] Progressive adipocyte hypertrophy in aquaporin-7-deficient mice- Adipocyte glycerol permeability as a novel regulator of fat accumulation. (2005)
  • Author(s): Hara-Chikuma M, et al.
  • Journal Title: J. Biol. Chem. 280 Pages: 15493-15496
• [Journal Article] Identification of a multiprotein "motor" complex binding to water channel aquaporin-2. (2005)
  • Author(s): Noda Y, et al.
  • Journal Title: Biochem. Biophys. Res. Commun. 330 Pages: 1041-1047
• [Journal Article] Regulation of apical localization of the thiazide-sensitive NaCl cotransporter by WNK4 in polarized epithelial cells. (2005)
  • Author(s): Yang SS, et al.
  • Journal Title: Biochem. Biophys. Res. Commun. 330 Pages: 410-414
• [Journal Article] Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells. (2005)
  • Author(s): Itoh T, et al.
  • Journal Title: Biochem. Biophys. Res. Commun. 330 Pages: 832-838
• [Journal Article] Hypertonicity regulates the aquaporin-2 promoter independently of arginine vasopressin. (2005)
  • Author(s): Kasono K, et al.
  • Journal Title: Nephrol. Dial. Transplant. 20 Pages: 509-515
• [Journal Article] CIC-3 chloride channels facilitate endosomal acidification and chloride accumulation. (2005)
  • Author(s): Hara-Chikuma et al.
  • Journal Title: J. Biol. Chem. 280 Pages: 1241-1247
• [Journal Article] Trafficking mechanism of water channel aquaporin-2 (2005)
  • Author(s): Noda Y, et al.
  • Journal Title: Biol. Cell. 97 Pages: 885-892
• [Journal Article] Function of chloride channeils in the kidney. (2005)
  • Author(s): Uchida S, et al.
  • Journal Title: Annu. Rev. Physiol. 67 Pages: 759-778
• [Journal Article] Expression and localization of two isoforms of AQP10 in human small intestine. (2005)
  • Author(s): Huiping Li, et al.
  • Journal Title: J. Cell Biol. 97 Pages: 823-829
• [Journal Article] Altered Expression profile of transporters in the IMCD of aquaporin 1 knockout mice. (2005)
  • Author(s): Morris RG, et al.
  • Journal Title: Am. J. Physiol. Renal Physiol. 289(1)
• [Presentation] アクアポリン2による細胞容積調節メカニズム (2010)
  • Author(s): 野田裕美
  • Organizer: 第20回バゾプレシン研究会
  • Place of Presentation: 東京
• [Presentation] Targeted disruption of pancreatic-specific water-Channel, aquaporin-12, results in increased susceptibility to drug-induced acute pancreatitis (2009)
  • Author(s): Ohta E, Itoh T, Nemoto T, Kumagai J, Ko S, Ishibashi K, Kawashima M, Uchida K, Ohta A, Rai T, Uchida S, Sasaki S.
  • Organizer: World Congress of Nephrology 2009
  • Place of Presentation: Milan
• [Presentation] PKA phosphorylation of recombinant aquaporin-2 at serine 256 increases its water permeability (2009)
  • Author(s): Eto K
  • Organizer: The 42nd Annual Meeting of American Society of Nephrology
  • Place of Presentation: San Diego, USA
• [Presentation] A NPC Motif of AQP11, Instead of the NPA Motif of Known AQPs, Hasan Important Role in Its Water Permeability (2009)
  • Author(s): Ikeda M
  • Organizer: The 42nd Annual Meeting of American Society of Nephrology
  • Place of Presentation: San Diego, USA
• [Presentation] Symposium : The role of AQP11 in intracellular organelle homeostasis (2009)
  • Author(s): 石橋賢一
  • Organizer: The 11th International Symposium on Exocrine Secretion(ISES)
  • Place of Presentation: Tokushima
• [Presentation] Symposium : The physiological roles of subcellular aquaporins (2009)
  • Author(s): 石橋賢一
  • Organizer: The 36th International Congress of Physiological Sciences
  • Place of Presentation: Kyoto
• [Presentation] Loss of Aquaporin-11 causes both the apoptosis and the enhanced cell proliferation of the renal proximal tubule cells (2009)
  • Author(s): 小林克樹
  • Organizer: The 42nd Annual Meeting of American Society of Nephrology
  • Place of Presentation: San Diego, USA
• [Presentation] Moving mechanisms of aquaporin-2 water channel (2009)
  • Author(s): 野田裕美
  • Organizer: The 8th World Congress on Neurohypophysial Hormones(WCNH)
  • Place of Presentation: Kitakyushu
• [Presentation] Targeted disruption of pancreatic-specific water-channel, aquaporin 12, results in increased susceptibility to drug-induced acute pancreatitis (2009)
  • Author(s): Ohta E
  • Organizer: World Congress of Nephrology 2009
  • Place of Presentation: Milan, Italy
• [Presentation] Pancreas-specific aquaporin12 null mice showed increased susceptibility to caerulein-induced acute pancreatitis (2009)
  • Author(s): Ohta E
  • Organizer: The 36th International Congress of Physiological Sciences
  • Place of Presentation: Kyoto
• [Presentation] The role of AQP11 in intracellular organelles (2009)
  • Author(s): Tanaka Y
  • Organizer: The 36th International Congress of Physiological Sciences
  • Place of Presentation: Kyoto
• [Presentation] アクアポリン11による細胞内オルガネラのイオン環境の制御 (2009)
  • Author(s): 石橋賢一
  • Organizer: 第52回日本腎臓学会学術総会
  • Place of Presentation: 横浜
• [Presentation] WNKキナーゼによる腎臓での新たな塩分出納調節機構 (2009)
  • Author(s): 内田信一
  • Organizer: 第44回日本小児腎臓病学会学術総会
  • Place of Presentation: 東京
• [Presentation] トランスポーター研究のパラダイムシフト:ヒトシステムの理解を目指して.ヒト遺伝性高血圧症原因遺伝子の機能解析から明らかになった腎臓での新たなNaCl出納調節系 (2009)
  • Author(s): 内田信一
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
• [Presentation] 水チャネルアクアポリン2はリン酸化で水透過性を高める (2009)
  • Author(s): 江渡加代子
  • Organizer: 第52回日本腎臓学会学術総会
  • Place of Presentation: 横浜
• [Presentation] AQP11ノックアウトマウスにおける primary cilia の解析 (2009)
  • Author(s): 小林克樹
  • Organizer: 第52回日本腎臓学会学術総会
  • Place of Presentation: 横浜
• [Presentation] シンポジウム発表.Aquaporins and kidney disease : Insight into molecular pathogenesis (2009)
  • Author(s): 佐々木成
  • Organizer: 第36回国際生理学会世界大会
  • Place of Presentation: 京都
• [Presentation] 創薬ターゲットとしての水チャネル、腎臓疾患でのアクアポリンの役割 (2008)
  • Author(s): 石橋賢一
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-26
• [Presentation] Reciprocal interaction with G-Actin and tropomyosin is critical for AQP2 translocation to the apical membrane (2008)
  • Author(s): Noda Y, Li Y, Eto K, Horikawa S, Sasaki S.
  • Organizer: The 41st Annual Meeting of American Society of Nephrology
  • Place of Presentation: Philadelphia
• [Presentation] アクアポリン11KOマウスにおけるのう胞腎形成機構の解析 (2008)
  • Author(s): 岡田晋治
  • Organizer: 日本農芸学会年会
  • Place of Presentation: 名古屋
• [Presentation] Interaction between AQP1 and AQP11 Regulates Plasma Membrane Expression of AQP1 (2008)
  • Author(s): Takamatsu N
  • Organizer: The 41^<st> Annual meeting of AmericanSociety of Nephrology
  • Place of Presentation: フィラデルフィア
• [Presentation] "Transport regulation by phosphorylation" Phosphorylation- dependent regulation of NCC by WNKs. (2008)
  • Author(s): Uchida S
  • Organizer: The 41^<st> Annual meeting of AmericanSociety of Nephrology
  • Place of Presentation: フィラデルフィア
• [Presentation] FAPP2 Is required for AQP2 apical sorting in polarized MDCK cells. (2008)
  • Author(s): Yui N
  • Organizer: The 41^<st> Annual meeting of AmericanSociety of Nephrology
  • Place of Presentation: フィラデルフィア
• [Presentation] Analysis of pancreatic exocrine function of aquaporin-12 knockoutmice. (2008)
  • Author(s): Ohta E
  • Organizer: The 41^<st> Annual meeting of AmericanSociety of Nephrology
  • Place of Presentation: フィラデルフィア
• [Presentation] Targeted disruption of the Wnk4 gene reduced the phosphohiation of OSR1/SPAK and Na-Cl cotransporter in mice. (2008)
  • Author(s): Ohta A
  • Organizer: The 41^<st> Annual meetins of AniericanSociety of Nephroloey
  • Place of Presentation: フィラデルフィア
• [Presentation] Reciprocal interaction with G-Actin and tropomyosin is critical for AQP2 translocation to the apical membrane. (2008)
  • Author(s): Noda Y
  • Organizer: The 41^<st> Annual meeting of AmericanSociety of Nephrology
  • Place of Presentation: フィラデルフィア
• [Presentation] WNK1 activity to OSR1 in COS cells is regulated not by hypotonicity but by low chloride. (2008)
  • Author(s): Naito S
  • Organizer: The 41^<st> Annual meeting of AmericanSociety of Nephrology
  • Place of Presentation: フィラデルフィア
• [Presentation] Role of AQP2 phosphorylation at serine 256 and serine 261 in cellvolume regulation. (2008)
  • Author(s): Li Y
  • Organizer: The 41^<st> Annual meeting of AmericanSociety of Nephrology
  • Place of Presentation: フィラデルフィア
• [Presentation] The primary cilia of the AQP11 knockout mouse kidney. (2008)
  • Author(s): Kobayashi K
  • Organizer: The 41^<st> Annual meeting of AmericanSociety of Nephrology
  • Place of Presentation: フィラデルフィア
• [Presentation] PKA phosphorylation of recombinant Aquaporin-2 reconstituted in liposomes increases its water permeability. (2008)
  • Author(s): Eto K
  • Organizer: The 41^<st> Annual meeting of AmericanSociety of Nephrology
  • Place of Presentation: フィラデルフィア
• [Presentation] New regulation mechanisms of renal aquaporin. (2007)
  • Author(s): Sasaki S.
  • Organizer: The Annual Meeting of Taiwan Society of Nephrology
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2007-12-08
• [Presentation] Neonatal kidney of AQP11-disrupted mice exhibit ER stress-induced apoptosis of the proximal tubules followed by a remarkable slowing of cyst-formation by rapamycin treatment. (2007)
  • Author(s): Kobayashi K, et. al.
  • Organizer: ASN(American Society of Nephrology) Renal Week 2007
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2007-11-02
• [Presentation] アクアポリン欠損マウスにみられた精巣内アポトーシス (2007)
  • Author(s): 吉永一也, ほか
  • Organizer: 日本解剖学会第63回九州支部学術集会
  • Place of Presentation: 長崎県長崎市
  • Year and Date: 2007-10-20
• [Presentation] シンポジウム 遺伝性高血圧尿細管機能異常症に学ぶ腎臟の電解質輸送の最新の知見 (2007)
  • Author(s): 内田 信一
  • Organizer: 第37回日本腎臟学会東部学術大会
  • Place of Presentation: 埼玉県大宮市
  • Year and Date: 2007-10-06
• [Presentation] アクアポリン研究の新展開 (2007)
  • Author(s): 石橋賢一
  • Organizer: 第37回日本腎臟学会東部学術大会
  • Place of Presentation: 埼玉県大宮市
  • Year and Date: 2007-10-05
• [Presentation] 教育講演 遺伝子異常に伴う尿細管疾患 (2007)
  • Author(s): 佐々木成
  • Organizer: 第37回日本腎臟学会東部学術大会
  • Place of Presentation: 埼玉県大宮市
  • Year and Date: 2007-10-05
• [Presentation] 溝演 上皮輸送の構成因子とその統合 (2007)
  • Author(s): 佐々木成
  • Organizer: 情報計算化学生物学会(CBI)学会2007年大会
  • Place of Presentation: 広島県東広島市
  • Year and Date: 2007-10-03
• [Presentation] Molecular mechanisms for dynamic regulation of aquaporin-2 trafficking. (2007)
  • Author(s): Noda Y, et. al.
  • Organizer: VIIth World Congress on Neurohypophysial Hormones
  • Place of Presentation: Regensburg, Germany
  • Year and Date: 2007-09-21
• [Presentation] 溝演 水・電解質代謝に関わるチャネル・トランスポーターと疾患 (2007)
  • Author(s): 佐々木成
  • Organizer: 第2回産業医科大学大学院シンポジウム
  • Place of Presentation: 福岡県北九州市
  • Year and Date: 2007-07-24
• [Presentation] Trafficking mechanism of water channel aquaporin-2. (2007)
  • Author(s): Noda Y, et. al.
  • Organizer: The 5th International Conference of Aquaporin
  • Place of Presentation: Nara, Japan
  • Year and Date: 2007-07-16
• [Presentation] Neonatal Kidneys of AQP11-Disrupted Mice Exhibit Enhanced Apoptosis Followed by a Remarkable Slowing of Cyst-formation by Rapamycin Treatment. (2007)
  • Author(s): Kobayashi K, et. al.
  • Organizer: The 5th International Conference of Aquaporin
  • Place of Presentation: Nara, Japan
  • Year and Date: 2007-07-15
• [Presentation] Comparison between AQP2 and ENaC in intracellular trafficking. (2007)
  • Author(s): Meng H, et. al.
  • Organizer: The 5th International Conference of Aquaporin
  • Place of Presentation: Nara, Japan
  • Year and Date: 2007-07-15
• [Presentation] Subcellular aquaporins: New and old memebers. (2007)
  • Author(s): Ishibashi K
  • Organizer: The 5th International Conference of Aquaporin
  • Place of Presentation: Nara, Japan
  • Year and Date: 2007-07-14
• [Presentation] Expression of aquaporin-1 in a newly established cell line of mouse macula densa. (2007)
  • Author(s): Kawada H, et. al.
  • Organizer: The 5th International Conference of Aquaporin
  • Place of Presentation: Nara, Japan
  • Year and Date: 2007-07-14
• [Presentation] Neonatal kidney of AQP11-disrupted mice exhibit ER stress-induced apoptosis of the proximal tubules followed by a remarkable slowing of cyst-formation by rapamycin treatment. (2007)
  • Author(s): Kobayashi K, et. al.
  • Organizer: The 5th International Conference of Aquaporin
  • Place of Presentation: Nara, Japan
  • Year and Date: 2007-07-14
• [Presentation] Microarray analysis of the kidney with vacuolized proximal tubules from AQP11 knockout mouse. (2007)
  • Author(s): Okada S, et. al.
  • Organizer: The 5th International Conference of Aquaporin
  • Place of Presentation: Nara, Japan
  • Year and Date: 2007-07-14
• [Presentation] Functional analysis of aquaporin-11 both in pure phospholipid membrane and in insect cell membrane. (2007)
  • Author(s): Yakata K, et. al.
  • Organizer: The 5th International Conference of Aquaporin
  • Place of Presentation: Nara, Japan
  • Year and Date: 2007-07-14
• [Presentation] President Address: New aspects of aquaporin. (2007)
  • Author(s): Sasaki S
  • Organizer: The 5th International Conference of Aquaporin
  • Place of Presentation: Nara, Japan
  • Year and Date: 2007-07-13
• [Presentation] 溝演 体内の水分調節とアクアポリン (2007)
  • Author(s): 佐々木成
  • Organizer: 第32回日本香粧品学会
  • Place of Presentation: 東京都港区
  • Year and Date: 2007-06-07
• [Presentation] 特別講演 尿細管疾患の生理学・分子生物学研究の流れと未来展望 (2007)
  • Author(s): 佐々木成
  • Organizer: 第50回日本腎臟学会学術総会
  • Place of Presentation: 静岡県浜松市
  • Year and Date: 2007-05-27
• [Presentation] Comparison of the regulated translocation between AQP2 and ENaC. (2007)
  • Author(s): Meng H, et. al.
  • Organizer: The 50th annual meeting of the Japanese Society of Nephrology
  • Place of Presentation: Hamamatsu, Japan
  • Year and Date: 2007-05-26
• [Presentation] 水チャネルAQP-1/AQP-11ダブルノックアウトマウスの腎病変 (2007)
  • Author(s): 石橋賢一, ほか
  • Organizer: 第50回日本腎臓学会学術総会
  • Place of Presentation: 静岡県浜松市
  • Year and Date: 2007-05-26
• [Presentation] AQP11ノックアウトマウスののう胞形成におけるアポトーシスの役割 (2007)
  • Author(s): 小林克樹, ほか
  • Organizer: 第50回日本腎臓学会学術総会
  • Place of Presentation: 静岡県浜松市
  • Year and Date: 2007-05-26
• [Presentation] 教育講演 水電解質疾患の展開 (2007)
  • Author(s): 佐々木成
  • Organizer: 第104回日本内科学会総会
  • Place of Presentation: 大阪府大阪市
  • Year and Date: 2007-04-04
• [Presentation] シンポジウム 遺伝子改変マウスを用いた水・電解質異常症の分子病態の解析 (2007)
  • Author(s): 内田 信一
  • Organizer: 第84回日本生理学会大会
  • Place of Presentation: 大阪府大阪市
  • Year and Date: 2007-03-21
• [Presentation] Neonatal kidneys of AQP11-disrupted mice exhibit enhanced apotosis followed by a remarkable slowing of cyst-formation by rapamycin treatment (2007)
  • Author(s): Kobayashi K, Ishibashi K, Sasaki S.
  • Organizer: The 5^<th> International Conference of Aquaporin
  • Place of Presentation: Nara
• [Presentation] Comparison between AQP2 and ENaC in intracellular trafficking (2007)
  • Author(s): Meng H, Noda Y, Yamashita M, Hirai K, Horikawa S, Sasaki S.
  • Organizer: The 5^<th> International Conference of Aquaporin
  • Place of Presentation: Nara
• [Presentation] 慢性腎不全の病態と治療 (2007)
  • Author(s): 佐々木成
  • Organizer: 平成19年度日本内科学会生涯教育講演会
  • Place of Presentation: 大阪府大阪市,神奈川横浜市,広島県広島市.
• [Presentation] Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice (2005)
  • Author(s): Sohara E, Rai T, Verkman A. S., Sasaki S, Uchida S.
  • Organizer: 38^<th> Annual Meeting of American Society of Nephrology
  • Place of Presentation: Philadelphia
  • Year and Date: 2005-11-11
• [Book] 尿細管の生理, SIADH.専門医のための腎臓病学 第2版 (2009)
  • Author(s): 大井克征
  • Total Pages: 640
  • Publisher: 医学書院
• [Book] New members of mammalian aquaporins: AQP10-AQP12. 「Handbook of Experimental Pharmacoloav 19O」 pp251-262. ed by Eric Beitz (2009)
  • Author(s): Kenichi Ishibashi
  • Total Pages: 424
  • Publisher: Springer
• [Book] 水とアクアポリンの生物学 (2008)
  • Author(s): 佐々木成, 編
  • Total Pages: 216
  • Publisher: 中山書店
• [Book] からだと水の事典 (2008)
  • Author(s): 佐々木成, 石橋賢一, 編
  • Publisher: 朝倉書店
• [Book] 運動と水補給のサイエンスほか7項目、「水とアクアポリンの生物学」佐々木成編 (2008)
  • Author(s): 石橋賢一
  • Total Pages: 206
  • Publisher: 中山書店
• [Book] アクアポリンの仲間たちほか7項目, 「からだと水の事典」、佐々木成, 石橋賢一編 (2008)
  • Author(s): 石橋賢一
  • Total Pages: 357
  • Publisher: 朝倉書店
• [Book] 「水とアクアポリンの生物学」佐々木成編 (2008)
  • Author(s): 佐々木成
  • Total Pages: 206
  • Publisher: 中山書店
• [Book] 水と健康の関わり〜アクアボリンの働き〜. フードスタイル21 pp43-45, vol. 12 No. 7 (2008)
  • Author(s): 佐々木成
  • Publisher: 食品化学新聞社
• [Book] アクアポリン-水はどうやって細胞膜を通るか-増補四訂版サイエンスビュ-生物総合資料. pp43 (2008)
  • Author(s): 佐々木成
  • Publisher: 実教出版
• [Book] からだと水の事典. 体内水分量. pp7-8, アクアポリンの病気. pp64-70, 腎臓での水輸送の概要. pp179, 佐々木成, 石橋賢一編 (2008)
  • Author(s): 佐々木成
  • Total Pages: 357
  • Publisher: 朝倉書店
• [Book] 今日の治療指針2007、輸液療法 (2007)
  • Author(s): 内田 信一
  • Publisher: 医学書院
• [Book] みずみずしい体のしくみ (2005)
  • Author(s): 佐々木成, 編
  • Total Pages: 183
  • Publisher: クバプロ
• [Book] みずみずしい体のしくみ (2005)
  • Author(s): 佐々木 成
  • Publisher: クバプロ
• [Remarks] ホームページ
  • URL: http://www.tmd.ac.jp/grad/kid/aquaporin/index.html
• [Remarks] アクアポリン
  • URL: http://www.tmd.ac.jp/grad/kid/aquaporin/index.html
• [Remarks] 東京医科歯科大学腎臓内科
  • URL: http://www.tmd.ac.jp/grad/kid/kid-J.htm
• [Remarks]
  • URL: http://www.my-pharm.ac.jp/~kishiba/sub3.html
• [Remarks]
  • URL: http://www.tmd.ac.ji/grad/kid/aquaporin/index.html
• [Remarks] アクアポリン
  • URL: http://www.tmd.ac.jp/grad/kid/aquaporin/index.html
• [Remarks] 東京医科歯科大学腎臟内科
  • URL: http://www.tmd.ac.jp/grad/kid/kid-j.htm
• [Remarks] 明治薬科大学病態生理
  • URL: http://www.my-pharm.ac.jp/~kishiba/sub4.html