| Budget Amount *help |
¥43,030,000 (Direct Cost: ¥33,100,000、Indirect Cost: ¥9,930,000)
Fiscal Year 2021: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2020: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2019: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2018: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2017: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
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| Outline of Final Research Achievements |
In this study, we considered dioxins as a chemical substance capable of disturbing both the internal and external environments. We examined the adverse effects of dioxins evoked on the next generation by using pregnant rats and mice, aiming to develop a safe and efficient preventive method toward these substances’ undesirable effects. DAPL1 was identified as an important gene for reducing growth hormone at critical period. Then, Dapl1-deficient mice were constructed and are continuously being used for further research and characterization. We comprehensively investigated UGT in rats and mice, identified the major isoform involved in glucocorticoid conjugation. In addition, the hetero-knockout mice have been established. Further, we showed that lipoic acid-enriched diet until weaning is effective to improve sexual immaturity at puberty. Finally, with regards to prolactin’s decrease in the dams, we were also able to elucidate the decrease in milk yield for the second next generation.
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