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Investigation of functional roles of ongoing brain activity in cognition and consciousness

Research Project

Project/Area Number 17H00891
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Basic / Social brain science
Research InstitutionKochi University of Technology

Principal Investigator

Nakahara Kiyoshi  高知工科大学, 情報学群, 教授 (50372363)

Co-Investigator(Kenkyū-buntansha) 長谷川 功  新潟大学, 医歯学系, 教授 (60282620)
地村 弘二  慶應義塾大学, 理工学部(矢上), 准教授 (80431766)
青木 隆太  東京都立大学, 人文科学研究科, 特任准教授 (50751103)
天野 薫  国立研究開発法人情報通信研究機構, 脳情報通信融合研究センター脳情報通信融合研究室, 主任研究員 (70509976)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥43,420,000 (Direct Cost: ¥33,400,000、Indirect Cost: ¥10,020,000)
Fiscal Year 2020: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2019: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2018: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2017: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Keywordsエピソード記憶 / 記憶記銘 / 自発的脳活動 / 遠隔記憶 / システムレベルの固定化 / 前頭葉機能 / 機能的磁気共鳴画像法 / 皮質脳波法 / 前頭前野 / 脳広域ネットワーク / 記憶 / fMRI / ECoG / MVPA / 大規模脳ネットワーク / 長期記憶 / 近時記憶 / 記憶痕跡 / 陳述記憶 / 記憶の記銘 / 記憶の貯蔵 / 記憶の想起 / 神経科学 / MEG
Outline of Final Research Achievements

In the first half of this research project, we conducted an fMRI study to determine the relationship between encoding performance of episodic memory and temporal changes in networks throughout the brain. Graph analysis revealed that network integration in specific brain regions is enhanced when encoding performance is high. The results were published in the journal eLife.
In the second half of the project, we conducted an fMRI study on system-level consolidation of remote memory and are currently preparing to publish a paper.
In addition, we conducted collaborative fMRI studies on frontal lobe function and a ECoG study on macaque monkeys, and published several papers.

Academic Significance and Societal Importance of the Research Achievements

本研究の成果によって、エピソードが記憶として脳に記銘される際の記憶成績と、脳の全体にわたるネットワークの結合状態の時間的変動との関係について、また、遠隔記憶のシステムレベル固定化においてどの脳領域が関与するかについて、世界で初めて明らかとなった。
特に、システムレベル固定化において、海馬がどのように関与するかについて大きく2つの仮説が存在し、依然として決着がついていない。本研究の結果は2つの仮説のどちらでもない新しいシステムレベル固定化のメカニズムを示唆するものであり、記憶の神経科学研究に大きな一歩を記す特に重要な研究成果である。

Report

(5 results)
  • 2021 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report

Research Products

(11 results)

All 2022 2021 2020 2019 2018

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 5 results) Presentation (3 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Journal Article] Executive control by fronto-parietal activity explains counterintuitive decision behavior in complex value-based decision-making2022

    • Author(s)
      Matsui Teppei、Hattori Yoshiki、Tsumura Kaho、Aoki Ryuta、Takeda Masaki、Nakahara Kiyoshi、Jimura Koji
    • Journal Title

      NeuroImage

      Volume: 249 Pages: 118892-118892

    • DOI

      10.1016/j.neuroimage.2022.118892

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reversible Fronto-occipitotemporal Signaling Complements Task Encoding and Switching under Ambiguous Cues2021

    • Author(s)
      Tsumura Kaho、Kosugi Keita、Hattori Yoshiki、Aoki Ryuta、Takeda Masaki、Chikazoe Junichi、Nakahara Kiyoshi、Jimura Koji
    • Journal Title

      Cerebral Cortex

      Volume: 32 Pages: 1911-1931

    • DOI

      10.1093/cercor/bhab324

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cross-Hemispheric Complementary Prefrontal Mechanisms during Task Switching under Perceptual Uncertainty2021

    • Author(s)
      Tsumura Kaho、Aoki Ryuta、Takeda Masaki、Nakahara Kiyoshi、Jimura Koji
    • Journal Title

      J Neurosci

      Volume: 41 Pages: 2197-2213

    • DOI

      10.1523/jneurosci.2096-20.2021

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Self-Controlled Choice Arises from Dynamic Prefrontal Signals That Enable Future Anticipation2020

    • Author(s)
      Tanaka Daiki、Aoki Ryuta、Suzuki Shinsuke、Takeda Masaki、Nakahara Kiyoshi、Jimura Koji
    • Journal Title

      J Neurosci

      Volume: 40 Pages: 9736-9750

    • DOI

      10.1523/jneurosci.1702-20.2020

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neural signals in amygdala predict implicit prejudice toward an ethnic outgroup2019

    • Author(s)
      Izuma Keise、Aoki Ryuta、Shibata Kazuhisa、Nakahara Kiyoshi
    • Journal Title

      NeuroImage

      Volume: 189 Pages: 341-352

    • DOI

      10.1016/j.neuroimage.2019.01.019

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Elucidating the role of the posterior medial frontal cortex in social conflict processing2019

    • Author(s)
      Wake Stephanie J.、Aoki Ryuta、Nakahara Kiyoshi、Izuma Keise
    • Journal Title

      Neuropsychologia

      Volume: 132 Pages: 107124-107124

    • DOI

      10.1016/j.neuropsychologia.2019.107124

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Large-scale network integration in the human brain tracks temporal fluctuations in memory encoding performance2018

    • Author(s)
      Keerativittayayut Ruedeerat、Aoki Ryuta、Sarabi Mitra Taghizadeh、Jimura Koji、Nakahara Kiyoshi
    • Journal Title

      eLife

      Volume: 7 Pages: 1-31

    • DOI

      10.7554/elife.32696

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Locally induced neuronal synchrony precisely propagates to specific cortical areas without rhythm distortion.2018

    • Author(s)
      Toda H, Kawasaki K, Sato S, Horie M, Nakahara K, Bepari AK, Sawahata H, Suzuki T, Okado H, Takebayashi H, Hasegawa I.
    • Journal Title

      SCIENTIFIC REPORTS

      Volume: - Pages: 1-15

    • DOI

      10.1038/s41598-018-26054-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Dynamic reconfiguration of large-scale brain networks during memory encoding: Involvement of default-mode submodules.2020

    • Author(s)
      Nakahara K.
    • Organizer
      第43回日本神経科学大会・エルゼビア/NSRシンポジウム "The default mode network: the mastermind behind the scenes"
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Dynamic integration of large-scale brain network predicts incidental memory encoding performance2018

    • Author(s)
      Ruedeerat Keerativittayayut, Ryuta Aoki, Mitra T. Sarabi, Koji Jimura, Kiyoshi Nakahara
    • Organizer
      24th Annual meeting of the organization for human brain mapping
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dynamic reconfiguration of default-mode submodules associates with memory-encoding performance.2018

    • Author(s)
      Ruedeerat Keerativittayayut, Ryuta Aoki, Koji Jimura, Kiyoshi Nakahara
    • Organizer
      The 2nd Japanese Meeting of Human Brain Imaging
    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2023-01-30  

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