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Postnatal neuronal migration and differentiation: regulatory mechanisms and their manipulation

Research Project

Project/Area Number 17H01392
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionNagoya City University

Principal Investigator

SAWAMOTO KAZUNOBU  名古屋市立大学, 医薬学総合研究院(医学), 教授 (90282350)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Discontinued (Fiscal Year 2020)
Budget Amount *help
¥41,860,000 (Direct Cost: ¥32,200,000、Indirect Cost: ¥9,660,000)
Fiscal Year 2020: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
Fiscal Year 2019: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2018: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2017: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Keywords再生医学 / 神経化学 / 脳・神経 / 脳神経疾患 / ニューロンの移動
Outline of Final Research Achievements

New neurons are continuously generated from neural stem cells in the postnatal brain. These new neurons migrate toward their destinations, where they are differentiated into mature neurons. After brain injuries, new neurons migrate toward the injured area for regeneration. Neuronal migration is restricted by the meshwork of activated astrocytes. Radial glial fibers in the injured neonatal mouse brain provide a scaffold on which new neurons migrate toward the injured cerebral cortex. New neuron migration toward the lesion can be promoted by clearing the path of astrocytic processes, and by inserting artificial scaffolds that mimic the endogenous scaffolds. These treatments facilitate neuronal regeneration and neurological recovery. These findings suggest that strategies designed to help migrating neurons reach the lesion may improve stem/progenitor cell-based therapies for brain injury.

Academic Significance and Societal Importance of the Research Achievements

本課題の研究により、生理的なニューロンの移動・成熟機構と傷害後における再生機構の一端が解明された。また、そのメカニズムを操作することによって、傷害後に必要な種類の細胞を再生し、適切な場所へ移動させる新しい再生医療技術の基盤を確立した。細胞を移植せずに神経回路を再生することができれば、より低コストで安全性・有効性の高い再生医療を開発することができる。将来的には、薬学や工学系分野との連携によって、新たな産業の創出にも役立つことも期待できると考えられる。

Report

(4 results)
  • 2020 Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (97 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (6 results) Journal Article (18 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 16 results,  Open Access: 11 results,  Acknowledgement Compliant: 1 results) Presentation (63 results) (of which Int'l Joint Research: 28 results,  Invited: 28 results) Book (1 results) Remarks (9 results)

  • [Int'l Joint Research] バレンシア大学(スペイン)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] コペンハーゲン大学(デンマーク)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] バレンシア大学(スペイン)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] コペンハーゲン大学(デンマーク)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] バレンシア大学(スペイン)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] コペンハーゲン大学(デンマーク)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Dynamic Changes in the Neurogenic Potential in the Ventricular-Subventricular Zone of Common Marmoset during Postnatal Brain Development2020

    • Author(s)
      Akter M, Kaneko N, Herranz-Perez V, Nakamura S, Oishi H, Garcia-Verdugo JM, Sawamoto K
    • Journal Title

      Cerebral Cortex

      Volume: なし Issue: 7 Pages: 4092-4109

    • DOI

      10.1093/cercor/bhaa031

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dynamic changes in ultrastructure of the primary cilium in migrating neuroblasts in the postnatal brain2019

    • Author(s)
      Matsumoto Mami、Sawada Masato、Garcia-Gonzalez Diego、Herranz-Perez Vicente、Ogino Takashi、Bang Nguyen Huy、Quynh Thai Truc、Narita Keishi、Kumamoto Natsuko、Ugawa Shinya、Saito Yumiko、Takeda Sen、Kaneko Naoko、Khodosevich Konstantin、Monyer Hannah、Garcia-Verdugo Jose Manuel、Ohno Nobuhiko、Sawamoto Kazunobu
    • Journal Title

      The Journal of Neuroscience

      Volume: 39 Issue: 50 Pages: 9967

    • DOI

      10.1523/jneurosci.1503-19.2019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Blood vessels as a scaffold for neuronal migration.2019

    • Author(s)
      Fujioka T, Kaneko N, Sawamoto K.
    • Journal Title

      Neurochemistry International

      Volume: 126 Pages: 69-73

    • DOI

      10.1016/j.neuint.2019.03.001

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生後脳におけるニューロン移動の調節機構2019

    • Author(s)
      澤田雅人, 澤本和延
    • Journal Title

      生化学

      Volume: 91 Pages: 178-190

    • NAID

      40021942468

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ventricular-subventricular zone fractones are speckled basement membranes that function as a neural stem cell niche.2019

    • Author(s)
      Sato Y, Kiyozumi D, Futaki S, Nakano I, Shimono C, Kaneko N, Ikawa M, Okabe M, Sawamoto K, Sekiguchi K.
    • Journal Title

      Molecular Biology of the Cell

      Volume: 30 Issue: 1 Pages: 56-68

    • DOI

      10.1091/mbc.e18-05-0286

    • NAID

      120006626421

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] New neurons use Slit-Robo signaling to migrate through the glial meshwork and approach a lesion for functional regeneration.2018

    • Author(s)
      Kaneko N, Herranz-Perez V, Otsuka T, Sano H, Ohno N, Omata T, Nguyen HB, Thai TQ, Nambu A, Kawaguchi Y, Garcia-Verdugo JM, Sawamoto K.
    • Journal Title

      Science Advances

      Volume: 4 Issue: 12 Pages: 0618-0618

    • DOI

      10.1126/sciadv.aav0618

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Heterogeneous distribution of doublecortin-expressing cells surrounding the rostral migratory stream in the juvenile mouse2018

    • Author(s)
      Aoyagi Yuka、Hibi Terumasa、Kimori Yoshitaka、Sawada Masato、Kawakami Ryosuke、Sawamoto Kazunobu、Nemoto Tomomi
    • Journal Title

      Journal of Comparative Neurology

      Volume: 526 Issue: 16 Pages: 2631-2646

    • DOI

      10.1002/cne.24521

    • NAID

      120006734165

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Shootin1b Mediates a Mechanical Clutch to Produce Force for Neuronal Migration.2018

    • Author(s)
      Minegishi T, Uesugi Y, Kaneko N, Yoshida W, Sawamoto K, Inagaki N.
    • Journal Title

      Cell Reports

      Volume: 25 Issue: 3 Pages: 624-639

    • DOI

      10.1016/j.celrep.2018.09.068

    • NAID

      120006537407

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Adult neurogenesis and its role in brain injury and psychiatric diseases2018

    • Author(s)
      Hayashi Yoshitaka、Jinnou Hideo、Sawamoto Kazunobu、Hitoshi Seiji
    • Journal Title

      Journal of Neurochemistry

      Volume: 147 Issue: 5 Pages: 584-594

    • DOI

      10.1111/jnc.14557

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Go with the Flow: Cerebrospinal Fluid Flow Regulates Neural Stem Cell Proliferation.2018

    • Author(s)
      Kaneko N, Sawamoto K.
    • Journal Title

      Cell Stem Cell

      Volume: 22 Issue: 6 Pages: 783-784

    • DOI

      10.1016/j.stem.2018.05.015

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Detachment of Chain-Forming Neuroblasts by Fyn-Mediated Control of cell-cell Adhesion in the Postnatal Brain.2018

    • Author(s)
      Fujikake K, Sawada M, Hikita T, Seto Y, Kaneko N, Herranz-Perez V, Dohi N, Homma N, Osaga S, Yanagawa Y, Akaike T, Garcia-Verdugo JM, Hattori M, Sobue K, Sawamoto K.
    • Journal Title

      Journal of Neuroscience

      Volume: 38 Issue: 19 Pages: 4598-4609

    • DOI

      10.1523/jneurosci.1960-17.2018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] PlexinD1 signaling controls morphological changes and migration termination in newborn neurons2018

    • Author(s)
      Sawada Masato、Ohno Nobuhiko、Kawaguchi Mitsuyasu、Huang Shih‐hui、Hikita Takao、Sakurai Youmei、Bang Nguyen Huy、Quynh Thai Truc、Ishido Yuri、Yoshida Yutaka、Nakagawa Hidehiko、Uemura Akiyoshi、Sawamoto Kazunobu
    • Journal Title

      The EMBO Journal

      Volume: 37 Issue: 4

    • DOI

      10.15252/embj.201797404

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Radial glial fibers support neuronal migration and regeneration after neonatal brain injury.2018

    • Author(s)
      Jinnou H, Sawada M, Kawase K, Kaneko N, Herranz-Perez V, Miyamoto T, Kawaue T, Miyata T, Tabata Y, Akaike T, Garcia-Verdugo JM, Ajioka I, Saitoh S, Sawamoto K.
    • Journal Title

      Cell Stem Cell

      Volume: 22 Issue: 1 Pages: 128-137

    • DOI

      10.1016/j.stem.2017.11.005

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Daple Coordinates Planar Polarized Microtubule Dynamics in Ependymal Cells and Contributes to Hydrocephalus2017

    • Author(s)
      Maki Takagishi, Masato Sawada, Shinya Ohata, Naoya Asai, Atsushi Enomoto, Kunihiko Takahashi, Liang Weng, Kaori Ushida, Hosne Ara, Shigeyuki Matsui, Kozo Kaibuchi,3Kazunobu Sawamoto, and Masahide Takahashi.
    • Journal Title

      Cell Reports

      Volume: 20 Issue: 4 Pages: 960-972

    • DOI

      10.1016/j.celrep.2017.06.089

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Unique Organization of the Nuclear Envelope in the Post-natal Quiescent Neural Stem Cells.2017

    • Author(s)
      Arantxa Cebrian-Silla, Clara Alfaro-Cervello, Vicente Herranz-Perez, Naoko Kaneko, Dae Hwi Park, Kazunobu Sawamoto, Arturo Alvarez-Buylla, Daniel A.Lim, Jose Manuel Garcia-Verdugo.
    • Journal Title

      Stem Cell Report

      Volume: 9 Issue: 1 Pages: 203-216

    • DOI

      10.1016/j.stemcr.2017.05.024

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Angiogenic Biomaterials for Brain Ischemia Using Affinity-Immobilized VEGF on Laminin Porous Sponge.2017

    • Author(s)
      Oshikawa M, Okada K, Kaneko N, Sawamoto K, Ajioka I.
    • Journal Title

      Advanced Healthcare Materials

      Volume: 6 Issue: 11

    • DOI

      10.1002/adhm.201700183

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanisms of neuronal migration in the adult brain2017

    • Author(s)
      Kaneko N, Sawada M, Sawamoto K
    • Journal Title

      J Neurochem

      Volume: - Issue: 6 Pages: 835-847

    • DOI

      10.1111/jnc.14002

    • NAID

      10018687194

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 生後脳における新生ニューロンの移動・分化機構とその操作技術2017

    • Author(s)
      澤本和延
    • Journal Title

      科研費NEWS

      Volume: 3

    • Related Report
      2017 Annual Research Report
  • [Presentation] Spatiotemporal regulation of primary cilium in migrating neuroblasts in the adult brain2020

    • Author(s)
      Matsumoto M, Sawada M, Garcia-Gonzalez D, Herranz-Perez V, Ogino T, Bang Nguyen H, Quynh Thai T, Narita K, Kumamoto N, Ugawa S, Saito Y, Takeda S, Kaneko N, Khodosevich K, Monyer H, Garcia-Verdugo JM, Ohno N, Sawamoto K
    • Organizer
      第16回成体脳ニューロン新生懇談会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Dynamics of primary cilium in migrating new neurons in the adult brain. ABiS Symposium Forefront and Future of Electron Microscopic Imaging2020

    • Author(s)
      Matsumoto M, Sawada M, Garcia-Gonzalez D, Herranz-Perez V, Ogino T, Bang Nguyen H, Quynh Thai T, Narita K, Kumamoto N, Ugawa S, Saito Y, Takeda S, Kaneko N, Khodosevich K, Monyer H, Garcia-Verdugo JM, Ohno N, Sawamoto K
    • Organizer
      ABiS Symposium Forefront and Future of Electron Microscopic Imaging
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脳細胞の移動・再生機構とその操作技術2020

    • Author(s)
      澤本和延
    • Organizer
      ニューロカンファレンス和歌山
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Neuronal migration for development, maintenance and repair of the postnatal brain2020

    • Author(s)
      澤本和延
    • Organizer
      New Frontier in Neuroscience 2020
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Neuronal migration: strategies for development, maintenance and repair of the postnatal brain2019

    • Author(s)
      澤本和延
    • Organizer
      Cell Biology, Developmental Biology, and Systems Biology Course Meeting
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 生後脳におけるニューロン新生・再配置2019

    • Author(s)
      澤本和延
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 新生児脳に内在する神経再生機構2019

    • Author(s)
      澤本和延
    • Organizer
      第64回日本新生児生育医学会学術集会シンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] New neurons migrate through the glial meshwork using slit1 to approach the lesion for functional recovery2019

    • Author(s)
      Kaneko N, Herranz-Perez V, Otsuka T, Sano H, Ohno N, Omata T, Nguyen HB, Thai TQ, Nambu A, Kawaguchi Y, Garcia-Verdugo JM, Sawamoto K
    • Organizer
      Neuroscience2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 神経再生過程における細胞形態・接着の制御2019

    • Author(s)
      澤本和延
    • Organizer
      第60回日本組織細胞化学会総会・学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] New neurons reach and regenerate stroke-injured brain tissue by clearing a path through glia2019

    • Author(s)
      Kanek N, Herranz-Perez V, Otsuka T, Sano H, Ohno N, Omata T, Bang Nguyen H, Quynh Thai T, Nambu A, Kawaguchi Y, Garcia-Verdugo JM, Sawamoto K
    • Organizer
      ISN-ASN Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 坐骨神経傷害後のシュワン細胞遊走におけるSlit-Roboシグナルの機能2019

    • Author(s)
      齋藤 瑳智子, 齋藤 志郎, 岩田 英敏, 福冨 妃菜, 金子 奈穂子, 澤本 和延
    • Organizer
      NEURO2019 第42回日本神経科学大会 第62回日本神経化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 成体脳内を移動する新生ニューロンにおける一次繊毛の時空間的な動態2019

    • Author(s)
      松本 真実, 澤田 雅人, Nguyen Bang Huy, Herranz-Perez Vicente, Thai Quynh Truc, 成田 啓之, 熊本 奈都子, 鵜川 眞也, 斎藤 祐見子, 竹田 扇, 金子 奈穂子, Garcia-Verdugo Jose Manue, 大野 伸彦, 澤本 和延
    • Organizer
      NEURO2019 第42回日本神経科学大会 第62回日本神経化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 成体嗅球の新生ニューロン移動における血流の役割2019

    • Author(s)
      荻野 崇, 澤田 雅人, 稲田 浩之, 金子 奈穂子, 鍋倉 淳一, 澤本 和延
    • Organizer
      NEURO2019 第42回日本神経科学大会 第62回日本神経化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] グリアの形態調節によるニューロンの移動・再生促進2019

    • Author(s)
      澤本和延, 神農英雄, 金子奈穂子
    • Organizer
      第40回日本炎症・再生医学会シンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 若い嗅覚神経回路をキープする2019

    • Author(s)
      澤本和延
    • Organizer
      第19回日本抗加齢医学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 新しい脳細胞を増やすには - 最新科学による解明2019

    • Author(s)
      澤本和延
    • Organizer
      第22回国際福祉健康産業展~ウェルフェア2019~
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 生後脳組織の維持・再生における新生ニューロンの移動2019

    • Author(s)
      澤本和延
    • Organizer
      第17回幹細胞シンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 早産による生後のニューロン新生低下のメカニズム2019

    • Author(s)
      五軒矢桜、川瀬恒哉、澤田雅人、澤本和延
    • Organizer
      全国学生リトリート2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] Enhanced neuronal migration through activated glia promotes post- stroke neuronal regeneration2019

    • Author(s)
      Kaneko N, Herranz-Perez V, Otsuka T, Sano H, Ohno N, Omata T, Nguyen HB, Thai TQ, Garcia-Verdugo JM, Sawamoto K
    • Organizer
      第9回アジア・オセアニア生理学会連合大会&第96回日本生理学会合同大会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脳梗塞部位への新生ニューロンの移動を支持する足場としての血管の形態解析2019

    • Author(s)
      岩田英敏、金子奈穂子、大竹杏佳、戸室幸太郎、柴田帝式、村上英樹、澤本和延
    • Organizer
      第18回日本再生医療学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 新生ニューロンの移動・分布の制御による脳梗塞後の神経再生の促進2019

    • Author(s)
      金子奈穂子、澤本和延
    • Organizer
      第18回日本再生医療学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Neuronal migration: strategies for development, maintenance and repair of the postnatal brain2019

    • Author(s)
      澤本和延
    • Organizer
      Japan-UK Neuroscience Symposium 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Neuronal migration: strategies for maintenance and repair of the postnatal brain tissue2019

    • Author(s)
      松本真実、澤田雅人、金子奈穂子、Nguyen HB、Thai TQ、大野伸彦、澤本和延
    • Organizer
      第15回成体脳ニューロン新生懇談会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脳梗塞部へのニューロンの移動と血管・アストロサイト2019

    • Author(s)
      金子奈穂子、澤本和延
    • Organizer
      The 3rd Neuro-Vascular meeting
    • Related Report
      2018 Annual Research Report
  • [Presentation] Morphological changes and migration termination in newborn neurons controlled by Sema3E-PlexinD1 signaling2018

    • Author(s)
      Sawada M, Sawamoto K
    • Organizer
      The 3rd NCU&HALLYM International Joint Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 生後脳における新生ニューロンの移動機構と意義2018

    • Author(s)
      澤本和延
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 成体脳における新生ニューロンの傷害部への移動制御機構とニューロン再生2018

    • Author(s)
      金子奈穂子、澤本和延
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 神経再生過程におけるニューロンの移動2018

    • Author(s)
      澤本和延
    • Organizer
      第40回神経組織培養研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Morphological changes and migration termination of newborn neurons controlled by PlexinD1 signaling2018

    • Author(s)
      Sawada M, Ohno N, Kawaguchi M, Huang SH, Hikita T, Sakurai Y, Nguyen HB, Thai TQ, Ishido Y, Yoshida Y, Nakagawa H, Uemura A, Sawamoto K
    • Organizer
      Neuroscience 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生後脳組織の維持・再生における新生ニューロンの移動機構と意義2018

    • Author(s)
      澤本和延
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Ezrin controls morphology and proliferation of neural stem cells in the postnatal ventricular-subventricular zone2018

    • Author(s)
      Kaneko N, Ishizaki T, Tamura A, Higuchi K, Tsukita S, Sawamoto K
    • Organizer
      第61回日本神経化学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Reelin-Dab1 signaling controls detachment of chain-forming new neurons by regulating cell-cell adhesion2018

    • Author(s)
      Sawada M, Fujikake K, Kaneko N, Herranz-Perez V, Homma N, Yanagawa Y, Garcia-Verdugo JM, Hattori M, Sawamoto K
    • Organizer
      第61回日本神経化学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The role of newly-generated astrocytes and blood vessels in scaffold formation for neuroblasts migrating toward the injured region after ischemic stroke2018

    • Author(s)
      Otake K, Iwata H, Shibata T, Kaneko N, Sawamoto K
    • Organizer
      第61回日本神経化学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Endogenous and artificial scaffolds for neuronal migration and regeneration in the injured brain2018

    • Author(s)
      澤本和延
    • Organizer
      5thTERMIS-WC
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mechanisms for the proper migration and positioning of newborn neurons in postnatal brain circuits2018

    • Author(s)
      Sawada M, Sawamoto K
    • Organizer
      21thKSBNS Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A transient postnatal peak of neurogenesis supports neuronal migration to the non-human primate neocortex2018

    • Author(s)
      Akter M, Kaneko N, Sawamoto K
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] PlexinD1 signaling controls morphological changes and migration termination in newborn neurons2018

    • Author(s)
      Sawada M, Ohno N, Kawaguchi M, Huang SH, Hikita T, Sakurai Y, Nguyen HB, Thai TQ, Ishido Y, Yoshida Y, Nakagawa H, Uemura A, Sawamoto K
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Scaffolds for brain development, maintenance and repair2018

    • Author(s)
      Sawamoto K
    • Organizer
      The 5th Eastern Asia Dermatology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 放射状グリアを足場にした新生児期脳傷害後のニューロン再生2018

    • Author(s)
      神農英雄、澤田雅人、川瀬恒哉、金子奈穂子、Vicente Herranz-Perez、宮本拓哉、川上巧、宮田卓樹、田畑泰彦、赤池敏弘、Jose Manuel Garcia-Verdugo、味岡逸樹、齋藤伸治、澤本和延
    • Organizer
      第162回名古屋市立大学医学会例会
    • Related Report
      2018 Annual Research Report
  • [Presentation] PlexinD1 signaling controls morphological changes and migration termination in newborn neurons2018

    • Author(s)
      Sawada M, Ohno N, Kawaguchi M, Huang SH, Hikita T, Sakurai Y, Nguyen HB, Thai TQ, Ishido Y, Yoshida Y, Nakagawa H, Uemura A, Sawamoto K
    • Organizer
      日韓神経発生学共同シンポジウム2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Aberration of the Soluble protein Tsukushi leads alteration of adult neurogenesis resulting lateral ventricule expansion with neuronal disease2018

    • Author(s)
      Ito N, Riyadh MA, Ito A, Ishtiyaq Ahmad SA, Anam MB, Kanemura Y, Shinmyo Y, Abdulhaleem M. FA, Hatakeyama J, Kiyonari H, Shimamura K, Takahashi Y, Sawamoto K, Ohta K
    • Organizer
      第51回日本発生生物学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脳の発達・再生過程における新生ニューロンの移動の足場2018

    • Author(s)
      澤本和延
    • Organizer
      第123 回日本解剖学会総会・全国学術集会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 脳質下帯由来オリゴデンドロサイト前駆細胞の傷害部への移動・分化過程の解析2018

    • Author(s)
      山本誠也, 金子奈穂子, 橋本真耶佳, 宮本拓哉, 竹林浩秀, 池中一裕, 澤本和延.
    • Organizer
      第17回日本再生医療学会総会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PlexinD1は新生ニューロンの形態変化と移動停止を調節する2018

    • Author(s)
      Sawada M, Ohno N, Kawaguchi M, Huang SH, Hikita T, Sakurai Y, Nguyen HB, Thai TQ, Ishido Y, Yoshida Y, Nakagawa H, Uemura A, Sawamoto K
    • Organizer
      第11回神経発生討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Scaffolds for neuronal migration and brain repair2018

    • Author(s)
      Sawamoto K
    • Organizer
      Joint-Symposium between HYU and NCU
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cellular adhesion between chain-forming new neurons in the normal and injured adult brain.2017

    • Author(s)
      Matsumoto M, Sawada M, Kaneko N, Nguyen HB, Thai TQ, Kumamoto N, Ugawa S, Ohno N, Sawamoto K
    • Organizer
      第13回成体脳のニューロン新生懇談会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Netrin-5 is upregulated in the peri-infarct region after middle cerebral artery occlusion.2017

    • Author(s)
      Yamagishi S, Takarada M, Sawada M, Sawamoto K, Hori O, Sato K.
    • Organizer
      Neuroscience 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脳に内在する再生機構2017

    • Author(s)
      澤本和延
    • Organizer
      第3回川島カンファレンス
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Migration and differentiation of V-SVZ-derived oligodendrocyte progenitors in the injured cortex.2017

    • Author(s)
      Hashimoto M, Kaneko N, Yamamoto S, Miyamoto T, Takebayashi H, Ikenaka K, Sawamoto K
    • Organizer
      第60回日本神経化学大会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fyn promotes detachment of chain-forming new neurons by controlling N-cadherin-mediated adherens junction in the postnatal brain2017

    • Author(s)
      Seto Y, Fujikake K, Sawada M, Hikita T, Kaneko N, Sobue K, Sawamoto K
    • Organizer
      第60回日本神経化学大会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Three dimensional ultrastructure of new neurons migrating in the normal and injured adult brain.2017

    • Author(s)
      Matsumoto M, Sawada M, Kaneko N, Nguyen HB, Thai TQ, Kumamoto N, Ugawa S, Ohno N, Sawamoto K
    • Organizer
      第60回日本神経化学大会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Microglial phagocytosis of dying neurons promotes new neuron addition in the adult olfactory bulb.2017

    • Author(s)
      Sawada M, Inada H, Kohsaka S, Nabekura J, Sawamoto K
    • Organizer
      第60回日本神経化学大会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Netrin-5 is upregulated in the peri-infarct region after middle cerebral artery occlusion.2017

    • Author(s)
      Yamagishi S, Takarada M, Sawada M, Sawamoto K, Hori O, Sato K
    • Organizer
      第60回日本神経化学大会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脳に内在する再生メカニズムとその操作技術2017

    • Author(s)
      澤本和延
    • Organizer
      第4回包括的緩和医療科学学術研究会・第5回Tokyo疼痛緩和次世代研究会 合同研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Neuronal migration for maintenance and repair of adult brain. S13 Adult neurogenesis - New roles in normal and pathological conditions.2017

    • Author(s)
      澤本和延
    • Organizer
      2017ISN-ESN MEETING
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Blood vessels work as a scaffold for neuronal migration in the post-stroke non-human primate.2017

    • Author(s)
      Akter M, Kaneko N, Hara K, Inoue K, Adachi K, Okano H, Sawamoto K
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Relationship between neuronal turnover and blood flow in the adult olfactory bulb.2017

    • Author(s)
      Ogino T, Sawada M, Inada H, Nabekura J, Sawamoto K
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Appropriate positioning of new neurons is critical for the functional rewiring of neuronal circuit in the post-stroke brain.2017

    • Author(s)
      Kaneko N, Sawamoto K
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Resting microglia eliminate dying neurons by phagocytosis in the adult olfactory bulb.2017

    • Author(s)
      Sawada M, Inada H, Kohsaka S, Nabekura J, Sawamoto K
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Migration of new neurons for maintenance and repair of adult brain.2017

    • Author(s)
      澤本和延
    • Organizer
      International Meeting on "Pathogenic mechanisms and emerging therapies for PD and other neurological disorders"
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Migration of new neurons for maintenance and repair of adult brain.2017

    • Author(s)
      澤本和延
    • Organizer
      コペンハーゲン大学招待講演
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 脳の老化・再生過程における繊毛の変化2017

    • Author(s)
      澤本和延, 松本真実, 澤田雅人, 金子奈穂子, 大野伸彦
    • Organizer
      第69回日本細胞生物学会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 生後の脳内を移動する新生ニューロンの三次元形態解析2017

    • Author(s)
      澤本和延, 松本真実, 澤田雅人, 金子奈穂子, 大野伸彦
    • Organizer
      第73回日本顕微鏡学会学術講演会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Book] ライフサイエンス新着論文レビュー2018

    • Author(s)
      神農英雄, 澤本和延
    • Publisher
      ライフサイエンス統合データベースセンター
    • Related Report
      2017 Annual Research Report
  • [Remarks] 澤本和延研究室ホームページ

    • URL

      http://k-sawamoto.com/

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report 2017 Annual Research Report
  • [Remarks] 神経化学トピックス30

    • URL

      http://www.neurochemistry.jp/mu1qe6y76-15/#_15

    • Related Report
      2018 Annual Research Report
  • [Remarks] 名古屋市立大学ホームページ 脳梗塞後の神経再生メカニズムを発見

    • URL

      https://www.nagoya-cu.ac.jp/about/press/press/release/files/20181210/301213.pdf

    • Related Report
      2018 Annual Research Report
  • [Remarks] 生理学研究所ホームページ 脳梗塞後の神経再生メカニズムを発見

    • URL

      https://www.nips.ac.jp/release/2018/12/post_381.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] EurekAlert! 神経細胞が脳内を移動するための仕組みを解明

    • URL

      https://www.eurekalert.org/pub_releases_ml/2018-10/nios-j101718.php

    • Related Report
      2018 Annual Research Report
  • [Remarks] 神経細胞の脳内の位置を決定するしくみ

    • URL

      http://www.nagoya-cu.ac.jp/about/press/press/release/files/20180118/300119.pdf

    • Related Report
      2017 Annual Research Report
  • [Remarks] 神経細胞の脳内の位置を決定するしくみ

    • URL

      http://www.nips.ac.jp/release/2018/01/post_355.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 新生児期に存在する脳障害後の神経再生メカニズムを発見

    • URL

      http://www.nagoya-cu.ac.jp/about/press/press/release/files/20171222/291222.pdf

    • Related Report
      2017 Annual Research Report
  • [Remarks] 新生児期に存在する脳障害後の神経再生メカニズムを発見

    • URL

      http://www.nips.ac.jp/release/2017/12/post_354.html

    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2022-01-27  

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