| Budget Amount *help |
¥44,070,000 (Direct Cost: ¥33,900,000、Indirect Cost: ¥10,170,000)
Fiscal Year 2019: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2018: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2017: ¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
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| Outline of Final Research Achievements |
Following the inhibition of monkey ventral medial frontal cortex (vMFC) by low-frequency repetitive transcranial stimulation (lf-rTMS), we observed changes in behavior suggesting the decrease of resilience and effort, together with the increase of blood cortisol level. Such symptoms were ameliorated by the low-dose application of Ketamine, which is thought to be a fast-acting antidepressant. Neurotracing experiments using virus vectors revealed that vMFC is densely and topographically connected to amygdala and nucleus accumbens. These results suggest that the vMFC is playing a major role in controlling emotion and mood, and its dysfunction leads to depression.
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