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Development of in vivo recruitment of macrophages and stem cells aiming at regenerative therapy of natural healing potential enhancement

Research Project

Project/Area Number 17H00862
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionKyoto University

Principal Investigator

Tabata Yasuhiko  京都大学, ウイルス・再生医科学研究所, 教授 (50211371)

Co-Investigator(Kenkyū-buntansha) 山本 雅哉  東北大学, 工学研究科, 教授 (10332735)
菰原 義弘  熊本大学, 大学院生命科学研究部(医), 准教授 (40449921)
梅澤 明弘  国立研究開発法人国立成育医療研究センター, 再生医療センター, 副所長/再生医療センター長 (70213486)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥42,770,000 (Direct Cost: ¥32,900,000、Indirect Cost: ¥9,870,000)
Fiscal Year 2019: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2018: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2017: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Keywords生体材料 / 免疫学 / 移植・再生医療 / 薬学 / 生体機能利用
Outline of Final Research Achievements

The objective of this research is to enhance the natural healing potentials for regenerative therapy by making use of the in vivo recruitment of anti-inflammatory(M2) macrophages(Mφ) and stem cells. An agonist of sphingosine-1-phosphate type Ⅰ receptor (SEW) and pioglitazone of a Mφ functional modifier were controlled release from gelatin hydrogel and poly(lactic acid) microspheres, respectively. The release profiles could be changed by altering the degradation profiles of microspheres. In vitro cell culture experiments revealed that the SEW and pioglitazone were effective in enhancing the Mφ migration and the M2 percentage of Mφ for a promoted anti-inflammatory, wound healing function. When applied to a skin defect model and evaluated the in vivo cells recruitment and skin regeneration, the microspheres for the two drugs release promoted the regenerative and repairing of skin tissues.

Academic Significance and Societal Importance of the Research Achievements

本研究では、炎症の慢性化と治癒修復化とのスイッチングで重要な役割をしているマクロファージ(Mφ)と体内に存在する組織幹細胞本来のもつ自然治癒力を活用することにより、新規な再生治療技術を創生する。基礎生物学の知見とDDS 技術と組み合わせ、期待通りの研究成果が得られたならば、再生治療と炎症学とをつなぐ新しい学問体系が構築され、Mφ と幹細胞との体内動態の制御による再生治療を促す革新的な技術となる。再生治療に対する社会的要求度と期待度がますます高まっている中、生体本来のもつ自然治癒力の増強を介した実現可能な再生治療技術の研究開発の学術的・社会的意義はきわめて大きい。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (35 results)

All 2019 2018 2017

All Journal Article (3 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (32 results) (of which Int'l Joint Research: 2 results,  Invited: 17 results)

  • [Journal Article] Preparation of fibrin hydrogels to promote the recruitment of anti-inflammatory macrophages2019

    • Author(s)
      Tanaka Ryusuke、Saito Yoichi、Fujiwara Yukio、Jo Jun-ichiro、Tabata Yasuhiko
    • Journal Title

      Acta Biomaterialia

      Volume: in press Pages: 152-165

    • DOI

      10.1016/j.actbio.2019.03.011

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of polymer microspheres capable for pioglitazone release to modify macrophages function2019

    • Author(s)
      Momotori Naoki、Jo Jun-ichiro、Tabata Yasuhiko
    • Journal Title

      Regenerative Therapy

      Volume: 11 Pages: 131-138

    • DOI

      10.1016/j.reth.2019.06.008

    • NAID

      120006784408

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 薬物徐放化フィブリンハイドロゲルによるマクロファージ機能の修飾2019

    • Author(s)
      田畑泰彦、田中隆介、城潤一郎
    • Journal Title

      公益財団法人日本化学繊維研究所講演集(第76集)

      Volume: 76 Pages: 87-90

    • NAID

      40021847753

    • Related Report
      2019 Annual Research Report
  • [Presentation] Technology of Cell Recruitment Molecules to Induce In Situ Tissue Regeneration Therapy.2019

    • Author(s)
      田畑泰彦
    • Organizer
      13th International Symposium on Frontiers in Biomedical Polymers, Canary Islands,Tenerife,Spain.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Tissue Engineering Technology of Cell Recruitment for Tissue Regeneration Therapy.2019

    • Author(s)
      田畑泰彦
    • Organizer
      IC-EAST2019 International Conference on Emerging Advancement in Science &Technology. New Delhi, India.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] バイオマテリアルが具現化する先進医療.2019

    • Author(s)
      田畑泰彦
    • Organizer
      第39回日本眼薬理学会、名古屋
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] The possibility of CD163 as a tool of macrophage origin analysis in mouse; CD163 is expressed on resident macrophages, but not on bone marrow-derived macrophages.2019

    • Author(s)
      Saito Y, Fujiwara Y, and Komohara Y.
    • Organizer
      第52回 日本発生生物学会大会、大阪
    • Related Report
      2019 Annual Research Report
  • [Presentation] マウスにおいてCD163は組織在住マクロファージのマーカーとなる可能性がある(奨励賞受賞)2019

    • Author(s)
      西東洋一
    • Organizer
      第29回 日本樹状細胞研究会、出雲
    • Related Report
      2019 Annual Research Report
  • [Presentation] 医療材料開発研究領域における病理学のニーズ:再生医療応用を目指したフィブリンハイドロゲルとマクロファージとの反応性解析2019

    • Author(s)
      西東洋一、藤原章雄、菰原義弘、田畑泰彦
    • Organizer
      第16回 日本病理学会カンファレンス、札幌
    • Related Report
      2019 Annual Research Report
  • [Presentation] Local Drug Delivery Technology to Allow Cells to Active their Potentials of Proliferation and Differentiation.2018

    • Author(s)
      田畑泰彦
    • Organizer
      International Advanced Drug Delivery Symposium 2018
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Local Drug Delivery Technology to Activate the Cell Potentials for Tissue Regeneration Therapy.2018

    • Author(s)
      田畑泰彦
    • Organizer
      5th Asian Symposium on Pharmaceutical Science and Technology(ASPST2018) .
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Biomaterials technology indispensable to realize regenerative medicine.2018

    • Author(s)
      田畑泰彦
    • Organizer
      THERMEC’2018.
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Drug Delivery Systems for Tissue Engineering and Regenerative Medicine.2018

    • Author(s)
      田畑泰彦
    • Organizer
      Advances in Tissue Engineering 2018.
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Frontier of Regenerative Medicine Based on Biomaterials Technology.2018

    • Author(s)
      田畑泰彦
    • Organizer
      THE 1st JOINT SEMINAR ON TISSUE ENGINEERING & REGENERATIVE MEDICINE.
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Polymer Hydrogels Necessary for Regenerative Medicine.2018

    • Author(s)
      田畑泰彦
    • Organizer
      2018 Functional Polymers for Human Health.
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Hydrogel Technology Indispensable to Realize Regenerative Medicine.2018

    • Author(s)
      田畑泰彦
    • Organizer
      ICPM(International Conference of Pharmacy&Medicine.
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Regenerative Medicine Realized by Biomaterials Technology.2018

    • Author(s)
      田畑泰彦
    • Organizer
      日越外交関係樹立45周年記念 第5回 国際先端生物学・医学・工学会議.
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] バイオマテリアル技術の次世代応用としての再生医療-自然治癒力を高めて病気を治す-2018

    • Author(s)
      田畑泰彦
    • Organizer
      近畿化学協会 高機能材料セミナー、大阪
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 獣医再生医療に期待すること - 細胞能力を高める医療の実現2018

    • Author(s)
      田畑泰彦
    • Organizer
      第13回日本獣医再生医療学会年次大会、横浜
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 炎症応答から見たバイオ材料開発2018

    • Author(s)
      田畑泰彦
    • Organizer
      科学技術未来戦略ワークショップ「生体との相互作用を自在制御するバイオ材料工学」、東京
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 生体組織の再生治療に与える炎症環境制御の影響2018

    • Author(s)
      田畑泰彦
    • Organizer
      日本DDS学会学術集会 シンポジウム3、長崎
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] マクロファージの体内動態を変化させるための2種類の薬物の徐放化2018

    • Author(s)
      百鳥直樹、田中隆介、田畑泰彦
    • Organizer
      第34回日本DDS学会、長崎
    • Related Report
      2018 Annual Research Report
  • [Presentation] 2種類の薬物徐放化がマクロファージ機能へ与える効果2018

    • Author(s)
      百鳥直樹、田中隆介、田畑泰彦
    • Organizer
      第39回炎症・再生医学会、東京、2018年
    • Related Report
      2018 Annual Research Report
  • [Presentation] 2種類の薬物徐放化による抗炎症性マクロファージの動員2018

    • Author(s)
      百鳥直樹、田中隆介、田畑泰彦
    • Organizer
      日本バイオマテリアル学会関西ブロック 第13回若手研究発表会、京都
    • Related Report
      2018 Annual Research Report
  • [Presentation] Preparation of gelatin hydrogels for dual drug release to modify macrophages polarization2018

    • Author(s)
      百鳥直樹、田中隆介、田畑泰彦
    • Organizer
      5th TERMIS world congress, Kyoto
    • Related Report
      2018 Annual Research Report
  • [Presentation] 薬物徐放化技術を活用した組織修復性マクロファージの体内誘導2018

    • Author(s)
      百鳥直樹、田中隆介、田畑泰彦
    • Organizer
      第40回日本バイオマテリアル学会大会、神戸
    • Related Report
      2018 Annual Research Report
  • [Presentation] Delivery Technology of Bio-Signals to Realize Tissue Regeneration2017

    • Author(s)
      田畑泰彦
    • Organizer
      12thInternational Symposium on Frontiers in Biomedical Polymer(FBPS'17)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Delivery Technology of Bio-Signals to Realize Tissue Regeneration2017

    • Author(s)
      田畑泰彦
    • Organizer
      The 6th Asian Biomaterials Congress
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Release Technology of Cell Recruitment Molecules to Induse In Situ Tissue Regeneration Therapy2017

    • Author(s)
      田畑泰彦
    • Organizer
      International Seminar on Biomaterials and Regenerative Medicine(BioReMed2017)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 炎症細胞をあやつるバイオマテリアル技術2017

    • Author(s)
      田畑泰彦
    • Organizer
      医工学フォーラム-2016年度特別学術講演会-
    • Related Report
      2017 Annual Research Report
  • [Presentation] 単球動員作用をもつ難水溶性薬剤を徐放可能なフィブリンゲルの作製2017

    • Author(s)
      田中隆介、Kim Yanghee、田畑泰彦
    • Organizer
      第33回日本DSS学会学術集会、京都
    • Related Report
      2017 Annual Research Report
  • [Presentation] 組織再生のための単球遊走薬物徐放システムを組み込んだフィブリンゲルの調製と抗炎症性マクロファージ分化作用2017

    • Author(s)
      田中隆介、Kim Yanghee、田畑泰彦
    • Organizer
      第38回日本炎症・再生医学会、大阪
    • Related Report
      2017 Annual Research Report
  • [Presentation] 抗炎症性マクロファージ動員のための疎水性薬剤徐放化フィブリンゲルハイドロゲルの作製2017

    • Author(s)
      田中隆介、田畑泰彦
    • Organizer
      第39回日本バイオマテリアル学会大会、東京
    • Related Report
      2017 Annual Research Report
  • [Presentation] pioglitazone 徐放化粒子の作製とマクロファージへの作用2017

    • Author(s)
      百鳥直樹、田中隆介、田畑泰彦
    • Organizer
      日本バイオマテリアル学会関西ブロック 第12回若手研究発表会、奈良
    • Related Report
      2017 Annual Research Report
  • [Presentation] マクロファージに作用する2種類の疎水性薬物の徐放化材料の作製2017

    • Author(s)
      百鳥直樹、田中隆介、田畑泰彦
    • Organizer
      第39回日本バイオマテリアル学会大会、東京
    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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