Osteoimmunology

• Project/Area Number: 17GS0313
• Research Category: Grant-in-Aid for Creative Scientific Research
• Allocation Type: Single-year Grants
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: TAKAYANAGI Hiroshi Tokyo Medical and Dental University, 医歯学総合研究科, 教授 (20334229)
• Co-Investigator(Kenkyū-buntansha): 朝霧 成挙 東京医科歯科大学, 大学院・医歯学総合研究科, 特任講師 (20372435) ; 篠原 正浩 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (60345733) ; 中島 友紀 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (00346959) ; 春宮 覚 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (50301792) ; 古賀 貴子 東京医科歯科大学, 大学院・医歯学総合研究科, 特任助教 (90451905) ; 佐藤 浩二郎 東京医科歯科大学, 大学院医歯学総合研究科, 助手 (10372434)
• Co-Investigator(Renkei-kenkyūsha): SHINOHARA Masahiro 東京医科歯科大学, 医歯学総合研究科, 助教 (60345733) ; NAKASHIMA Tomoki 東京医科歯科大学, 医歯学総合研究科, 助教 (00346959)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥703,430,000 (Direct Cost: ¥541,100,000、Indirect Cost: ¥162,330,000); Fiscal Year 2009: ¥133,640,000 (Direct Cost: ¥102,800,000、Indirect Cost: ¥30,840,000); Fiscal Year 2008: ¥142,090,000 (Direct Cost: ¥109,300,000、Indirect Cost: ¥32,790,000); Fiscal Year 2007: ¥151,450,000 (Direct Cost: ¥116,500,000、Indirect Cost: ¥34,950,000); Fiscal Year 2006: ¥149,760,000 (Direct Cost: ¥115,200,000、Indirect Cost: ¥34,560,000); Fiscal Year 2005: ¥126,490,000 (Direct Cost: ¥97,300,000、Indirect Cost: ¥29,190,000)
• Keywords: 骨免疫学 / 骨代謝 / 骨疾患 / 自己免疫 / 疾患モデル / 破骨細胞 / 骨芽細胞 / リンパ球 / 骨細胞 / Th17細胞 / ノックアウトマウス / トランスクリプトーム / プロテオーム / 骨代謝学 / 整形外科学 / シグナル伝達 / 生理学 / 免疫学 / 細胞・組織

Research Abstract

骨代謝と免疫学の融合分野である骨免疫学の確立を目指した。特に、骨代謝に関与する細胞と免疫担当細胞の分化・活性化メカニズムならびに相互作用を、網羅的解析手法や新規の遺伝子改変マウスを作成することにより解析し、関節リウマチや骨粗鬆症などの疾患治療に対する分子基盤の確立を行った

Research Products

• [Journal Article] IκBζ regulates T_H17 development by cooperating with ROR nuclear receptors (2010)
  • Author(s): Okamoto K., Iwai Y., Oh-hora M., Yamamoto M., Morio T., Aoki K., Ohya K., Jetten A. M., Akira S., Muta T., Takayanagi H.
  • Journal Title: Nature 464 Pages: 1381-1385
• [Journal Article] Ly49Q, an ITIM-bearing NK receptor, positively regulates osteoclast differentiation (2010)
  • Author(s): Hayashi M., Nakashima T., Kodama T., Makrigiannis A P., Toyama-Sorimachi N., Takayanagi, H.
  • Journal Title: Biochem Biophys Res Commun. 393 Pages: 432-438
• [Journal Article] Blimp1-mediated repression of negative regulators is required for osteoclast differentiation (2010)
  • Author(s): Nishikawa, K., Nakashima, T., Hayashi, M., Fukunaga, T., Kato, S., Kodama, T., Takahashi S., Calame K., Takayanagi, H.
  • Journal Title: Proc Natl Acad Sci USA 107(7) Pages: 3117-22
• [Journal Article] 特集骨・軟骨疾患の分子医学(3)Osteoimmunology の現状と展望 (2010)
  • Author(s): 高柳広
  • Journal Title: Bio Clinica 25 Pages: 25-31
• [Journal Article] Roles of IL-6 and PTHrP in osteoclast formation associated with oral cancers : The significance of IL-6 synthesized by stromal cells in response to cancer cells (2010)
  • Author(s): 栢森高
  • Journal Title: American Journal of Pathology 176 Pages: 968-80
  • Peer Reviewed
• [Journal Article] The unexpected link between osteoclasts and the immune system (2010)
  • Author(s): 高柳広
  • Journal Title: Advances in Experimental Medicine and Biology(Review) 658 Pages: 61-68
• [Journal Article] Blimpl-mediated repression of negative regulators is required for osteoclast differentiation (2010)
  • Author(s): 西川恵三
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America 16 Pages: 3117-3122
  • Peer Reviewed
• [Journal Article] Ly49Q, an ITIM-bearing NK receptor, positively regulates osteoclast differentiation (2010)
  • Author(s): 林幹人
  • Journal Title: Biochemical and Biophysical Research Communications 393 Pages: 432-438
  • Peer Reviewed
• [Journal Article] IκBζ regulates T_H17 development by cooperating with ROR nuclear receptors (2010)
  • Author(s): 岡本一男
  • Journal Title: Nature 464 Pages: 1381-1385
  • Peer Reviewed
• [Journal Article] Osteoimmunology and the effects of the immune system on bone (2009)
  • Author(s): Takayanagi, H.
  • Journal Title: Nat Rev Rheumatol. 5(12) Pages: 667-76
• [Journal Article] Ca^<2+>-NFATc1 signaling is an essential axis of osteoclast differentiation (2009)
  • Author(s): Negishi-Koga, T., Takayanagi, H.
  • Journal Title: Immunological Reviews 231 Pages: 241-256
• [Journal Article] Osteoclasts and the immune systems (2009)
  • Author(s): 中島友紀
  • Journal Title: Journal of Bone and Mineral Metabolism(Review) 27 Pages: 519-529
  • NAID: 10027205348
• [Journal Article] Osteoimmunology : crosstalk between the immune and bone systems (2009)
  • Author(s): 中島友紀
  • Journal Title: Journal of Clinical Immunology(Review) 29 Pages: 555-567
• [Journal Article] Rheumatoid arthritis associated with osteopetrosis (2009)
  • Author(s): 門野夕峰
  • Journal Title: Modern Rheumatology 19 Pages: 687-90
  • Peer Reviewed
• [Journal Article] NFATc1 Mediates Toll-Like Receptor-Independent Innate Immune Responses during Trypanosoma cruzi Indection (2009)
  • Author(s): 香山尚子
  • Journal Title: PLoS Pathogens 5
  • Peer Reviewed
• [Journal Article] Mysteries in Ca^<2+> Signaling During Osteoclast Differentiation (2009)
  • Author(s): 古賀貴子
  • Journal Title: IBMS BoneKEy Pages: 301-306
• [Journal Article] Interferon Regulatory Factor-8 Regulates Bone Metabolism by Suppressing Osteoclastogenesis (2009)
  • Author(s): Baohong Zhao
  • Journal Title: Nature Medicine 15 Pages: 1066-1071
  • Peer Reviewed
• [Journal Article] Ca^<2+>-NFATc1 signaling is an essential axis of osteoclast differentiation (2009)
  • Author(s): 古賀貴子
  • Journal Title: Immunological Reviews(Review) 231 Pages: 241-256
• [Journal Article] The interactions and shared mechanisms of T cells and osteoclasts (2009)
  • Author(s): Hans-Juergen Gober
  • Journal Title: Inflammation and Regeneration(Review) 29 Pages: 239-248
• [Journal Article] Osteoimmunology and the effects of the immune system on bone (2009)
  • Author(s): 高柳広
  • Journal Title: Nature Reviews Rheumatology(Review) 5 Pages: 667-76
• [Journal Article] A unique domain in RANK is required for Gab2 and PLCgamma2 bindiing to establish osteoclastogenic signals (2009)
  • Author(s): 田口祐
  • Journal Title: Genes to Cells 14 Pages: 1331-1345
  • Peer Reviewed
• [Journal Article] 破骨細胞分化を司る免疫制御分子ネットワーク (2009)
  • Author(s): 篠原正浩
  • Journal Title: 実験医学 27 Pages: 852-859
• [Journal Article] 概論 骨と免疫の不可分な関係に立脚した新たな生体理解 (2009)
  • Author(s): 高柳広
  • Journal Title: 実験医学 27 Pages: 846-851
• [Journal Article] 骨免疫学のアップデート -臨床への展開- (2009)
  • Author(s): 高柳広
  • Journal Title: 日本臨床 67 Pages: 1031-1037
• [Journal Article] 破骨細胞分化決定の分子メカニズムと骨免疫学 (2009)
  • Author(s): 高柳広
  • Journal Title: 臨床血液 50 Pages: 447-452
  • NAID: 10024960212
• [Journal Article] 骨破壊制御の新たなアプローチ (2009)
  • Author(s): 中島友紀
  • Journal Title: 医薬ジャーナル社 45 Pages: 87-92
• [Journal Article] 自己免疫性関節炎とカテプシンKの関連を探る (2009)
  • Author(s): 岡本一男
  • Journal Title: 分子リウマチ治療 2 Pages: 13-18
• [Journal Article] Overview -Osteoimmunology- (2009)
  • Author(s): 高柳広
  • Journal Title: THE BONE 23 Pages: 25-29
• [Journal Article] Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals (2008)
  • Author(s): Shinohara, M., Koga, T., Okamoto, K., Sakaguchi, S., Arai, K., Yasuda, H., Takai, T., Kodama, T., Morio, T., Geha, R. S., Kitamura, D., Kurosaki, T., Ellmeier, W., Takayanagi, H.
  • Journal Title: Cell 132 Pages: 794-806
• [Journal Article] Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis (2008)
  • Author(s): Asagiri, M., Hirai, T., Kunigami, T., Kamano, S., Gober, HJ., Okamoto, K., Nishikawa, K., Latz, E., Golenbock, D.T., Aoki, K., Ohya, K., Imai, Y., Morishita, Y., Miyazono, K., Kato, S., Saftig, P., Takayanagi, H.
  • Journal Title: Science 319 Pages: 624-627
• [Journal Article] Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development (2008)
  • Author(s): Mori, Y., et al.
  • Journal Title: J Immunol 181 Pages: 4742-4751
  • Peer Reviewed
• [Journal Article] The tumor necrosis factor family receptors RANK and CD40 co operatively establish the thymic medullary microenvironment and self-tolerance (2008)
  • Author(s): Akiyama, T.
  • Journal Title: Immunity 29 Pages: 438-450
  • Peer Reviewed
• [Journal Article] The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator (2008)
  • Author(s): Hikosaka, Y.
  • Journal Title: Immunity 29 Pages: 438-450
  • Peer Reviewed
• [Journal Article] Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals. (2008)
  • Author(s): Shinohara, M.
  • Journal Title: Cell 132 Pages: 794-806
  • Peer Reviewed
• [Journal Article] Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis (2008)
  • Author(s): Asagiri, M.
  • Journal Title: Science 319 Pages: 624-627
  • Peer Reviewed
• [Journal Article] The dynamic interplay between osteoclasts and the immune system (2008)
  • Author(s): Nakashima, T.
  • Journal Title: Arch Biochem Biophys (Highlight Issue: Bone Remodeling) 473 Pages: 166-171
  • Peer Reviewed
• [Journal Article] 自己免疫疾患にかかわるcathepsin Kの新たな役割 (2008)
  • Author(s): 岡本一男
  • Journal Title: 実験医学 26 Pages: 182-187
• [Journal Article] 破骨細胞分化制御と骨免疫学 (2008)
  • Author(s): 高柳広
  • Journal Title: 最新医学 63 Pages: 2176-2181
• [Journal Article] 自己免疫性炎症におけるカテプシンKとToll-like receptor9の役割 (2008)
  • Author(s): 國上敏浩
  • Journal Title: 内分泌・糖尿病科 27 Pages: 264-269
• [Journal Article] 骨免疫学研究の歴史とup to date (2008)
  • Author(s): 古賀貴子
  • Journal Title: リウマチ科 40 Pages: 105-111
• [Journal Article] 破骨細胞分化シグナルと骨免疫学(第18回婦人科骨粗鬆症研究会, 特別講演I) (2008)
  • Author(s): 高柳広
  • Journal Title: Osteoporosis Japan 16 Pages: 446-455
• [Journal Article] 炎症性骨破壊におけるTh17細胞の役割-Th17細胞による破骨細胞制御のメカニズム (2008)
  • Author(s): 岡本一男
  • Journal Title: 医学のあゆみ 226 Pages: 291-294
• [Journal Article] 関節破壊のメカニズム (2008)
  • Author(s): 高柳広
  • Journal Title: 整形外科 59 Pages: 850-854
• [Journal Article] 骨免疫学の最先端 (2008)
  • Author(s): 中島友紀
  • Journal Title: Mebio 25 Pages: 24-35
• [Journal Article] 免疫と骨:骨免疫学Osteoimmunologyの幕開け (2008)
  • Author(s): 林幹人
  • Journal Title: 臨床検査 52 Pages: 556-560
• [Journal Article] 骨免疫学 (2008)
  • Author(s): 高柳広
  • Journal Title: The BONE 22 Pages: 57-61
• [Journal Article] 破骨細胞形成のメカニズム-新たな骨破壊疾患治療法の可能性 (2008)
  • Author(s): 篠原正浩
  • Journal Title: DENTAL DIAMOND 33 Pages: 68-71
• [Journal Article] Osteoimmunologyと破骨細胞 (2008)
  • Author(s): 高柳広
  • Journal Title: 医学部のあゆみ 別冊 骨粗鎧症-臨床と研究の最新動向 Pages: 37-45
• [Journal Article] 関節リウマチ骨破壊のメカニズムと骨免疫学(第8回日本リウマチ財団中国・四国リウマチ外科セミナー記録集) (2008)
  • Author(s): 高柳広
  • Journal Title: Pharma Medica 26 Pages: 27-31
• [Journal Article] Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals. (2008)
  • Author(s): Shinohara, M., et. al.
  • Journal Title: Cell 132 Pages: 794-806
  • Peer Reviewed
• [Journal Article] Toll-like Receptor 9 Signaling Revealed in Experimental Arthritis. (2008)
  • Author(s): Asagiri, M., et. al.
  • Journal Title: Science 319 Pages: 624-627
  • Peer Reviewed
• [Journal Article] Pathological role of osteoclast costimulation in arthritis-induced bone loss (2007)
  • Author(s): Ochi, S., Shinohara, M., Sato, K., Gober H. J., Koga, T., Kodama, T., Takai T., Miyasaka N., Takayanagi H.
  • Journal Title: Proc Natl Acad Sci USA 104 Pages: 11394-11399
• [Journal Article] Osteoimmunology : shared mechanisms and crosstalk between the immune and bone systems (2007)
  • Author(s): Takayanagi, H.
  • Journal Title: Nat Rev Immunol. 7 Pages: 292-304
• [Journal Article] Estrogen Prevents Bone Loss via Estrogen Receptor a and Induction of Fas Ligand in Osteoclasts. (2007)
  • Author(s): Nakamura, T., et. al.
  • Journal Title: Cell 130 Pages: 797-810
  • Peer Reviewed
• [Journal Article] Pathological role of osteoclast costimulation in arthritis-induced bone loss. (2007)
  • Author(s): Ochi, S., et. al.
  • Journal Title: Proc Natl Acad Sci USA 104 Pages: 11394-11399
  • Peer Reviewed
• [Journal Article] The role of NFAT in osteoclast formation. Skeletal Biology and Medicine, Part A. Aspects of Bone Morphogenesis and Remodeling. (2007)
  • Author(s): Takayanagi H.
  • Journal Title: Annals of the New York Academy of Sciences 1116 Pages: 227-237
  • Peer Reviewed
• [Journal Article] Interaction between the immune system and bone metabolism: an emerging field of osteoimmunology. (2007)
  • Author(s): Takayanagi H.
  • Journal Title: Proc Jpn Acad, Ser B 83 Pages: 136-143
  • NAID: 130000093902
  • Peer Reviewed
• [Journal Article] Novel osteoclast signaling mechanisms. (2007)
  • Author(s): Shinohara M, Takayanagi H.
  • Journal Title: Curr Osteoporos Rep 5 Pages: 67-72
• [Journal Article] Osteoimmunology-shared mechanisms and crosstalk between the immune and bone systems. (2007)
  • Author(s): Takayanagi, H
  • Journal Title: Nat Rev Immunol 7 Pages: 292-304
  • Peer Reviewed
• [Journal Article] 特集 骨と免疫 Overview (他に、特集内容の企画・編集) (2007)
  • Author(s): 高柳広
  • Journal Title: 腎と骨代謝 21 Pages: 7-12
• [Journal Article] 炎症と骨吸収:Th17細胞の役割 (2007)
  • Author(s): 佐藤浩二郎、高柳広
  • Journal Title: The BONE 21 Pages: 61-65
  • Peer Reviewed
• [Journal Article] Osteoimmunologyの進歩 (2007)
  • Author(s): 高柳広
  • Journal Title: Frontiers in Rheumatology & Clinical Immunologyl 1 Pages: 39-45
• [Journal Article] Osteoimmunology-破骨細胞の誘導と炎症. (2007)
  • Author(s): 中島友紀、高柳広
  • Journal Title: 整形外科 58 Pages: 1615-1624
• [Journal Article] 抗リウマチ薬によるNFATc1抑制を介した破骨細胞分化制御 (2007)
  • Author(s): 末松綾子、高柳広
  • Journal Title: リウマチ科 38 Pages: 59-63
• [Journal Article] 破骨細胞と免疫系 (2007)
  • Author(s): 中島友紀、高柳広
  • Journal Title: 生体の科学 58 Pages: 196-204
• [Journal Article] Osteoimmunologyと破骨細胞 (2007)
  • Author(s): 高柳広
  • Journal Title: 医学のあゆみ 221 Pages: 37-45
• [Journal Article] 破骨細胞分化・活性化の分子機構 (2007)
  • Author(s): 高柳広
  • Journal Title: CLINICAL CALCIUM 17 Pages: 484-492
• [Journal Article] The molecular understanding of osteoclast differentiation. (2007)
  • Author(s): Asagiri, M, Takayanagi, H.
  • Journal Title: Bone 40 Pages: 251-264
• [Journal Article] Regulation of osteoclast differentiation and function by the CaMK-CREB pathway (2006)
  • Author(s): Sato, K., Suematsu, A., Nakashima, T., Takemoto-Kimura, S., Aoki, K., Morishita, Y., Asahara, H., Ohya, K., Yamaguchi, A., Takai, T., Kodama, T., Chatila, T. A., Bito, H., Takayanagi, H.
  • Journal Title: Nat Med. 12 Pages: 1410-1416
• [Journal Article] Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction (2006)
  • Author(s): Sato, K., Suematsu, A., Okamoto, K., Yamaguchi, A., Morishita, Y., Kadono, Y., Tanaka, S., Kodama, T., Akira, S., Iwakura, Y., Cua, D. J., Takayanagi, H.
  • Journal Title: J Exp Med. 203 Pages: 2673-2682
• [Journal Article] Regulation of osteoclast differentiation and function by the CaMK-CREB pathway. (2006)
  • Author(s): Sato, K, Suematsu, A, Nakashima, T, Takemoto-Kimura, S, Aoki, K, Morishita, Y, Asahara, H, Ohya, K, Yamaguchi, A, Takai, T, Kodama, T, Chatila, TA, Bito, H, Takayanagi, H.
  • Journal Title: Nat Med 12・12 Pages: 1410-1416
• [Journal Article] Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. (2006)
  • Author(s): Sato, K, Suematsu, A, Okamoto, K, Yamaguchi, A, Morishita, Y, Kadono, Y, Tanaka, S, Kodama, T, Akira, S, Iwakura, Y, Cua, DJ, Takayanagi, H.
  • Journal Title: J Exp Med 203・12 Pages: 2673-2682
• [Journal Article] Scientific basis for the efficacy of combined use of antirheumatic drugs against bone destruction in rheumatoid arthritis. (2006)
  • Author(s): Suematsu, A, Tajiri, Y, Nakashima, T, Taka, J, Ochi, S, Oda, H, Nakamura, K, Tanaka S, Takayanagi H.
  • Journal Title: Mod Rheumatol 17 Pages: 17-23
  • NAID: 10018733776
• [Journal Article] Evidence for licensing of IFN-γ-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program. (2006)
  • Author(s): Negishi, H, Fujita, Y, Yanai, H, Sakaguchi, S, Ouyang, X, Shinohara, M, Takayanagi, H, Ohba, Y, Taniguchi, T, Honda, K.
  • Journal Title: Proc Natl Acad Sci 103・41 Pages: 15136-41
• [Journal Article] Osteoclasts, rheumatoid arthritis, and osteoimmunology. (2006)
  • Author(s): Sato, K, Takayanagi, H.
  • Journal Title: Curr Opin Rheumatol 18 Pages: 419-426
• [Journal Article] Amazing multifunctionality of calcineurin and NFAT signaling in bone homestasis. (2006)
  • Author(s): Takayanagi, H.
  • Journal Title: BoneKEy-osteovision 3 Pages: 28-31
• [Journal Article] Autoamplification of NFATc1 expression determines its essential role in bone homeostasis (2005)
  • Author(s): Asagiri, M., Sato, K., Usami, T., Ochi, S., Nishina, H., Yoshida, H., Morita, I., Wagner, E. F., Mak, T. W., Serfling, E., Takayanagi, H.
  • Journal Title: J Exp Med 202 Pages: 1261-1269
• [Journal Article] NFAT and Osterix cooperatively regulate bone formation (2005)
  • Author(s): Koga, T., Matsui, Y., Asagiri, M., Kodama, T., de Crombrugghe, B., Nakashima K., Takayanagi, H.
  • Journal Title: Nat Med 11 Pages: 880-885
• [Journal Article] Autoamplification of NFATcl determines its essential role in bone homeostasis. (2005)
  • Author(s): Asagiri, M., Sato, K., Usami, T., Ochi, S., Nishina, H., Yoshida, H., Morita, I., Wagner, E.F., Mak, T.W., Serfling, E., Takayanagi, H.
  • Journal Title: J Exp Med 202・9 Pages: 1261-1269
• [Journal Article] NFAT and Osterix cooperatively regulate bone formation. (2005)
  • Author(s): Koga, T., Matsui, Y., Asagiri, M., Kodama, T., Crombrugghe, B., Nakashima K., Takayanagi, H.
  • Journal Title: Nat Med 11・8 Pages: 880-885
• [Journal Article] Contribution of NFATcl to the transcriptional control of immunoreceptor OSCAR but not TREM-2 during osteoclastogenesis. (2005)
  • Author(s): Kim, Y., Sato, K., Asagiri, M., Morita, I., Soma, K., Takayanagi, H.
  • Journal Title: J Biol Chem 280・38 Pages: 32905-32913
• [Journal Article] u-calpain regulates RANKL-supported osteoclastogenesis via NF-kB activation in raw 264.7 cells. (2005)
  • Author(s): Lee, F.Y., Kim, D.W., Karmin, J.A., Hong, D., Chang, S.S., Fujisawa, M., Takayanagi, H., Bigliani, L.U., Blaine, T.A., Lee, H.J.
  • Journal Title: J Biol Chem 280・33 Pages: 29929-29936
• [Journal Article] RANK-mediated amplification of TRAF6 signaling leads to NFATcl induction during osteoclastogenesis. (2005)
  • Author(s): Gohda, J., Akiyama, T., Koga, T., Takayanagi, H., Tanaka, S., Inoue, J.
  • Journal Title: EMBO 24・4 Pages: 790-799
• [Journal Article] Inhibition of RANKL-induced Osteoclastogenesis by (-)-DHMEQ, a Novel NF-k B Inhibitor, through Downregulation of NFATcl. (2005)
  • Author(s): Takatsuna, H., Asagiri, M., Kubota, T., Oka, K., Osada, T., Sugiyama, C., Saito, H., Aoki, K., Ohya, K., Takayanagi, H., Umezawa, K.
  • Journal Title: J Bone Mineral Res 20・4 Pages: 653-662
• [Journal Article] Interplay between interferon and other cytokine systems in bone metabolism. (2005)
  • Author(s): Takayanagi, H., Sato, K., Takaoka, A., Taniguchi, T.
  • Journal Title: Immunol Rev 208 Pages: 181-193
• [Journal Article] Osteoimmunological insight into bone damage in rheumatoid arthritis. (2005)
  • Author(s): Takayanagi, H.
  • Journal Title: Mod Rheumatol 15 Pages: 225-231
• [Journal Article] Inflammatory bone destruction and osteoimmunology. (2005)
  • Author(s): Takayanagi, H.
  • Journal Title: J Periodontal Res 40・4 Pages: 287-293
• [Journal Article] Mechanistic insight into osteo clast differentiation in osteoimmunology. (2005)
  • Author(s): Takayanagi, H.
  • Journal Title: J Mol Med 83・3 Pages: 170-179
• [Journal Article] Statl-mediated cytoplasmic attenuation in osteoimmunology. (2005)
  • Author(s): Takayanagi, H., Kim, S., Koga, T., Taniguchi, T.
  • Journal Title: J Cell Biochem 94・2 Pages: 232-240
• [Presentation] Mechanism of osteoclast differentiation (2010)
  • Author(s): 高柳広
  • Organizer: 14th International Congress of Endocrinology ICE 2010 JES-Sponsored Symposia、第83回日本内分泌学会学術総会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-29
• [Presentation] Osteoimmunology (2010)
  • Author(s): 高柳広
  • Organizer: 第30回東北免疫研究会
  • Place of Presentation: 宮城
  • Year and Date: 2010-03-19
• [Presentation] 骨免疫学とオステオネットワーク (2010)
  • Author(s): 高柳広
  • Organizer: 第9回日本再生医療学会総会 ランチョンセミナー
  • Place of Presentation: 広島
  • Year and Date: 2010-03-18
• [Presentation] 作用機序「カテプシンKとTLR9シグナル活性化」 (2010)
  • Author(s): 高柳広
  • Organizer: NC-2300基礎研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-03-13
• [Presentation] Different Ca^<2+> sensitivity of the development of T-lineage cells (2010)
  • Author(s): Oh-hora, M., Takayanagi, H., Rao, A.
  • Organizer: Keystone Symposia(poster)
  • Place of Presentation: Colorado U.S.A.
  • Year and Date: 2010-02-27
• [Presentation] 骨代謝と免疫学の接点 (2010)
  • Author(s): 高柳広
  • Organizer: 第52回分子生命科学セミナー
  • Place of Presentation: 佐賀
  • Year and Date: 2010-02-19
• [Presentation] 破骨細胞分化における正と負のシグナルのバランス維持機構 (2010)
  • Author(s): 高柳広
  • Organizer: 松本歯科大学大学院セミナー
  • Place of Presentation: 長野
  • Year and Date: 2010-02-12
• [Presentation] リウマチにおける新たなサイトカインについて (2009)
  • Author(s): 高柳広
  • Organizer: 第32回日本分子生物学会リウマチサイトカイン研究会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-11
• [Presentation] (2009)
  • Author(s): 高柳広
  • Organizer: Rheumatology Association, R. O. C. (Taiwan)
  • Place of Presentation: Yilan, Taiwan
  • Year and Date: 2009-12-06
• [Presentation] Bone destruction in arthritis and osteoimmunology (2009)
  • Author(s): 高柳広
  • Organizer: Rheumatology Association, R.O.C.(Taiwan)
  • Place of Presentation: Yilan, Taiwan
  • Year and Date: 2009-12-06
• [Presentation] Osteoimmunology の最先端 (2009)
  • Author(s): 高柳広
  • Organizer: 第37回日本臨床免疫学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-11-14
• [Presentation] RANK Ligand and Osteoimmunology (2009)
  • Author(s): 高柳広
  • Organizer: 第26回内藤コンファレンス
  • Place of Presentation: 淡路
  • Year and Date: 2009-11-07
• [Presentation] Identification of novel genes regulated by NFATc1 in osteoclastogenesis (2009)
  • Author(s): 中島友紀、林幹人、高柳広
  • Organizer: 第26回内藤コンファレンス(ポスター)
  • Place of Presentation: 淡路
  • Year and Date: 2009-11-05
• [Presentation] (2009)
  • Author(s): 高柳広
  • Organizer: ACR/ARHP Scientific Meeting
  • Place of Presentation: Philadelphia, U.S.A.
  • Year and Date: 2009-10-18
• [Presentation] 関節リウマチにおける骨破壊とRANKL (2009)
  • Author(s): 高柳広
  • Organizer: 第34回東京都リウマチ膠原病懇話会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-03
• [Presentation] Beckman Research Institute of the City of Hope, Division of Hematopietic Stem Cell and Leukemia Research (2009)
  • Author(s): 高柳広
  • Organizer: Osteoimmunology -interaction between bone and the immune system
  • Place of Presentation: Los Angeles, U.S.A.
  • Year and Date: 2009-09-09
• [Presentation] Feγ Receptors Control Bone Homeostasis by Regulating Costimulation Signals in Osteoclast Lineage Cells (2009)
  • Author(s): Hans-Jurgen Gober、古賀貴子、高柳広
  • Organizer: 第27回日本骨代謝学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-07-25
• [Presentation] 破骨細胞と骨免疫学 (2009)
  • Author(s): 高柳広
  • Organizer: 第27回日本骨代謝学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-07-24
• [Presentation] (2009)
  • Author(s): 高柳広
  • Organizer: The Bone & Teeth Gordon Research Conference
  • Place of Presentation: Maine, U.S.A.
  • Year and Date: 2009-07-15
• [Presentation] Anti-Osteoclast Therapy for Bone Destruction in Inflammation (2009)
  • Author(s): 高柳広
  • Organizer: The 9^<th> World Congress on Inflammation
  • Place of Presentation: Tokyo
  • Year and Date: 2009-07-10
• [Presentation] TNF-α and Bone Destruction in Arthritis -from the Viewpoint of Basic Research- (2009)
  • Author(s): 高柳広
  • Organizer: The 9^<th> World Congress on Inflammation
  • Place of Presentation: Tokyo
  • Year and Date: 2009-07-08
• [Presentation] (2009)
  • Author(s): 高柳広
  • Organizer: The 3rd Global COE International Symposium, Tokyo Medical and Dental University
  • Place of Presentation: Tokyo
  • Year and Date: 2009-06-10
• [Presentation] Immune Regulation of Osteoclastogenesis (2009)
  • Author(s): 高柳広
  • Organizer: The 3^<rd> Global COE International Symposium, Tokyo Medical and Dental University
  • Place of Presentation: Tokyo
  • Year and Date: 2009-06-10
• [Presentation] 関節リウマチの骨破壊とIL-6 (2009)
  • Author(s): 高柳広
  • Organizer: 第82回日本整形外科学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2009-05-17
• [Presentation] (2009)
  • Author(s): 高柳広
  • Organizer: The 66th KSBMB Annual Meeting, World Trade Center
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2009-05-13
• [Presentation] RANKL Signaling and Osteoimmunology (2009)
  • Author(s): 高柳広
  • Organizer: The 66^<th> KSBMB Annual Meeting, World Trade Center
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2009-05-13
• [Presentation] (2009)
  • Author(s): 高柳広
  • Organizer: The 3rd New York Skeletal Biology and Medicine Conference, Mount Sinai School of Medicine
  • Place of Presentation: New York, U.S.A.
  • Year and Date: 2009-04-30
• [Presentation] New Immune Connections During Osteoclatogenesis (2009)
  • Author(s): 高柳広
  • Organizer: The 3^<rd> New York Skeletal Biology and Medicine Conference, Mount Sinai School of Medicine
  • Place of Presentation: New York, U.S.A.
  • Year and Date: 2009-04-30
• [Presentation] 関節リウマチ骨破壊への新たなアプローチ (2009)
  • Author(s): 高柳広
  • Organizer: 第53回日本リウマチ学会総会・学術集会、第18回国際リウマチシンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2009-04-23
• [Presentation] 関節リウマチ骨破壊と骨免疫学 (2009)
  • Author(s): 高柳広
  • Organizer: 第37回九州リウマチ学会イブニングセミナー
  • Place of Presentation: 長崎
  • Year and Date: 2009-03-14
• [Presentation] 関節リウマチ骨破壊と骨免疫学 (2009)
  • Author(s): 高柳広
  • Organizer: 兵庫県リウマチ医の会
  • Place of Presentation: 兵庫
  • Year and Date: 2009-03-07
• [Presentation] Osteoimmunology-Interactions and shared mechanisms between the immune sys tem and bone. (2009)
  • Author(s): Takayanagi, H.
  • Organizer: The Annual Symposium of IFReC (Immunology Frontier Research Center), Osaka University
  • Place of Presentation: Osaka
  • Year and Date: 2009-02-12
• [Presentation] 炎症性骨破壊と骨免疫学 (2009)
  • Author(s): 高柳広
  • Organizer: 第32回皮膚脈管膠原病研究会
  • Place of Presentation: 京都
  • Year and Date: 2009-01-23
• [Presentation] 関節リウマチの骨破壊と骨免疫学 (2009)
  • Author(s): 高柳広
  • Organizer: 山口県整形外科医会
  • Place of Presentation: 山口
  • Year and Date: 2009-01-17
• [Presentation] 運動器疾患の分子ネットワークの解明と治療応用 (2009)
  • Author(s): 高柳広
  • Organizer: ゲノムネットワークプロジェクト公開シンポジウム『ゲノムネットワークが拓く新しい医学・生物学」
  • Place of Presentation: 東京
  • Year and Date: 2009-01-16
• [Presentation] (2009)
  • Author(s): 高柳広
  • Organizer: The 9th World Congress on Inflammation
  • Place of Presentation: Tokyo
• [Presentation] 骨免疫学研究の現状・課題・展望 (2009)
  • Author(s): 高柳広
  • Organizer: 第29回コスモ・バイオ バイオプロダクトセミナー
  • Place of Presentation: 東京、大阪
• [Presentation] 加齢に伴い発現変動する転写因子Mafの細胞分化に及ぼす影響 (2008)
  • Author(s): 西川恵三, 他
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] Tecファミリーチロシンキナーゼによる破骨細胞分化制御 (2008)
  • Author(s): 古賀貴子, 他
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] ERR2と相互作用するタンパク質の探索 (2008)
  • Author(s): 春宮覚, 他
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] Molecular mechanism in osteoclastogenesis (2008)
  • Author(s): Takayanagi, H.
  • Organizer: JSPS Core-to-Core Program International Workshop on Advanced Bone and Joint Science (ABJS)
  • Place of Presentation: Tokyo
  • Year and Date: 2008-12-04
• [Presentation] 関節リウマチ骨破壊と骨免疫学 (2008)
  • Author(s): 高柳広
  • Organizer: 病態代謝血管医学セミナー
  • Place of Presentation: 熊本
  • Year and Date: 2008-11-13
• [Presentation] (2008)
  • Author(s): 高柳広
  • Organizer: Annual Meeting of Korean Endocrine Society
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2008-11-08
• [Presentation] Bone and Immune System (2008)
  • Author(s): Takayanagi, H.
  • Organizer: Annual Meeting of Korean Endocrine Society
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2008-11-08
• [Presentation] 『骨免疫学の最前線』破骨細胞の新たな制御メカニズム (2008)
  • Author(s): 高柳広
  • Organizer: 第26回日本骨代謝学会学術集会ランチョンセミナー
  • Place of Presentation: 大阪
  • Year and Date: 2008-10-31
• [Presentation] EANKLと骨免疫学 (2008)
  • Author(s): 高柳広
  • Organizer: 第26回日本骨代謝学会学術集会イブニングセミナー
  • Place of Presentation: 大阪
  • Year and Date: 2008-10-30
• [Presentation] 加齢に伴う骨量減少の原因となる転写メカニズムの探索 (2008)
  • Author(s): 西川恵三, 他
  • Organizer: 第26回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2008-10-29
• [Presentation] (2008)
  • Author(s): 高柳広
  • Organizer: 2008 ACR Basic Research conference
  • Place of Presentation: San Francisco
  • Year and Date: 2008-10-24
• [Presentation] Th17 Cytokines and their Effects (2008)
  • Author(s): Takayanagi, H.
  • Organizer: 2008 ACR Basic Research conference
  • Place of Presentation: San Francisco
  • Year and Date: 2008-10-24
• [Presentation] カテプシンKはToll-like receptor 9シグナルを介して自己免疫性炎症を制御する (2008)
  • Author(s): 國上敏浩, 他
  • Organizer: 第36回日本臨床免疫学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-18
• [Presentation] Molecular determinant in osteoclast differentiation (2008)
  • Author(s): 高柳広
  • Organizer: 第70回日本血液学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-10-10
• [Presentation] 炎症性骨破壊と骨免疫学 (2008)
  • Author(s): 高柳広
  • Organizer: 第3回大阪皮膚アンチエイジング研究会
  • Place of Presentation: 大阪
  • Year and Date: 2008-10-09
• [Presentation] The crucial role of RANKL in bone loss and canser metastasis (2008)
  • Author(s): Nakashima T., et al.
  • Organizer: The 13th Asia Pacific League of Associations for Rheumatology Congress
  • Place of Presentation: Yokohama
  • Year and Date: 2008-09-26
• [Presentation] Tec kinases form an OSteoclastogenic signal ing complex with SLP adaptor proteins (2008)
  • Author(s): Koga T., et al.
  • Organizer: The 13th Asia Pacific League of Associations for Rheumatology Congress
  • Place of Presentation: Yokohama
  • Year and Date: 2008-09-26
• [Presentation] Therapeutic potential of Tec kinase inhibitors on bone destruction (2008)
  • Author(s): Arai R., et al.
  • Organizer: The 13th Asia Pacific League of Associations for Rheumatology Congress
  • Place of Presentation: Yokohama
  • Year and Date: 2008-09-26
• [Presentation] Tyrosine kinases Btk and Tec are essential for osteoclast differentiation (2008)
  • Author(s): Shinohara M., et al.
  • Organizer: The 13th Asia Pacific League of Associations for Rheumatology Congress
  • Place of Presentation: Yokohama
  • Year and Date: 2008-09-25
• [Presentation] A Novel Role of Catheps in K In Autoimmunity: Regulation of Toll-Like Receptor 9 signaling in Dendritic Cells (2008)
  • Author(s): Okamoto M., et al.
  • Organizer: The 13th Asia Pacific League of Associations for Rheumatology Congress
  • Place of Presentation: Yokohama
  • Year and Date: 2008-09-24
• [Presentation] NFATcl-dependent program of osteoclast differentiation and function. (2008)
  • Author(s): Hayashi M., et al.
  • Organizer: The 13th Asia Pacific League of Associations for Rheumatology Consrress
  • Place of Presentation: Yokohama
  • Year and Date: 2008-09-24
• [Presentation] Effect of coibined use of anti-rheumatic drugs on osteoclast differentiation. (2008)
  • Author(s): Suematsu A., et al.
  • Organizer: The 13th Asia Pacific League of Associations for Rheumatology Congress
  • Place of Presentation: Yokohama
  • Year and Date: 2008-09-24
• [Presentation] (2008)
  • Author(s): 高柳広
  • Organizer: The 13th Congress of the Asia Pacific League of Associations for Rheumatology
  • Place of Presentation: Yokohama
  • Year and Date: 2008-09-23
• [Presentation] Osteoclasts in Arthritis and Osteoimmunology (2008)
  • Author(s): Takayanagi, H.
  • Organizer: The 13^<th> Asia Pacific League of Associations for Rheumatology Congress
  • Place of Presentation: Yokohama
  • Year and Date: 2008-09-23
• [Presentation] Use of mouse genetics in bone biology and osteoimmunology. (2008)
  • Author(s): Takayanagi, H.
  • Organizer: EMBO Practice Course on "Anatomy and Embryoloey of the Mouse"
  • Place of Presentation: Zagreb, Croatia
  • Year and Date: 2008-09-10
• [Presentation] 新たな破骨細胞制御メカニズム (2008)
  • Author(s): 高柳広
  • Organizer: 第28回骨形態計測学会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-26
• [Presentation] 関節リウマチ骨破壊と骨免疫学 (2008)
  • Author(s): 高柳広
  • Organizer: 東京骨関節フォーラム
  • Place of Presentation: 東京
  • Year and Date: 2008-07-12
• [Presentation] 免疫不全と骨代謝-Tecファミリーチロシンキナーゼによる破骨細胞分化制御- (2008)
  • Author(s): 篠原正浩, 他
  • Organizer: 第29回日本炎症・再生医学会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-10
• [Presentation] 関節リウマチ骨破壊と骨免疫 (2008)
  • Author(s): 高柳広
  • Organizer: 免疫シンフォニー
  • Place of Presentation: 大阪
  • Year and Date: 2008-06-28
• [Presentation] 関節リウマチ骨破壊と骨免疫学 (2008)
  • Author(s): 高柳広
  • Organizer: 城北関節炎・RA・OA・AS談話会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-26
• [Presentation] The role of Tec family kinases in osteoclast differentiation (2008)
  • Author(s): Shinohara M., et al.
  • Organizer: 2^<nd> International Conference on Osteoimmunology: Interactions of the Immune and Skeletal Systems
  • Place of Presentation: Rhodos, Greece
  • Year and Date: 2008-06-13
• [Presentation] Cathepsin K regulated TH17 cell polarization through toll-like receptor 9 signaling in dendritic cells (2008)
  • Author(s): Gober H. J., et al.
  • Organizer: 2^<nd> International Conference on Osteoimmunology: Interactions of the Immune and Skeletal Systems
  • Place of Presentation: Rhodos, Greece
  • Year and Date: 2008-06-13
• [Presentation] (2008)
  • Author(s): 高柳広
  • Organizer: 2nd International Conference on Osteoimmunology : Interactions of the Immune and Skeletal Systems
  • Place of Presentation: Rhodes, Greece
  • Year and Date: 2008-06-11
• [Presentation] Unexpected link between osteoclast and the immune system (2008)
  • Author(s): Takayanagi, H.
  • Organizer: 2^<nd> International Conference on Osteoimmunology: Interactions of the Immune and Skeletal Systems
  • Place of Presentation: Rhodos, Greece
  • Year and Date: 2008-06-11
• [Presentation] (2008)
  • Author(s): 高柳広
  • Organizer: 第86回膠原病研究会
  • Place of Presentation: 新潟
  • Year and Date: 2008-06-03
• [Presentation] 関節リウマチ骨破壊と骨免疫学 (2008)
  • Author(s): 高柳広
  • Organizer: 埼玉医大整形同門会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-31
• [Presentation] 関節リウマチの骨破壊と骨免疫学 (2008)
  • Author(s): 高柳広
  • Organizer: 第81回日本整形外科学会教育研修講演
  • Place of Presentation: 札幌
  • Year and Date: 2008-05-22
• [Presentation] Tecファミリーキナーゼによる破骨細胞分化制御機構(The role of Tec family kinases in osteoclast differentiation) (2008)
  • Author(s): 篠原正浩, 他
  • Organizer: 第52回日本リウマチ学会総会・学術集会ワークショップ32「骨代謝と骨粗鬆症」
  • Place of Presentation: 札幌
  • Year and Date: 2008-04-23
• [Presentation] 破骨細胞の新たな制御メカニズム (2008)
  • Author(s): 高柳広
  • Organizer: 第52回日本リウマチ学会総会・学術集会シンポジウム「関節リウマチ病態解明のトピックス」
  • Place of Presentation: 札幌
  • Year and Date: 2008-04-23
• [Presentation] カテプシンKはToll様受容体9シグナルを介して自己免疫性炎症疾患の重症度を決定する (2008)
  • Author(s): 朝霧成挙, 他
  • Organizer: 第52回日本リウマチ学会総会・学術集会ワークショップ9「関節リウマチの病因・病態1」
  • Place of Presentation: 札幌
  • Year and Date: 2008-04-22
• [Presentation] サイトカインと骨破壊 (2008)
  • Author(s): 高柳広
  • Organizer: 第52回日本リウマチ学会総会・学術集会イブニングセミナー
  • Place of Presentation: 札幌
  • Year and Date: 2008-04-22
• [Presentation] (2008)
  • Author(s): 高柳広
  • Organizer: International Bone & Mineral Society Davos Workshops
  • Place of Presentation: Davos, Switzerland
  • Year and Date: 2008-03-10
• [Presentation] Osteoclast-Independent Function of Cathepsin K: Regulation of Toll-like Receptor 9 Signaling in Autoimmunity (2008)
  • Author(s): Okamoto, K., et al.
  • Organizer: The 30th Annual Meeting of the American Society for Bone and Mineral Research.
  • Place of Presentation: Montreal, Canada
• [Presentation] Tec Kinases, Therapeutic Targets for Bone Destructive Diseases. (2008)
  • Author(s): Shinohara M., et al.
  • Organizer: The 30th Annual Meeting of the American Society for Bone and Mineral Research.
  • Place of Presentation: Montreal, Canada
• [Presentation] 骨芽細胞・脂肪細胞運命決定における転写因子c-Mafの役割 (2007)
  • Author(s): 西川恵三, 他
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-12
• [Presentation] Regulation of dendritic cell function by cathepsin K. (2007)
  • Author(s): 朝霧成挙, 他
  • Organizer: 日本免疫学会総会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-22
• [Presentation] 炎症関節での破骨細胞分化におけるpaired immunoglobulin-likereceptor-Aの病的意義について (2007)
  • Author(s): 越智小枝, 他
  • Organizer: 日本免疫学会総会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-21
• [Presentation] 関節リウマチ骨破壊と骨免疫学 (2007)
  • Author(s): 高柳広
  • Organizer: 第35回日本臨床免疫学会ランチョンセミナー
  • Place of Presentation: 大阪
  • Year and Date: 2007-10-19
• [Presentation] Bone Destruction in Arthritis and Osteoimmunology. (2007)
  • Author(s): Takayanagi. H
  • Organizer: 4th International Symposium of Chosun University Hospital
  • Place of Presentation: Kyang Ju, Korea
  • Year and Date: 2007-09-29
• [Presentation] Meet-the-Professor Session (2007)
  • Author(s): 高柳広
  • Organizer: The 29th Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: Honolulu, U.S.A.
  • Year and Date: 2007-09-19
• [Presentation] Mechanism of osteoclast differentiation (2007)
  • Author(s): Takayanagi H
  • Organizer: The 29th Annual Meeting of the American Society for Bone and Mineral Research.
  • Place of Presentation: Honolulu, U.S.A.
  • Year and Date: 2007-09-19
• [Presentation] Tec Tyrosine Kinases Are Essential For Osteoclast Differentiation. (2007)
  • Author(s): Shinohara, M. et. al
  • Organizer: The 29th Annual Meeting of the American Society for Bone and Mineral Research.
  • Place of Presentation: Honolulu, U.S.A.
  • Year and Date: 2007-09-19
• [Presentation] The CaMK-CREB Pathway Regulates Osteoclast Differentiation and Function. (2007)
  • Author(s): Suematsu, A., et. al.
  • Organizer: The 29th Annual Meeting of the American Society for Bone and Mineral Research.
  • Place of Presentation: Honolulu, U.S.A.
  • Year and Date: 2007-09-19
• [Presentation] 骨と免疫の世界 (2007)
  • Author(s): 高柳広
  • Organizer: 第28回日本炎症再生医学会
  • Place of Presentation: 東京
  • Year and Date: 2007-08-03
• [Presentation] 破骨細胞分化と骨免疫学 (2007)
  • Author(s): 高柳広
  • Organizer: 第28回日本炎症再生医学会
  • Place of Presentation: 東京
  • Year and Date: 2007-08-03
• [Presentation] 炎症性骨破壊における破骨細胞共刺激因子の役割 (2007)
  • Author(s): 越智小枝, 他
  • Organizer: 第28回日本炎症再生医学会
  • Place of Presentation: 東京
  • Year and Date: 2007-08-03
• [Presentation] 破骨細胞分化促進性T細胞サブセットの同定 (2007)
  • Author(s): 佐藤浩二郎, 他
  • Organizer: 第28回日本炎症再生医学会
  • Place of Presentation: 東京
  • Year and Date: 2007-08-02
• [Presentation] Tecキナーゼファミリーによる破骨細胞分化制御機構 (2007)
  • Author(s): 篠原正浩, 他
  • Organizer: 第25回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2007-07-21
• [Presentation] CaMK/CREB経路による破骨細胞制御メカニズム (2007)
  • Author(s): 末松綾子, 他
  • Organizer: 第25回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2007-07-21
• [Presentation] The regulation of bone metabolism by the immune system. (2007)
  • Author(s): Takayanagi, H
  • Organizer: 第25回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2007-07-20
• [Presentation] 関節リウマチ骨破壊のメカニズムと骨免疫学 (2007)
  • Author(s): 高柳 広
  • Organizer: 第8回日本リウマチ財団 中国四国リウマチ外科セミナー
  • Place of Presentation: 高知
  • Year and Date: 2007-07-07
• [Presentation] Th17は炎症と骨破壊を結びつける破骨細胞誘導性T細胞である (2007)
  • Author(s): 高柳 広
  • Organizer: 日本インターフェロンサイトカイン学会
  • Place of Presentation: 京都
  • Year and Date: 2007-07-05
• [Presentation] 破骨細胞分化のメカニズム (2007)
  • Author(s): 高柳 広
  • Organizer: 大阪骨代謝研究会
  • Place of Presentation: 大阪
  • Year and Date: 2007-07-02
• [Presentation] 骨吸収制御のための新たな治療標的を求めて (2007)
  • Author(s): 高柳 広
  • Organizer: 日本骨形態計測学会ゴッホセミナー
  • Place of Presentation: 長崎
  • Year and Date: 2007-06-01
• [Presentation] 抗リウマチ薬の併用による破骨細胞分化抑制作用の増強 (2007)
  • Author(s): 末松綾子, 他
  • Organizer: 第51回日本リウマチ学会総会・学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2007-04-27
• [Presentation] Th17はリウマチ骨破壊を促進する破骨細胞誘導生ヘルパーT細胞サブセットである (2007)
  • Author(s): 佐藤浩二郎, 他
  • Organizer: 第51回日本リウマチ学会総会・学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2007-04-27
• [Presentation] (2007)
  • Author(s): 高柳広
  • Organizer: 2nd Conference on Skeletal Biology and Medicine
  • Place of Presentation: New York, U.S.A.
  • Year and Date: 2007-04-26
• [Presentation] Role of NFAT in Osteoclast Formation (2007)
  • Author(s): Takayanagi H
  • Organizer: 2nd Conference on Skeletal Biology and Medicine
  • Place of Presentation: New York, U.S.A.
  • Year and Date: 2007-04-26
• [Presentation] (2007)
  • Author(s): Hiroshi Takayanagi
  • Organizer: INSERM The 2nd Annual Meeting of PRO-A, Institut Curie
  • Place of Presentation: Paris, France
  • Year and Date: 2007-01-25
• [Presentation] (2006)
  • Author(s): 高柳広
  • Organizer: International Conference on Progress in Bone and Mineral Research on the occasion of the Awarding of the 2006 International Research Prize
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2006-11-17
• [Presentation] (2006)
  • Author(s): 高柳広
  • Organizer: 3rd IOF Asia-Pacific Regional Conference on Osteoporosis and 16th Annual Meeting of the Australian & New Zealand Bone & Mineral Society
  • Place of Presentation: Port Douglas, Australia
  • Year and Date: 2006-10-23
• [Presentation] (2006)
  • Author(s): 高柳広
  • Organizer: The 28th Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: Philadelphia, U.S.A.
  • Year and Date: 2006-09-15
• [Presentation] (2006)
  • Author(s): 高柳広
  • Organizer: The 2005 Gordon Conference on Bones and Teeth
  • Place of Presentation: University of New England, U.S.A.
  • Year and Date: 2006-07-11
• [Presentation] (2006)
  • Author(s): 高柳広
  • Organizer: 1st International Conference on Osteoimmunology
  • Place of Presentation: Crete, Greece
  • Year and Date: 2006-05-31
• [Presentation] (2006)
  • Author(s): 高柳広
  • Organizer: International Symposium on Osteoporosis, Korean Society of Osteoporosis
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2006-04-08
• [Presentation] (2005)
  • Author(s): 高柳広
  • Organizer: 5th Global Arthritis Research Network (GARN)
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2005-09-16
• [Presentation] (2005)
  • Author(s): 高柳広
  • Organizer: European Calcified Tissue Society and International Bone and Mineral Society (ECTS, IBMS)
  • Place of Presentation: Geneva, Switzerland
  • Year and Date: 2005-06-26
• [Presentation] (2005)
  • Author(s): 高柳広
  • Organizer: Annual European Congress of Rheumatology "EULAR 2005"
  • Place of Presentation: Vienna
  • Year and Date: 2005-06-08
• [Book] 5. 骨・関節-b. 破骨細胞、炎症・再生医学事典 (2009)
  • Author(s): 高柳広
• [Book] Cytokine and growth factor regulation of osteoclastogenesis(The Skeletal System) (2009)
  • Author(s): Takayanagi, H.
• [Book] The Skeletal System「9 : Cytokine and Growth Factor Regulation of Osteoclastogenesis」 (2009)
  • Author(s): 高柳広
  • Total Pages: 13
  • Publisher: Cold Spring Harbor Laboratory Press
• [Book] 炎症・再生医学事典5.骨・関節-b.破骨細胞 (2009)
  • Author(s): 高柳広
  • Total Pages: 4
  • Publisher: 朝倉書店
• [Book] Osteoimmunology と破骨細胞 医学部のあゆみ 別冊 骨粗鬆症-臨床と研究の最新動向 (2008)
  • Author(s): 高柳広
• [Book] 骨免疫学と疾患、免疫応答と免疫病態の統合的分子理解(編者 : 谷口維紹、山本一彦) (2007)
  • Author(s): 高柳広
  • Publisher: 南光堂
• [Book] Osteoimmunology Interactions of the Immune and Skeletal Systems-Advances in Experimental Medicine and Biology (2007)
  • Author(s): H. Takayanagi
  • Total Pages: 156
  • Publisher: Springer
• [Book] 免疫応答と免疫病態の統合的分子理解 編者:谷口維紹、山本一彦 (2007)
  • Author(s): 高柳広
  • Total Pages: 269
  • Publisher: 南光堂
• [Book] NFATc1による破骨細胞分化のメカニズム、Annual Review 免疫2007(編集 : 奥村康、平野俊夫、佐藤昇志) (2006)
  • Author(s): 篠原正浩, 高柳広
  • Publisher: 中外医学社
• [Book] Annual Review 免疫 2007 (2006)
  • Author(s): 篠原正浩, 高柳広
  • Publisher: 中外医学社
• [Book] RA関節破壊における破骨細胞の役割、リウマチ・膠原病最新トピックス(竹原和彦、佐藤伸一、桑名正隆 編著) (2005)
  • Author(s): 高柳広
  • Publisher: 診断と治療社
• [Book] 骨研究がわかる、実験医学 (2005)
  • Author(s): 高柳広 <編集>
  • Publisher: 羊土社
• [Remarks] ホームページ等
  • URL: http://www.osteoimmunology.com/
• [Remarks]
  • URL: http://osteoimmunology.com/
• [Remarks]
  • URL: http://osteoimmunology.com/
• [Remarks]
  • URL: http://osteoimmunology.com/
• [Patent(Industrial Property Rights)] カテプシン阻害剤を有効成分として含有するToll様受容体のシグナル伝達の調整剤 (2007)
  • Inventor(s): 高柳広、朝霧成挙、平井利武
  • Industrial Property Rights Holder: 東京医科歯科大学、日本ケミファ株式会社
  • Filing Date: 2007-10-24