Biomedical Application of Gas Biology through Multidisciplinary Approaches

• Project/Area Number: 17GS0419
• Research Category: Grant-in-Aid for Creative Scientific Research
• Allocation Type: Single-year Grants
• Research Institution: Keio University
• Principal Investigator: SUEMATSU Makoto Keio University, 医学部, 教授 (00206385)
• Co-Investigator(Kenkyū-buntansha): SAITOU Masao 東北大学, 多元物質研究所, 教授 (70302239) ; SOGA Tomoyoshi 慶應義塾大学, 環境情報学部, 教授 (60338217) ; HIRAO Atsushi 金沢大学, がん研究所, 教授 (90343350) ; TANAKA Hirotoshi 東京大学, 医科学研究所, 准教授 (00171794) ; 足立 健 慶應義塾大学, 医学部, 准教授 (50231931)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥331,110,000 (Direct Cost: ¥254,700,000、Indirect Cost: ¥76,410,000); Fiscal Year 2009: ¥64,350,000 (Direct Cost: ¥49,500,000、Indirect Cost: ¥14,850,000); Fiscal Year 2008: ¥64,350,000 (Direct Cost: ¥49,500,000、Indirect Cost: ¥14,850,000); Fiscal Year 2007: ¥64,350,000 (Direct Cost: ¥49,500,000、Indirect Cost: ¥14,850,000); Fiscal Year 2006: ¥64,350,000 (Direct Cost: ¥49,500,000、Indirect Cost: ¥14,850,000); Fiscal Year 2005: ¥73,710,000 (Direct Cost: ¥56,700,000、Indirect Cost: ¥17,010,000)
• Keywords: 一酸化炭素 / ガスバイオロジー / 酸素センサー / メタボローム / cytochrome oxidase / 構造生物学 / ミトコンドリア / Hypoxia inducible factor / 生体情報工学 / グルタチオン / 一酸化窒素

Research Abstract

The multiplicity of gas actions and gas targets and the difficulty in measuring local gas concentrations obscures detailed mechanisms whereby gases exert their actions, and many questions remain unanswered. In this project, advanced mass spectrometry combined with high-performance computer technology allowed us to mine biological mechanisms for gas-responsive signal transducing systems. We also take an integrated approach to the interaction of gases by considering the physiological significance of CO, NO, and H2S on metabolic systems and energy-supporting enzyme systems including cytochrome c oxidase, a key target and central mediator of mitochondrial respiration. By evaluating gas-mediated control functions from both in vitro and in vivo perspectives, we attempted to elaborate on the complex multiple interactions of O(2), NO, CO, and H2S

Research Products

• [Journal Article] Regulation of the HIF-1α level is essential for hematopoietic stem cells. (2010)
  • Author(s): Takubo K, Goda N, Yamada W, Ikeda E Kubota Y, Shima H Johnson RS, Hirao A, Suematsu M, Suda T
  • Journal Title: Cell Stem Cell (in press)
• [Journal Article] Paradoxical ATP elevation in ischemic penumbra revealed by quantitative imaging mass spectrometry. (2010)
  • Author(s): Hattori K, Kajimura M, Nakanishi T, Fujiwake H, Ogawa K, Nagahata Y, Hishiki T, Kubo A, Setou M, Suematsu M
  • Journal Title: Antioxid Redox Signal (In press)
• [Journal Article] von Hippel-Lindau protein regulates transition from fetal to adult circulatory system in retina. (2010)
  • Author(s): Kurihara T, Kubota Y, Ozawa Y, Takubo K, Noda K, M. Simon C, Johnson RS, Suematsu M, Tsubota K, Ishida S, Goda N, Suda T, Okano H
  • Journal Title: Development 137(9) Pages: 1563-1571
• [Journal Article] Interactions of multiple gas-transducing systems: Hallmarks and uncertainties of CO, NO and H2S gas biology. (2010)
  • Author(s): Kajimura M, Fukuda R, Bateman RM, Yamamoto T, Suematsu M
  • Journal Title: Antioxid Redox Signal (In press)
• [Journal Article] TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia. (2010)
  • Author(s): Naka K, Hoshii T, Muraguchi T, Tadokoro Y, Ooshio T, Kondo Y, Nakao S, Motoyama N, Hirao A
  • Journal Title: Nature 463 Pages: 676-680
• [Journal Article] Hypotaurine is an energy-saving hepatoprotective compound against ischemia-reperfusion injury of the rat liver (2010)
  • Author(s): Sakuragawa T, Hishiki T, Ueno Y, Ikeda S, Soga T, Yachie-Kinoshita A, Kajimura M, Suematsu M.
  • Journal Title: J Clin Biochem Nutr 46(2) Pages: 126-134
  • NAID: 130004466603
  • Peer Reviewed
• [Journal Article] von Hippel-Lindau protein regulates transition from fetal to adult circulatory system in retina (2010)
  • Author(s): Kurihara T, Kubota Y, Ozawa Y, Takubo K, Noda K, M.Simon C, Johnson RS, Suematsu M, Tsubota K, Ishida S, Goda N, Suda T, Okano H.
  • Journal Title: Development (in press)
  • Peer Reviewed
• [Journal Article] Interactions of multiple gas-transducing systems : Hallmarks and uncertainties of CO, NO and H_2S gas biology (2010)
  • Author(s): Kajimura M, Fukuda R, Bateman RM, Yamamoto T, Suematsu M.
  • Journal Title: Antioxid. Redox Signal. (In press(Invited review))
  • Peer Reviewed
• [Journal Article] Phosphorescence-assisted microvascular O_2 measurements reveal alterations of oxygen demand in human metastatic colan cancer in the liver of superimmunodeficient NOG mice (2010)
  • Author(s): Handa K, Ohmura M, Nishime C, Hishiki T, Nagahata Y, Kawai K, Suemizu H, Nakamura M, Wakui M, Kitagawa Y, Suematsu M, Tsukada K.
  • Journal Title: Adv Exp Med Biol. 662 Pages: 423-429
  • Peer Reviewed
• [Journal Article] T-state stabilization of hemoglobin by nitric oxide to form α-nitrosyl heme causes constitutive release of ATP from human erythrocytes (2010)
  • Author(s): Akatsu T, Tsukada K, Hishiki T, Suga-Numa K, Tanabe M, Shimazu M, Kitagawa Y, Yachie-Kinoshita A, Suematsu M.
  • Journal Title: Adv Exp Med Biol. 662 Pages: 109-114
  • Peer Reviewed
• [Journal Article] Assessing a shift of glucose biotransformation by LC-MS/MS-based metabolome analysis in carbon monoxide-exposed cells (2010)
  • Author(s): Takano N, Yamamoto T, Adachi T, Suematsu M.
  • Journal Title: Adv Exp Med Biol. 662 Pages: 101-107
  • Peer Reviewed
• [Journal Article] The Effects of cilostazol on tissue oxygenation upon an ischemic-reperfusion injury in the mouse cerebrum (2010)
  • Author(s): Morikawa T, Hattori K, Kajimura M, Suematsu M.
  • Journal Title: Adv Exp Med Biol. 662 Pages: 89-94
  • Peer Reviewed
• [Journal Article] Fenofibrate, a peroxisome proliferator-activated receptor α agonist, improves hepatic microcirculatory patency and oxygen availability in a high-fat-diet-induced fatty liver in mice (2010)
  • Author(s): Kondo K, Sugioka T, Tsukada K, Aizawa M, Takizawa M, Shimizu K, Morimoto M, Suematsu M, Goda N.
  • Journal Title: Adv Exp Med Biol. 662 Pages: 77-82
  • Peer Reviewed
• [Journal Article] Cytotoxic effect of amide derivatives of trifluoromethionine a gainst the enteric protozoan parasite Entamoeba histolytica (2010)
  • Author(s): Sato D, Kobayashi S, Yasui H, Shibata N, Toru T, Yamamoto M, Tokoro G, Ali V, Soga T, Takeuchi T, Suematsu M, Nozaki T.
  • Journal Title: Int J Antimicrob Agents 35(1) Pages: 56-61
  • Peer Reviewed
• [Journal Article] Tubulointerstitial nephritis antigen-like 1 is expressed in extraembryonic tissues and interacts with laminin 1 in the reichert membrane at postimplantation in the mouse (2010)
  • Author(s): Tajiri Y, Igarashi T, Li D, Mukai K, Suematsu M, Fukui E, Yoshizawa M, Matsumoto H.
  • Journal Title: Biol Reprod 82(2) Pages: 263-270
  • Peer Reviewed
• [Journal Article] Metabolic remodeling induced by mitochondrial aldehyde stress stimulates tolerance to oxidative stress in the heart. (2009)
  • Author(s): Endo J, Sano M, Katayama T, Hishiki T, Shinmura K, Morizane S, Matsuhashi T, Katsumata Y, Zhang Y, Ito H, Nagahata Y, Marchitti S, Nishimaki K, Wolf AM, Nakanishi H, Hattori F, Vasiliou V, Adachi T, Ohsawa I, Taguchi R, Hirabayashi Y, Ohta S, Suematsu M, Endo J, Sano M, K
  • Journal Title: Circ Res 105(11) Pages: 1118-1127
• [Journal Article] Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin. (2009)
  • Author(s): Tamase A, Muraguchi T, Naka K, Tanaka S, Kinoshita M, Hoshii T, Ohmura M, Shugo H, Ooshio T, Nakada M, Sawamoto K, Onodera M, Matsumoto K, Oshima M, Asano M, Saya H, Okano H, Suda T, Hamada JI, Hirao A
  • Journal Title: Proc Natl Acad Sci U S A. 106 Pages: 17163-17168
• [Journal Article] Measurement of Internal Body Time by Blood Metabolomics. (2009)
  • Author(s): Minami, Y., Kasukawa, T., Kakazu, Y., Iigo, M., Sugimoto, M., Ikeda, S., Yasui, A., van der Horst, G., Soga, T., Ueda, H.
  • Journal Title: Proc. Natl. Acad. Sci. USA 106 Pages: 9890-9895
• [Journal Article] Ligand-based gene expression profiling identifies critical role of glucocorticoid receptor in rat neonatal cardiomyocytes. (2009)
  • Author(s): Yoshikawa N, Nagasaki M, Sano M, Tokudome S, Ueno K, Shimizu N, Imoto S, Miyano S, Suematsu M, Fukuda K, Morimoto C, Tanaka H
  • Journal Title: Am J Physiol Endocrinol Metab 296(6)
• [Journal Article] Quantitative Metabolome Profiling of Colon and Stomach Cancer Microenvironment by Capillary Electrophoresis Time-of-flight Mass Spectrometry. (2009)
  • Author(s): Hirayama, A., Kami, K., Sugimoto, M., Sugawara, M., Toki, N., Onozuka, H., Kinoshita, T., Saito, N., Ochiai, A., Tomita, M., Esumi, H., *Soga, T.
  • Journal Title: Cancer Res 69 Pages: 4918-4925
• [Journal Article] Metabolomic Profiling of Anionic Metabolites by Capillary Electrophoresis Mass Spectrometry. (2009)
  • Author(s): Soga, T., Igarashi, K., Itoh, C., Mizobuchi, K., Zimmermann, H., Tomita, M.
  • Journal Title: Anal. Chem 81 Pages: 6165-6174
• [Journal Article] Metabolite profiling reveals YihU as a novel hydroxybutyrate dehydrogenase for alternative succinic semialdehyde metabolism in Escherichia coli. (2009)
  • Author(s): Saito, N., Robert, M., Kochi, H., Matsuo, G., Kakazu, Y., Soga, T., Tomita, M.
  • Journal Title: J. Biol. Chem. 109 Pages: 16442-16451
• [Journal Article] Rescue of anemia and autoimmune responses in SOD1-deficient mice by transgenic expression of human SOD1 in erythrocytes. (2009)
  • Author(s): Iuchi, Y., Okada, F., Takamiya, R., Kibe, N., Tsunoda, S., Nakajima, O., Toyoda, K., Nagae, R., Suematsu, M., Soga, T., Uchida, K., Fujii, J.
  • Journal Title: Biochem. J 422 Pages: 313-320
• [Journal Article] HIF-1α is necessary to support gluconeogenesis during liver regeneration Biochem. Biophys. (2009)
  • Author(s): Tajima, T., Goda, N., Fujiki, N., Hishiki, T., Nishiyama, Y., Senoo-Matsuda, N., Shimazu, M., Soga, T., Yoshimura, Y., Johnson, R.S., Suematsu, M.
  • Journal Title: Biochem. Biophys. Res. Commun. 387 Pages: 789-794
• [Journal Article] Mono-(2-ethylhexyl) phthalate Targets Glycogen Debranching Enzyme and Affects Glycogen Metabolism in Rat Testis. (2009)
  • Author(s): Kuramori, C., Hase, Y., Hoshikawa, K., Watanabe, K., Nishi, T., Hishiki, T., Soga, T., Nashimoto, A., Kabe, Y., Yamaguchi, Y., Watanabe, H., Kataoka, K., Suematsu, M., Handa, H.
  • Journal Title: Toxicol. Sci 109 Pages: 143-151
• [Journal Article] Cystathionine β-synthase as a Carbon Monoxide-sensitive Regulator of Bile Excretion. (2009)
  • Author(s): Shintani, T., Iwabuchi, T., Soga, T., Kato, Y., Yamamoto, T., Takano, N., Hishiki, T., Ueno, Y., Ikeda, S., Sakurakawa, T., Ishikawa, K., Goda, N., Yitagawa, Y., Kajiyama, M., Matsumoto, K., Suematsu, M.
  • Journal Title: Hepatology 49 Pages: 141-150
• [Journal Article] Rapid and reversible inhibition of aquaporin-4 by zinc (2009)
  • Author(s): Yukutake Y, Hirano Y, Suematsu M, Yasui M.
  • Journal Title: Biochemistry 48(51) Pages: 12059-12061
  • Peer Reviewed
• [Journal Article] Metabolic remodeling induced by mitochondrial aldehyde stress stimulates tolerance to oxidative stress in the heart (2009)
  • Author(s): Endo J, Sano M, Katayama T, Hishiki T, Shinmura K, Morizane S, Matsuhashi T, Katsumata Y, Zhang Y, Ito H, Nagahata Y, Marchitti S, Nishimaki K, Wolf AM, Nakanishi H, Hattori F, Vasiliou V, Adachi T, Ohsawa I, Taguchi R, Hirabayashi Y, Ohta S, Suematsu M, Ogawa S, Fukuda K.
  • Journal Title: Circ Res 105(11) Pages: 1118-27
  • Peer Reviewed
• [Journal Article] Visualization of volatile substances in different organelles with an atmospheric-pressure mass microscope (2009)
  • Author(s): Harada T, Yuba-Kubo A, Sugiura Y, Zaima N, Hayasaka T, Goto-Inoue N, Wakui M, Suematsu M, Takeshita K, Ogawa K, Yoshida Y, Setou M.
  • Journal Title: Analyt Chem 81(21) Pages: 9153-9157
  • Peer Reviewed
• [Journal Article] Ligand-based gene expression profiling reveals novel roles of glucoc orticoid receptor in cardiac metabolism (2009)
  • Author(s): Yoshikawa N, Nagasaki M, Sano M, Tokudome S, Ueno K, Shimizu N, Imoto S, Miyano S, Suematsu M, Fukuda K, Morimoto C, Tanaka H.
  • Journal Title: Am J Physiol Endocrinol Metab 296
  • Peer Reviewed
• [Journal Article] In silico modeling and metabolome analysis of long-stored erythrocytes to improve blood storage methods (2009)
  • Author(s): Nishino T, Yachie-Kinoshita A, Hirayama A, Soga T, Suematsu M, Tomita M.
  • Journal Title: J Biotechnol 144(3) Pages: 212-223
  • Peer Reviewed
• [Journal Article] HIF-1α is necessary to support gluconeogenesis during liver regeneration (2009)
  • Author(s): Tajima T, Goda N, Fujiki N, Hishiki T, Nishiyama Y, Senoo-Matsuda N, Shimazu M, Soga T, Yoshimura Y, Johnson RS, Suematsu M.
  • Journal Title: Biochem Biophys Res Commun 387(4) Pages: 789-794
  • Peer Reviewed
• [Journal Article] Rescue of anemia and autoimmune responses in SOD1-deficient mice by transgenic expression of human SOD1 in eryth rocytes (2009)
  • Author(s): Iuchi Y, Okada F, Takamiya R, Kibe N, Tsunoda S, Nakajima O, Toyoda K, Nagae R, Suematsu M, Soga T, Uchida K, Fujii J.
  • Journal Title: Biochem J 422(2) Pages: 313-320
  • Peer Reviewed
• [Journal Article] Cystathionine β-synthase as a carbon monoxide-sensitive regulator of bile excretion (2009)
  • Author(s): Shintani, T., Iwabuchi, T., Soga, T., Kato, Y., Yamamoto, T., Takano, N., Hishiki, T., Ueno, Y., Ikeda, S., Sakuragawa, T., Ishikawa, K., Goda, N., Kitagawa, Y., Kajimura, M., Matsumoto, K., Suematsu, M.
  • Journal Title: Hepatology 49 Pages: 141-150
  • Peer Reviewed
• [Journal Article] Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nucleus (2009)
  • Author(s): Kuramori, C., Azuma, M., Kume, K., Kaneko, Y., Inoue, A., Yamaguchi, Y., Kabe, Y., Hosoya, T., Kizaki, M., Suematsu, M., Handa, H.
  • Journal Title: Biochem. Biophys. Res. Commun. (印刷中)
  • Peer Reviewed
• [Journal Article] Mono-(2-ethylhexyl) phthalate targets glycogen debranching enzyme and affects glycogen metabolism in rat testis (2009)
  • Author(s): Kuramori, C., Hase, Y., Hoshikawa, K., Watanabe, K., Nishi, T., Hishiki, T., Soga, T., Nashimoto, A., Kabe, Y., Yamaguchi, Y., Watanae, H., Kataoka, K., Suematsu. M., Handa, H.
  • Journal Title: Toxicol. Sci. (印刷中)
  • Peer Reviewed
• [Journal Article] The effects of cilostazol on tissue oxygenation upon anischemic-reperfusion injury in the mouse cerebrum (2009)
  • Author(s): Morikawa T., Hattori K., Kajimura M., Suematsu M
  • Journal Title: Advances in Experimental Medicine and Biology (印刷中)
  • Peer Reviewed
• [Journal Article] Identification of Stem Cells During Prepubertal Spermatogenesis Via Monitoring of Nucleostemin Promoter Activity. (2008)
  • Author(s): Ohmura M, Naka K, Hoshii T, Muraguchi T, Shugo H, Tamase A, Uema N, Ooshio T, Arai F, Takubo K, Nagamatsu G, Hamaguchi I, Takagi M, Ishihara M, Sakurada K, Miyaji H, Suda T, *Hirao A
  • Journal Title: Stem Cells 26 Pages: 3237-3246
• [Journal Article] Exacerbating Role of γδ T Cells in Chronic Colitis of T Cell Receptor αMutant Mice. (2008)
  • Author(s): Nanno, M., Kanari, Y., Naito, T., Inoue, N., Hisamatsu, T., Chinen, H., Sugimoto, K., Shimomura, Y., Yamagishi, H., Shiohara, T., Ueha, S., Matsushima, K., Suematsu, M., Mizoguchi, A., Hibi, T., Bhan, A.K., Ishikawa, H
  • Journal Title: Gastroenterology 134 Pages: 481-490
• [Journal Article] Genetic background conversion ameliorates semi-lethality and permits behavioral analyses in cystathionine beta-synthase-deficient mice, an animal model for hyperhomocysteinemia. (2008)
  • Author(s): Akahoshi N, Kobayashi C, Ishizaki Y, Izumi T, Himi T, Suematsu M, Ishii I
  • Journal Title: Hum. Mol. Genet 17 Pages: 1994-2005
• [Journal Article] Exacerbating role of γδ T cells in chronic colitis of T cell receptorα mutant mice (2008)
  • Author(s): Nanno, M., Kanari, Y., Naito, T., Inoue, N., Hisamatsu, T., Chinen, H., Sugimoto, K., Shimomura, Y., Yamagishi, H., Shiohara, T., Uehara, S., Matsushima, K., Suematsu. M., Mizoguchi A., Hibi, T., Bhan, A. K., Ishikawa H.
  • Journal Title: Gastroenterology 134 Pages: 481-490
  • Peer Reviewed
• [Journal Article] RORγt is dispensable for the development of intestinal mucosal T cells (2008)
  • Author(s): Naito, T., Shiohara, T., Hibi, T., Suematsu. M., Ishikawa, H.
  • Journal Title: Mucosal Immunology 1 Pages: 198-207
  • Peer Reviewed
• [Journal Article] Mercury chloride decreases the water permeability of aquapolin-4-reconstituted Droteoliposomes (2008)
  • Author(s): Yukutake, Y., Tsuji, S., Hirano, Y., Adachi, T., Takahashi, T., Fuiihara, K., Agre, P., Yasui, M., Suematsu, M.
  • Journal Title: Biol. Cell 100 Pages: 355-363
  • Peer Reviewed
• [Journal Article] Genetic background conversion ameliorates semi-lethality and permits behavioral analyses in cystathionine β-synthase-deficient mice, an animal model for hyperhomocystinemia (2008)
  • Author(s): Akahoshi, N., Kobayashi, C., Ishizaka, Y., Izumi, T., Himi, T., Suematsu, M., Ishii, I.
  • Journal Title: Hum. Mol. Genet. 17 Pages: 1994-2005
  • Peer Reviewed
• [Journal Article] Cytochrome P-450_<17α>in β-cells of rat pancreas and its local steroidogenesis (2008)
  • Author(s): Ogishima, T., Mitani, F., Suematsu. M.
  • Journal Title: J. Steroid Biochem. Mol. Biol. 111 Pages: 80-86
  • Peer Reviewed
• [Journal Article] Tissue- and context-dependent modulation of hormonal sensitivity of glucocorticoid-sensitive genes by HEXIM1 (2008)
  • Author(s): Shimizu, N., Yoshikawa, N. Wada, T., Handa, H., Sano, M., Fukuda, K., Suematsu, M., Sawai, T., Morimoto, C., Tanaka, H.
  • Journal Title: Mol. Endocrinol. 22 Pages: 2609-2623
  • Peer Reviewed
• [Journal Article] α-ketoglutarate oxidoreductase, an essential salvage enzyme of energy metabolism, in coccoid form of Helicobacter pylori. (2008)
  • Author(s): Tsugawa, H., Suzuki, H., Nakagawa, I., Nishizawa, T., Saito, Y., Suematsu. M., Hibi, T.
  • Journal Title: Biochem. Biophys. Res. Commun. 376 Pages: 46-51
  • Peer Reviewed
• [Journal Article] Establishment of a humanized model of liver using NOD/Shi-scid IL2R γ^<null> mice (2008)
  • Author(s): Suemizu, H., Hasegawa, M., Kawai, K., Taniguchi, K., Monnai, M., Wakui, M., Suematsu. M., Ito, M., Peltz, G., Nakamura, M.
  • Journal Title: Biochem. Biophys. Res. Commun. 377 Pages: 248-252
  • Peer Reviewed
• [Journal Article] Three-dimensional imaging of growing thrombus in vivo (2008)
  • Author(s): Morikawa T., Kajimura M, Ichikawa M., Suematsu M.
  • Journal Title: Microvascular Reviews and Communications 2 Pages: 8-12
  • NAID: 130004942918
  • Peer Reviewed
• [Journal Article] Exacerbating role of γδ T cells in chronic colitis T cell receptor α mutant mice. (2008)
  • Author(s): Nanno, M., Kanari, Y., Naito, T., Inoue, N., Hisamatsu, T., Chinen, H., Sugimoto, K., Shimomura, Y., Yamagishi, H., Shiohara, T., Uehara, S., Matsushima, K., Suematsu, M., Mizoguchi, A., Hibi, T., Bhan, A. K., Ishikawa, H.
  • Journal Title: Gastroenterology 134 Pages: 481-490
  • Peer Reviewed
• [Journal Article] Multiple Highthroughput Analyses Monitor The Response of E. coli to Perturbations" (2007)
  • Author(s): Ishii, N., Nakahigashi, K., Baba, T., Robert, M., Soga, T., Kanai, A., Hirasawa, T., Naba, M., Hirai, K., Hoque, A., Ho, P.Y., Kakazu, Y., Sugawara, K., Igarashi, S., Harada, S., Masuda, T., Sugiyama, N., Togashi, T., Hasegawa, M., Takai, Y., Yugi, K., AraIshii, N., Nakahigashi, K., Baba, T., Robert, M., Soga, T., Kanai, A., Hirasawa, T., Naba
  • Journal Title: Science 316 Pages: 593-597
• [Journal Article] A peptide bond provides unidirectional respiratory proton pumping in bovine cytochrome c oxidase. (2007)
  • Author(s): Shimokata K, Katayama Y, Murayama H, Suematsu M, Tsukihara T, Muramoto K, Yoshikawa S, Shimada H
  • Journal Title: Proc Natl Acad Sci USA 104(10) Pages: 4200-4205
• [Journal Article] Method for determination of association and dissociation rate constants of reversible biomolecular reactions by isothermal titration calorimeters. (2007)
  • Author(s): Egawa, T., Tsuneshige, A., Suematsu, M., Yonetani, T
  • Journal Title: Anal. Biochem 79(7) Pages: 2972-2978
• [Journal Article] Microvascular and systemic effects following top load administration of saturated carbon monoxide-saline solution. (2007)
  • Author(s): Hangai-Hoger, N., Tsai, A.G., Carbales, P., Suematsu, M., Intaglietta, M
  • Journal Title: Crit Care Med 35(4) Pages: 1123-1132
• [Journal Article] Roles of hemoglobin allostery in hypoxia-induced metabolic alterations in erythrocytes: simulation and its verification by metabolome analysis. (2007)
  • Author(s): Kinoshita, A., Tsukada, K., Soga, T., Hishiki, T., Ueno, Y., Nakayama, Y., Tomita, M., Suematsu, M.
  • Journal Title: J Biol Chem 282(14) Pages: 10731-10741
• [Journal Article] Menage-a-Trois 1 is critical for the transcriptional function of PPARgamma coactivator 1. (2007)
  • Author(s): Sano M, Izumi Y, Helenius K, Asakura M, Rossi DJ, Xie M, Taffet G, Hu L, Pautler RG, Wilson CR, Boudina S, Abel ED, Taegtmeyer H, Scaglia F, Graham BH, Kralli A, Shimizu N, Tanaka H, Makela TP, Schneider MD
  • Journal Title: Cell Metab 5(2) Pages: 129-142
• [Journal Article] Visualization of three-way comparisons of omics data. (2007)
  • Author(s): Baran, R., Robert, M., Suematsu, M., Soga, T., Tomita, M.
  • Journal Title: BMC Bioinformatics 8(1)
• [Journal Article] Curriculum vitae of intestinal intraepithelial T cells: their developmental and behavioral characteristics. (2007)
  • Author(s): Ishikawa H, Naito T, Iwanaga T, Takahashi-Iwanaga H, Suematsu M, Hibi T, Nanno M
  • Journal Title: Immunol Rev 215 Pages: 154-165
• [Journal Article] Regulation of reactive oxygen species by atm is essential for proper response to DNA double-strand breaks in lymphocytes. (2007)
  • Author(s): Ito K, Takubo K, Arai F, Satoh H, Matsuoka S, Ohmura M, Naka K, Azuma M, Miyamoto K, Hosokawa K, Ikeda Y, Mak TW, Suda T, Hirao A
  • Journal Title: J Immunol 178 Pages: 103-110
• [Journal Article] Curriculum vitae of intestinal intraepithelial T cells: their developmental and behavioral characteristics. (2007)
  • Author(s): Ishikawa, H., Naito, T., Iwanaga, T., Takahashi-Iwanaga, H., Suematsu, M., Hibi, T., Nanno, M.
  • Journal Title: Immunol. Rev. 215 Pages: 154-165
  • Peer Reviewed
• [Journal Article] Roles of hemoglobin allostery in hypoxia-induced metabolic alterations in erythrocytes: simulation and its verification by metabolome analysis. (2007)
  • Author(s): Kinoshita, A., Tsukada, K., Soga, T., Hishiki, T., Ueno, Y., Nakayama, Y., Tomita, M., Suematsu, M.
  • Journal Title: J. Biol. Chem. 14 Pages: 10731-10741
  • Peer Reviewed
• [Journal Article] A peptide bond provides unidirectional respiratory proton pumping in bovine cytochrome c oxidase. (2007)
  • Author(s): Shimokata, K., Katayama, Y., Murayama, H., Suematsu, M., Tsukihara, T., Muramoto, K., Yoshikawa, S., Shimada, H.
  • Journal Title: Proc. Natl. Acad. Sci. USA. 10 Pages: 4200-4205
  • Peer Reviewed
• [Journal Article] Method for determination of association and dissociation rate constants of reversible biomolecular reactions by isothermal titration calorimeters. (2007)
  • Author(s): Egawa, T., Tsuneshige, A., Suematsu. M., Yonetani, T.
  • Journal Title: Anal. Biochem. 7 Pages: 2972-2978
  • Peer Reviewed
• [Journal Article] Microvascular and systemic effects following top load administration of saturated carbon monoxide-saline solution. (2007)
  • Author(s): Hangai-Hoger, N., Tsai, A. G., Carbales, P., Suematsu, M., Intaglietta, M.
  • Journal Title: Crit. Care Med 4 Pages: 1123-1132
  • Peer Reviewed
• [Journal Article] Visualization of three-way comparisons of omics data. (2007)
  • Author(s): Baran, R., Robert, M., Suematsu, M., Soga, T., Tomita, M.
  • Journal Title: BMC Bioinformatics 1 Pages: 72-72
  • Peer Reviewed
• [Journal Article] Targeting NAD(P)H oxidase: Ets-1 regulates p47^<phox> expression. (2007)
  • Author(s): Adachi, T., Yamamoto, M., Suematsu, M.
  • Journal Title: Circ. Res. 101 Pages: 962-964
  • Peer Reviewed
• [Journal Article] Roles of hemoglobin allostery in hypoxia-induced metabolic alterations in erythrocytes : simulation and its verification by metabolome analysis (2007)
  • Author(s): Kinoshita A, Tsukada K, Soga T, Hishiki T, et al.
  • Journal Title: The Journal of Biological Chemistry 282(14) Pages: 10731-10741
• [Journal Article] A peptide bond provides unidirectional respiratory proton pumping in bovine cytochrome c oxidase. (2007)
  • Author(s): Shimokata K, Katayama Y, Murayama H, Suematsu M, et al.
  • Journal Title: Proceedings of National Academy of Sciences USA 104(10) Pages: 4200-4205
• [Journal Article] Method for determination of association and dissociation rate constants of reversible biomolecular reactions by isothermal titration calorimeters. (2007)
  • Author(s): Egawa T, Tsuneshige A, Suematsu, M, Yonetani T
  • Journal Title: Analytical Biochemistry 79(7) Pages: 2972-2978
• [Journal Article] MathDAMP: a package for differential analysis of metabolite profiles. (2006)
  • Author(s): Baran, R., Kochi, H., Saito, N., Suematsu, M., Soga, T., Nishioka, T., Robert, M., Tomita, M.
  • Journal Title: BMC Bioinformatics 7
• [Journal Article] Design of metal cofactors activated by a protein-protein electron transfer system. (2006)
  • Author(s): Ueno T, Yokoi N, Unno M, Matsui T, Tokita M, Yamada M, Ikeda-Saito M, Nakajima H, Watanabe Y
  • Journal Title: Proc Natl Acad Sci USA 103, 14 Pages: 9416-9421
• [Journal Article] Compound I of heme oxygenase cannot hydroxylate its heme meso-carbon J. Am. (2006)
  • Author(s): Matsui T, Kim SH, Jin H, Hoffman BM, Ikeda-Saito M
  • Journal Title: J. Am. Chem. Soc 128 Pages: 1090-1091
• [Journal Article] T-state stabilization of hemoglobin allostery by nitric oxide: a protection against post-ischemic hepatobiliary dysfunction. (2006)
  • Author(s): Suganuma K, Tsukada K, Tsuneshige A, Kashiba M, Yonetani T, Suematsu M
  • Journal Title: Antioxid Redox Signal 8 Pages: 1847-1855
• [Journal Article] Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption. (2006)
  • Author(s): Soga T, Baran R, Suematsu M, Ueno Y, Ikeda S, Sakuragawa T, Kakazu Y, Ishikawa T, Robert M, Nishioka, T., Tomita, M.
  • Journal Title: J Biol Chem 281(24) Pages: 16768-16776
• [Journal Article] Maintaining the redox balance intact: gosha-jinki-gan but not insulin activates guanylate cyclase in diabetic rats. (2006)
  • Author(s): Cameron-Scaefer S, Kondo K, Ishige A, Tsuyama S, Uchida K, Hanawa T, Suematsu M, Watanabe K.
  • Journal Title: Ophthalmic Res 38(2) Pages: 95-104
• [Journal Article] Various adhesion molecules impair microvascular leukocyte kinetics in ventilator-induced lung injury. (2006)
  • Author(s): Miyao N, Suzuki Y, Takeshita K, Kudo H, Ishii M, Hiraoka R, Nishio K, Tamatani T, Sakamoto S, Suematsu M, Tsumura H, Ishizaka A, Yamaguchi K
  • Journal Title: Am J Physiol Lung Cell Mol Physiol 290
• [Journal Article] Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption. (2006)
  • Author(s): Soga T, Baran R, Suematsu M, et al.
  • Journal Title: The Journal of Biological Chemistry 281(24) Pages: 16768-16776
• [Journal Article] T-state stabilization of hemoglobin allostery by nitric oxide : a protection against post-ischemic hepatobiliary dysfunction. (2006)
  • Author(s): Suganuma K, Tsukada K, et al.
  • Journal Title: Antioxidants and Redox Signaling 8(9-10) Pages: 1847-1855
• [Journal Article] MathDAMP : A package for differential analysis of metabolomic profiles. (2006)
  • Author(s): Baran R, Kochi H, Saito N, Suematsu M, et al.
  • Journal Title: BMC Bioinformatics 7
• [Journal Article] S-glutathiolation by peroxynitrite of p21Ras at cysteine-118 mediates its direct activation and downstream signaling in endothelial cells. (2006)
  • Author(s): Clavreul N, Adachi T, Pimentel DR, et al.
  • Journal Title: FASEB Journal (in press)
• [Journal Article] T-state stabilization of hemoglobin allostery by nitric oxide : A protection against post-ischemic hepatobiliary dysfunction (2006)
  • Author(s): Suganuma K, Tsukada K, Tsuneshige A, Kashiba M, Yonetani T, Suematsu M.
  • Journal Title: Antioxidants and Redox Signaling (in press)
• [Journal Article] O2-and H2O2-dependent verdoheme degradation by heme oxygenase: Reaction mechanisms and potential physiological roles of the dual pathway degradation J (2005)
  • Author(s): Matsui T, Nakajima A, Fujii H, Mansfield K, Matera C. Migita T, Yoshida T, Ikeda-Saito M.
  • Journal Title: Biol Chem 280 Pages: 36833-40
• [Journal Article] Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: Identification of??-ketoglutarate decarboxylase. (2005)
  • Author(s): Tian J, Bryk R, Itoh M, Suematsu, M, Nathan C
  • Journal Title: Proc Natl Acad Sci USA 102 Pages: 10670-10675
• [Journal Article] Carbon monoxide from heme oxygenase-2 is a tonic regulator against nitric oxide-dependent vasodilatation in the adult rat cerebral microcirculation. (2005)
  • Author(s): Ishikawa M, Kajimura M, Adachi T, Maruyama K, Makino N, Goda N, Yamaguchi T, Sekizuka E, Suematsu M
  • Journal Title: Circ Res 97(12)
• [Journal Article] Hydrogen sulfide as an endogenous modulator of biliary bicarbonate excretion in the rat liver. (2005)
  • Author(s): Fujii K, Sakuragawa T, Kashiba M, Sugiura Y, Maruyama K, Goda N, Nimura Y, Suematsu M
  • Journal Title: Antioxid Redox Signal 7(5-6) Pages: 788-794
• [Journal Article] Cadmium exposure alters metabolomics of sulfur-containing amino acids in rat testes. (2005)
  • Author(s): Sugiura, Y., Kashiba, M., Hoshikawa, K., Sasaki, R., Saito, K., Kimura, H., Maruyama, K., Goda, N., Suematsu M.
  • Journal Title: Antioxid. Redox Signal 7(5-6) Pages: 781-787
• [Journal Article] Hydrogen sulfide as an endogenous modulator of biliary bicarbonate excretion in the rat liver. (2005)
  • Author(s): Fujii K, Sakuragawa T, Kashiba M, Sugiura Y, Maruyama K, et al.
  • Journal Title: Antioxidants and Redox Signaling 7(5-6) Pages: 781-787
• [Journal Article] Variant tricarboxylic acid cycle in Mycobacterium tuberculosis : Identification of α-ketoglutarate decarboxylase. (2005)
  • Author(s): Tian J, Bryk R, Itoh M, Suematsu M, Nathan C
  • Journal Title: Proceedings of National Academy of Sciences USA 102 Pages: 10670-10675
• [Journal Article] Carbon monoxide as a guardian against hepatobiliary dysfunction (2005)
  • Author(s): Suematsu M, Tsukada K, Tajima T, Yamamoto T, Ichiai D, et al.
  • Journal Title: Alcoholism Clinical and Experimental Researches 29(11)
• [Journal Article] Carbon monoxide from heme oxygenase-2 is a tonic regulator against nitric oxide-dependent vasodilation in the adult rat cerebral microcirculation (2005)
  • Author(s): Ishikawa M, Kajimura M, Adachi T, Maruyama K, Makino N, Suematsu M
  • Journal Title: Circulation Research 97(12)
• [Presentation] ガス分子による生体制御機構の系統的探索と医学応用 (2010)
  • Author(s): 末松誠
  • Organizer: 獣医生化学会シンポジウム
  • Place of Presentation: 日本獣医生命科学大学
  • Year and Date: 2010-03-28
• [Presentation] ガス分子による生体制御機構の系統的探索と医学応用:質量分析技術によるブレイクスル (2010)
  • Author(s): 末松誠
  • Organizer: 第26回臨床フリーラジカル会議「再考-臨床フリーラジカル学」
  • Place of Presentation: 琵琶湖ホテル
  • Year and Date: 2010-01-30
• [Presentation] ガス分子による臓器微小循環制御機構の系統的探索と医学応用 (2009)
  • Author(s): 末松誠
  • Organizer: 第37回日本潰瘍学会 特別講演
  • Place of Presentation: 北里大学薬学部コンベンションホール
  • Year and Date: 2009-11-07
• [Presentation] Cystathionine β-synthase accounts for the CO-responsive sensor regulating organ function : mining through metabolome (2009)
  • Author(s): 末松誠
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2009-10-23
• [Presentation] ガス分子による代謝システム制御機構の系統的探索と医学応用 (2009)
  • Author(s): 末松誠
  • Organizer: 第21回ゲノム創薬フォーラム
  • Place of Presentation: 日本薬学会・長井記念ホール
  • Year and Date: 2009-06-15
• [Presentation] CO-MEDIATED MODULATION OF H2S GENERATION VIA CBS : APUTATIVE TONIC MECHANISM FOR NEUROVASCULAR UNITS (2009)
  • Author(s): 末松誠
  • Organizer: 第10回血管拡張機序に関する国際シンポジウム ランチョンセミナー
  • Place of Presentation: ホテル松島 大観荘
  • Year and Date: 2009-06-03
• [Presentation] 質量分析技術を利用したガス分子によるエネルギー代謝制御機構の系統的探索 (2009)
  • Author(s): 末松誠
  • Organizer: 第52回日本糖尿病学会年次学術集会 Meet the Expert 1
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-05-22
• [Presentation] ガス分子による生体制御機構の系統的探索と医学応用 (2009)
  • Author(s): 末松誠
  • Organizer: 第57回循環力学研究会
  • Place of Presentation: 興和株式会社
  • Year and Date: 2009-05-16
• [Presentation] HIF-1 is necessary for coordinated control of gluconeogenesis during liver regeneration (2008)
  • Author(s): 末松誠
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会BMB2008
  • Place of Presentation: 神戸、日本
  • Year and Date: 2008-12-11
• [Presentation] Biomedical application of metabolome analysis: Systematic molecular mining for gaseous signal transducers (2008)
  • Author(s): Suematsu Makoto
  • Organizer: ISOTT2008 (Infernational Society on Oxygen Transport to Tissue 2008), Special lecture
  • Place of Presentation: 札幌、日本
  • Year and Date: 2008-08-06
• [Presentation] HIF-1 as a regulator of stress-induced adaptation of parenchymal and nonparenchymal cells in the liver (2008)
  • Author(s): Suematsu Makoto
  • Organizer: 3rd International Symposium on ALPD and Cirrhosis, Special lecture
  • Place of Presentation: Bilbao, Spain
  • Year and Date: 2008-07-18
• [Presentation] Biomedical application of metabolome analysis (2008)
  • Author(s): Suematsu M
  • Organizer: 37th Congress of Society for Critical Care Medicine
  • Place of Presentation: ホノルル 米国
  • Year and Date: 2008-02-04
• [Presentation] Biomedical application of metabolome analysis to mine gaseous signal transducers in the liver (2007)
  • Author(s): Suematsu M
  • Organizer: APS Symposium: Frontiers in the Cellular and Molecular Physiology of the Hepatic Microcirculation. for EB2007
  • Place of Presentation: Invited Lecture. Washington DC
  • Year and Date: 2007-04-29
• [Presentation] Biomedical application of metabolome analysis (2006)
  • Author(s): Suematsu M
  • Organizer: Harvard-Kitasato Symposium for Critical Path for Translational Research
  • Place of Presentation: Tokyo(Invited Lecture)
  • Year and Date: 2006-10-24
• [Presentation] Metabolome analyses reveal roles of cystathionine beta synthase as a CO-responsive metabolic regulator in mammals (2006)
  • Author(s): Suematsu M
  • Organizer: In NO and CO: distinct biological properties. The 20th IUBMB Symposium
  • Place of Presentation: Organizer, Kyoto
• [Presentation] Carbon monoxide as a guardian against the liver injury (2005)
  • Author(s): Suematsu M
  • Organizer: Plenary Lecture
  • Place of Presentation: ISBRA Satellite Symposium
  • Year and Date: 2005-09-02
• [Presentation] Erythrocytes as an oxygen-sensing metabomic sink determining microvascular tone (2005)
  • Organizer: IUPS Plenary Symposium
  • Place of Presentation: San Diego CA
• [Book] メタボローム解析技術による新しい代謝制御機構の系統的探索 細胞工学特集 (2006)
  • Author(s): 末松 誠, 菱木貴子, 岩渕卓也, 他
  • Total Pages: 110
  • Publisher: 秀潤社
• [Book] 細胞学 vol 25(2) 161-165 (2006)
  • Author(s): 末松 誠, 梶村真弓, 足立 健
  • Publisher: ヘムオキシゲナーゼ-CO系による血管機能制御機構とNOシステムとの相互作用
• [Patent(Industrial Property Rights)] ^<15>O_2で標識したヘモグロビンを含む生体組織検査薬及びその製造方法 (2005)
  • Inventor(s): 藤林靖久, 末松 誠
  • Industrial Property Rights Holder: (株)オキシジェニクス
  • Filing Date: 2005-11-18