Study on self-forming and self-healing mechanism of natural superlubricity in articular cartilage surface

• Project/Area Number: 17H01244
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Design engineering/Machine functional elements/Tribology
• Research Institution: Kyushu University
• Principal Investigator: Sawae Yoshinori 九州大学, 工学研究院, 教授 (10284530)
• Co-Investigator(Kenkyū-buntansha): 山口 哲生 九州大学, 工学研究院, 准教授 (20466783) ; 森田 健敬 九州大学, 工学研究院, 助教 (70175636) ; 中嶋 和弘 帝京大学, 公私立大学の部局等, 准教授 (70315109)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥45,110,000 (Direct Cost: ¥34,700,000、Indirect Cost: ¥10,410,000); Fiscal Year 2020: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2019: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2018: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000); Fiscal Year 2017: ¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
• Keywords: トライボロジー / 関節潤滑 / 超潤滑 / 細胞・組織 / 関節軟骨 / 関節液 / 生体分子 / 生物・生体工学 / 生体高分子 / 張潤滑

Outline of Final Research Achievements

This study aimed to explore details of the sophisticated lubrication mechanism in a natural synovial joint which always articulates smoothly with extremely low friction resistance. The highly hydrated and permeable polymer hydrogel was used as a physical model of articular cartilage and used in the friction test to evaluate the lubricating function of biological molecules contained in synovial fluid. As a result, a complex of hyaluronic acid and phosphides exhibited an excellent lubrication ability on the cartilage model. The pressurized water content of the cartilage model under the contact load played an important role to activate the lubricating effect of synovial constituents by preventing the adsorption of protein molecules on the model surface. The lubrication effect of synovial constituents was further enhanced by combining with extra-cellular matrix synthesized and supplied from cultured chondrocytes.

Academic Significance and Societal Importance of the Research Achievements

この研究から得られる成果には3つの意義が存在すると考える．一つ目は，生体関節の潤滑メカニズムを解明する基礎科学的意義．二つ目は，関節潤滑の破綻による変形性関節症の発症メカニズムについて新しい知見を与える臨床医学的意義，三つ目は，柔軟で透水性を有する高含水ハイドロゲルを摩擦材とし，生体高分子類似の分子構造を有する水溶性潤滑剤を用いた，画期的な超潤滑しゅう動システム開発につながるシーズ技術研究としての工学的意義である．

Research Products

• [Int'l Joint Research] Brno University of Technology(チェコ)
• [Int'l Joint Research] Lulea University of Technology(スウェーデン)
• [Int'l Joint Research] Lulea University of Technology(スウェーデン)
• [Int'l Joint Research] Indian Institute Technology Delhi(インド)
• [Int'l Joint Research] Universiti Teknologi Malaysia(マレーシア)
• [Int'l Joint Research] Lulea University of Technology(スウェーデン)
• [Int'l Joint Research] Brno University of Technology(チェコ)
• [Journal Article] Running-in friction of hip joint replacements can be significantly reduced: The effect of surface-textured acetabular cup (2020)
  • Author(s): Necas David、Usami Hatsuhiko、Niimi Tatsuya、Sawae Yoshinori、Krupka Ivan、Hartl Martin
  • Journal Title: Friction Volume: 8 Issue: 6 Pages: 1137-1152
  • DOI: 10.1007/s40544-019-0351-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Subsonic to Intersonic Transition in Sliding Friction for Soft Solids (2020)
  • Author(s): Yashiki Takuya、Morita Takehiro、Sawae Yoshinori、Yamaguchi Tetsuo
  • Journal Title: Physical Review Letters Volume: 124 Issue: 23 Pages: 238001-238001
  • DOI: 10.1103/physrevlett.124.238001
  • Peer Reviewed
• [Journal Article] Topology and Toughening of Sparse Elastic Networks (2020)
  • Author(s): Yamaguchi Tetsuo、Onoue Yudai、Sawae Yoshinori
  • Journal Title: Physical Review Letters Volume: 124 Issue: 6 Pages: 68002-68002
  • DOI: 10.1103/physrevlett.124.068002
  • Peer Reviewed
• [Journal Article] Effects of Synovial Fluid Constituents on Friction between UHMWPE and CoCrMo (2020)
  • Author(s): Shinmori Hironori、Kubota Mayo、Morita Takehiro、Yamaguchi Tetsuo、Sawae Yoshinori
  • Journal Title: Tribology Online Volume: 15 Issue: 4 Pages: 283-292
  • DOI: 10.2474/trol.15.283
  • NAID: 130007904778
  • Peer Reviewed / Open Access
• [Journal Article] Biomimetic artificial cartilage: fibre-reinforcement of PVA hydrogel to promote biphasic lubrication mechanism (2019)
  • Author(s): Nobuo Sakai, Seido Yarimitsu, Yoshinori Sawae, Mochimitsu Komori, Teruo Murakami
  • Journal Title: Biosurface and Biotribology Volume: 5 Issue: 1 Pages: 13-19
  • DOI: 10.1049/bsbt.2018.0031
  • Peer Reviewed / Open Access
• [Journal Article] Propagation of Fatigue Cracks in Friction of Brittle Hydrogels (2018)
  • Author(s): Yamaguchi Tetsuo、Sato Ryuichiro、Sawae Yoshinori
  • Journal Title: Gels Volume: 4 Issue: 2 Pages: 53-53
  • DOI: 10.3390/gels4020053
  • Peer Reviewed / Open Access
• [Journal Article] The Influence of Proteins and Speed on Friction and Adsorption of Metal/UHMWPE Contact Pair (2017)
  • Author(s): Necas D.、Sawae Y.、Fujisawa T.、Nakashima K.、Morita T.、Yamaguchi T.、Vrbka M.、Krupka I.、Hartl M.
  • Journal Title: Biotribology Volume: 11 Pages: 51-59
  • DOI: 10.1016/j.biotri.2017.03.003
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Superior lubrication mechanism in poly(vinyl alcohol) hybrid gel as artificial cartilage (2017)
  • Author(s): Murakami Teruo、Yarimitsu Seido、Sakai Nobuo、Nakashima Kazuhiro、Yamaguchi Tetsuo、Sawae Yoshinori、Suzuki Atsushi
  • Journal Title: Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology Volume: 231 Issue: 9 Pages: 1160-1170
  • DOI: 10.1177/1350650117712881
  • Peer Reviewed
• [Journal Article] Importance of Adaptive Multimode Lubrication Mechanism in Natural Synovial Joints (2017)
  • Author(s): T. Murakami, S. Yarimitsu, N. Sakai, K. Nakashima, T. Yamaguchi, Y. Sawae
  • Journal Title: Tribology International Volume: 印刷中 Pages: 306-315
  • DOI: 10.1016/j.triboint.2016.12.052
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Experimental study on synovial joint lubrication using natural articular cartilage and hydrogel cartilage models (2020)
  • Author(s): Yoshinori Sawae
  • Organizer: International Tribology Research Symposium
  • Int'l Joint Research / Invited
• [Presentation] モノマー組成の異なるハイドロゲルの摩擦に及ぼす関節液成分の影響 (2020)
  • Author(s): 平川 達大
  • Organizer: トライボロジー会議2020秋別府
• [Presentation] Friction Measurement of Articular cartilage using Nano Tribometer (2020)
  • Author(s): Wenxiao Li
  • Organizer: トライボロジー会議2020秋別府
• [Presentation] 擬似生体環境下での多方向滑り試験における超高分子量ポリエチレン由来のトライボフィルム形成 (2020)
  • Author(s): 新盛弘法
  • Organizer: トライボロジー会議2020秋別府
• [Presentation] 関節内環境における摩擦・摩耗・潤滑 (2020)
  • Author(s): 澤江義則
  • Organizer: トライボロジー会議2020秋別府
• [Presentation] 組成の異なるハイドロゲルの関節模擬環境における摩擦挙動に及ぼす関節液成分の影響 (2020)
  • Author(s): 平川達大
  • Organizer: 日本バイオマテリアル学会2020年度九州ブロック学術講演会
• [Presentation] ヒアルロン酸を充てんしたエポキシ/UHMWPE 複合材の生体模擬環境における摩耗特性 (2020)
  • Author(s): 西村竜成
  • Organizer: 日本バイオマテリアル学会2020年度九州ブロック学術講演会
• [Presentation] レオメータを用いたアガロース-軟骨細胞モデルの摩擦特性評価 (2020)
  • Author(s): 佐藤 巧
  • Organizer: トライボロジー会議2020秋別府
• [Presentation] Lubricity of synovial fluid constituents evaluated on UHMWPE and hydrogel cartilage tissue model (2019)
  • Author(s): Yoshinori Sawae
  • Organizer: International Symposium on Biosurfaces, Biotribology and Bionic-tribology
  • Int'l Joint Research / Invited
• [Presentation] Lubricity of synovial fluid constituents for hydrogel cartilage model (2019)
  • Author(s): Yoshinori Sawae
  • Organizer: 74th STLE Annual Meeting and Exhibition
  • Int'l Joint Research
• [Presentation] Tribological Behavior of Hydrogels in Model Synovial Fluids Containing Proteins, Lipids and Hyaluronic Acid (2019)
  • Author(s): Yoshinori Sawae
  • Organizer: 10th International Conference on Materials for Advanced Technologies
  • Int'l Joint Research / Invited
• [Presentation] Effect of proteins on frictional behavior of copolymer hydrogels consist of hydrophilic and hydrophobic monomers (2019)
  • Author(s): Tatsuhiro Hirakawa
  • Organizer: The 11th International Biotribology Forum
  • Int'l Joint Research
• [Presentation] Evaluation of Lubrication Effect of Protein, Phospholipids and Hyaluronic Acid on Hydrated Hydrogel Cartilage Model (2019)
  • Author(s): Yoshinori Sawae
  • Organizer: International Tribology Conference Sendai 2019
  • Int'l Joint Research
• [Presentation] Evaluation of Lubrication Effect of ECM Using Hydrogels-Chondrocyte Complex (2019)
  • Author(s): Yuki Doi
  • Organizer: International Tribology Conference Sendai 2019
  • Int'l Joint Research
• [Presentation] Effect of Synovial Constituents on the Wear of Artificial Joints Materials (2019)
  • Author(s): Hironori Shinmori
  • Organizer: International Tribology Conference Sendai 2019
  • Int'l Joint Research
• [Presentation] Why contact pressure changes frictional property of joint prosthesis material under boundary lubrication? (2019)
  • Author(s): Kazuhiro Nakashima
  • Organizer: 3rd Czech-Japan Tribology Workshop
  • Int'l Joint Research
• [Presentation] Polymer Biotribology for Evolution of Artificial Joints (2019)
  • Author(s): Yoshinori Sawae
  • Organizer: Malaysia-Singapore Research Symposium 2019
  • Int'l Joint Research / Invited
• [Presentation] I型コラーゲン-軟骨細胞複合体を用いた細胞外基質成分の潤滑効果評価 (2019)
  • Author(s): 土井 裕貴
  • Organizer: 日本機械学会九州支部沖縄講演会
• [Presentation] Effect of proteins on frictional behavior of copolymer hydrogels consist of hydrophilic and hydrophobic monomers (2019)
  • Author(s): Hironori Shinmori
  • Organizer: The 8th International Conference on BioSensors, BioElectronics, BioMedical Devices, BioMEMS/NEMS & Applications
  • Int'l Joint Research
• [Presentation] Lubricity of synovial fluid constituents for artificial joint and synovial joint model (2019)
  • Author(s): Yoshinori Sawae
  • Organizer: The 8th International Conference on BioSensors, BioElectronics, BioMedical Devices, BioMEMS/NEMS & Applications
  • Int'l Joint Research
• [Presentation] Study on synovial joint lubrication with macroscale experimental models of cartilage tissue and synovial fluid (2019)
  • Author(s): Yoshinori Sawae
  • Organizer: IndiaTrib 2019
  • Int'l Joint Research / Invited
• [Presentation] LUBRICITY OF SYNOVIA CONSTITUENTS ON HYDROGEL ARTIFICIAL CARTILAGE (2018)
  • Author(s): Yoshinori Sawae Mayo Kubota Takehiro Morita Tetsuo Yamaguchi
  • Organizer: The 18th Nordic Symposium on Tribology
  • Int'l Joint Research
• [Presentation] Contribution of Each Synovia Constituent to Friction of UHMWPE / CoCrMo sliding pair for joint prosthesis (2018)
  • Author(s): Hironori Shinmori Yoshinori Sawae Mayo Kubota Takehiro Morita Tetsuo Yamaguchi
  • Organizer: 6th Asia International Conference on Tribology
  • Int'l Joint Research
• [Presentation] Polymer Biotribology (2018)
  • Author(s): Yoshinori Sawae
  • Organizer: 3rd International Conference on Polymer Tribology
  • Int'l Joint Research / Invited
• [Presentation] Shape design and friction of polymer gels (2018)
  • Author(s): Tetsuo Yamaguchi Yoshinori Sawae
  • Organizer: 3rd International Conference on Polymer Tribology
  • Int'l Joint Research / Invited
• [Presentation] Effect of proteins and phospholipids for friction between UHMWPE and CoCrMo (2018)
  • Author(s): Hironori Shinmori Yoshinori Sawae Mayo Kubota Takehiro Morita Tetsuo Yamaguchi
  • Organizer: 4th International Conference on BioTribology
  • Int'l Joint Research
• [Presentation] Lubricity of synovial fluid constituents on highly hydrated hydrogel artificial cartilage (2018)
  • Author(s): Mayo Kubota Hironori Shinmori Takehiro Morita Tetsuo Yamaguchi Yoshinori Sawae
  • Organizer: 4th International Conference on BioTribology
  • Int'l Joint Research
• [Presentation] 関節液中でのUHMWPE/CoCrMo間の摩擦特性 (2018)
  • Author(s): 新盛 弘法 森田 健敬 山口 哲生 澤江 義則
  • Organizer: 日本機械学会2018年度年次大会
• [Presentation] Rheological Characteristics and Lubricity of Model Synovial Fluids containing Protein, Phospholipids and Hyaluronic Acid (2018)
  • Author(s): Yoshinori Sawae Hironori Shinmori Mayo Kubota Tetsuo Yamaguchi Takehiro Morita
  • Organizer: 2018 International Conference on Engineering Tribology and Applied Technology
  • Int'l Joint Research
• [Presentation] 生体高分子成分による超高分子量ポリエチレンの摩擦・摩耗への影響 (2018)
  • Author(s): 新盛弘法 久保田万葉 森田健 敬 山口哲生 澤江義則
  • Organizer: トライボロジー会議2018秋 伊勢
• [Presentation] Protein and phospholipids increase friction between CoCrMo and UHMWPE (2018)
  • Author(s): Hironori Shinmori
  • Organizer: The 10th International Biotribology Forum
  • Int'l Joint Research
• [Presentation] Lubricity of synovial fluid constituents on highly hydrated hydrogel artificial cartilage (2018)
  • Author(s): Mayo Kubota
  • Organizer: The 10th International Biotribology Forum
  • Int'l Joint Research
• [Presentation] Biotribology of Natural Synovial Joint and Joint Prosthesis (2017)
  • Author(s): Yoshinori Sawae
  • Organizer: The Japan Society of Mechanical Engineers Hokkaido Branch “Biomechanics Research Meeting” 29th Seminar
  • Invited
• [Presentation] Deformation Determination of Cultured Cells inside Scaffolds under Mechanical Load (2017)
  • Author(s): Hideaki Ariura
  • Organizer: 5th Malaysia-Japan Tribology Symposium 2017
  • Int'l Joint Research
• [Presentation] 再生軟骨組織への機械的負荷による内部細胞の変形 (2017)
  • Author(s): 有浦秀昭
  • Organizer: 第39回バイオトライボロジ研究会
• [Presentation] Cartilaginous tissue formation by cultured chondrocytes under traction loading (2017)
  • Author(s): Yoshinori Sawae
  • Organizer: 6th World Tribology Congress
  • Int'l Joint Research
• [Presentation] Effects of serum lubrication on friction between hydrogel acetabular liner and metal head (2017)
  • Author(s): Yoshinori Sawae
  • Organizer: Biosurface and Biotribology Chengdu 2017
  • Int'l Joint Research / Invited
• [Presentation] Deformation determination of cultured cell inside scaffolds under mechanical load (2017)
  • Author(s): Ariura Hideaki
  • Organizer: Biosurface and Biotribology Chengdu 2017
  • Int'l Joint Research
• [Presentation] Lubrication Effects of Model Synovial Fluid on Hydrated Hydrogel Artificial Cartilage (2017)
  • Author(s): Mayo Kubota
  • Organizer: 2nd Czech-Japan Tribology Workshop
  • Int'l Joint Research
• [Presentation] Effect of Synovial Constituents on Friction between UHMWPE and CoCrMo (2017)
  • Author(s): Hironori Shinmori
  • Organizer: 2nd Czech-Japan Tribology Workshop
  • Int'l Joint Research
• [Presentation] 機械的負荷を与えた足場材内部における 培養細胞の変形定量 (2017)
  • Author(s): 有浦秀昭
  • Organizer: 日本機械学会第30回バイオエンジニアリング講演会
• [Presentation] 培養軟骨細胞による組織形成に対する円 筒接触による力学負荷の影響 (2017)
  • Author(s): 岸幸直
  • Organizer: 日本機械学会第30回バイオエンジニアリング講演会
• [Book] Handbook of Polymer Tribology (2018)
  • Author(s): Sujeet Kumar Sinha
  • Total Pages: 694
  • Publisher: World Scientific Pub Co Inc
  • ISBN: 9813227788
• [Book] 数値解析と表面分析による トライボロジーの解明と制御 (2018)
  • Author(s): 佐々木 信也
  • Total Pages: 1192
  • Publisher: テクノシステム
  • ISBN: 9784924728806
• [Book] 高度物理刺激と生体応答 (2017)
  • Author(s): 佐藤岳彦
  • Total Pages: 197
  • Publisher: 養賢堂
  • ISBN: 9784842505626