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Study on self-forming and self-healing mechanism of natural superlubricity in articular cartilage surface

Research Project

Project/Area Number 17H01244
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Design engineering/Machine functional elements/Tribology
Research InstitutionKyushu University

Principal Investigator

Sawae Yoshinori  九州大学, 工学研究院, 教授 (10284530)

Co-Investigator(Kenkyū-buntansha) 山口 哲生  九州大学, 工学研究院, 准教授 (20466783)
森田 健敬  九州大学, 工学研究院, 助教 (70175636)
中嶋 和弘  帝京大学, 公私立大学の部局等, 准教授 (70315109)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥45,110,000 (Direct Cost: ¥34,700,000、Indirect Cost: ¥10,410,000)
Fiscal Year 2020: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2018: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2017: ¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
Keywordsトライボロジー / 関節潤滑 / 超潤滑 / 細胞・組織 / 関節軟骨 / 関節液 / 生体分子 / 生物・生体工学 / 生体高分子 / 張潤滑
Outline of Final Research Achievements

This study aimed to explore details of the sophisticated lubrication mechanism in a natural synovial joint which always articulates smoothly with extremely low friction resistance. The highly hydrated and permeable polymer hydrogel was used as a physical model of articular cartilage and used in the friction test to evaluate the lubricating function of biological molecules contained in synovial fluid. As a result, a complex of hyaluronic acid and phosphides exhibited an excellent lubrication ability on the cartilage model. The pressurized water content of the cartilage model under the contact load played an important role to activate the lubricating effect of synovial constituents by preventing the adsorption of protein molecules on the model surface. The lubrication effect of synovial constituents was further enhanced by combining with extra-cellular matrix synthesized and supplied from cultured chondrocytes.

Academic Significance and Societal Importance of the Research Achievements

この研究から得られる成果には3つの意義が存在すると考える.一つ目は,生体関節の潤滑メカニズムを解明する基礎科学的意義.二つ目は,関節潤滑の破綻による変形性関節症の発症メカニズムについて新しい知見を与える臨床医学的意義,三つ目は,柔軟で透水性を有する高含水ハイドロゲルを摩擦材とし,生体高分子類似の分子構造を有する水溶性潤滑剤を用いた,画期的な超潤滑しゅう動システム開発につながるシーズ技術研究としての工学的意義である.

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (61 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (7 results) Journal Article (9 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 9 results,  Open Access: 4 results) Presentation (42 results) (of which Int'l Joint Research: 28 results,  Invited: 9 results) Book (3 results)

  • [Int'l Joint Research] Brno University of Technology(チェコ)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Lulea University of Technology(スウェーデン)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Lulea University of Technology(スウェーデン)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Indian Institute Technology Delhi(インド)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Universiti Teknologi Malaysia(マレーシア)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Lulea University of Technology(スウェーデン)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Brno University of Technology(チェコ)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Running-in friction of hip joint replacements can be significantly reduced: The effect of surface-textured acetabular cup2020

    • Author(s)
      Necas David、Usami Hatsuhiko、Niimi Tatsuya、Sawae Yoshinori、Krupka Ivan、Hartl Martin
    • Journal Title

      Friction

      Volume: 8 Issue: 6 Pages: 1137-1152

    • DOI

      10.1007/s40544-019-0351-x

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Subsonic to Intersonic Transition in Sliding Friction for Soft Solids2020

    • Author(s)
      Yashiki Takuya、Morita Takehiro、Sawae Yoshinori、Yamaguchi Tetsuo
    • Journal Title

      Physical Review Letters

      Volume: 124 Issue: 23 Pages: 238001-238001

    • DOI

      10.1103/physrevlett.124.238001

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Topology and Toughening of Sparse Elastic Networks2020

    • Author(s)
      Yamaguchi Tetsuo、Onoue Yudai、Sawae Yoshinori
    • Journal Title

      Physical Review Letters

      Volume: 124 Issue: 6 Pages: 68002-68002

    • DOI

      10.1103/physrevlett.124.068002

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Synovial Fluid Constituents on Friction between UHMWPE and CoCrMo2020

    • Author(s)
      Shinmori Hironori、Kubota Mayo、Morita Takehiro、Yamaguchi Tetsuo、Sawae Yoshinori
    • Journal Title

      Tribology Online

      Volume: 15 Issue: 4 Pages: 283-292

    • DOI

      10.2474/trol.15.283

    • NAID

      130007904778

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biomimetic artificial cartilage: fibre-reinforcement of PVA hydrogel to promote biphasic lubrication mechanism2019

    • Author(s)
      Nobuo Sakai, Seido Yarimitsu, Yoshinori Sawae, Mochimitsu Komori, Teruo Murakami
    • Journal Title

      Biosurface and Biotribology

      Volume: 5 Issue: 1 Pages: 13-19

    • DOI

      10.1049/bsbt.2018.0031

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Propagation of Fatigue Cracks in Friction of Brittle Hydrogels2018

    • Author(s)
      Yamaguchi Tetsuo、Sato Ryuichiro、Sawae Yoshinori
    • Journal Title

      Gels

      Volume: 4 Issue: 2 Pages: 53-53

    • DOI

      10.3390/gels4020053

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Influence of Proteins and Speed on Friction and Adsorption of Metal/UHMWPE Contact Pair2017

    • Author(s)
      Necas D.、Sawae Y.、Fujisawa T.、Nakashima K.、Morita T.、Yamaguchi T.、Vrbka M.、Krupka I.、Hartl M.
    • Journal Title

      Biotribology

      Volume: 11 Pages: 51-59

    • DOI

      10.1016/j.biotri.2017.03.003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Superior lubrication mechanism in poly(vinyl alcohol) hybrid gel as artificial cartilage2017

    • Author(s)
      Murakami Teruo、Yarimitsu Seido、Sakai Nobuo、Nakashima Kazuhiro、Yamaguchi Tetsuo、Sawae Yoshinori、Suzuki Atsushi
    • Journal Title

      Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology

      Volume: 231 Issue: 9 Pages: 1160-1170

    • DOI

      10.1177/1350650117712881

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Importance of Adaptive Multimode Lubrication Mechanism in Natural Synovial Joints2017

    • Author(s)
      T. Murakami, S. Yarimitsu, N. Sakai, K. Nakashima, T. Yamaguchi, Y. Sawae
    • Journal Title

      Tribology International

      Volume: 印刷中 Pages: 306-315

    • DOI

      10.1016/j.triboint.2016.12.052

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Experimental study on synovial joint lubrication using natural articular cartilage and hydrogel cartilage models2020

    • Author(s)
      Yoshinori Sawae
    • Organizer
      International Tribology Research Symposium
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] モノマー組成の異なるハイドロゲルの摩擦に及ぼす関節液成分の影響2020

    • Author(s)
      平川 達大
    • Organizer
      トライボロジー会議2020秋別府
    • Related Report
      2020 Annual Research Report
  • [Presentation] Friction Measurement of Articular cartilage using Nano Tribometer2020

    • Author(s)
      Wenxiao Li
    • Organizer
      トライボロジー会議2020秋別府
    • Related Report
      2020 Annual Research Report
  • [Presentation] 擬似生体環境下での多方向滑り試験における超高分子量ポリエチレン由来のトライボフィルム形成2020

    • Author(s)
      新盛弘法
    • Organizer
      トライボロジー会議2020秋別府
    • Related Report
      2020 Annual Research Report
  • [Presentation] 関節内環境における摩擦・摩耗・潤滑2020

    • Author(s)
      澤江義則
    • Organizer
      トライボロジー会議2020秋別府
    • Related Report
      2020 Annual Research Report
  • [Presentation] 組成の異なるハイドロゲルの関節模擬環境における摩擦挙動に及ぼす関節液成分の影響2020

    • Author(s)
      平川達大
    • Organizer
      日本バイオマテリアル学会2020年度九州ブロック学術講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ヒアルロン酸を充てんしたエポキシ/UHMWPE 複合材の生体模擬環境における摩耗特性2020

    • Author(s)
      西村竜成
    • Organizer
      日本バイオマテリアル学会2020年度九州ブロック学術講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] レオメータを用いたアガロース-軟骨細胞モデルの摩擦特性評価2020

    • Author(s)
      佐藤 巧
    • Organizer
      トライボロジー会議2020秋別府
    • Related Report
      2020 Annual Research Report
  • [Presentation] Lubricity of synovial fluid constituents evaluated on UHMWPE and hydrogel cartilage tissue model2019

    • Author(s)
      Yoshinori Sawae
    • Organizer
      International Symposium on Biosurfaces, Biotribology and Bionic-tribology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Lubricity of synovial fluid constituents for hydrogel cartilage model2019

    • Author(s)
      Yoshinori Sawae
    • Organizer
      74th STLE Annual Meeting and Exhibition
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Tribological Behavior of Hydrogels in Model Synovial Fluids Containing Proteins, Lipids and Hyaluronic Acid2019

    • Author(s)
      Yoshinori Sawae
    • Organizer
      10th International Conference on Materials for Advanced Technologies
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Effect of proteins on frictional behavior of copolymer hydrogels consist of hydrophilic and hydrophobic monomers2019

    • Author(s)
      Tatsuhiro Hirakawa
    • Organizer
      The 11th International Biotribology Forum
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of Lubrication Effect of Protein, Phospholipids and Hyaluronic Acid on Hydrated Hydrogel Cartilage Model2019

    • Author(s)
      Yoshinori Sawae
    • Organizer
      International Tribology Conference Sendai 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of Lubrication Effect of ECM Using Hydrogels-Chondrocyte Complex2019

    • Author(s)
      Yuki Doi
    • Organizer
      International Tribology Conference Sendai 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of Synovial Constituents on the Wear of Artificial Joints Materials2019

    • Author(s)
      Hironori Shinmori
    • Organizer
      International Tribology Conference Sendai 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Why contact pressure changes frictional property of joint prosthesis material under boundary lubrication?2019

    • Author(s)
      Kazuhiro Nakashima
    • Organizer
      3rd Czech-Japan Tribology Workshop
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Polymer Biotribology for Evolution of Artificial Joints2019

    • Author(s)
      Yoshinori Sawae
    • Organizer
      Malaysia-Singapore Research Symposium 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] I型コラーゲン-軟骨細胞複合体を用いた細胞外基質成分の潤滑効果評価2019

    • Author(s)
      土井 裕貴
    • Organizer
      日本機械学会九州支部沖縄講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Effect of proteins on frictional behavior of copolymer hydrogels consist of hydrophilic and hydrophobic monomers2019

    • Author(s)
      Hironori Shinmori
    • Organizer
      The 8th International Conference on BioSensors, BioElectronics, BioMedical Devices, BioMEMS/NEMS & Applications
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Lubricity of synovial fluid constituents for artificial joint and synovial joint model2019

    • Author(s)
      Yoshinori Sawae
    • Organizer
      The 8th International Conference on BioSensors, BioElectronics, BioMedical Devices, BioMEMS/NEMS & Applications
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Study on synovial joint lubrication with macroscale experimental models of cartilage tissue and synovial fluid2019

    • Author(s)
      Yoshinori Sawae
    • Organizer
      IndiaTrib 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] LUBRICITY OF SYNOVIA CONSTITUENTS ON HYDROGEL ARTIFICIAL CARTILAGE2018

    • Author(s)
      Yoshinori Sawae Mayo Kubota Takehiro Morita Tetsuo Yamaguchi
    • Organizer
      The 18th Nordic Symposium on Tribology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Contribution of Each Synovia Constituent to Friction of UHMWPE / CoCrMo sliding pair for joint prosthesis2018

    • Author(s)
      Hironori Shinmori Yoshinori Sawae Mayo Kubota Takehiro Morita Tetsuo Yamaguchi
    • Organizer
      6th Asia International Conference on Tribology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Polymer Biotribology2018

    • Author(s)
      Yoshinori Sawae
    • Organizer
      3rd International Conference on Polymer Tribology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Shape design and friction of polymer gels2018

    • Author(s)
      Tetsuo Yamaguchi Yoshinori Sawae
    • Organizer
      3rd International Conference on Polymer Tribology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Effect of proteins and phospholipids for friction between UHMWPE and CoCrMo2018

    • Author(s)
      Hironori Shinmori Yoshinori Sawae Mayo Kubota Takehiro Morita Tetsuo Yamaguchi
    • Organizer
      4th International Conference on BioTribology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Lubricity of synovial fluid constituents on highly hydrated hydrogel artificial cartilage2018

    • Author(s)
      Mayo Kubota Hironori Shinmori Takehiro Morita Tetsuo Yamaguchi Yoshinori Sawae
    • Organizer
      4th International Conference on BioTribology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 関節液中でのUHMWPE/CoCrMo間の摩擦特性2018

    • Author(s)
      新盛 弘法 森田 健敬 山口 哲生 澤江 義則
    • Organizer
      日本機械学会2018年度年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Rheological Characteristics and Lubricity of Model Synovial Fluids containing Protein, Phospholipids and Hyaluronic Acid2018

    • Author(s)
      Yoshinori Sawae Hironori Shinmori Mayo Kubota Tetsuo Yamaguchi Takehiro Morita
    • Organizer
      2018 International Conference on Engineering Tribology and Applied Technology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生体高分子成分による超高分子量ポリエチレンの摩擦・摩耗への影響2018

    • Author(s)
      新盛弘法 久保田万葉 森田健 敬 山口哲生 澤江義則
    • Organizer
      トライボロジー会議2018秋 伊勢
    • Related Report
      2018 Annual Research Report
  • [Presentation] Protein and phospholipids increase friction between CoCrMo and UHMWPE2018

    • Author(s)
      Hironori Shinmori
    • Organizer
      The 10th International Biotribology Forum
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Lubricity of synovial fluid constituents on highly hydrated hydrogel artificial cartilage2018

    • Author(s)
      Mayo Kubota
    • Organizer
      The 10th International Biotribology Forum
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Biotribology of Natural Synovial Joint and Joint Prosthesis2017

    • Author(s)
      Yoshinori Sawae
    • Organizer
      The Japan Society of Mechanical Engineers Hokkaido Branch “Biomechanics Research Meeting” 29th Seminar
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Deformation Determination of Cultured Cells inside Scaffolds under Mechanical Load2017

    • Author(s)
      Hideaki Ariura
    • Organizer
      5th Malaysia-Japan Tribology Symposium 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 再生軟骨組織への機械的負荷による内部細胞の変形2017

    • Author(s)
      有浦秀昭
    • Organizer
      第39回バイオトライボロジ研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Cartilaginous tissue formation by cultured chondrocytes under traction loading2017

    • Author(s)
      Yoshinori Sawae
    • Organizer
      6th World Tribology Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of serum lubrication on friction between hydrogel acetabular liner and metal head2017

    • Author(s)
      Yoshinori Sawae
    • Organizer
      Biosurface and Biotribology Chengdu 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Deformation determination of cultured cell inside scaffolds under mechanical load2017

    • Author(s)
      Ariura Hideaki
    • Organizer
      Biosurface and Biotribology Chengdu 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Lubrication Effects of Model Synovial Fluid on Hydrated Hydrogel Artificial Cartilage2017

    • Author(s)
      Mayo Kubota
    • Organizer
      2nd Czech-Japan Tribology Workshop
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of Synovial Constituents on Friction between UHMWPE and CoCrMo2017

    • Author(s)
      Hironori Shinmori
    • Organizer
      2nd Czech-Japan Tribology Workshop
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 機械的負荷を与えた足場材内部における 培養細胞の変形定量2017

    • Author(s)
      有浦秀昭
    • Organizer
      日本機械学会第30回バイオエンジニアリング講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 培養軟骨細胞による組織形成に対する円 筒接触による力学負荷の影響2017

    • Author(s)
      岸幸直
    • Organizer
      日本機械学会第30回バイオエンジニアリング講演会
    • Related Report
      2017 Annual Research Report
  • [Book] Handbook of Polymer Tribology2018

    • Author(s)
      Sujeet Kumar Sinha
    • Total Pages
      694
    • Publisher
      World Scientific Pub Co Inc
    • ISBN
      9813227788
    • Related Report
      2018 Annual Research Report
  • [Book] 数値解析と表面分析による トライボロジーの解明と制御2018

    • Author(s)
      佐々木 信也
    • Total Pages
      1192
    • Publisher
      テクノシステム
    • ISBN
      9784924728806
    • Related Report
      2017 Annual Research Report
  • [Book] 高度物理刺激と生体応答2017

    • Author(s)
      佐藤岳彦
    • Total Pages
      197
    • Publisher
      養賢堂
    • ISBN
      9784842505626
    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2022-05-13  

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