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Development of ultrahigh, highly reproducible molecular detection system employing high-emittance optical metasurfaces

Research Project

Project/Area Number 17H01066
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Optical engineering, Photon science
Research InstitutionNational Institute for Materials Science

Principal Investigator

IWANAGA Masanobu  国立研究開発法人物質・材料研究機構, 機能性材料研究拠点, 主幹研究員 (20361066)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥43,550,000 (Direct Cost: ¥33,500,000、Indirect Cost: ¥10,050,000)
Fiscal Year 2020: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2019: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2018: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2017: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Keywordsメタ表面 / バイオセンサー / 蛍光検出 / 癌マーカー分子 / 抗体 / 抗原 / 核酸 / 蛍光バイオセンサー / 抗原検出 / 抗体検出 / 核酸検出 / 蛍光センシング / バイオマーカー / 分子検出 / 光バイオセンシング / 共鳴増強 / 蛍光標識 / バイオマーカー分子 / バイオセンシング / 蛍光 / 応用光学・量子光工学
Outline of Final Research Achievements

We aimed at establishing metasurface biosensors that have extremely high capability for fluorescence enhancement. At the beginning, plasmonic metasurfaces are assumed to be the good candidate. In addition, I explored other metasurfaces made of dielectrics and semiconductors. Consequently, I found all-dielectric metasurfaces that have excellent FL-enhancing capability at the early stage of this study. Going through this study, it has been established that metasurface biosensors can detect a wide range of targets from antibody/antigen (proteins) to DNA (nucleic acids) in a highly sensitive manner. This means that the metasurface biosensors are applicable for various targets.

Academic Significance and Societal Importance of the Research Achievements

高感度な蛍光バイオセンサーは多様な疾患マーカーや遺伝子検査に応用することができるが、1つのプラットフォームでそのような性能を満たすバイオセンサーはこれまで実現されていなかった。今回の研究を通じて、メタ表面センサーがその要件を満たすことを実証した。超高感度かつ高スループット(短時間)検出が可能であるため、今後医療検査の迅速化や検査対象となるバイオマーカーの対象拡大にたいする社会の需要に応える検査システムが生まれることにつながる成果である。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (47 results)

All 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (2 results) Journal Article (12 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 11 results,  Open Access: 7 results) Presentation (25 results) (of which Int'l Joint Research: 10 results,  Invited: 14 results) Remarks (6 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Int'l Joint Research] CNRS, Sophia-Antipolis(フランス)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] CNRS, Sophia-Antipolis(フランス)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] High-Sensitivity High-Throughput Detection of Nucleic Acid Targets on Metasurface Fluorescence Biosensors2021

    • Author(s)
      Iwanaga Masanobu
    • Journal Title

      Biosensors

      Volume: 11 Issue: 2 Pages: 33-33

    • DOI

      10.3390/bios11020033

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] All-Dielectric Metasurface Fluorescence Biosensors for High-Sensitivity Antibody/Antigen Detection2020

    • Author(s)
      Iwanaga Masanobu
    • Journal Title

      ACS Nano

      Volume: 14 Issue: 12 Pages: 17458-17467

    • DOI

      10.1021/acsnano.0c07722

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Non-Empirical Large-Scale Search for Optical Metasurfaces2020

    • Author(s)
      Iwanaga Masanobu
    • Journal Title

      Nanomaterials

      Volume: 10 Issue: 9 Pages: 1739-1739

    • DOI

      10.3390/nano10091739

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An Etching‐Free Approach Toward Large‐Scale Light‐Emitting Metasurfaces2019

    • Author(s)
      Briere. Gauthier、Ni Peinan、Heron Sebastien、Chenot. Sebastien、Vezian Stephane、Brandli Virginie、Damilano Benjamin、Duboz Jean‐Yves、Iwanaga Masanobu、Genevet Patrice
    • Journal Title

      Advanced Optical Materials

      Volume: 7 Issue: 14

    • DOI

      10.1002/adom.201801271

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] All-Dielectric Metasurfaces with High-Fluorescence-Enhancing Capability2018

    • Author(s)
      IWANAGA Masanobu
    • Journal Title

      Applied Sciences

      Volume: 8 Issue: 8 Pages: 1328-1328

    • DOI

      10.3390/app8081328

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enhanced High Performance of a Metasurface Polarizer Through Numerical Analysis of the Degradation Characteristics2018

    • Author(s)
      KUROSAWA Hiroyuki、CHOI Bongseok、IWANAGA Masanobu
    • Journal Title

      Nanoscale Research Letters

      Volume: 13 Issue: 1

    • DOI

      10.1186/s11671-018-2627-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Strongly polarized emissions from selectively controlled electric- and magnetic-dipole transitions in Er3+ ions2018

    • Author(s)
      CHOI Bongseok、IWANAGA Masanobu、MIYAZAKI Hideki T.
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 57 Issue: 11 Pages: 118002-118002

    • DOI

      10.7567/jjap.57.118002

    • NAID

      210000149778

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] メタマテリアル極小光波操作素子の実現2018

    • Author(s)
      岩長祐伸
    • Journal Title

      化学工業

      Volume: 69 Pages: 18-23

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Recent progress in emittance-controlled optical metasurfaces2018

    • Author(s)
      IWANAGA Masanobu
    • Journal Title

      Journal of Physics: Conference Series

      Volume: 1092 Pages: 012053-012053

    • DOI

      10.1088/1742-6596/1092/1/012053

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nonlinear optical response of embedded-semiconductor quantum dots covered by plasmonic metasurfaces2018

    • Author(s)
      IWANAGA Masanobu、MANO Takaaki、IEKDA Naoki
    • Journal Title

      Applied Physics A

      Volume: 124 Issue: 2

    • DOI

      10.1007/s00339-017-1548-3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optical-signal-enhancing metasurface platforms for fluorescent molecules at water-transparent near-infrared wavelengths2017

    • Author(s)
      KUROSAWA Hiroyuki、IWANAGA Masanobu
    • Journal Title

      RSC Advances

      Volume: 7 Issue: 59 Pages: 37076-37085

    • DOI

      10.1039/c7ra05664h

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Superlinear Photoluminescence Dynamics in Plasmon-Quantum-Dot Coupling Systems2017

    • Author(s)
      IWANAGA Masanobu、MANO Takaaki、IKEDA Naoki
    • Journal Title

      ACS Photonics

      Volume: 5 Issue: 3 Pages: 897-906

    • DOI

      10.1021/acsphotonics.7b01142

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] 全誘電体メタ表面バイオセンサーにおける抗原・抗体の高感度検出2021

    • Author(s)
      岩長祐伸
    • Organizer
      第 68 回応用物理学会春季学術講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] バイオマーカー分子を高感度に蛍光検出するメタ表面センサー2020

    • Author(s)
      岩長祐伸
    • Organizer
      次世代医療システム産業化フォーラム,
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Highly Sensitive Metasurface Biosensors Applicable for Targets from Antigen/Antibody toDNA/RNA2020

    • Author(s)
      Masanobu Iwanaga
    • Organizer
      India-Japan Webinar on Nanotechnology
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 光メタ表面センサーにおける高感度 DNA 検出2020

    • Author(s)
      岩長祐伸
    • Organizer
      第 81 回応用物理学会秋季学術講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] マルチターゲット検出型メタ表面バイオセンサーシステム2020

    • Author(s)
      岩長祐伸
    • Organizer
      2020 年電子情報通信学会ソサイエティ大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 高機能フォトニクスに向けた人工平面構造の精密解析2020

    • Author(s)
      岩長祐伸
    • Organizer
      第 7 回「京」を中核とする HPCI システム利用研究課題成果報告会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 高感度なバイオ分子検出メタ表面センサー2020

    • Author(s)
      岩長祐伸
    • Organizer
      NIMS WEEK 2020
    • Related Report
      2020 Annual Research Report
  • [Presentation] 光メタ表面センサーとウイルス検出に向けて2020

    • Author(s)
      岩長祐伸
    • Organizer
      シンポジウム「コロナウイルス感染症とナノメディシン」
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] メタ表面センサーによるバイオマーカー分子の蛍光検出2020

    • Author(s)
      岩長祐伸
    • Organizer
      第67回応用物理学会春季学術講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 超高感度なバイオマーカー検出のためのメタ表面センサー2020

    • Author(s)
      岩長祐伸
    • Organizer
      電子情報通信学会 2020 年総合大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Perfect Light Absorption Technologies2019

    • Author(s)
      Iwanaga Masanobu
    • Organizer
      IEEE 8th Asia-Pacific Conference on Antennas and Propagation (APCAP 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Recent progress in metasurface biosensors for highly efficient fluorescence detection2019

    • Author(s)
      Iwanaga Masanobu
    • Organizer
      SPIE Optics + Photonics (Conference 104). Plasmonics: Design, Materials, Fabrication, Characterization, and Applications XVII
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A3 Metamaterials Forum 20192019

    • Author(s)
      Iwanaga Masanobu
    • Organizer
      Large-scale optical metasurfaces: The designs and realization
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Recent progress in highly sensitive biosensing on optical metasurfaces2019

    • Author(s)
      Iwanaga Masanobu
    • Organizer
      The International Symposium on Plasmonics and Nano-photonics (iSPN2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 機能性光メタ表面の機械探索2019

    • Author(s)
      岩長祐伸
    • Organizer
      第66回応用物理学会春季学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Metasurface Spectroscopic Analyzers2018

    • Author(s)
      IWANAGA Masanobu
    • Organizer
      The 40th Progress In Electromagnetic Research Symposium (PIERS) 2018 in Toyama
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mie-Resonance-Enhancing Electric-Dipole Emissions on All-Dielectric Metasurfaces2018

    • Author(s)
      IWANAGA Masanobu
    • Organizer
      Metamaterials’2018, The 12th International Congress on Artificial Materials for Novel Wave Phenomena
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Recent progress in emittance-controlled optical metasurfaces2018

    • Author(s)
      IWANAGA Masanobu
    • Organizer
      METANANO 2018, The 3rd International Conference on Metamaterials and Nanophotonics
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 人工設計ナノ構造表面における光と物質の相互作用操作2018

    • Author(s)
      岩長祐伸
    • Organizer
      第2回RIKEN-NIMS マテリアルイノベーションコアワークショップ
    • Related Report
      2018 Annual Research Report
  • [Presentation] メタマテリアルと光学超解像---ハイパーレンズとその周辺---2018

    • Author(s)
      岩長祐伸
    • Organizer
      日本学術振興会産学協力委員会「メタマテリアル」第187委員会平成30年度第2回研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 光放射メタ表面の創製と応用2018

    • Author(s)
      宮崎英樹, 岩長祐伸
    • Organizer
      レーザー学会学術講演会, 第38回年次大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Metasurface Biosensors: Plasmonic vs Dielectric2018

    • Author(s)
      岩長祐伸
    • Organizer
      第8回電磁メタマテリアル講演会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Plasmonic Metasurfaces: Active Functions beyond Simple Electric-Field Enhancement2017

    • Author(s)
      IWANAGA Masanobu
    • Organizer
      The 9th International Conference on Materials for Advanced Technologies
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Nonlinear Optical Responses under Weak Excitation Regime from Embedded Quantum Dots in Semiconductors Covered by Plasmonic Metasurfaces2017

    • Author(s)
      IWANAGA Masanobu, MANO Takaaki, IKEDA Naoki
    • Organizer
      META 2017, The 8th International Conference on Metamaterials, Photonic Crystals and Plasmonics
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 量子ドット成長基板上に作製したプラズモニックメタ表面の超線形効果2017

    • Author(s)
      岩長祐伸, 間野高明, 池田直樹
    • Organizer
      第78回応用物理学会秋季学術講演会
    • Related Report
      2017 Annual Research Report
  • [Remarks] 機関公式ページ

    • URL

      https://samurai.nims.go.jp/profiles/IWANAGA_Masanobu

    • Related Report
      2020 Annual Research Report
  • [Remarks] NIMS SAMURAI site

    • URL

      https://samurai.nims.go.jp/profiles/IWANAGA_Masanobu

    • Related Report
      2019 Annual Research Report
  • [Remarks] 研究機関公式ウェブサイト

    • URL

      https://samurai.nims.go.jp/profiles/IWANAGA_Masanobu

    • Related Report
      2018 Annual Research Report
  • [Remarks] 研究代表者のウェブページ

    • URL

      https://www.nims.go.jp/nanophoto/iwanaga/

    • Related Report
      2018 Annual Research Report
  • [Remarks] 所属機関による研究者紹介ページ

    • URL

      https://samurai.nims.go.jp/profiles/IWANAGA_Masanobu

    • Related Report
      2017 Annual Research Report
  • [Remarks] 研究代表者のwebページ

    • URL

      http://www.nims.go.jp/nanophoto/iwanaga/

    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 蛍光検出用生体分子検査チップ2020

    • Inventor(s)
      岩長祐伸
    • Industrial Property Rights Holder
      物質・材料研究機構
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2020 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 蛍光検出用生体分子検査チップ2019

    • Inventor(s)
      岩長祐伸
    • Industrial Property Rights Holder
      国立研究開発法人物質・材料研究機構
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report

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Published: 2017-04-28   Modified: 2022-01-27  

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