• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Rapid detection of threat signals in primate amygdala

Research Project

Project/Area Number 17H01381
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionOsaka University

Principal Investigator

Fujita Ichiro  大阪大学, 生命機能研究科, 教授 (60181351)

Co-Investigator(Kenkyū-buntansha) 井上 謙一  京都大学, 霊長類研究所, 助教 (90455395)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥39,650,000 (Direct Cost: ¥30,500,000、Indirect Cost: ¥9,150,000)
Fiscal Year 2019: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2018: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2017: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
Keywords扁桃体 / 大脳皮質視覚野 / 表情認識 / 迅速経路仮説 / 狂犬病ウイルス / 危険認知 / 新生児微笑 / 自閉症 / 視床枕 / 上丘 / 表情弁別 / 皮質下経路 / 霊長類 / サポートベクターマシン / 情動 / 顔表情 / 脅威信号 / 顔認識 / 大脳皮質側頭葉 / ディープラーニング / 側頭葉視覚連合野 / 単一細胞活動 / 神経科学 / 生理学
Outline of Final Research Achievements

A subcortical pathway through the superior colliculus and pulvinar has been proposed to provide the amygdala with rapid but coarse visual information about emotional faces. Here we showed that ensemble responses of amygdala neurons in monkeys carried robust information about open-mouthed (threatening) faces within 50 ms after stimulus onset. Temporal analysis revealed that the early response contained excitatory and suppressive components. The excitatory component may be useful for sending rapid signals downstream, while the sharpening of the rising phase of later-arriving inputs by the suppressive component might improve the processing of facial expressions over time. Injection of a retrograde trans-synaptic tracer into the amygdala revealed presumed monosynaptic labeling in the pulvinar and disynaptic labeling in the superior colliculus. We suggest that the early amygdala responses originating from the colliculo-pulvino-amygdalar pathway play dual roles in threat detection.

Academic Significance and Societal Importance of the Research Achievements

本研究は、大脳皮質経路とは別に皮質下経路が他者の威嚇表情を伝えていることを生理学に示し、またそれを実現する解剖学経路の存在を証明した。この成果は、サルにおける視覚喚起性情動の神経経路を明らかにし情動の神経機構の理解を進めるのみならず、ヒトを対象としたfMRI研究の結果の解釈に本質的な示唆を与える(例:情動系からのフィードバックが大脳皮質の活動を変容させるか)。また、盲視・視覚意識のメカニズムや相補的神経回路間の適応制御など、システム神経科学における問題に新しい視点をもたらす。さらに、情動障害、パニック障害、自閉症などの病態と原因の理解を進展させ、これらの疾患・障害のケアの方法開発に貢献する。

Report

(4 results)
  • 2021 Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (29 results)

All 2022 2021 2019 2018 2017 Other

All Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 10 results) Presentation (15 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Remarks (4 results)

  • [Journal Article] Rapid processing of threatening faces in the amygdala of nonhuman primates: subcortical inputs and dural roles2022

    • Author(s)
      Mikio Inagaki, Ken-ichi Inoue, Soshi Tanabe, Kei Kimura, Masahiko Takada, Ichiro Fujita
    • Journal Title

      Cerebral Cortex

      Volume: - Issue: 3 Pages: 1-21

    • DOI

      10.1093/cercor/bhac109

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Processing of visual statistics of naturalistic videos in macaque visual areas V1 and V42022

    • Author(s)
      Gaku Hatanaka, Mikio Inagaki, Ryosuke F. Takeuchi, Shinji Nishimoto, Koji Ikezoe, Ichiro Fujita
    • Journal Title

      Brain Structure and Function

      Volume: - Issue: 4 Pages: 1-19

    • DOI

      10.1007/s00429-022-02468-z

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Explaining coarse visual processing in the subcortical pathway with convolutional neural networks2021

    • Author(s)
      Chanseok Lim, Mikio Inagaki, Takashi Shinozaki, Ichiro FUjita
    • Journal Title

      IEICE Technical Report

      Volume: 121 Pages: 1-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Spatial pooling inherent to intrinsic signal optical imaging might cause V2 to resemble a solution to the stereo correspondence problem2018

    • Author(s)
      Doi T, Abdolrahamani M, Fujita I
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 115 Issue: 30

    • DOI

      10.1073/pnas.1807687115

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Microstructural properties of the vertical occipital fasciculus explain the variability in human stereoacuity2018

    • Author(s)
      Oishi H, Takemura H, Aoki SC, Fujita I, Amano K
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 115 Issue: 48 Pages: 12289-12294

    • DOI

      10.1073/pnas.1804741115

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cortical and subcortical responses to biological motion2018

    • Author(s)
      Chang DHF, Ban H, Ikegaya Y, Fujita I, Troje NF
    • Journal Title

      Neuroimage

      Volume: 174 Pages: 87-96

    • DOI

      10.1016/j.neuroimage.2018.03.013

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mapping stimulus feature selectivity in macaque V1 by two-photon Ca 2+ imaging: Encoding-model analysis of fluorescence responses to natural movies2018

    • Author(s)
      Ikezoe Koji、Amano Mahya、Nishimoto Shinji、Fujita Ichiro
    • Journal Title

      NeuroImage

      Volume: 印刷中 Pages: 1-12

    • DOI

      10.1016/j.neuroimage.2018.01.009

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Microstructural properties of the vertical occipital fasciculus explain the variability in human stereoacuity2018

    • Author(s)
      Oishi H, Takemura H, Aoki SC, Fujita I, Amano K
    • Journal Title

      BioRxiv

      Volume: 未定 Pages: 1-22

    • Related Report
      2017 Annual Research Report
    • Open Access
  • [Journal Article] A relative frame of reference underlies reversed depth perception in anticorrelated random-dot stereograms2017

    • Author(s)
      Aoki SC, Shiozaki SM, Fujita I
    • Journal Title

      Journal of Vision

      Volume: 17(12):17 Issue: 12 Pages: 1-17

    • DOI

      10.1167/17.12.17

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rapid reponses of amygdala neurons discriminate facial expressions2017

    • Author(s)
      Inagaki M, Fujita I
    • Journal Title

      BioRxiv

      Volume: - Pages: 1-31

    • Related Report
      2017 Annual Research Report
    • Open Access
  • [Presentation] A CNN model for the subcortical pathway acquires amygdala neuron-like properties when trained in human-like experiences2022

    • Author(s)
      Chanseok Lim, Mikio Inagaki, Takashi Shinozaki, Ichiro Fujita
    • Organizer
      The 7th CiNet Conference: New horizons in brain mapping
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 大脳皮質経路と皮質下経路の表情表現:畳み込みニューラルネットワークを用いた比較2021

    • Author(s)
      赤星宏知, 稲垣未来男, 林 燦碩, 小松優介, 篠崎隆志, 藤田一郎.
    • Organizer
      日本視覚学会2021年夏季大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 畳み込みニューラルネットワークを用いた皮質下経路の粗い情報処理の説明2021

    • Author(s)
      林燦碩, 稲垣未来男, 篠崎隆志, 藤田一郎
    • Organizer
      ニューロコンピューティング研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 脳の情報処理戦略:「粗いが速い」と「遅いが精確」の併用2019

    • Author(s)
      藤田一郎
    • Organizer
      次世代人工知能シンポジウム2019
    • Related Report
      2018 Annual Research Report
  • [Presentation] 顔表情弁別を行う畳込みニューラルネットワークにおける内部表現2018

    • Author(s)
      小松優介、稲垣未来男、篠崎隆志、藤田一郎
    • Organizer
      第41回日本神経科学会(Neuroscience2018)
    • Related Report
      2018 Annual Research Report
  • [Presentation] ヒト視覚体験の適用によるCNNモデルの扁桃体類似特性の獲得2018

    • Author(s)
      林 燦碩、稲垣未来男、篠崎隆志、藤田一郎
    • Organizer
      第41回日本神経科学会(Neuroscience2018)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 大脳皮質経路と皮質下経路における顔処理のモデル化の試み2018

    • Author(s)
      稲垣未来男、林 燦碩、小松優介、篠崎隆志、藤田一郎
    • Organizer
      日本視覚学会2018年夏季学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 大脳皮質と扁桃体における顔の視覚的表現の違い2018

    • Author(s)
      稲垣未来男、藤田一郎
    • Organizer
      第23回日本顔学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] CNNにおける扁桃体細胞類似特性獲得のための視覚体験的学習法2018

    • Author(s)
      林 燦碩、稲垣未来男、小松優介、篠崎隆志、藤田一郎
    • Organizer
      ニューロコンピューティング研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 顔表情弁別を行う畳み込みニューラルネットワーックの内部における空間周波数特性2018

    • Author(s)
      小松優介、 林 燦碩、稲垣未来男、篠崎隆志、藤田一郎
    • Organizer
      ニューロコンピューティング研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 表情知覚の脳内経路と深層・浅層ニューラルネットワーク2018

    • Author(s)
      稲垣未来男、林燦碩、小松優介、篠崎隆志、藤田一郎
    • Organizer
      次世代人工知能シンポジウム2018
    • Related Report
      2017 Annual Research Report
  • [Presentation] 『無理しない』:脳に学ぶ情報処理ストラテジー2018

    • Author(s)
      藤田一郎
    • Organizer
      次世代人工知能シンポジウム2018
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Rapid discrimination of emotional faces by population activity of amygdala neurons2017

    • Author(s)
      Inagaki M, Fujita I
    • Organizer
      Neuroscience 2017(The 40th Annual Meeting of the Japan Neuroscience Society.
    • Related Report
      2017 Annual Research Report
  • [Presentation] 大脳皮質および皮質下視覚情報処理のモデル化の試み2017

    • Author(s)
      稲垣未来男、林燦碩、小松優介、篠崎隆志、藤田一郎
    • Organizer
      質感の集い2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 機械学習およびDNNを用いた眼球運動解析による統合失調症患者と健常者の弁別2017

    • Author(s)
      藤田一郎、岡田研一、稲垣未来男、檀上大輝、篠崎隆志
    • Organizer
      第14回IGC・第10回COCORO合同会議
    • Related Report
      2017 Annual Research Report
  • [Remarks] 認知脳科学研究室

    • URL

      http://www2.bpe.es.osaka-u.ac.jp/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 大阪大学大学院生命機能研究科

    • URL

      http://www.fbs.osaka-u.ac.jp/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 大阪大学基礎工学部生物工学コース

    • URL

      http://www.bpe.es.osaka-u.ac.jp/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 脳情報通信融合研究センター

    • URL

      https://cinet.jp/

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2023-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi