Diamond quantum image sensor for molecular targeted dynamics of cancer
Project/Area Number |
17H01262
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Electronic materials/Electric materials
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Research Institution | Tokyo Institute of Technology |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
関野 正樹 東京大学, 大学院工学系研究科(工学部), 准教授 (20401036)
日下部 守昭 東京大学, 大学院農学生命科学研究科(農学部), 特任教授 (60153277)
八井 崇 東京大学, 大学院工学系研究科(工学部), 准教授 (80505248)
|
Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
|
Budget Amount *help |
¥44,070,000 (Direct Cost: ¥33,900,000、Indirect Cost: ¥10,170,000)
Fiscal Year 2019: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2018: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2017: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
|
Keywords | 電子デバイス・機器 / 電気電子材料 / 電気・電子材料 |
Outline of Final Research Achievements |
For highly accurate detection of cancer metastasis to lymph nodes, aiming at higher sensitivity of quantum sensor using nitrogen-vacancy (NV) center in diamond and application of prototype to animal experiments, we researched in collaboration with engineering and medicine. As a result, we aim to improve the performance of the sensor film and device by controlling the atomic level of the NV center by the nitrogen-doped CVD method, enlarging the area by forming a diamond film on the Si substrate, and improving the efficiency of light emission from the NV center. We have also constructed a quantum measurement technology and realized a highly sensitive magnetic sensor. Furthermore, we made a prototype of a small handheld type prototype and succeeded in detecting magnetic nanoparticles accumulated in the lymph nodes of rats.
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Academic Significance and Societal Importance of the Research Achievements |
乳癌の罹患数の増加は顕著である。乳癌の転移診断では、乳房から癌細胞が初めに到達するリンパ節を同定→病理検査→リンパ節の切除の判断、を行っている。この同定法としてラジオアイソトープ法が主流であるが、放射性物質を使用のため大病院に導入が限られる。これに対して、本研究では、高感度なダイヤモンド量子センサを開発し、癌病巣からリンパ系へ導入した磁性粒体を非侵襲で高精度かつ深部の診断の可能性を示した。癌が転移するシステムを模擬しており、ヒト臨床試験へと進むための重要な結果である。迅速・高精度・低侵襲化によるQuality of Lifeの向上につながる次世代医療の計測技術として、社会的意義が深いと考える。
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Report
(4 results)
Research Products
(140 results)
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[Presentation] ダイヤモンド横型pn 接合ダイオードを用いたGeV センターの電気励起2020
Author(s)
須田弘平, 室岡拓也, 楊 棒,汪 鵬,加藤 宙光,牧野 俊晴,小倉 政彦,山崎 聡,谷口 尚, 波多野 睦子,岩崎 孝之
Organizer
第67回応用物理学会春季学術講演会
Related Report
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[Presentation] NV Quantum Sensors in Diamond Electronic Devices2019
Author(s)
Takayuki Iwasaki, Takuya Murooka, Bang Yang, Masafumi Shiigai, Motoki Nakamura, Hiromitsu Kato, Toshiharu Makino, Masahiko Ogura, Satoshi Yamasaki, Mutsuko Hatano
Organizer
The 2nd International Forum on Quantum Metrology and Sensing
Related Report
Int'l Joint Research
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[Presentation] Impoving magnetic sesitivity in magnetometer with Nitrogen-Vacancy center in a bluk diamond using grating coupler2019
Author(s)
Takumi Sato, Takahiro Kitaizumi, Kota Saichi, Akihiro Kuwahata, Ryuji Igarashi, Takeshi ohshima, Yuta Masuyama, Takayuki Iwasaki, Mutsuko Hatano, Fedor Jelezko, Moriaki Kusakabe, Masaki Sekino, Takashi Yatsui
Organizer
The 2nd International Forum on Quantum Metrology and Sensing
Related Report
Int'l Joint Research
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[Presentation] グレーティング結合によるダイヤモンド磁気センサの光取り出し効率に関する検討2019
Author(s)
佐藤匠,北泉隆裕,齋地康太, 桑波田晃弘,五十嵐龍治,大島武,増山雄太,岩崎孝之,波多野睦子,Fedor Jelezko,日下部守昭,関野正樹,八井崇
Organizer
Optics & Photonics Japan 2019
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[Presentation] Development of Highly Sensitive Magnetic Probe of Nitrogen-Vacancy center in diamond2019
Author(s)
Kota Saichi, Takumi Sato, Takahiro Kitaizumi, Akihiro Kuwahata, Masaki Sekino, Ryuji Igarashi, Yuta Masuyama, Takayuki Iwasaki, Mutsuko Hatano, Fedor Jelezko, and Takashi Yatsui
Organizer
The 1st International Forum on Quantum Sensing (IFQS2019)
Related Report
Int'l Joint Research
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[Presentation] Development of magnetometer with Diamond NV center for detection of magnetic nanoparticles in biomedical tissues2019
Author(s)
Akihiro Kuwahata, Takahiro Kitaizumi, Kota Saichi, Takumi Sato, Ryuji Igarashi, Yuta Masuyama, Takayuki Iwasaki, Mutsuko Hatano, Fedor Jelezko, Takashi Yatsui, Masaki Sekino
Organizer
The 1st International Forum on Quantum Sensing (IFQS2019)
Related Report
Int'l Joint Research
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[Presentation] Magnetic Field and Temperature Sensing with Silicon Vacancy in 4H-SiC2019
Author(s)
M-T. Hoang, K. Mizuno, Y. Masuyama, S-I. Sato, Y. Yamazaki, T. Ohshima, S-Y. Lee, K. Kojima, T. Iwasaki, D. Hisamoto, M. Hatano
Organizer
The 1st International Forum on Quantum Sensing (IFQS2019)
Related Report
Int'l Joint Research
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[Presentation] Development of magnetic sensing probe of Nitrogen-Vacancy center in diamond2018
Author(s)
K. Saichi, T. Sato, T. Kitaizumi, A. Kuwahata, M. Sekino, R. Igarashi, Y. Masuyama, T. Iwasaki, M. Hatano, F. Jelezko, and T. Yatsui
Organizer
JSPS Core-to-Core Japan Workshop 2018
Related Report
Int'l Joint Research
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[Presentation] Evaluation of illumination and collection efficiency of Nitrogen-Vacancy center in diamond by fiber optical system2018
Author(s)
T. Sato, K. Saichi, T. Kitaizumi, A. Kuwahata, M. Sekino, R. Igarashi, Y. Masuyama, T. Iwasaki, M. Hatano, F. Jelezko, and T. Yatsui
Organizer
JSPS Core-to-Core Japan Workshop 2018
Related Report
Int'l Joint Research
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[Presentation] ダイヤモンド JFET の高電界強度計測へ向けた量子センサアレイの形成2018
Author(s)
楊 棒, 金 光秀, マレク・シュミット, 牧野 俊晴, 加藤 宙光, 小倉 政彦, 竹内 大輔, 山崎 聡, 水田 博, 波多野 睦子, 岩崎 孝之
Organizer
第32回ダイヤモンドシンポジウム
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[Presentation] 転移癌検出に向けたNVセンター磁気プローブの開発2018
Author(s)
齋地 康太, 佐藤 匠, 北泉 隆裕 , 桑波田 晃弘 , 関野 正樹, 五十嵐 龍治, 増山 雄太, 岩崎 孝之, 波多野 睦子, Jelezko Fedor, 八井 崇
Organizer
第79回応用物理学会秋季学術講演会
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[Presentation] Process Damage Influence for Electrical Property of Diamond Schottky Barrier Diodes2018
Author(s)
T. Murooka, K. Takizawa, Y. Kato, T. Makino, M. Ogura, H. Kato, R. Wada, S. Yamasaki, T. Iwasaki, H. Nohira, M. Hatano
Organizer
2018International Conference on Solid State Devices and Materials
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Int'l Joint Research
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[Presentation] Development of magnetic techniques for intraoperative diagnosis of breast cancer metastasis2017
Author(s)
Masaki Sekino, Akihiro Kuwahata, Miki Kaneko, Shinichi Chikaki, Norio Tanabe, Takayuki Nakagawa, Kohei Saeki, Mikio Shiozawa, Hiroyuki Takei, Seigo Nakamura, and Moriaki Kusakabe
Organizer
Tsinghua-Todai joint symposium on Bioengineering and Biomedical Engineering
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Int'l Joint Research / Invited
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