Development of an ultrahigh sensitivity terahertz biochip
| Project/Area Number |
17H01269
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Electron device/Electronic equipment
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
川山 巌 京都大学, エネルギー科学研究科, 准教授 (10332264)
村上 博成 大阪大学, レーザー科学研究所, 准教授 (30219901)
芹田 和則 大阪大学, レーザー科学研究所, 特任研究員 (00748014)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥45,500,000 (Direct Cost: ¥35,000,000、Indirect Cost: ¥10,500,000)
Fiscal Year 2019: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2018: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2017: ¥29,120,000 (Direct Cost: ¥22,400,000、Indirect Cost: ¥6,720,000)
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| Keywords | テラヘルツ / バイオチップ / 非線形光学 / 局所場光物性 / 局所光物性 / メタアトム |
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| Outline of Final Research Achievements |
We proposed the world's first combination of a meta-atom and a local THz (terahertz) point light source, and developed a THz biochip that can directly observe molecular functions such as kinetic behavior and chemical reactions of extremely small amounts of biological and macromolecular compounds. In order to achieve our goal, we proposed the combination of meta-atom and local THz point source, and succeeded in the solution of about 600 attomole of methylcytosine in 50 petaliter by using various designs such as Fano resonant meta-atom array. By doing so, we were able to overcome the weakness of terahertz time-domain spectroscopy in detecting trace amounts and high sensitivity, and obtained the world's top data.
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| Academic Significance and Societal Importance of the Research Achievements |
メタマテリアルの基本単位であるメタアトムとテラヘルツ電磁波局所点光源の融合を用いた高感度バイオチップを世界に先駆けて提案したもので、世界トップのデータを提供すること成功し、テラヘルツ時間領域分光法の弱点であった、微量、高感度検出の性能を大きく向上させた。この提案はフェムト秒時間スケールでのテラヘルツ波の局所場発生とメタサーフェイスの時間領域相互作用を科学する新しい学術を創生するとともに、医療・製薬などの幅広い分野の産業応用に展開できる基盤を提供するものである。
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Report
(4 results)
Research Products
(64 results)
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[Presentation] Scanning laser terahertz near-field reflection microscope for biological analysis2019
Author(s)
Kosuke Okada, Kazunori Serita, Zirui Zang, Hironaru Murakami, Iwao Kawayama, Quentin Cassar, Amel Al-Ibadi, Gatan MacGrogan, Thomas Zimmer, Jean-Paul Guillet, Patrick Mounaix, and Masayoshi Tonouchi
Organizer
OSA Biophotonics Congress: Optics in the Life Sciences
Related Report
Int'l Joint Research
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[Presentation] Development of a Scanning Near-field Terahertz Reflection Microscope for Highly Sensitive Bio-sensing2019
Author(s)
K. Okada, K. Serita, Z. Zang, H. Murakami, I. Kawayama, Q. Cassar, A. Al-Ibadi, G. MacGrogan, T. Zimmer, J. Guillet, P. Mounaix, and M. Tonouchi
Organizer
International Workshop on Optical Terahertz Science and Technology (OTST 2019)
Related Report
Int'l Joint Research
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[Presentation] Intense Terahertz Response of Superconductive Thin Films and Metamaterials2018
Author(s)
M. Tonouchi, H. Murakami, I. Kawayama, C. Zhang, J. Wu, B. Jin, X. Jia, L. Kang, W. Xu, H. Wang, J. Chen, and P. Wu
Organizer
The 14th International Workshop of High-Temperature Superconductors in High Frequency Field
Related Report
Invited
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[Presentation] New method to estimate oxygen adsorption energy on 2D materials with terahertz emission microscopy2017
Author(s)
F. R. Bagsican, A. Winchester, S. Ghosh, X. Zhang, L. Ma, M. Wang, H. Murakami, S. Talapatra, R. Vajtai, P. M. Ajayan, J. Kono, M. Tonouchi, and I. Kawayama
Organizer
The 4th International Symposium on Microwave/Terahertz Science and Applications
Related Report
Int'l Joint Research / Invited
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