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Elucidation of the homology search mechanism and its regulation occurring in a chromatin environment during homologous recombination

Research Project

Project/Area Number 17H01408
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Genome biology
Research InstitutionThe University of Tokyo (2018-2019)
Waseda University (2017)

Principal Investigator

Kurumizaka Hitoshi  東京大学, 定量生命科学研究所, 教授 (80300870)

Co-Investigator(Kenkyū-buntansha) 清水 光弘  明星大学, 理工学部, 教授 (80231364)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥41,860,000 (Direct Cost: ¥32,200,000、Indirect Cost: ¥9,660,000)
Fiscal Year 2019: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2018: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2017: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Keywordsゲノム維持修復 / ゲノム多様性 / ゲノム進化・再編 / 遺伝情報複製・再編 / ゲノム機能 / 活性発現の分子機構 / 染色体構築・機能・分配 / 生体高分子構造・機能 / ゲノム / 遺伝子 / 癌 / 蛋白質 / 放射線 / 構造活性相関
Outline of Final Research Achievements

The purpose of this study is to clarify how "DNA homology search", a key reaction step of homologous recombination, takes place on the chromatin structure. Homologous recombination is essential for the maintenance and reorganization of genomic DNA. However, its mechanism has been elusive. By combining chromatin reconstitution technology, in vitro recombination assays, and structural biological analysis by X-ray crystallography and cryo-electron microscopy, we studied the mechanisms underlying DNA homology search taking place on the chromatin. We have elucidated (1) the biochemical properties of SYCP3, a factor that plays a role in meiotic recombination, (2) the fundamental structure of the highly condensed heterochromatin, and (3) the complex structures of RAD52 and DNA that provide important insights into the mechanisms of DNA homology search.

Academic Significance and Societal Importance of the Research Achievements

DNAの二重鎖切断損傷は、ゲノム情報に重篤なダメージを与える。それゆえ、その正確な修復は生物の生存に必須の機構であり、相同組換えはその中心的な役割を果たす。相同組換えは、原核生物から真核生物に至るまで生物界に保存されている重要な生命維持機構である。また減数分裂期において、雌雄由来のゲノムDNA情報を交換する遺伝的組換えにおいても機能し、生物の多様性を生む機構をも担っている。二重鎖切断損傷修復の破綻が、がんなどの重篤な疾病の原因になっていることも報告されており、そのメカニズムの理解は、学術的および社会的に大きな意義を持つ。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (64 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (4 results) Journal Article (29 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 29 results,  Open Access: 25 results) Presentation (29 results) (of which Int'l Joint Research: 7 results,  Invited: 25 results) Book (2 results)

  • [Int'l Joint Research] Gregor Mendel Institute/University of Vienna(オーストリア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of Rhode Island/Indiana University(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of Birmingham(英国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] 国立環境衛生科学研究所(米国)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Improved Methods for Preparing the Telomere Tethering Complex Bqt1-Bqt2 for Structural Studies2020

    • Author(s)
      Yuzurihara H, Aizawa Y, Saotome M, Ichikawa Y, Yokoyama H, Chikashige Y, Haraguchi T, Hiraoka Y, Kurumizaka H, Kagawa W
    • Journal Title

      Protein J

      Volume: - Issue: 2 Pages: 174-181

    • DOI

      10.1007/s10930-020-09887-z

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nucleosome destabilization by nuclear non-coding RNAs.2020

    • Author(s)
      †Fujita R, †Yamamoto T, Arimura Y, Fujiwara S, Tachiwana H, Ichikawa Y, Sakata S, Yang L, Maruyama R, Hamada M, Nakao M, *Saitoh N, *Kurumizaka H
    • Journal Title

      Commun Biol

      Volume: 3 Issue: 1 Pages: 60-60

    • DOI

      10.1038/s42003-020-0784-9

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural Studies of Overlapping Dinucleosomes in Solution2020

    • Author(s)
      Matsumoto Atsushi、Sugiyama Masaaki、Li Zhenhai、Martel Anne、Porcar Lionel、Inoue Rintaro、Kato Daiki、Osakabe Akihisa、Kurumizaka Hitoshi、Kono Hidetoshi
    • Journal Title

      Biophysical Journal

      Volume: 118 Issue: 9 Pages: 2209-2219

    • DOI

      10.1016/j.bpj.2019.12.010

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Transcription through the nucleosome2020

    • Author(s)
      Kujirai Tomoya、Kurumizaka Hitoshi
    • Journal Title

      Current Opinion in Structural Biology

      Volume: 61 Pages: 42-49

    • DOI

      10.1016/j.sbi.2019.10.007

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cryo-EM Structures of Centromeric Tri-nucleosomes Containing a Central CENP-A Nucleosome.2020

    • Author(s)
      Yoshimasa Takizawa, Cheng-Han Ho, Hiroaki Tachiwana, Hideyuki Matsunami, Wataru Kobayashi, Midori Suzuki, Yasuhiro Arimura, Tetsuya Hori, Tatsuo Fukagawa, Melanie D Ohi, Matthias Wolf, Hitoshi Kurumizaka
    • Journal Title

      Structure

      Volume: 28 Issue: 1 Pages: 44-53

    • DOI

      10.1016/j.str.2019.10.016

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Yeast Minichromosome System Consisting of Highly Positioned Nucleosomes <i>in Vivo</i>2019

    • Author(s)
      Fuse Tomohiro、Yanagida Akio、Shimizu Mitsuhiro
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 42 Issue: 2 Pages: 289-294

    • DOI

      10.1248/bpb.b18-00732

    • NAID

      130007600274

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2019-02-01
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biochemical and structural analyses of the nucleosome containing human histone H2A.J2019

    • Author(s)
      Tanaka Hiroki、Sato Shoko、Koyama Masako、Kujirai Tomoya、Kurumizaka Hitoshi
    • Journal Title

      The Journal of Biochemistry

      Volume: 167 Issue: 4 Pages: 419-427

    • DOI

      10.1093/jb/mvz109

    • NAID

      40022211009

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structure determination of the nucleosome core particle by selenium SAD phasing2019

    • Author(s)
      Saotome Mika、Horikoshi Naoki、Urano Kazuki、Kujirai Tomoya、Yuzurihara Hidetaka、Kurumizaka Hitoshi、Kagawa Wataru
    • Journal Title

      Acta Crystallographica Section D Structural Biology

      Volume: 75 Issue: 10 Pages: 930-936

    • DOI

      10.1107/s2059798319012713

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural transition of the nucleosome during chromatin remodeling and transcription2019

    • Author(s)
      Kobayashi Wataru、Kurumizaka Hitoshi
    • Journal Title

      Current Opinion in Structural Biology

      Volume: 59 Pages: 107-114

    • DOI

      10.1016/j.sbi.2019.07.011

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biochemical analysis of nucleosome targeting by Tn5 transposase2019

    • Author(s)
      Sato S, Arimura Y, Kujirai T, Harada A, Maehara K, Nogami J, Ohkawa Y, Kurumizaka H.
    • Journal Title

      Open Biol.

      Volume: 9 Issue: 8 Pages: 190116-190116

    • DOI

      10.1098/rsob.190116

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structure-based design of an H2A.Z.1 mutant stabilizing a nucleosome in vitro and in vivo2019

    • Author(s)
      Horikoshi Naoki、Kujirai Tomoya、Sato Koichi、Kimura Hiroshi、Kurumizaka Hitoshi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 515 Issue: 4 Pages: 719-724

    • DOI

      10.1016/j.bbrc.2019.06.012

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural and biochemical analyses of the nuclear pore complex component ELYS identify residues responsible for nucleosome binding2019

    • Author(s)
      Kobayashi Wataru、Takizawa Yoshimasa、Aihara Maya、Negishi Lumi、Ishii Hajime、Kurumizaka Hitoshi
    • Journal Title

      Communications Biology

      Volume: 2 Issue: 1 Pages: 163-163

    • DOI

      10.1038/s42003-019-0385-7

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biochemical characterization of the placeholder nucleosome for DNA hypomethylation maintenance2019

    • Author(s)
      Hirano Rina、Kujirai Tomoya、Negishi Lumi、Kurumizaka Hitoshi
    • Journal Title

      Biochemistry and Biophysics Reports

      Volume: 18 Pages: 100634-100634

    • DOI

      10.1016/j.bbrep.2019.100634

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Homologous pairing activities of Arabidopsis thaliana RAD51 and DMC1.2019

    • Author(s)
      Kobayashi, W., Liu, E., Ishii, H., Matsunaga, S., Schlogelhofer, P., and Kurumizaka, H.
    • Journal Title

      J. Biochem.

      Volume: 165 Issue: 3 Pages: 289-295

    • DOI

      10.1093/jb/mvy105

    • NAID

      40021845884

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The CENP-A centromere targeting domain facilitates H4K20 monomethylation in the nucleosome by structural polymorphism.2019

    • Author(s)
      Arimura Y, Tachiwana H, Takagi H, Hori T, Kimura H, Fukagawa T, Kurumizaka H
    • Journal Title

      Nature Commun.

      Volume: 10 Issue: 1 Pages: 576-576

    • DOI

      10.1038/s41467-019-08314-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration2018

    • Author(s)
      Harada Akihito、Maehara Kazumitsu、Ono Yusuke、Taguchi Hiroyuki、Yoshioka Kiyoshi、Kitajima Yasuo、Xie Yan、Sato Yuko、Iwasaki Takeshi、Nogami Jumpei、Okada Seiji、Komatsu Tetsuro、Semba Yuichiro、Takemoto Tatsuya、Kimura Hiroshi、Kurumizaka Hitoshi、Ohkawa Yasuyuki
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 1400-1400

    • DOI

      10.1038/s41467-018-03845-1

    • NAID

      120006949474

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MNase, as a probe to study the sequence-dependent site exposures in the +1 nucleosomes of yeast2018

    • Author(s)
      Luo Di、Kato Daiki、Nogami Jumpei、Ohkawa Yasuyuki、Kurumizaka Hitoshi、Kono Hidetoshi
    • Journal Title

      Nucleic Acids Research

      Volume: 46 Issue: 14 Pages: 7124-7137

    • DOI

      10.1093/nar/gky502

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD22018

    • Author(s)
      Higgs Martin R.、Sato Koichi、Reynolds John J.、Begum Shabana、Bayley Rachel、Goula Amalia、Vernet Audrey、Paquin Karissa L.、Skalnik David G.、Kobayashi Wataru、Takata Minoru、Howlett Niall G.、Kurumizaka Hitoshi、Kimura Hiroshi、Stewart Grant S.
    • Journal Title

      Molecular Cell

      Volume: 71 Issue: 1 Pages: 25-41.e6

    • DOI

      10.1016/j.molcel.2018.05.018

    • NAID

      120006491714

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Histone H2A variants confer specific properties to nucleosomes and impact on chromatin accessibility2018

    • Author(s)
      Osakabe Akihisa、Lorkovic Zdravko J、Kobayashi Wataru、Tachiwana Hiroaki、Yelagandula Ramesh、Kurumizaka Hitoshi、Berger Frederic
    • Journal Title

      Nucleic Acids Research

      Volume: 46 Issue: 15 Pages: 7675-7685

    • DOI

      10.1093/nar/gky540

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cancer-associated mutations of histones H2B, H3.1 and H2A.Z.1 affect the structure and stability of the nucleosome2018

    • Author(s)
      Arimura Yasuhiro、Ikura Masae、Fujita Risa、Noda Mamiko、Kobayashi Wataru、Horikoshi Naoki、Sun Jiying、Shi Lin、Kusakabe Masayuki、Harata Masahiko、Ohkawa Yasuyuki、Tashiro Satoshi、Kimura Hiroshi、Ikura Tsuyoshi、Kurumizaka Hitoshi
    • Journal Title

      Nucleic Acids Research

      Volume: - Pages: 10007-10018

    • DOI

      10.1093/nar/gky661

    • NAID

      120006545208

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Methods for Preparing Nucleosomes Containing Histone Variants2018

    • Author(s)
      Kujirai Tomoya、Arimura Yasuhiro、Fujita Risa、Horikoshi Naoki、Machida Shinichi、Kurumizaka Hitoshi
    • Journal Title

      Methods Mol Biol.

      Volume: 1832 Pages: 3-20

    • DOI

      10.1007/978-1-4939-8663-7_1

    • ISBN
      9781493986620, 9781493986637
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural Basis of Homology-Directed DNA Repair Mediated by RAD522018

    • Author(s)
      Saotome, M., Saito, K., Yasuda, T., Ohtomo, H., Sugiyama, S., Nishimura, Y., Kurumizaka, H., Kagawa, W.
    • Journal Title

      iScience

      Volume: 3 Pages: 50-62

    • DOI

      10.1016/j.isci.2018.04.005

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A chromatin integration labelling method enables epigenomic profiling with lower input2018

    • Author(s)
      Harada Akihito、Maehara Kazumitsu、Handa Tetsuya、Arimura Yasuhiro、Nogami Jumpei、Hayashi-Takanaka Yoko、Shirahige Katsuhiko、Kurumizaka Hitoshi、Kimura Hiroshi、Ohkawa Yasuyuki
    • Journal Title

      Nature Cell Biology

      Volume: 21 Issue: 2 Pages: 287-296

    • DOI

      10.1038/s41556-018-0248-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural Basis of Heterochromatin Formation by Human HP12018

    • Author(s)
      Machida Shinichi、Takizawa Yoshimasa、Ishimaru Masakazu、Sugita Yukihiko、Sekine Satoshi、Nakayama Jun-ichi、Wolf Matthias、Kurumizaka Hitoshi
    • Journal Title

      Molecular Cell

      Volume: 69 Issue: 3 Pages: 385-397

    • DOI

      10.1016/j.molcel.2017.12.011

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cryo-EM structure of the nucleosome containing the ALB1 enhancer DNA sequence2018

    • Author(s)
      Takizawa Yoshimasa、Tanaka Hiroki、Machida Shinichi、Koyama Masako、Maehara Kazumitsu、Ohkawa Yasuyuki、Wade Paul A.、Wolf Matthias、Kurumizaka Hitoshi
    • Journal Title

      Open Biology

      Volume: 8 Issue: 3 Pages: 170255-170255

    • DOI

      10.1098/rsob.170255

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Replication stress induces accumulation of FANCD2 at central region of large fragile genes.2018

    • Author(s)
      Okamoto Y, Iwasaki WM, Kugou K, Takahashi KK, Oda A, Sato K, Kobayashi W, Kawai H, Sakasai R, Takaori-Kondo A, Yamamoto T, Kanemaki MT, Taoka M, Isobe T, Kurumizaka H, Innan H, Ohta K, Ishiai M, Takata M.
    • Journal Title

      Nucleic Acids Res.

      Volume: 46(6) Issue: 6 Pages: 2932-2944

    • DOI

      10.1093/nar/gky058

    • NAID

      120006488604

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Parallel mapping with site-directed hydroxyl radicals and micrococcal nuclease reveals structural features of positioned nucleosomes in vivo.2017

    • Author(s)
      Fuse T, Katsumata K, Morohoshi K, Mukai Y, Ichikawa Y, Kurumizaka H, Yanagida A, Urano T, Kato H, Shimizu M.
    • Journal Title

      PLoS One

      Volume: 12 Issue: 10 Pages: e0186974-e0186974

    • DOI

      10.1371/journal.pone.0186974

    • NAID

      120006539368

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] SYCP3 regulates strand invasion activities of RAD51 and DMC12017

    • Author(s)
      Kobayashi Wataru、Hosoya Noriko、Machida Shinichi、Miyagawa Kiyoshi、Kurumizaka Hitoshi
    • Journal Title

      Genes to Cells

      Volume: 22 Issue: 9 Pages: 799-809

    • DOI

      10.1111/gtc.12513

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural diversity of the nucleosome2017

    • Author(s)
      Koyama M., Kurumizaka H.
    • Journal Title

      The Journal of Biochemistry

      Volume: 163 Issue: 2 Pages: 85-95

    • DOI

      10.1093/jb/mvx081

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Chromatin structure and dynamics as the platform for DNA repair.2020

    • Author(s)
      Yoshimasa Takizawa, Cheng-han Ho, Wataru Kobayashi, Hajime Ishii, Yasuhiro Arimura, Hitoshi Kurumizaka.
    • Organizer
      DNA Replication and Repair Structures & Cancer Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Structural studies of chromatin: Toward understanding the regulation of genomic DNA.2019

    • Author(s)
      Hitoshi Kurumizaka.
    • Organizer
      Multiscale Modeling of Chromatin: Bridging Experiment with Theory
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Structural studies of chromatin towards the understanding of epigenetics mechanisms.2019

    • Author(s)
      Hitoshi Kurumizaka.
    • Organizer
      Telluride workshop
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Structural studies of the chromatin: Towards the understanding of epigenetics2019

    • Author(s)
      胡桃坂 仁志
    • Organizer
      第13回日本エピジェネティクス研究会年会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Cryo-EM imaging of the chromatin architecture2019

    • Author(s)
      胡桃坂 仁志
    • Organizer
      第19回日本蛋白質科学会年会 第71回日本細胞生物学会大会 合同年次大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Cryo-EM studies for nucleosome and chromatin2019

    • Author(s)
      胡桃坂 仁志
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 出芽酵母ゲノムにおけるヒストンバリアントH2A.Zヌクレオソームの動態:部位特異的化学切断法による解析2019

    • Author(s)
      讓原秀隆、今井洸志、布施智博、柳田顕郎、胡桃坂仁志、香川亘、清水光弘
    • Organizer
      第92回 日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] In vivoでポジショニングしたヌクレオソームにおけるヒストンH4のN末端テールのDNA結合部位:部位特異的化学切断法による解析2019

    • Author(s)
      高附宏暢、布施智博、柳田顕郎、清水光弘
    • Organizer
      第92回 日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 出芽酵母ゲノムにおけるヒストン-DNA結合部位からのヌクレオソーム動態の考察2019

    • Author(s)
      清水光弘
    • Organizer
      平成31年度遺伝研研究会「クロマチン・核構造の形成とダイナミクスによるゲノム制御」
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 出芽酵母セントロメアにおけるヒストンH3バリアントCse4による部位特異的化学切断2019

    • Author(s)
      讓原秀隆、野上尭弘、高附宏暢、柳田顕郎、香川亘、清水光弘
    • Organizer
      第42回 日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 出芽酵母RPS5、RPS11B座におけるHMGBホモログHmo1のDNA結合部位の解析2019

    • Author(s)
      高附宏暢、布施智博、柳田顕郎、清水光弘
    • Organizer
      第42回 日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] クロマチンにおける遺伝子発現の構造基盤2019

    • Author(s)
      胡桃坂仁志
    • Organizer
      性スペクトラムー連続する表現型としての雌雄 第1 回 若手研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 部位特異的化学切断によるヒストン-DNA 結合部位のゲノムワイド解析への展開2018

    • Author(s)
      清水光弘
    • Organizer
      平成30年度国立遺伝学研究所研究会「クロマチン・細胞核の動的構造変換とゲノム機能制御」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] クロマチン基盤構造の多様性とDNA損傷修復2018

    • Author(s)
      胡桃坂仁志
    • Organizer
      本放射線影響学会第61回大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Nucleosome Remodeling and Structure2018

    • Author(s)
      Hitoshi Kurumizaka
    • Organizer
      INDO-JAPAN Conference (2018): Epigenetics, Human Microbiomes and Disease
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] クロマチンの高次構造とダイナミクスの相関構造解析2018

    • Author(s)
      胡桃坂 仁志
    • Organizer
      第31回日本放射光学会年会・放射光科学合同シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] クロマチンコーディングの構造基盤2018

    • Author(s)
      胡桃坂 仁志
    • Organizer
      染色体研究の最前線2018
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Chromatin contribution in DNA repair2017

    • Author(s)
      Hitoshi Kurumizaka
    • Organizer
      The 6th US-Japan DNA Repair Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Structural versatility and dynamics of chromatin units2017

    • Author(s)
      Hitoshi Kurumizaka
    • Organizer
      EMBO CONFERENCE “The Nucleosome: From Atoms to Genomes”
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Structural Biology of Epigenetic Chromatin Regulation2017

    • Author(s)
      Hitoshi Kurumizaka
    • Organizer
      15th Chinese Biophysics Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] エピジェネティクスの制御基盤としてのクロマチン構造多様性2017

    • Author(s)
      胡桃坂 仁志
    • Organizer
      DSSBシンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Structural studies for dynamic chromatin architecture2017

    • Author(s)
      胡桃坂 仁志
    • Organizer
      Dynamic Structural Biology"(DSB)第一回研究報告会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ヌクレオソームの構造と動的多様性によるゲノムDNA機構制御2017

    • Author(s)
      胡桃坂 仁志
    • Organizer
      第17回日本蛋白質科学会年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 細胞核でのクロマチン機能制御の構造基盤2017

    • Author(s)
      胡桃坂 仁志
    • Organizer
      日本大学文理学部生命科学科セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ゲノムDNA機能制御のクロマチン構造基盤2017

    • Author(s)
      胡桃坂 仁志
    • Organizer
      大阪大学蛋白質研究所セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ヌクレオソームのリモデリング機構2017

    • Author(s)
      胡桃坂 仁志
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] クロマチン構造とゲノム機能制御機構2017

    • Author(s)
      胡桃坂 仁志
    • Organizer
      平成29年度遺伝研研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 再構成クロマチンによるエピジェネティクス機構の解析2017

    • Author(s)
      胡桃坂 仁志
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ヒストンのDNA結合部位特異的切断によるヌクレオソームの解析2017

    • Author(s)
      清水 光弘
    • Organizer
      平成29年度年度国立遺伝学研究所研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Book] 生体の科学, vol. 68 No. 3(担当:パイオニア転写因子によるクロマチン構造変換)2017

    • Author(s)
      小山昌子, 胡桃坂仁志
    • Total Pages
      99
    • Publisher
      金原一郎記念医学医療振興財団
    • Related Report
      2017 Annual Research Report
  • [Book] ナノバイオ・メディシン2017

    • Author(s)
      宇理須 恒雄、佐久間 哲史、高田 望、竹中 繁織、小澤 岳昌、吉村 英哲、胡桃坂 仁志、越阪部 晃永、原田 昌彦、束田 裕一、宮成 悠介、塩見 美喜子、大西 遼
    • Total Pages
      232
    • Publisher
      近代科学社
    • ISBN
      4764950286
    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2022-02-28  

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