Development of novel adenovirus vectors through the analysis of the virus with mammalian cells
| Project/Area Number |
17H00863
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥42,770,000 (Direct Cost: ¥32,900,000、Indirect Cost: ¥9,870,000)
Fiscal Year 2019: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2018: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2017: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
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| Keywords | ウイルス / 遺伝子 / 癌 / 免疫学 / バイオテクノロジー |
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| Outline of Final Research Achievements |
In this study, we have done several basic studies about adenoviruses (Ad) in terms of viral replication, microRNA, immune responses, etc. And then, through such basic studies, we tried to develop several types of novel recombinant Ad vectors for gene therapy, vaccine, viral therapy, etc. We also developed novel Ad vectors having gene editing functions.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、Adと宿主の攻防を理解し、研究代表者が有する世界で最先端のAdベクター改変技術を駆使することで、新しい視点からベクター開発（改良）と関連する応用研究を進めるものであり、独創性が高く、学術的意義が大きい。また、日本独自の高性能ベクター開発は、その汎用性の観点から国益を考えたうえでも最重要研究課題の一つであり、その社会的意義は極めて大きい。
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] Oncolytic Virus-Mediated Targeting of the ERK Signaling Pathway Inhibits Invasive Propensity in Human Pancreatic Cancer.2020
Author(s)
Koujima T., Tazawa H., Ieda T., Araki H., Fushimi T., Shoji R., Kuroda S., Kikuchi S., Yoshida R., Umeda Y., Teraishi F., Urata Y., Mizuguchi H., Fujiwara T.
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Journal Title
Mol. Ther. Oncolysis.
Volume: 17
Pages: 107-117
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Immune Modulation by Telomerase-Specific Oncolytic Adenovirus Synergistically Enhances Antitumor Efficacy with Anti-PD1 Antibody.2020
Author(s)
Kanaya N., Kuroda S., Kakiuchi Y., Kumon K., Tsumura T., Hashimoto M., Morihiro T., Kubota T., Aoyama K., Kikuchi S., Nishizaki M., Kagawa S., Tazawa H., Mizuguchi H., Urata Y., Fujiwara T.
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Journal Title
Mol. Ther.
Volume: 28
Issue: 3
Pages: 794-804
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Clinical features of squamous cell lung cancer with anaplastic lymphoma kinase (ALK)-rearrangement: a retrospective analysis and review.2018
Author(s)
Watanabe J, Togo S, Sumiyoshi I, Namba Y, Suina K, Mizuno T, Kadoya K, Motomura H, Iwai M, Nagaoka T, Sasaki S, Hayashi T, Uekusa T, Abe K, Urata Y, Sakurai F, Mizuguchi H, Kato S, Takahashi K.
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Journal Title
Oncotarget
Volume: 9(35)
Issue: 35
Pages: 24000-24013
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Th17 promotes the induction of antigen-specific gut-mucosal CTLs following intramuscular vaccination of an adenovirus vector,2017
Author(s)
Hemmi M., Tachibana M., Fujimoto N., Shoji M., Sakurai F., Kobiyama K., Ishii K. J., Akira S., Mizuguchi H.
Organizer
第46回日本免疫学会学術集会,
Related Report
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