Unraveling molecular mechanisms to recreate 3D organ architecture

• Project/Area Number: 17GS0318
• Research Category: Grant-in-Aid for Creative Scientific Research
• Allocation Type: Single-year Grants
• Research Institution: Kyoto University
• Principal Investigator: AGATA Kiyokazu Kyoto University, 大学院・理学研究科, 教授 (70167831)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥552,760,000 (Direct Cost: ¥425,200,000、Indirect Cost: ¥127,560,000); Fiscal Year 2009: ¥108,680,000 (Direct Cost: ¥83,600,000、Indirect Cost: ¥25,080,000); Fiscal Year 2008: ¥108,420,000 (Direct Cost: ¥83,400,000、Indirect Cost: ¥25,020,000); Fiscal Year 2007: ¥108,160,000 (Direct Cost: ¥83,200,000、Indirect Cost: ¥24,960,000); Fiscal Year 2006: ¥109,590,000 (Direct Cost: ¥84,300,000、Indirect Cost: ¥25,290,000); Fiscal Year 2005: ¥117,910,000 (Direct Cost: ¥90,700,000、Indirect Cost: ¥27,210,000)
• Keywords: 幹細胞 / 位置情報 / 器官形成 / 脳 / プラナリア / マウス / ES細胞 / シグナル伝達 / 再生 / 全能性幹細胞 / ニッチ / 極性 / 組織構築

Research Abstract

We investigated the mechanisms underlying organ regeneration from pluripotent stem cells in planarians. We applied these strategies to organ formation from mouse ES cells in vitro.

Research Products

• [Journal Article] Different requirements for post-transcriptional regulators and translational initiation factors during planarian regeneration and stem cell maintenance. (2010)
  • Author(s): L. Rouhana, N. Shibata, K. Agata
  • Journal Title: Dev. Biol. 341 Pages: 429-443
  • Peer Reviewed
• [Journal Article] Analysis of motor function modulated by cholonergic neurins in planarian Dugesia japonica (2010)
  • Author(s): K. Nishimura, Y. Kitamura, T. Taniguchi, K. Agata
  • Journal Title: Neuroscience 168 Pages: 18-30
  • Peer Reviewed
• [Journal Article] Single-cell gene profiling of planarian stem cells using fluorescent activated cell sorting and its "index sorting" function for stem cell research. (2010)
  • Author(s): T. Hayashi, N. Shibata, R. Okumura, T. Kudome, O. Nishimura, H. Taru, K. Agata
  • Journal Title: Dev. Growth Differ. 52 Pages: 131-144
  • Peer Reviewed
• [Journal Article] Cellular and molecular dissection of pluripotent adult somatic stem cells in planarians. (2010)
  • Author(s): N. Shibata, L. Rouhana, K. Agata
  • Journal Title: Dev. Growth Differ. 52 Pages: 27-41
  • Peer Reviewed
• [Journal Article] Cellular and molecular dissection of pluripotent adult somaticstem cells in planarians (2010)
  • Author(s): Norito Shibata, Labib Rouhana, Kiyokazu Agata
  • Journal Title: Develop.Growth Differ. 52 Pages: 27-41
  • Peer Reviewed
• [Journal Article] Single-cell gene profiling of planarian stem cells using fluorescent activated cell sorting and its "index sorting" function for stem cell research (2010)
  • Author(s): Tetsutaro Hayashi, Norito Shibata, Ryo Okumura, Tomomi Kudome, Osamu Nishimura, Hiroshi Tarui, Kiyokazu Agata
  • Journal Title: Develop.Growth Differ. 52 Pages: 131-144
  • Peer Reviewed
• [Journal Article] Analysis of motor function modulated by cholonergic neurins in planarian Dugesia japonica (2010)
  • Author(s): Kaneyasu Nishimura, Yoshihisa Kitamura, Takashi Taniguchi, Kiyokazu Agata
  • Journal Title: Neuroscience
  • Peer Reviewed
• [Journal Article] Different requirements for post-transcriptional regulators and translational initiation factors during planarian regeneration and stem cell maintenance (2010)
  • Author(s): Labib Rouhana, Norito Shibata, Kiyokazu Agata
  • Journal Title: Dev.Biol.
  • Peer Reviewed
• [Journal Article] Planarian Hedgehog/Patched establishes anterior-posterior polarity by regulating Wnt signaling. (2009)
  • Author(s): S. Yazawa, Y. Umesono, T. Hayashi, H. Tarui, K. Agata
  • Journal Title: Proc. Natl. Acad. Sci. USA 106 Pages: 22329-22334
  • Peer Reviewed
• [Journal Article] Planarians maintain a constant ratio of different cell types during changes in body size by using the stem cell system (2009)
  • Author(s): H. Takeda, K. Nishimura, K. Agata
  • Journal Title: Zool. Sci. 26 Pages: 805-813
  • Peer Reviewed
• [Journal Article] Identification of a novel planarian G-protein-coupled receptor that responds to serotonin in Xenopus laevis oocytes K. Nishimura (2009)
  • Author(s): K. Unemura, J. Tsushima, Y. Yamauchi, J. Otomo, T. Taniguchi, S. Kaneko, K. Agata, Y. Kitamura
  • Journal Title: Biol. Pharm. Bull. 32 Pages: 1672-1677
  • Peer Reviewed
• [Journal Article] Evolution and regeneration of the planarian central nervous system (2009)
  • Author(s): Y. Umesono, K. Agata
  • Journal Title: Growth Differ. 51 Pages: 185-195
  • Peer Reviewed
• [Journal Article] Identification of a Novel Planarian G-Protein-Coupled Receptor That Responds to Serotonin in Xenopus laevis Oocytes (2009)
  • Author(s): Kaneyasu Nishimura, Kazuhiro Unemura, Jun Tsushima, Yosuke Yamauchi, Jun Otomo, Takashi Taniguchi, Shuji Kaneko, Kiyokazu Agata, Yoshihisa Kitamura
  • Journal Title: Biol.Pharm.Bull. 32(10) Pages: 1672-1677
  • Peer Reviewed
• [Journal Article] Planarians Maintain a Constant Ratio of Different Cell Types During Changes in Body Size by Using the Stem Cell System (2009)
  • Author(s): Hiroyuki Takeda, Kaneyasu Nishimura, Kiyokazu Agata
  • Journal Title: Zoological Science 26 Pages: 805-813
  • Peer Reviewed
• [Journal Article] Planarian Hedgehog/Patched establishes anterior-posterior polarity by regulating Wnt signaling (2009)
  • Author(s): Shigenobu Yazawa, Yoshihiko Umesono, Tetsutaro Hayashi, Hiroshi Tarui, Kiyokazu Agata
  • Journal Title: PNAS(Proceedings of the National Academy of Sciences of the United States of America) 106 Pages: 22329-22334
  • Peer Reviewed
• [Journal Article] Evolution and regeneration of the planarian central nervous system (2009)
  • Author(s): Yoshihiko Umesono, Kiyokazu Agata
  • Journal Title: Develop. Growth Differ. 51 Pages: 185-195
  • Peer Reviewed
• [Journal Article] Charactization of tyramine β-hydroxylase in planarian Dugesia japonica, Cloning and expression. (2008)
  • Author(s): K. Nishimura, Y. Kitamura, T. Inoue, Y. Umesono, K. Yoshimoto, T. Taniguchi, K. Agata
  • Journal Title: Neurochemi. Inter. 53 Pages: 184-192
  • Peer Reviewed
• [Journal Article] Identification of glutamic acid decarboxylase gene and distribution of GABAergic nervous system in the planarian Dugesia laponica. (2008)
  • Author(s): K. Nishimura, Y. Kitamura, Y. Umesono, K. Takeuchi. K. Takata, T. Taniguchi, K. Agata
  • Journal Title: Neuroscience 153 Pages: 1103-1114
  • Peer Reviewed
• [Journal Article] Expression and functional analysis of musashi-like genes in planarian CNS regeneration. (2008)
  • Author(s): S. Higuchi, T. Hayashi, H. Tarui, O. Nishimura, K. Nishimura, N. Shibata, H. Sakamoto, K. Agata
  • Journal Title: Mech. Dev. 25 Pages: 631-645
  • Peer Reviewed
• [Journal Article] Brain regeneration from pluripotent stem cells in planarian. (2008)
  • Author(s): K. Agata, Y. Umesono
  • Journal Title: Phil. Trans. R. Soc. Lond. B. Biol. Sci. 363 Pages: 2071-2078
  • Peer Reviewed
• [Journal Article] Identification of glutamic acid decarboxylase gene and distribution of GABAergic nervous system in the planarian Dugesia japonica. (2008)
  • Author(s): K. Nishimura, Y. Kitamura, Y. Umesono, K. Takeuchi, K. Takata, T. Taniguchi, K. Agata
  • Journal Title: Neurosci. 153 Pages: 1103-1114
  • Peer Reviewed
• [Journal Article] Brain regeneration from pluripotent stem cells in planarian (2008)
  • Author(s): Kiyokazu Agata, Yoshihiko Umesono
  • Journal Title: Philos. Trans. R. Soc. Lond. B Biol. Sci. 363 Pages: 2071-2078
  • Peer Reviewed
• [Journal Article] Expression and functional analysis of musashi-like genes in planarian CNS regeneration (2008)
  • Author(s): Sayaka Higuchi, Tetsutaro Hayashi, Hiroshi Tarui, Osamu Nishimura, Kaneyasu Nishimura, Norito Shibata, Hiroshi Sakamoto, Kiyokazu Agata
  • Journal Title: Mech. Dev. 125 Pages: 631-645
  • Peer Reviewed
• [Journal Article] IDENTIFICATION OF GLUTAMIC ACID DECARBOXYLASE GENE AND DISTRIBUTION OF GABAergic NERVOUS SYSTEM IN THE PLANARIAN DUGESIA JAPONICA (2008)
  • Author(s): Kaneyasu Nishimura, Yoshihisa Kitamura, Yoshihko Umesono, Kousei Takeuchi, Kazuyuki Takata, Takashi Taniguchi, Kiyokazu Agata
  • Journal Title: Neuroscience 153 Pages: 1103-1114
  • Peer Reviewed
• [Journal Article] Charactization of tyramine β-hydroxylase inplanarian Dugesia japonica: Cloning and exparassion (2008)
  • Author(s): Kaneyasu Nishimura, Yoshihisa Kitamura, Takeshi Inoue, Yoshihiko Umesono, Kanji Yoshimoto, Takashi Taniguchi, Kiyokazu Agata
  • Journal Title: Neurochemistry Internationl 53 Pages: 184-192
  • Peer Reviewed
• [Journal Article] Characterization and categorization of FACS-sorted planarian stem cells by ultrastructural analysis. (2007)
  • Author(s): S. Higuchi, T. Hayashi, I. Hori, N. Shibata, H. Sakamot, K. Agata
  • Journal Title: Dev. Growth Differ. 49 Pages: 571-581
  • Peer Reviewed
• [Journal Article] Wnt signaling is required for antero-posterior patterning of the planarian brain. (2007)
  • Author(s): C. Kobayashi, K. Ogawa, K. Agata
  • Journal Title: Dev. Biol. 306 Pages: 714-724
  • Peer Reviewed
• [Journal Article] Clathrin-mediated endocytic signal is required for the regeneration as well as homeostasis of planarian CNS. (2007)
  • Author(s): T. Inoue, T. Hayashi, K. Takechi, K. Agata
  • Journal Title: Development 134 Pages: 1679-1689
  • Peer Reviewed
• [Journal Article] Reconstruction of dopaminergic neural network and locomotion function in planarian regenerates. (2007)
  • Author(s): K. Nishimura, Y. Kitamura, T. Inoue, Y. Umesono, S. Sano, K. Yoshimoto, M. Inden, K. Takata, T. Taniguchi, S. Shimohama, K. Agata
  • Journal Title: Dev. Neurobiol. 67 Pages: 1059-1078
  • Peer Reviewed
• [Journal Article] Regeneration-dependent conditional gene knockdown (Readyknock) in planarian: Demonstration of requirement for Djsnap-25 expression in the brain for negative phototactic behavior. (2007)
  • Author(s): T. Takano, J. Pulvers, T. Inoue, H. Tarui, H. Sakamoto, K. Agata, Y. Umesono
  • Journal Title: Dev. Growth Differ. 49 Pages: 383-394
  • Peer Reviewed
• [Journal Article] Unifying principles of regeneration I: epimorphosis versus morphallaxis. (2007)
  • Author(s): K. Agata, Y. Saito, E. Nakajima
  • Journal Title: Dev. Growth Differ. 49 Pages: 73-78
  • Peer Reviewed
• [Journal Article] Clathrin-mediated endocytic signals are required for the regeneration of, as homeostasis in, the planarian CNS (2007)
  • Author(s): Takeshi Inoue, Tetsutaro Hayashi, Katusaki Takechi and Kiyokazu Agata
  • Journal Title: Devolopment 134 Pages: 1679-1689
  • Peer Reviewed
• [Journal Article] Reconstruction of Dopaminergic Neurl Natwork and Locomotion Function in Planarian Regenerates (2007)
  • Author(s): Kaneyasu Nishimura, Yoshihisa Kitamura, Takeshi Inoue, Yoshihiko Umesono, Shozo Sano, Kanji Yoshimoto, Masatoshi Inden, Kazuyuki Takata, Takashi Taniguchi, Shun Shimohama, Kiyokazu Agata
  • Journal Title: Developmental Neurobiology 67 Pages: 1059-1078
  • Peer Reviewed
• [Journal Article] Regeneration-dependent conditional gene knockdown (Readyknock) in planarian: Demonstration of requirement for Djsnap-25 expression in the brain for negative phototactic behavior (2007)
  • Author(s): Tomomi Takano, Jeremy N. Pulvers, Takeshi Inoue, Hiroshi Tarui, Hiroshi Sakamoto, Kiyokazu Agata, and Yoshihiko Umesono
  • Journal Title: Develop. Growth Differ. 49 Pages: 383-394
  • Peer Reviewed
• [Journal Article] Wnt signaling is required for antero-posterior patterning of the planarian brain (2007)
  • Author(s): Chiyoko Kobayashi, Yumi Saito, Kazuya Ogawa, Kiyokazu Agata
  • Journal Title: Developmental Biology 306 Pages: 714-724
  • Peer Reviewed
• [Journal Article] Identification and distribution of tryptophan hydroxylase (TPH)-positive neurons in the planarian Dugesia japonica (2007)
  • Author(s): Kaneyasu Nishimura, Yoshihisa Kitamura, Takeshi Inoue, Yoshihiko Umesono, Kanji Yoshimoto, Kosei Takeuchi, Takashi Taniguchi, Kiyokazu Agata
  • Journal Title: Neuroscience Research 59 Pages: 101-106
  • Peer Reviewed
• [Journal Article] Characterization and categorization of fluorescence activated cell sorted planarian stem cells by ultrastructural analysis (2007)
  • Author(s): Sayaka Higuchi, Tetsutaro Hayashi, Isao Hori, Norito Shibata, Hiroshi Sakamoto and Kiyokazu Agata
  • Journal Title: Develop. Growth Differ. 49 Pages: 571-581
  • Peer Reviewed
• [Journal Article] DjCBC-1, a Conserved DEAD Box RNA Helicase of the RCK/p54/Me31B Family, Is a Component of RNA-Protein Complexes in Planarian Stem Cells and Neurons (2007)
  • Author(s): Maki Yoshida-Kashikawa, Norito Shibata, Katsuaki Takechi, and Kiyokazu Agata
  • Journal Title: Developmental Dynamics 236 Pages: 3436-3450
  • Peer Reviewed
• [Journal Article] Two different evolutionary origins of stem cell systems and their molecular basis (2006)
  • Author(s): K. Agata, E. Nakajima, N. Funayama, N. Shibata, Y. Saito, Y. Umesno
  • Journal Title: Semin. Cell Dev. Biol. 17 Pages: 503-509
  • Peer Reviewed
• [Journal Article] Structure and function of primitive immunoglobulin superfamily neural cell adhesion molecules: a lesson from studies on planarian (2006)
  • Author(s): E. Fusaoka, T. Inoue, K. Mineta, K. Agata, K. Takeuchi
  • Journal Title: Genes to Cells 11 Pages: 541-555
  • Peer Reviewed
• [Journal Article] Isolation of planarian X-ray-sensitive stem cells by fluorescence-activated cell sorting (2006)
  • Author(s): T. Hayashi, M. Asami, S. Higuchi, N. Shibata, K. Agata
  • Journal Title: Dev. Growth Differ. 48 Pages: 371-379
• [Journal Article] Isolation of planarian X-ray-sensitive stem cells by fluorescence-activated cell sorting (2006)
  • Author(s): T.Hayashi, M.Asami, S.Higuchi, N.Shibata, K.Agata
  • Journal Title: Dev.Growth Differ. 48 Pages: 371-379
• [Journal Article] Two different evolutionary origins of stem cell systems and their molecular basis (2006)
  • Author(s): K.Agata, E.Nakajima, N.Funayama, N.Shibata, Y.Saito, Y.Umesono
  • Journal Title: Seminars in Cell ＆ Developmental Biology 17 Pages: 503-509
• [Journal Article] Structure and function of primitive immunoglobulin superfamily neural cell adhesion molecules : a lesson from studies on planarian (2006)
  • Author(s): E.Fusaoka, T.Inoue, K.Mineta, K.Agata, K.Takeuchi
  • Journal Title: Genes to Cells 11 Pages: 541-555
• [Journal Article] Unifying principles of regeneration I : epimorphosis versus morphallaxis (2006)
  • Author(s): K.Agata, Y.Saito, E.Nakajima
  • Journal Title: Dev.Growth Differ. 49 Pages: 77-78
• [Journal Article] Neural projections in planarian brain revealed by fluorescent dye tracing. (2005)
  • Author(s): K. Okamoto, K. Takeuchi, K. Agata
  • Journal Title: Zool. Sci. 22 Pages: 535-546
  • Peer Reviewed
• [Journal Article] Isolation of Ef silicatein and Ef lectin as Molecular Markers for Sclerocytes and Cells Involved in Innate Immunity in the Freshwater Sponge Ephydatia fluviatilis. (2005)
  • Author(s): Noriko Funayama, Mikiko Nakatsukasa, Shigehiro Kuraku, Katsuaki Takechi, Mikako Dohi, Naoyuki Iwabe, Takashi Miyata, Kiyokazu Agata
  • Journal Title: Zoological Science 22 Pages: 1113-1122
• [Journal Article] Isolation of the choanocyte in the fresh water sponge, Ephydatia fluviatilis and its lineage marker, Ef annexin. (2005)
  • Author(s): Noriko Funayama, Mikiko Nakatsukasa, Tetsutaro Hayashi, Kiyokazu Agata
  • Journal Title: Development, Growth ＆ Differentiation 47 Pages: 243-253
• [Journal Article] Neural Projection in Planarian Brain Revealed by Fluorescent Dye Tracing. (2005)
  • Author(s): Keiji Okamoto, Kosei Takeuchi, Kiyokazu Agata
  • Journal Title: Zoological Science 22 Pages: 535-546
• [Presentation] プラナリアおよびイモリの脳におけるドパミン神経再生機構に関する研究 (2010)
  • Author(s): Kaneyash Nishimura, Takeshi Inoue, Yoshihisa Kitamura, Kiyokazu Agata
  • Organizer: 第4回神経発生討論会
  • Place of Presentation: 岡崎市・岡崎コンファレンスセンター
  • Year and Date: 2010-03-19
• [Presentation] プラナリアにおけるアセチルコリン神経が制御する運動機能の解析 (2010)
  • Author(s): Kaneyash Nishimura, Yoshihisa Kitamura, Takashi Taniguchi, Kiyokazu Agata
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪市・大阪国際会議場
  • Year and Date: 2010-03-18
• [Presentation] Analysis of the molecular machanisms and neural network required for the photosensing behavior in planarian/プラナリアの走光性行動に関わる分子機構および神経回路の解析 (2009)
  • Author(s): Takeshi Inoue, Taiga Yamashita, Tomomi Takano, Kaneyasu Nishimura, Manami Fushiki, Kiyokazu Agata
  • Organizer: 日本分子生物学会第32回年会
  • Place of Presentation: 横浜市・パシフィコ横浜
  • Year and Date: 2009-12-12
• [Presentation] Integrated behavioral analysis and molecular analysis in planaria (2009)
  • Author(s): Taiga Yamashita, Takeshi Inoue, Kaneyasu Nishimura, Clement Lamy, Kiyokazu Agata
  • Organizer: 日本分子生物学会第32回年会
  • Place of Presentation: 横浜市・パシフィコ横浜
  • Year and Date: 2009-12-12
• [Presentation] Clarification of StemCell Reguratory Mechanism by piwi in Planarian/プラナリアでの piwi による全能性幹細胞の分化制御機構の解明 (2009)
  • Author(s): Taisuke Ishiko, Norito Shibata, Osamu Nishimura, Labib Rouhana, Kuniaki Saito, Mikiko Shiomi, Haruhiko Shiomi, Kiyokazu Agata
  • Organizer: 日本分子生物学会第32回年会
  • Place of Presentation: 横浜市・パシフィコ横浜
  • Year and Date: 2009-12-09
• [Presentation] Analysis of P2X mediated molecilar mechanism of mitotic control in planarian stem cell/P2Xを介したプラナリア幹細胞の分子的増殖制御機構の解析 (2009)
  • Author(s): Toshihide Sakurai, Norito Shibata, Kiyokazu Agata
  • Organizer: 日本分子生物学会第32回年会
  • Place of Presentation: 横浜市・パシフィコ横浜
  • Year and Date: 2009-12-09
• [Presentation] Regeneration in planarian (2009)
  • Author(s): K. Agata
  • Organizer: Frontiers in Stem Cells and Regeneration Advanced Training Course
  • Place of Presentation: Woods Hole, USA
  • Year and Date: 2009-10-07
• [Presentation] Regeneration in Planaria (2009)
  • Author(s): Kiyokazu Agata
  • Organizer: Frontiers in Stem Cells Regeneration Advanced Training Courese
  • Place of Presentation: Woods Hole, MA U.S.A.
  • Year and Date: 2009-10-07
• [Presentation] プラナリア脳におけるドパミン神経新生機序の解析 (2009)
  • Author(s): Kaneyash Nishimura, Takeshi Inoue, Yoshihisa Kitamura, Kanji Yoshimoto, Hiroshi Ikegaya, Takashi Taniguchi, Kiyokazu Agata
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋市・名古屋国際会議場
  • Year and Date: 2009-09-16
• [Presentation] Analysis of genes involved on post-transcriptional regulation of gene expression in planarians (2009)
  • Author(s): Labib Rouhana, Kiyokazu Agata
  • Organizer: 16th International Society of Devlopmental Biologists Congress 2009
  • Place of Presentation: Edinburgh, Scotland, UK
  • Year and Date: 2009-09-09
• [Presentation] Cellular and molecular dynamics of stem cell differentation during planarian regeneration (2009)
  • Author(s): Junichi Tasaki, Yoshihiko Umesono, Norito Shibata, Kazu Itomi, Osamu Nishimura, Yoshimichi Tabata, Fuyan Son, Nobuko Suzuki, Ryoko Araki, Masumi Abe, Kiyokazu Agata
  • Organizer: 16th International Society of Devlopmental Biologists Congress 2009
  • Place of Presentation: Edinburgh, Scotland, UK
  • Year and Date: 2009-09-09
• [Presentation] Molecular cascades along cell commitment to differentiation of pluripotent adult somatic stem cells in planarian, D.japonica (2009)
  • Author(s): Norito Shibata, Tetsutaro Hayashi, Max Brueck, Reiko Amikura, Satoru Kobayashi, Osamu Nishimura, Hiroshi Tarui, Kiyokazu Agata
  • Organizer: 42th Annual Meeting for the Japanese Society of Developmental Biologists
  • Place of Presentation: 新潟市・朱鷺メッセ
  • Year and Date: 2009-05-30
• [Presentation] Requirement for Lim-homeobox gene(DjlimA)activity for proper morphologic events from the middle stage of planarian regeneration (2009)
  • Author(s): Tetsutaro Hayashi, Minako Motoishi, Asuka Momiyama, Kazu Itomi, Chiharu Tanegashima, Kiyokazu Agata, Hiroshi Tarui
  • Organizer: 42th Annual Meeting for the Japanese Society of Developmental Biologists
  • Place of Presentation: 新潟市・朱鷺メッセ
  • Year and Date: 2009-05-30
• [Presentation] Molecular basis of anterior-posterior patterning during planarian regeneration (2009)
  • Author(s): Yoshihiko Umesono, Junichi Tasaki, Kazu Itomi, Yoshimichi Tabata, Fuyan Son, Nobuko Suzuki, Ryoko Araki, Masumi Abe, Kiyokazu Agata
  • Organizer: 42th Annual Meeting for the Japanese Society of Developmental Biologists
  • Place of Presentation: 新潟市・朱鷺メッセ
  • Year and Date: 2009-05-29
• [Presentation] Genome Analysis of the Planaria Schmidtea mediterranea sheds light into the evolution of 7-transmembrane receptors in metazoans (2009)
  • Author(s): Clement Lamy, Osamu Nishimura, Eric Bobb, Sofia Ross, Alejandro Sanchez Alvarado, Kiyokazu Agata
  • Organizer: 42th Annual Meeting for the Japanese Society of evelopmental Biologists
  • Place of Presentation: 新潟市・朱鷺メッセ
  • Year and Date: 2009-05-29
• [Presentation] Cloning and expression of piwi-and vasa-related genes in the triclads Polycelis auriculata and Phagocata kawakatsui (2009)
  • Author(s): Martina Hrouda, Shigenobu Yzawa, Norito Shibata, Kiyokazu Agata
  • Organizer: 42th Annual Meeting for the Japanese Society of Developmental Biologists
  • Place of Presentation: 新潟市・朱鷺メッセ
  • Year and Date: 2009-05-29
• [Presentation] Cellular and molecular dynamics of stem cell differentiation during planarian regeneration (2009)
  • Author(s): Junichi Tasaki, Yoshihiko Umesono, Norito Shibata, Kazu Itomi, Osamu Nishimura, Yoshimichi Tabata, Fuyan Son, Nobuko Suzuki, Ryoko Araki, Masumi Abe, Kiyokazu Agata
  • Organizer: 42th Annual Meeting for the Japanese Society of Developmental Biologists
  • Place of Presentation: 新潟市・朱鷺メッセ
  • Year and Date: 2009-05-28
• [Presentation] Brain regeneration from pluripotent stem cells in planarian German (2009)
  • Author(s): K. Agata
  • Organizer: Dev. Biol. Meeting
  • Place of Presentation: Hannover Germany
  • Year and Date: 2009-03-28
• [Presentation] Brain regeneration from pluripotent stem cells in planarian (2009)
  • Author(s): Kiyokazu Agata
  • Organizer: 18th Annual Meeting of German Devel. Biol. Society
  • Place of Presentation: Hannover Gamany
  • Year and Date: 2009-03-28
• [Presentation] プラナリアにおけるGABA神経・ドパミン神経の機能比較 (2009)
  • Author(s): 西村周泰, 北村佳久, 谷口隆之, 阿形清和
  • Organizer: 第82回日本薬理学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-03-16
• [Presentation] ニワトリ胚微小環境内のおけるマウスES細胞由来神経管様構造の移植解析 (2008)
  • Author(s): 芹澤崇, 岡崎賢二, 阿形清和
  • Organizer: Biochemistry and Molecular Biology 2008
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2008-12-11
• [Presentation] プラナリア視神経再生における軸索ガイダンスの分子機構 (2008)
  • Author(s): 山本寛, 阿形清和
  • Organizer: Biochemistry and Molecular Biology 2008
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2008-12-10
• [Presentation] Evolution of the Complex Breain by Increasing Cellular Com When was the Neuralv Stem Cell System First Established? (2008)
  • Author(s): Kiyokazu Agata
  • Organizer: The 8th NIBB-EMBL Joint Meeting Evolution: Genomes, Cell Types and Shapes
  • Place of Presentation: 基礎生物学研究所
  • Year and Date: 2008-11-23
• [Presentation] Maintenance and regulation of planarian pluripotent stem cells (2008)
  • Author(s): K. Agata
  • Organizer: 23th Naito Conference
  • Place of Presentation: Shonan Village Centaer, Kanagawa Japan
  • Year and Date: 2008-11-12
• [Presentation] Maintenance and Regulation of Planarian Pluripotent Stem Cells (2008)
  • Author(s): Kiyokazu Agata
  • Organizer: 内藤シンポジウムMolecular Basis for Maintenance and Differentiation of Stem Cells[III]
  • Place of Presentation: 湘南ビレッジセンター
  • Year and Date: 2008-11-12
• [Presentation] 僕らはプラナリアから何を学び、学ぶのかーブレイクスルーはモデル生物選びからー (2008)
  • Author(s): 阿形清和
  • Organizer: 生化学若い研究者の会
  • Place of Presentation: 京大会館
  • Year and Date: 2008-11-02
• [Presentation] プラナリアの脳の再生・成長過程における各種神経細胞の変化 (2008)
  • Author(s): 竹田啓行, 西村周泰, 阿形清和
  • Organizer: 日本動物学会第79回大会
  • Place of Presentation: 福岡大学七隈キャンパス
  • Year and Date: 2008-09-07
• [Presentation] プラナリアにおけるドパミン・セロトニン・GABAの機能および局在分布の比較研究 (2008)
  • Author(s): 西村周泰, 北村佳久, 谷口隆之, 阿形清和
  • Organizer: 日本動物学会第79回大会
  • Place of Presentation: 福岡大学七隈キャンパス
  • Year and Date: 2008-09-07
• [Presentation] プラナリア生物学の新展開 (2008)
  • Author(s): 阿形清和
  • Organizer: 日本動物学会第79回大会<第11回ホメオスタシス研究会>
  • Place of Presentation: 福岡大学七隈キャンパス
  • Year and Date: 2008-09-05
• [Presentation] Stem Cells and Regeneration (2008)
  • Author(s): 阿形清和
  • Organizer: 日本発生生物学会第41回大会
  • Place of Presentation: 徳島県郷土文化会館
  • Year and Date: 2008-05-28
• [Presentation] 再生を科学する-プラナリアの再生からiPS細胞まで (2008)
  • Author(s): 阿形 清和
  • Organizer: 新適塾「進化する再生医学」
  • Place of Presentation: 千里サイエンスセンタービル
  • Year and Date: 2008-02-08
• [Presentation] Regenerating chemosensation in the planaria Dugesia japonica (2008)
  • Author(s): Clement Lamy, Kiyokazu Agata
  • Organizer: 日本発生生物学会第41回大会
  • Place of Presentation: 徳島県郷土文化会館
• [Presentation] Contribution of Lim-homeobox gene to organization of planarian CNS (2008)
  • Author(s): Tetsutaro Hayashi, Osamu Nishimura, Jeremy Pulvers, Kiyokazu Agata, Hiroshi Tarui
  • Organizer: 日本発生生物学会第41回大会
  • Place of Presentation: 徳島県郷土文化会館
• [Presentation] Photostimulation-dependent upregulation of 1020HH gene expression during planarian brain regeneration (2008)
  • Author(s): Tomomi Takano, Yoahihiko Umesono, Tetsutaro Hayashi, Hiroshi Tarui, Shigeru Kuratani, Kiyokazu Agata
  • Organizer: 日本発生生物学会第41回大会
  • Place of Presentation: 徳島県郷土文化会館
• [Presentation] Molecular dissection of the early steps of planarian regeneration (2008)
  • Author(s): Tasaki Junichi, Umesono Yoshihiko, Itomi Kazu, Nishimura Osamu, Tabata Yoshimichi, Son Fuyan, Suzuki Nobuko, Araki Ryoko, Abe Masumi, Agata Kiyokazu
  • Organizer: 日本発生生物学会第41回大会
  • Place of Presentation: 徳島県郷土文化会館
• [Presentation] 再生メカニズムと幹細胞システムの理解に貢献するプラナリア (2007)
  • Author(s): 阿形 清和
  • Organizer: BMB2007第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-12-13
• [Presentation] Heterogeneity of planarian stem cells (2007)
  • Author(s): 柴田 典人
  • Organizer: BMB2007第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-12-11
• [Presentation] Brain regeneration from pluripotent stem cells in planarian (2007)
  • Author(s): K. Agata
  • Organizer: Biology Seminar
  • Place of Presentation: UC Berkeley USA
  • Year and Date: 2007-10-31
• [Presentation] 有性生殖と無性生殖の両方を支える幹細胞システム (2007)
  • Author(s): 阿形 清和
  • Organizer: 第4回自然科学研究機構シンポジウム
  • Place of Presentation: 東京国際ファーラムホール
  • Year and Date: 2007-09-23
• [Presentation] プラナリアの脳形成を制御している遺伝子プログラム (2007)
  • Author(s): 梅園 良彦
  • Organizer: 日本進化学会第9回京都大会
  • Place of Presentation: 京都大学吉田キャンパス
  • Year and Date: 2007-09-02
• [Presentation] プラナリアの再生過程におけるパターン形成を司る分子基盤 (2007)
  • Author(s): 梅園 良彦
  • Organizer: 第40回日本発生生物学会・第59回日本細胞生物学会合同大会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2007-05-30
• [Presentation] プラナリアの再生メカニズム (2007)
  • Author(s): 阿形 清和
  • Organizer: 日本分子生物学会第7回春季シンポジウム・市民講座
  • Place of Presentation: 徳島大学 長井記念ホール
  • Year and Date: 2007-04-22
• [Book] Brain and Neural Networks (2009)
  • Author(s): Kaneyasu Nishimura, Hiroshi Yamamoto, Kiyokazu Agata, Yoshihisa Kitamura
  • Total Pages: 9
  • Publisher: Landes Bioscience
• [Book] Planaria: A Model for Drug Action and Abuse (Brain and neural networks) (2008)
  • Author(s): K. Nishimura, H. Yamamoto, Y. Kitamura, K. Agata
  • Total Pages: 12
  • Publisher: LANDES BIOSCIENCE
• [Book] Stem Cells: From Hydra To Man (Stem cells in planarian.) (2008)
  • Author(s): K. Agata
  • Publisher: Springer
• [Book] Planarian nervous system (2008)
  • Author(s): H. Takeda, K. Nishimura, K. Agata
  • Total Pages: 5558
  • Publisher: Scholarpedia
• [Book] BRAIN and NERVE第60巻 第4号 (2008)
  • Author(s): 西村周泰, 北村佳久, 阿形清和
  • Total Pages: 11
  • Publisher: 医学書院
• [Book] Planarian nervous system (2008)
  • Author(s): Hiroyuki Takeda, Kaneyasu Nishimura, Kiyokazu Agata
  • Total Pages: 9
  • Publisher: Scholarpedia
• [Book] Stem cells in planarian (2008)
  • Author(s): Kiyokazu Agata
  • Total Pages: 17
  • Publisher: Springer
• [Remarks]
  • URL: http://mbd.biophys.kyoto-u.ac.jp
• [Remarks]
  • URL: http://mdb.biophys.kyoto-u.ac.jp/