| Budget Amount *help |
¥43,550,000 (Direct Cost: ¥33,500,000、Indirect Cost: ¥10,050,000)
Fiscal Year 2019: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Fiscal Year 2018: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Fiscal Year 2017: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
|
|---|
| Outline of Final Research Achievements |
We constructed a flexible synthetic route to supply all possible stereoisomers of coronatine and constructed a compound library consisting of all 16 stereoisomers of coronatine. Next, the affinities of the isomers in this stereoisomer library for each receptor subtype were comprehensively evaluated by COI1-JAZ co-receptor subtype affinity test.
As a result, one of the 16 stereoisomers was an agonist with high selectivity for COI1-JAZ9. This stereoisomer was found to selectively activate the defense response and not induce other responses. Therefore, it is possible that COI1-JAZ9, and thus, we were able to comprehensively identify defense-response-related genes that function downstream of COI1-JAZ9.
|
